Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82624 | Target Info | |||
| Target Name | Inositol 1,4,5-trisphosphate receptor (ITPR) | ||||
| Synonyms |
InsP3R; InsP3 receptor; IP3R; IP3 receptor
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| Target Type | Successful Target | ||||
| Gene Name | ITPR1; ITPR2; ITPR3 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4,5,-IP2
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Investigative | Compound Info | ||
| Synonyms |
1D-myo-inositol 4,5-bisphosphate
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
2,2-Difluoro-2-deoxy-inositol 1,4,5-trisphosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161466; 2,2-F-IP3; DL-2,2-Difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate; DTXSID60927704; (2,2-difluoro-3,6-dihydroxy-4,5-diphosphonooxycyclohexyl) dihydrogen phosphate; DL-myo-Inositol, 2-deoxy-2,2-difluoro-, 1,4,5-tris(dihydrogen phosphate); 5,5-Difluoro-3,6-dihydroxycyclohexane-1,2,4-triyl tris[dihydrogen (phosphate)]
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| Activity |
EC50 = 53000 nM
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[2] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2,5-Dihydroxy-3,4-diphosphonooxycyclohexyl) dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161456; BDBM50211666
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| Activity |
Ki = 292000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Synthesis and binding properties of myo-inositol 4,5,6-tris(phosphate) an analogue of myo-inositol 1,4,5-tris(phosphate). Correlation with the ionization state of the molecules. Bioorg Med Chem Lett. 1995 Jun 22;5(12):1225-30. | ||||
| REF 2 | Total synthesis of L-2,2-difluoro-2-deoxy-MYO-inositol 1,4,5-trisphosphate, a potent inhibitor of the enzymes of d-MYO-inositol 1,4,5-trisphosphate metabolism. Bioorg Med Chem Lett. 1991;1(12):705-10. | ||||
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