Target Validation Information
Target ID T55959
Target Name Sodium-dependent dopamine transporter
Target Type
Successful
Drug Potency against Target ISOTETRANDRINE Drug Info IC50 = 4200 nM
SECOCULARIDINE Drug Info IC50 = 13400 nM
1-Benzo[b]thiophen-2-yl-cyclohexylamine Drug Info IC50 = 123 nM [533891]
1-Benzo[b]thiophen-2-yl-cyclopentylamine Drug Info IC50 = 630 nM [533891]
N,Ndimethyl milnacipran Drug Info IC50 = 4500 nM [529263]
Bip-tyr(3bzl)-thr-pro-lys-thr Drug Info IC50 = 10000 nM [528289]
AMINOBENZTROPINE Drug Info IC50 = 373 nM [534349]
1-(1,4-diphenylbutan-2-yl)piperazine Drug Info IC50 = 400 nM [528226]
DIMETHYLGRISABINE Drug Info IC50 = 1100 nM
Methyl 2-(naphthalen-2-yl)benzoate Drug Info Ki = 4060 nM [528794]
Cis-3-phenoxy-2,3-dihydro-1H-inden-1-amine Drug Info IC50 = 2000 nM [529530]
(RS/SR)-2-[1-(4-chlorophenyl)pentyl]piperidine Drug Info IC50 = 170 nM [528619]
(RS/SR)-2-[1-(4-chlorophenyl)hexyl]piperidine Drug Info IC50 = 650 nM [528619]
(RS/SR)-2-[1-(4-chlorophenyl)ethyl]piperidine Drug Info IC50 = 1500 nM [528619]
ANONAINE Drug Info IC50 = 800 nM
4-(2-(3-fluorophenoxy)-4-methylphenyl)piperidine Drug Info Ki = 1450 nM [530474]
4-(2-(benzyloxy)-3-fluorophenyl)piperidine Drug Info Ki = 7370 nM [530474]
1-(2-(4-fluorophenoxy)phenyl)piperazine Drug Info Ki = 4420 nM [530474]
2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine Drug Info IC50 = 3800 nM [533479]
Benzyl-(2-phenyl-quinazolin-4-yl)-amine Drug Info Ki = 7900 nM [535513]
4-(2-phenoxyphenyl)piperidine Drug Info Ki = 284 nM [530474]
1-(1-Benzo[b]thiophen-2-yl-cyclopentyl)-azepane Drug Info IC50 = 21 nM [533891]
NORBOLDINE Drug Info IC50 = 16500 nM
RTI-336 Drug Info IC50 = 4.09 nM [552655]
1-(naphthalen-2-yl)-3-aza-bicyclo[3.1.0]hexane Drug Info IC50 = 190 nM [529523]
1-(thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexane Drug Info IC50 = 7500 nM [529523]
1-(4-aminophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 7 nM [530137]
PYROVALERONE Drug Info IC50 = 32 nM [530137]
(+/-)-threo-N-(2-Chlorobenzyl)methylphenidate Drug Info IC50 = 243 nM [531163]
PSEUDOCOCAINE Drug Info Ki = 13800 nM [525537]
GB-12819 Drug Info Ki = 595 nM [526396]
10R-hydroxylobel-7-ene Drug Info Ki = 290 nM [528364]
ANTIOQUINE Drug Info IC50 = 3400 nM
4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Drug Info Ki < 1000 nM [531079]
2-Amino-1-(4-methylthiophenyl)propane Drug Info IC50 = 3073 nM [530347]
2-((2-iodophenoxy)(phenyl)methyl)morpholine Drug Info Ki = 410 nM [528517]
Methylphenidate Drug Info Ki = 17 nM [552643]
4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine Drug Info Ki = 278 nM [530596]
1-(3,4-dichlorophenyl)-3-aza-bicyclo[3.1.0]hexane Drug Info IC50 = 380 nM [529523]
2-(Aminomethyl)-5-(1'-naphthyl)tetrahydrofuran Drug Info IC50 = 463 nM [529955]
2-(Aminomethyl)-5-(2'-naphthyl)tetrahydrofuran Drug Info IC50 = 28 nM [529955]
LITOXETINE Drug Info IC50 = 6700 nM [530367]
Bip-tyr-thr-pro-lys-thr(obzl)-gly Drug Info IC50 = 1800 nM [528289]
Bip-tyr-thr-pro-thr(obzl)-gly Drug Info IC50 = 300 nM [528289]
(2R,3R)-iodoreboxetine Drug Info Ki = 716 nM [529666]
WIN-35066-2 Drug Info IC50 = 23 nM [527309]
D-257C Drug Info Ki = 66.5 nM [529287]
