Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0O7HP
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| Former ID |
DIB018019
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| Drug Name |
example 98 (WO2011020806)
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| Synonyms |
GTPL6540; SCHEMBL1173236; example 98 [WO2011020806]
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| Drug Type |
Small molecular drug
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| Indication | Focal segmental glomerulosclerosis [ICD-11: MF8Y] | Clinical trial | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C18H18ClFN4O2
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| Canonical SMILES |
CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)C3(COCC(=N3)N)C)Cl
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| InChI |
1S/C18H18ClFN4O2/c1-10-5-11(19)7-22-16(10)17(25)23-12-3-4-14(20)13(6-12)18(2)9-26-8-15(21)24-18/h3-7H,8-9H2,1-2H3,(H2,21,24)(H,23,25)/t18-/m0/s1
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| InChIKey |
RAFVKOLBEOKYJW-SFHVURJKSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Beta-site APP-cleaving enzyme 2 (BACE2) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6540). | |||
| REF 2 | BACE2 as a new diabetes target: a patent review (2010 - 2012). Expert Opin Ther Pat. 2013 May;23(5):649-63. | |||
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