Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T63609 Target Info
Target Name Adenylate cyclase type 1 (ADCY1)
Synonyms
Ca(2+)/calmodulin-activated adenylyl cyclase; Adenylyl cyclase 1; Adenylate cyclase type I; ATP pyrophosphate-lyase 1
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Target Type Successful Target
Gene Name ADCY1
Biochemical Class Phosphorus-oxygen lyase
UniProt ID
ADCY1_HUMAN
Co-Targets of This Target  Top
Co-Target Name Human immunodeficiency virus Protease (HIV PR) Successful Target
UniProt ID POL_HV1B1
Gene Name HIV PR
Synonyms
HIV Retropepsin; HIV PR
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Representative Drug(s) Adenosine monophosphate Drug Info Ki = 0.23 nM [1]
Co-Target Name Proto-oncogene c-Src (SRC) Successful Target
UniProt ID SRC_HUMAN
Gene Name SRC
Synonyms
pp60c-src; Tyrosine kinase (pp60(src)); Src tyrosine kinase; SRC1; Proto-oncogene tyrosine-protein kinase Src; Pp60(src); P60-Src; C-src TK; C-Src
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Representative Drug(s) Adenosine monophosphate Drug Info IC50 = 100 nM [2]
Co-Target Name Adenosine A1 receptor (ADORA1) Successful Target
UniProt ID AA1R_HUMAN
Gene Name ADORA1
Synonyms
Adenosine receptor A1; A(1) adenosine receptor
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Representative Drug(s) Adenosine monophosphate Drug Info EC50 = 500 nM [3]
Co-Target Name P2Y purinoceptor 2 (P2RY2) Clinical trial Target
UniProt ID P2RY2_HUMAN
Gene Name P2RY2
Synonyms
P2Y2; P2U1; P2U receptor; P2U purinoceptor 1; P2U nucleotide receptor; P2RY2; Adenosine P2Y2 receptor
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Representative Drug(s) Adenosine monophosphate Drug Info EC50 = 85 nM [4]
Co-Target Name Fructose-1,6-bisphosphatase (FBP1) Co-Target
UniProt ID F16P1_HUMAN
Gene Name FBP1
Synonyms
Fructose-1,6-bisphosphatase 1; FBPase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase
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Representative Drug(s) Adenosine monophosphate Drug Info IC50 = 140 nM [5]
References  Top
REF 1 Relationships between structure and interaction kinetics for HIV-1 protease inhibitors. J Med Chem. 2002 Dec 5;45(25):5430-9.
REF 2 Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60.
REF 3 Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. J Med Chem. 2012 Jul 26;55(14):6467-77.
REF 4 Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. J Med Chem. 2002 Jan 3;45(1):208-18.
REF 5 Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes. Bioorg Med Chem Lett. 2010 Jan 15;20(2):594-9

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