(+/-)-threo-3',5'-Dichloromethylphenidate Drug Info IC50 = 65.6 nM [531163]
1S,2R-milnacipran Drug Info IC50 = 3200 nM [529776]
O-methyldauricine Drug Info IC50 = 5800 nM
ANOLOBINE Drug Info IC50 = 8100 nM
1-(3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 52 nM [528036]
1-(2-(2-chlorophenyl)-1-phenylethyl)piperazine Drug Info IC50 = 1300 nM [528224]
4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine Drug Info Ki = 139 nM [530474]
1-(2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 63 nM [528036]
4-(3-fluoro-2-phenoxyphenyl)piperidine Drug Info Ki = 239 nM [530474]
2-Aminomethyl-5-(p-t-butylphenyl)tetrahydrofuran Drug Info IC50 = 4301 nM [529955]
2-(tert-butylamino)-1-p-tolylpropan-1-one Drug Info IC50 = 1950 nM [530728]
2-(Aminomethyl)-5-phenethyltetrahydrofuran Drug Info IC50 = 513 nM [529955]
4-(2-(benzyloxy)-6-fluorophenyl)piperidine Drug Info Ki = 1030 nM [530474]
1-(3-chlorophenyl)-2-(piperidin-1-yl)propan-1-one Drug Info IC50 = 852 nM [530728]
4-(2-(2-fluorobenzyloxy)phenyl)piperidine Drug Info Ki = 1810 nM [530474]
2-(N-Pyrrolidinyl)-3'-fluoropropiophenone Drug Info IC50 = 156 nM [530728]
(R)-3-(naphthalen-2-ylmethoxy)pyrrolidine Drug Info IC50 = 3800 nM [530012]
4-(2-(4-fluorobenzyloxy)phenyl)piperidine Drug Info Ki = 9120 nM [530474]
3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol Drug Info IC50 = 1400 nM [528224]
2-(tert-Butylamino)-3',4'-dichloropentanophenone Drug Info Ki = 43.7 nM [530442]
2-(tert-Butylamino)-3',5'-difluoropropiophenone Drug Info IC50 = 5600 nM [530442]
8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane Drug Info IC50 = 10.2 nM [525906]
2-(N-Cyclopentylamino)-3'-fluoropropiophenone Drug Info IC50 = 693 nM [530728]
D-211B Drug Info Ki = 8.63 nM [529287]
D-211A Drug Info Ki = 41.8 nM [529287]
R-NORDULOXETINE Drug Info Ki = 3549 nM [530368]
2-(N-Pyrrolidinyl)-3'-methylpropiophenone Drug Info IC50 = 414 nM [530728]
2-Aminomethyl-5-(p-bromophenyl)tetrahydrofuran Drug Info IC50 = 167 nM [529955]
2-(N-Isopropylamino)-3'-chloropropiophenone Drug Info Ki = 3980 nM [530442]
1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol Drug Info Ki = 40 nM [527062]
1-(4-nitrophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 1110 nM [528036]
1-(4-bromophenyl)-2-(tert-butylamino)propan-1-one Drug Info IC50 = 689 nM [530728]
2pyrrolidin-1-yl-1-phenylpentan-1-one Drug Info IC50 = 52.3 nM [528036]
4-(2-fluoro-6-phenoxyphenyl)piperidine Drug Info Ki = 45 nM [530474]
2-(tert-Butylamino)-3',4'-dichlorobutyrophenone Drug Info IC50 = 175 nM [530442]
4-(2-(3-fluorophenoxy)phenyl)piperidine Drug Info Ki = 166 nM [530474]
2-Aminomethyl-5-(phenyl)tetrahydrofuran Drug Info IC50 = 147 nM [529955]
2-(N-Cyclopentylamino)-3'-bromopropiophenone Drug Info IC50 = 845 nM [530728]
(R)-Norfluoxetine Drug Info IC50 = 7133 nM [529814]
8S-hydroxylobelane Drug Info Ki = 1260 nM [528364]
1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine Drug Info Ki = 1950 nM [530918]
10S-hydroxylobelane Drug Info Ki = 1390 nM [528364]
8R-hydroxylobelane Drug Info Ki = 1880 nM [528364]
(2S,3S)-iodoreboxetine Drug Info Ki = 1457 nM [529666]
