Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53378 | Target Info | |||
| Target Name | Carbonic anhydrase IV (CA-IV) | ||||
| Synonyms |
Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV
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| Target Type | Successful Target | ||||
| Gene Name | CA4 | ||||
| Biochemical Class | Alpha-carbonic anhydrase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
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| Co-Target Name | Carbonic anhydrase VI (CA-VI) | Successful Target | ||||
| UniProt ID | CAH6_HUMAN | |||||
| Gene Name | CA6 | |||||
| Synonyms |
Secreted carbonic anhydrase; Salivary carbonic anhydrase; Carbonic anhydrase 6; Carbonate dehydratase VI
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| Representative Drug(s) | Drug Info | Ki = 0.07 nM | Click to Show More | [1] | ||
| 2 | Brinzolamide | Drug Info | Ki = 0.9 nM | [4] | ||
| Co-Target Name | Carbonic anhydrase II (CA-II) | Successful Target | ||||
| UniProt ID | CAH2_HUMAN | |||||
| Gene Name | CA2 | |||||
| Synonyms |
Carbonic anhydrase C; Carbonic anhydrase 2; Carbonate dehydratase II; CAC
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| Representative Drug(s) | Brinzolamide | Drug Info | Ki = 0.1259 nM | Click to Show More | [2] | |
| 2 | Drug Info | Ki = 1.13 nM | [1] | |||
| 3 | Drug Info | Ki = 25 nM | [9] | |||
| 4 | Sulfamylon | Drug Info | Ki = 170 nM | [10] | ||
| Co-Target Name | Carbonic anhydrase XII (CA-XII) | Successful Target | ||||
| UniProt ID | CAH12_HUMAN | |||||
| Gene Name | CA12 | |||||
| Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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| Representative Drug(s) | Sulfamylon | Drug Info | Ki = 0.3 nM | Click to Show More | [3] | |
| 2 | Brinzolamide | Drug Info | Ki = 3 nM | [6] | ||
| Co-Target Name | Carbonic anhydrase I (CA-I) | Successful Target | ||||
| UniProt ID | CAH1_HUMAN | |||||
| Gene Name | CA1 | |||||
| Synonyms |
Carbonic anhydrase B; Carbonic anhydrase 1; Carbonate dehydratase I; CAB
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| Representative Drug(s) | Drug Info | Ki = 0.31 nM | Click to Show More | [1] | ||
| 2 | Brinzolamide | Drug Info | Ki = 3 nM | [5] | ||
| Co-Target Name | Steryl-sulfatase (STS) | Successful Target | ||||
| UniProt ID | STS_HUMAN | |||||
| Gene Name | STS | |||||
| Synonyms |
Steryl-sulfate sulfohydrolase; Steroid sulfatase; STS; Estrone sulfatase; Arylsulfatase C; ASC
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| Representative Drug(s) | Drug Info | IC50 = 10 uM tube-1 | [7] | |||
| Co-Target Name | Carbonic anhydrase XIV (CA-XIV) | Successful Target | ||||
| UniProt ID | CAH14_HUMAN | |||||
| Gene Name | CA14 | |||||
| Synonyms |
UNQ690/PRO1335; Carbonic anhydrase 14; Carbonate dehydratase XIV
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| Representative Drug(s) | Brinzolamide | Drug Info | Ki = 24 nM | [8] | ||
| Co-Target Name | Amyloid beta A4 protein (APP) | Successful Target | ||||
| UniProt ID | A4_HUMAN | |||||
| Gene Name | APP | |||||
| Synonyms |
Protease nexin-II; PreA4; PN-II; Cerebral vascular amyloid peptide; CVAP; Amyloid-beta precursor protein; Amyloid-beta A4 protein; Alzheimer disease amyloid protein; APPI; APP; AD1; ABPP; A4
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| Representative Drug(s) | Curcumin | Drug Info | IC50 = 630 nM | [11] | ||
| Co-Target Name | Monoamine oxidase type A (MAO-A) | Successful Target | ||||
