Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T88338 | Target Info | |||
| Target Name | Bacterial 23S ribosomal RNA (Bact 23S rRNA) | ||||
| Synonyms |
RrnL; Plastid 23S rRNA
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Human immunodeficiency virus Protease (HIV PR) | Successful Target | ||||
| UniProt ID | POL_HV1B1 | |||||
| Gene Name | HIV PR | |||||
| Synonyms |
HIV Retropepsin; HIV PR
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| Representative Drug(s) | Drug Info | Ki = 0.0013 nM | Click to Show More | [1] | ||
| 2 | Drug Info | Ki = 0.005 nM | [2] | |||
| 3 | Drug Info | Ki = 0.026 nM | [3] | |||
| 4 | Drug Info | Ki = 0.029 nM | [3] | |||
| Co-Target Name | Monoamine oxidase type A (MAO-A) | Successful Target | ||||
| UniProt ID | AOFA_HUMAN | |||||
| Gene Name | MAOA | |||||
| Synonyms |
Monoamine oxidase A; Amine oxidase [flavin-containing] A
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| Representative Drug(s) | Linezolid | Drug Info | IC50 = 3.8 ug.mL-1 | [4] | ||
| Co-Target Name | Albendazole monooxygenase (CYP3A4) | Clinical trial Target | ||||
| UniProt ID | CP3A4_HUMAN | |||||
| Gene Name | CYP3A4 | |||||
| Synonyms |
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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| Representative Drug(s) | Drug Info | Ki = 410 nM | [5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4;11(11):1351-3. | ||||
| REF 2 | Rational approaches to improving selectivity in drug design. J Med Chem. 2012 Feb 23;55(4):1424-44. | ||||
| REF 3 | Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance. J Med Chem. 2008 Aug 14;51(15):4839-43. | ||||
| REF 4 | New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. J Med Chem. 2014 Jun 12;57(11):4487-97. | ||||
| REF 5 | Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54. | ||||
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