1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine Drug Info IC50 = 11000 nM [528224]
3-Phenyl-2-nortropene Drug Info Ki = 1222 nM [530502]
2-(N-Cyclopropylamino)-3-chloropropiophenone Drug Info IC50 = 265 nM [530442]
4-(2-(4-fluorophenoxy)-4-methylphenyl)piperidine Drug Info Ki = 1680 nM [530474]
2-(N-tert-Butylamino)-3'-chloropentanophenone Drug Info IC50 = 33 nM [530442]
3-(3,4-dichlorophenyl)-2-nortropene Drug Info Ki = 16 nM [530502]
4-(2-(phenoxymethyl)phenyl)piperidine Drug Info Ki = 396 nM [530474]
Threo-1-aza-5-phenyl[4.4.0]decane hydrochloride Drug Info IC50 = 244 nM [528826]
7-(piperidin-4-ylmethoxy)-2-naphthonitrile Drug Info IC50 = 8800 nM [530012]
4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine Drug Info Ki = 6 nM [530474]
2-(N-tert-Butylamino)-4'-chloropropiophenone Drug Info Ki = 2195 nM [530442]
1-Biphenyl-4-yl-3-aza-bicyclo[3.1.0]hexane Drug Info IC50 = 2300 nM [529523]
METHYLENEDIOXYMETHAMPHETAMINE Drug Info IC50 = 1442 nM [530347]
(R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide Drug Info IC50 = 9500 nM [530367]
8R-hydroxylobel-9-ene Drug Info Ki = 44 nM [530601]
(S)-3-(naphthalen-2-ylmethoxy)pyrrolidine Drug Info IC50 = 15000 nM [530012]
2-Aminomethyl-5-(p-methoxyphenyl)tetrahydrofuran Drug Info IC50 = 668 nM [529955]
6-(3-aza-bicyclo[3.1.0]hexan-1-yl)quinoline Drug Info IC50 = 3900 nM [529523]
2-(2'-Aminoethyl)-5-benzyltetrahydrofuran Drug Info IC50 = 565 nM [529955]
1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 40 nM [528036]
Threo-ritalinol methyl ether hydrochloride Drug Info IC50 = 281 nM [528826]
2-phenoxy-3-(piperidin-4-yl)pyridine Drug Info Ki = 4310 nM [530596]
2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine Drug Info Ki = 6410 nM [530596]
2-(N,N-Diethylamino)-3'-chloropropiophenone Drug Info IC50 = 1744 nM [530442]
1-(4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 32 nM [528036]
(2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine Drug Info Ki = 525.9 nM [530282]
[3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine Drug Info Ki = 2 nM [527062]
1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol Drug Info Ki = 11 nM [527062]
DIFLUOROBENZTROPINE Drug Info Ki = 4.11 nM [528473]
1-phenyl-3-aza-bicyclo[3.1.0]hexane Drug Info IC50 = 2700 nM [529523]
D-254C Drug Info Ki = 10.6 nM [529287]
WIN-35065-2 Drug Info IC50 = 23 nM [534240]
1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) Drug Info Ki = 2620 nM [530918]
(+/-)-threo-N-Benzyl-3'-chloromethylphenidate Drug Info IC50 = 41.2 nM [531163]
8S-hydroxylobel-9-ene Drug Info Ki = 960 nM [528364]
(+/-)-threo-N-(2-Methylfuran)methylphenidate Drug Info IC50 = 536 nM [531163]
10S-hydroxylobel-7-ene Drug Info Ki = 110 nM [528364]
Bip-tyr-thr-pro-lys-thr Drug Info IC50 = 19000 nM [528289]
(+/-)-threo-N-(4-Chlorobenzyl)methylphenidate Drug Info IC50 = 31.2 nM [531163]
1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) Drug Info Ki = 3160 nM [530918]
(+/-)-threo-N-(3-Methylthiopene)methylphenidate Drug Info IC50 = 143 nM [531163]
(+/-)-threo-Ritalinol methyl ether Drug Info IC50 = 97.1 nM [531163]
METHYLENEDIOXYAMPHETAMINE Drug Info IC50 = 890 nM [530914]
