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| Target and Pathway |
Top |
| Target(s) |
Voltage-gated calcium channel (Cav) |
Target Info
|
Modulator |
[2], [3] |
| Voltage-gated sodium channel alpha Nav1.9 (SCN11A) |
Target Info
|
Modulator |
[1], [2] |
| References |
Top |
| REF 1 |
Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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| REF 2 |
Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46.
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| REF 3 |
Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34.
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