| UniProt ID | AOFA_HUMAN | |||||
| Gene Name | MAOA | |||||
| Synonyms |
Monoamine oxidase A; Amine oxidase [flavin-containing] A
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| Representative Drug(s) | Curcumin | Drug Info | Ki = 710 nM | [12] | ||
| Co-Target Name | Lactoylglutathione lyase (GLO1) | Clinical trial Target | ||||
| UniProt ID | LGUL_HUMAN | |||||
| Gene Name | GLO1 | |||||
| Synonyms |
S-D-lactoylglutathione methylglyoxal lyase; Methylglyoxalase; Ketone-aldehyde mutase; Glyoxalase I; GlxI; Glx I; GLO1; Aldoketomutase
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| Representative Drug(s) | Curcumin | Drug Info | Ki = 5 nM | [13] | ||
| Co-Target Name | Tissue factor (F3) | Successful Target | ||||
| UniProt ID | TF_HUMAN | |||||
| Gene Name | F3 | |||||
| Synonyms |
Thromboplastin; TF; F3; Coagulation factor III; CD142 antigen
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| Representative Drug(s) | Curcumin | Drug Info | IC50 = 13.16 nM | [14] | ||
| Co-Target Name | Carbonic anhydrase IX (CA-IX) | Clinical trial Target | ||||
| UniProt ID | CAH9_HUMAN | |||||
| Gene Name | CA9 | |||||
| Synonyms |
Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; PMW1; P54/58N; Membrane antigen MN; MN; G250 antigen (MN/CA IX/G250); G250; Carbonic anhydrase 9; Carbonate dehydratase IX; CAIX
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| Representative Drug(s) | Brinzolamide | Drug Info | Ki = 36 nM | Click to Show More | [4] | |
| 2 | Sulfamylon | Drug Info | Ki = 103 nM | [15] | ||
| Co-Target Name | Prostaglandin E synthase (PTGES) | Clinical trial Target | ||||
| UniProt ID | PTGES_HUMAN | |||||
| Gene Name | PTGES | |||||
| Synonyms |
p53-induced gene 12 protein; PIG12; PGES; PGE synthase; P53-induced apoptosis protein 12; Microsomal prostaglandin E synthase 1; Microsomal glutathione S-transferase 1-like 1; MPGES1; MPGES-1; MGST1L1; MGST1-L1
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| Representative Drug(s) | Curcumin | Drug Info | IC50 = 200 nM | [16] | ||
| Co-Target Name | Carbonic anhydrase VII (CA-VII) | Patented-recorded Target | ||||
| UniProt ID | CAH7_HUMAN | |||||
| Gene Name | CA7 | |||||
| Synonyms |
Carbonic anhydrase 7; Carbonate dehydratase VII
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| Representative Drug(s) | Brinzolamide | Drug Info | Ki = 2.8 nM | Click to Show More | [4] | |
| 2 | Sulfamylon | Drug Info | Ki = 75 nM | [17] | ||
| Co-Target Name | Nicotinate phosphoribosyltransferase (NAPRT) | Co-Target | ||||
| UniProt ID | PNCB_HUMAN | |||||
| Gene Name | NAPRT | |||||
| Synonyms |
NAPRTase; FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1
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| Representative Drug(s) | Salicyclic acid | Drug Info | Ki = 0.16 nM | [18] | ||
| Co-Target Name | Carbonic anhydrase V (CA5) | Co-Target | ||||
| UniProt ID | CAH5A_HUMAN; CAH5B_HUMAN | |||||
| Gene Name | CA5A; CA5B | |||||
| Synonyms |
Carbonate dehydratase V; Carbonic anhydrase V; CA-V
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| Representative Drug(s) | Drug Info | Ki = 0.84 nM | [19] | |||
| Co-Target Name | Carbonic anhydrase XIII (CA13) | Co-Target | ||||
| UniProt ID | CAH13_HUMAN | |||||
| Gene Name | CA13 | |||||
| Synonyms |
Carbonic anhydrase 13; Carbonate dehydratase XIII; CA-XIII
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| Representative Drug(s) | Brinzolamide | Drug Info | Ki = 11 nM | [4] | ||