COCAINE.HCL Drug Info IC50 = 404 nM [528826]
Bip-tyr-thr-pro-ala-thr(obzl)-gly Drug Info IC50 = 1700 nM [528289]
Bip-tyr-thr-ala-pro-phe Drug Info IC50 = 900 nM [528289]
3-(4-Fluorophenyl)-2-nortropene Drug Info Ki = 1056 nM [530502]
Threo-ritalinol hydrochloride Drug Info IC50 = 1520 nM [528826]
Bip-tyr-ala-pro-lys-thr(obzl)-gly Drug Info IC50 = 11000 nM [528289]
(+/-)-threo-N-(3-Phenylpropyl)methylphenidate Drug Info IC50 = 267 nM [531163]
(+/-)-threo-4'-Ethylmethylphenidate Drug Info IC50 = 737 nM [531163]
2-(tert-Butylamino)-3'-fluoropropiophenone Drug Info Ki = 4510 nM [530442]
(+/-)-threo-N-(4-Methylpyridine)methylphenidate Drug Info IC50 = 128 nM [531163]
3-(4-Chlorophenyl)-2-nortropene Drug Info Ki = 231 nM [530502]
(+/-)-threo-N-(2-Methylthiopene)methylphenidate Drug Info IC50 = 224 nM [531163]
(+/-)-threo-N-Methyl-30-methylmethylphenidate Drug Info IC50 = 108 nM [531163]
2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine Drug Info Ki = 5150 nM [530596]
2-phenylpiperidine hydrochloride Drug Info IC50 = 8800 nM [528826]
4-(2-(3-chlorophenoxy)phenyl)piperidine Drug Info Ki = 310 nM [530474]
(+/-)-threo-N-(2-Phenylethyl)ritalinol Drug Info IC50 = 1430 nM [531163]
(+/-)-threo-Benzylphenidate Drug Info IC50 = 1020 nM [531163]
(+/-)-threo-N-Allylmethylphenidate Drug Info IC50 = 597 nM [531163]
(+/-)-threo-N-Ethylritalinol Drug Info IC50 = 2340 nM [531163]
1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-azepane Drug Info IC50 = 18 nM [533891]
1-(2-phenoxyphenyl)piperazine Drug Info Ki = 4730 nM [530474]
2-(tert-butylamino)-1-m-tolylpropan-1-one Drug Info IC50 = 1470 nM [530728]
1-Benzo[b]thiophen-2-yl-cycloheptylamine Drug Info IC50 = 416 nM [533891]
4-(2-((3-fluorophenoxy)methyl)phenyl)piperidine Drug Info Ki = 461 nM [530474]
(+/-)-threo-3',4'-Dichlororitalinol Drug Info IC50 = 4.2 nM [531163]
2-(N-Pyrrolidinyl)-3'-bromopropiophenone Drug Info IC50 = 750 nM [530728]
(+/-)-threo-3',4'-Dichlororitalinol methyl ether Drug Info IC50 = 1.7 nM [531163]
4-(2-(4-fluorophenoxy)phenyl)piperidine Drug Info Ki = 13 nM [530474]
4-(2-(benzyloxy)phenyl)piperidine Drug Info Ki = 1000 nM [530474]
1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one Drug Info IC50 = 1750 nM [530728]
2-(N-tert-Butylamino)-3'-chlorohexanophenone Drug Info IC50 = 69 nM [530442]
Threo-3,4-dichlororitalinol hydrochloride Drug Info IC50 = 22.5 nM [528826]
Trans-3-(o-tolyloxy)-2,3-dihydro-1H-inden-1-amine Drug Info IC50 = 600 nM [529530]
2-(N-Cyclopentylamino)-3'-chloropropiophenone Drug Info IC50 = 980 nM [530442]
(+/-)-threo-N-Benzyl-3',4'-dichlororitalinol Drug Info IC50 = 2.74 nM [531163]
(+/-)-threo-3',4'-Dichloromethylphenidate amide Drug Info IC50 = 16.4 nM [531163]
1-(benzofuran-2-yl)-3-aza-bicyclo[3.1.0]hexane Drug Info IC50 = 330 nM [529523]
N-Benzylmethylphenidate Drug Info IC50 = 52.9 nM [531163]
(+/-)-threo-N-(3-Chlorobenzyl)methylphenidate Drug Info IC50 = 106 nM [531163]
(+/-)-threo-N-Propargylmethylphenidate Drug Info IC50 = 821 nM [531163]
2-(tert-butylamino)-1-(3-chlorophenyl)butan-1-one Drug Info IC50 = 209 nM [530728]
(+/-)-threo-N-(6-Phenylhexyl)methylphenidate Drug Info IC50 = 656 nM [531163]
