Co-Target(s) Information
| Target General Information | Top | ||||
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| Target ID | T18143 | Target Info | |||
| Target Name | MERS-CoV papain-like proteinase (PL-PRO) | ||||
| Synonyms |
MERS-CoV PLpro; MERS-CoV Non-structural protein 3; MERS-CoV nsp3
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| Gene Name | MERS-CoV rep; MERS-CoV 1a-1b | ||||
| Biochemical Class | Coronaviruses polyprotein 1ab family | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
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| Co-Target Name | Lysyl oxidase homolog 2 (LOXL2) | Clinical trial Target | ||||
| UniProt ID | LOXL2_HUMAN | |||||
| Gene Name | LOXL2 | |||||
| Synonyms |
Lysyl oxidaserelated protein WS914; Lysyl oxidaserelated protein 2; Lysyl oxidaselike protein 2; LOXL2
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| Representative Drug(s) | Drug Info | IC50 = 150 nM | [1] | |||
| Co-Target Name | Monoglyceride lipase (MAGL) | Clinical trial Target | ||||
| UniProt ID | MGLL_HUMAN | |||||
| Gene Name | MGLL | |||||
| Synonyms |
Monoacylglycerol lipase; MGL; Lysophospholipaselike; Lysophospholipase-like; Lysophospholipase homolog; HUK5; HU-K5
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| Representative Drug(s) | Drug Info | IC50 = 360 nM | [2] | |||
| Co-Target Name | Lysyl oxidase (LOX) | Literature-reported Target | ||||
| UniProt ID | LYOX_HUMAN | |||||
| Gene Name | LOX | |||||
| Synonyms |
Protein-lysine 6-oxidase
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| Representative Drug(s) | Drug Info | IC50 = 320 nM | [1] | |||
| Co-Target Name | Histone-lysine N-methyltransferase EHMT2 (EHMT2) | Literature-reported Target | ||||
| UniProt ID | EHMT2_HUMAN | |||||
| Gene Name | EHMT2 | |||||
| Synonyms |
Protein G9a; NG36; Lysine N-methyltransferase 1C; KMT1C; Histone H3-K9 methyltransferase 3; HLA-B-associated transcript 8; H3-K9-HMTase 3; G9A; Euchromatic histone-lysine N-methyltransferase 2; C6orf30; BAT8
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| Representative Drug(s) | Drug Info | IC50 = 600 nM | [3] | |||
| Co-Target Name | Lysyl oxidase homolog 4 (LOXL4) | Co-Target | ||||
| UniProt ID | LOXL4_HUMAN | |||||
| Gene Name | LOXL4 | |||||
| Synonyms |
Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C
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| Representative Drug(s) | Drug Info | IC50 = 59 nM | [1] | |||
| Co-Target Name | Lysyl oxidase homolog 3 (LOXL3) | Co-Target | ||||
| UniProt ID | LOXL3_HUMAN | |||||
| Gene Name | LOXL3 | |||||
| Synonyms |
Lysyl oxidase-like protein 3
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| Representative Drug(s) | Drug Info | IC50 = 93 nM | [1] | |||
| Co-Target Name | Gasdermin-D (GSDMD) | Co-Target | ||||
| UniProt ID | GSDMD_HUMAN | |||||
| Gene Name | GSDMD | |||||
| Synonyms |
Gasdermin domain-containing protein 1
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| Representative Drug(s) | Drug Info | IC50 = 400 nM | [4] | |||
| References | Top | ||||
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| REF 1 | Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3113-3118. | ||||
| REF 2 | Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors. J Med Chem. 2017 Jan 12;60(1):4-46. | ||||
| REF 3 | Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II). Bioorg Med Chem Lett. 2018 Apr 15;28(7):1234-1238. | ||||
| REF 4 | Gasdermin D (GSDMD) as a new target for the treatment of infection. Med. Chem. Commun. 2019;10:660-667. | ||||
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