Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T79400 | Target Info | |||
| Target Name | Kallikrein-4 (KLK4) | ||||
| Synonyms |
Serine protease 17; Prostase; PSTS; PRSS17; Kallikreinlike protein 1; Kallikrein4; Kallikrein-like protein 1; KLKL1; KLK-L1; Enamel matrix serine proteinase 1; EMSP1
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| Target Type | Patented-recorded Target | ||||
| Gene Name | KLK4 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
9-(3,5-Difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL567134; MLS002471787; SCHEMBL3353019; HMS2198O14; BDBM50303441; NCGC00182110-01; NCGC00182110-02; SMR001395200; Q27165373; 9-(3,5-difluorophenyl)-6-(ethylamino)purine-2-carbonitrile; 9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile
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| Activity |
IC50 = 177827.94 nM
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[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-((3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)amino)-2-oxoethyl 2-(2-methyl-1H-indol-3-yl)acetate
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Investigative | Compound Info | ||
| Synonyms |
DKFZ-251; CHEMBL4218203; SCHEMBL20037008; GTPL10575; TQP0912; BDBM50459538; compound 11 [PMID: 30212625]; [2-[(3,5-dimethyl-1-phenylpyrazol-4-yl)amino]-2-oxoethyl] 2-(2-methyl-1H-indol-3-yl)acetate
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| Activity |
IC50 > 200000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14;53(1):52-60. | ||||
| REF 2 | Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity. J Med Chem. 2018 Oct 11;61(19):8859-8874. | ||||
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