(+/-)-threo-N-(3-Methylfuran)methylphenidate Drug Info IC50 = 459 nM [531163]
1-phenyl-1-(piperidin-2-yl)propan-2-one Drug Info IC50 = 190 nM [528619]
3-p-Tolyl-8-aza-bicyclo[3.2.1]octane Drug Info IC50 = 33.6 nM [525906]
(+/-)-threo-N-(3-Phenylpropyl)ritalinol Drug Info IC50 = 194 nM [531163]
(+/-)-threo-N-(5-Phenylpentyl)methylphenidate Drug Info IC50 = 1570 nM [531163]
2-(N-tert-Butylamino)-3'-chlorooctanophenone Drug Info IC50 = 135 nM [530442]
(+/-)-threo-N-(2-Methylpyridine)methylphenidate Drug Info IC50 = 369 nM [531163]
(+/-)-threo-Methylphenidate amide Drug Info IC50 = 1730 nM [531163]
(+/-)-threo-N-(3-Methylpyridine)methylphenidate Drug Info IC50 = 173 nM [531163]
(RS/SR)-2-[1-(3,4-dichlorophenyl)butyl]piperidine Drug Info Ki = 43 nM [528619]
1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one Drug Info IC50 = 511 nM [530728]
(+/-)-threo-N-(4-Nitrobenzyl)methylphenidate Drug Info IC50 = 113 nM [531163]
2-(N-tert-Butylamino)-3',4'-dichloropropiophenone Drug Info IC50 = 271 nM [530442]
(RS/SR)-2-[1-(4-chlorophenyl)propyl]piperidine Drug Info IC50 = 2800 nM [528619]
(2R,3S)-2-[(4-Iodophenoxy)phenylmethyl]morpholine Drug Info Ki = 2100 nM [530282]
Erythro-3,4-dichloromethylphenidate hydrochloride Drug Info IC50 = 317 nM [528826]
3-(4-Trifluoromethylphenyl)-2-nortropene Drug Info Ki = 1494 nM [530502]
(cis)-1,6-diphenyl-3-aza-bicyclo[3.1.0]hexane Drug Info IC50 = 8700 nM [529523]
2-Aminomethyl-5-(p-chlorophenyl)tetrahydrofuran Drug Info IC50 = 313 nM [529955]
(+/-)-threo-Ritalinol Drug Info IC50 = 448 nM [531163]
(+/-)-threo-3-Fluororitalinol Drug Info IC50 = 281 nM [531163]
1-(1-Benzo[b]thiophen-2-yl-cycloheptyl)-azepane Drug Info IC50 = 67 nM [533891]
2-(N-tert-Butylamino)-3'-chloroheptanophenone Drug Info Ki = 709 nM [530442]
(+/-)-threo-3',5'-Dimethylmethylphenidate Drug Info IC50 = 4690 nM [531163]
PF-526014 Drug Info Ki = 2650 nM [530918]
1-(3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 62.9 nM [528036]
(+/-)-threo-N-(2-Phenylethyl)methylphenidate Drug Info IC50 = 678 nM [531163]
(+/-)-threo-N-(4-Phenylbutyl)ritalinol Drug Info IC50 = 623 nM [531163]
Threo-N-ethylritalinol hydrochloride Drug Info IC50 = 10400 nM [528826]
(+/-)-threo-N-(4-Methoxybenzyl)methylphenidate Drug Info IC50 = 79.1 nM [531163]
4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine Drug Info Ki = 1080 nM [530474]
1-(2-(phenoxymethyl)phenyl)piperazine Drug Info Ki = 701 nM [530474]
2-(N-tert-Butylamino)propiophenone Drug Info Ki = 5730 nM [530442]
1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 39.5 nM [528036]
2-(N-Pyrrolidinyl)-3'-nitropropiophenone Drug Info IC50 = 10000 nM [530728]
(+/-)-threo-N-Benzylmethylphenidate amide Drug Info IC50 = 384 nM [531163]
4-(2-pyrrolidin-1-yl-pentanoyl)benzonitrile Drug Info IC50 = 1000 nM [528036]
(RS/SR)-2-[1-(4-chlorophenyl)butyl]piperidine Drug Info IC50 = 450 nM [528619]
6-(piperidin-4-ylmethoxy)-2-naphthonitrile Drug Info IC50 = 6000 nM [530012]
(+/-)-3-((naphthalen-2-yloxy)methyl)pyrrolidine Drug Info IC50 = 1000 nM [530012]
(R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol Drug Info Ki = 2070 nM [530918]
Benzhydryl-(2-phenyl-quinazolin-4-yl)-amine Drug Info Ki = 530 nM [535513]
Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amine Drug Info Ki = 2470 nM [529592]
2-(N-Cyclopentylamino)-3'-methylpropiophenone Drug Info IC50 = 842 nM [530728]
1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one Drug Info IC50 = 185 nM [528036]
(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol Drug Info IC50 = 1065 nM [530946]
2-(N-Pyrrolidinyl)-3'-methoxypropiophenone Drug Info IC50 = 452 nM [530728]
2-(N-Cyclopentylamino)-3'-methoxypropiophenone Drug Info IC50 = 2270 nM [530728]
1-benzylpiperidine hydrochloride Drug Info IC50 = 1060 nM [528826]
D-257A Drug Info Ki = 204 nM [529287]
WIN-35065 Drug Info IC50 = 23 nM [528932]
(R)-DULOXETINE Drug Info IC50 = 660 nM [529824]
10R-hydroxylobelane Drug Info Ki = 570 nM [528364]
Para-chloroamphetamine Drug Info IC50 = 424 nM [530347]
ISOPILINE Drug Info IC50 = 2500 nM
2-((3-iodophenyl)(o-tolyloxy)methyl)morpholine Drug Info Ki = 740 nM [528517]
RTI-219 Drug Info IC50 = 5.7 nM [528932]
HOMOAROMOLINE Drug Info IC50 = 10900 nM
3alpha-(bis-chloro-phenylmethoxy)tropane Drug Info IC50 = 23.4 nM [528473]
(1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine Drug Info Ki = 1800 nM [535513]
3-alpha-Phenylmethoxy-3-beta-phenyl-nortropane Drug Info Ki = 117 nM [530502]
D-166A Drug Info Ki = 82.9 nM [529287]
PF-18298 Drug Info Ki = 544 nM [530918]
PF-3409409 Drug Info Ki = 2290 nM [530265]
(+/-)-threo-N-(4-Phenylbutyl)methylphenidate Drug Info IC50 = 205 nM [531163]
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine Drug Info IC50 = 12 nM [529569]
Vanoxerine Drug Info IC50 = 0.8 nM [552989]
(2R,3S)-2-[(3-Iodophenoxy)phenylmethyl]morpholine Drug Info Ki = 1900 nM [530282]
(S)-Norfluoxetine Drug Info IC50 = 6488 nM [529814]
1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine Drug Info IC50 = 10000 nM [533479]
COCLAURINE Drug Info IC50 = 14100 nM
(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol Drug Info IC50 = 2600 nM [530946]
NORSTEPHALAGINE Drug Info IC50 = 1400 nM
R-226161 Drug Info Ki = 583 nM [528772]
OBABERINE Drug Info IC50 = 3900 nM
WIN_35428 Drug Info IC50 = 21 nM [534240]
[N-[2-[(3'-N'-PROPYL-3''ALPHA-(BIS(4-FLUORORPHENYL)METHOXY)TROPANE-2''BETA-CARBOXYLIC ACID METHYL ESTER)(2-MERCAPTOETHYL)AMINO]ACETYL]-2-AMINOETHANETHIOLATO]RHENIUM(V) OXIDE (DIASTEREOMERIC MIX) Drug Info IC50 = 616 nM [534407]
NISOXETINE Drug Info IC50 = 2400 nM [529530]
References
Ref 533891J Med Chem. 1993 Apr 30;36(9):1188-93.Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites.
Ref 533891J Med Chem. 1993 Apr 30;36(9):1188-93.Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites.
Ref 529263Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. Epub 2008 Jan 9.Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.
Ref 528289J Med Chem. 2006 Jul 13;49(14):4048-51.Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction.
Ref 534349J Med Chem. 1997 Mar 14;40(6):851-7.3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile.
Ref 528226Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. Epub 2006 Jun 5.Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.
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