| Co-Target Name | Carbonic anhydrase VB (CA5B) | Co-Target | ||||
| UniProt ID | CAH5B_HUMAN | |||||
| Gene Name | CA5B | |||||
| Synonyms |
Carbonic anhydrase 5B, mitochondrial; Carbonate dehydratase VB; Carbonic anhydrase VB; CA-VB
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| Representative Drug(s) | Brinzolamide | Drug Info | Ki = 30 nM | [20] | ||
| Co-Target Name | Carbonic anhydrase VA (CA5A) | Co-Target | ||||
| UniProt ID | CAH5A_HUMAN | |||||
| Gene Name | CA5A | |||||
| Synonyms |
Carbonic anhydrase 5A, mitochondrial; Carbonate dehydratase VA; CA-VA
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| Representative Drug(s) | Brinzolamide | Drug Info | Ki = 50 nM | [20] | ||
| Co-Target Name | CDGSH iron-sulfur domain-containing protein 1 (CISD1_HUMAN) | Co-Target | ||||
| UniProt ID | CISD1_HUMAN | |||||
| Gene Name | CISD1 | |||||
| Synonyms |
MitoNEET
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| Representative Drug(s) | Curcumin | Drug Info | Ki = 101 nM | [21] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata. Bioorg Med Chem Lett. 2011 Jan 15;21(2):710-4. | ||||
| REF 2 | A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma. Bioorg Med Chem Lett. 2013 Feb 15;23(4):939-43. | ||||
| REF 3 | Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. | ||||
| REF 4 | Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases. Bioorg Med Chem. 2013 Nov 15;21(22):7210-5. | ||||
| REF 5 | Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1005-9. | ||||
| REF 6 | Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett. 2007 Feb 15;17(4):987-92. | ||||
| REF 7 | Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). Bioorg Med Chem Lett. 2002 May 20;12(10):1343-6. | ||||
| REF 8 | Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2669-74. | ||||
| REF 9 | Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. | ||||
| REF 10 | Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV. Bioorg Med Chem Lett. 2000 May 15;10(10):1117-20. | ||||
| REF 11 | Neuritogenic activity of bi-functional bis-tryptoline triazole. Bioorg Med Chem. 2017 Feb 1;25(3):1195-1201. | ||||
| REF 12 | Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis. ACS Med Chem Lett. 2015 Dec 1;7(1):56-61. | ||||
| REF 13 | Recent advances in the discovery and development of glyoxalase I inhibitors. Bioorg Med Chem. 2020 Feb 15;28(4):115243. | ||||
| REF 14 | Microbial hydroxylation and glycosylation of pentacyclic triterpenes as inhibitors on tissue factor procoagulant activity. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1026-30. | ||||
| REF 15 | Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26. | ||||
| REF 16 | Targeting microsomal prostaglandin E2 synthase-1 (mPGES-1): the development of inhibitors as an alternative to non-steroidal anti-inflammatory drugs (NSAIDs). Medchemcomm. 2015;6:2081-123. | ||||
| REF 17 | Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6. | ||||
| REF 18 | WHO patent application no. 2017162840A1, SENSITIZATION OF CANCER CELLS TO NAMPT INHIBITORS BY NICOTINIC ACID PHOSPHORIBOSYLTRANSFERASE NEUTRALIZATION. | ||||
| REF 19 | Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. | ||||
| REF 20 | Carbonic anhydrases as targets for medicinal chemistry. Bioorg Med Chem. 2007 Jul 1;15(13):4336-50. | ||||
| REF 21 | Identification of small molecules that bind to the mitochondrial protein mitoNEET. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5350-5353. | ||||
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