Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82393 | Target Info | |||
| Target Name | TNF alpha converting enzyme (ADAM17) | ||||
| Synonyms |
TNFalpha converting enzyme; TNF-alpha-converting enzyme; TNF-alpha converting enzyme; TNF-alpha convertase; TACE; Snake venom-like protease; Disintegrin and metalloproteinase domain-containing protein 17; CSVP; CD156b antigen; CD156b; ADAM 17; A disintegrin and metalloproteinase domain 17
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| Target Type | Clinical trial Target | ||||
| Gene Name | ADAM17 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Matrix metalloproteinase-1 (MMP-1) | Successful Target | ||||
| UniProt ID | MMP1_HUMAN | |||||
| Gene Name | MMP1 | |||||
| Synonyms |
Interstitial collagenase; Fibroblast collagenase; CLG
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| Representative Drug(s) | Apratastat | Drug Info | IC50 = 33 nM | [1] | ||
| Co-Target Name | Matrix metalloproteinase-13 (MMP-13) | Clinical trial Target | ||||
| UniProt ID | MMP13_HUMAN | |||||
| Gene Name | MMP13 | |||||
| Synonyms |
Matrix metalloproteinase 13; Collagenase-3; Collagenase 3
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| Representative Drug(s) | Apratastat | Drug Info | IC50 = 8 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1605-9. | ||||
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