Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67103 | Target Info | |||
| Target Name | Integrin alpha-V (ITGAV) | ||||
| Synonyms | Vitronectin receptor subunit alpha; Vitronectin receptor alpha subunit; Vitronectin receptor; VTNR; VNRA; MSK8; CD51 antigen; CD51 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ITGAV | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (2S)-2-(1,3-benzothiazole-2-carbonylamino)-4-[5-(1,8-naphthyridin-2-yl)pentanoylamino]butanoic acid | Ligand Info | |||||
| Structure Description | Integrin AlphaVBeta3 ectodomain bound to antagonist TDI-4161 | PDB:6MK0 | ||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [1] |
| PDB Sequence |
FNLDVDSPAE
10 YSGPEGSYFG20 FAVDFFVPSA30 SSRMFLLVGA40 PKANTTQPGI50 VEGGQVLKCD 60 WSSTRRCQPI70 EFDATGNRDY80 AKDDPLEFKS90 HQWFGASVRS100 KQDKILACAP 110 LYHWRTEMKQ120 EREPVGTCFL130 QDGTKTVEYA140 PCRSQDIDAD150 GQGFCQGGFS 160 IDFTKADRVL170 LGGPGSFYWQ180 GQLISDQVAE190 IVSKYDPNVY200 SIKYNNQLAT 210 RTAQAIFDDS220 YLGYSVAVGD230 FNGDGIDDFV240 SGVPRAARTL250 GMVYIYDGKN 260 MSSLYNFTGE270 QMAAYFGFSV280 AATDINGDDY290 ADVFIGAPLF300 MDRGSDGKLQ 310 EVGQVSVSLQ320 RASGDFQTTK330 LNGFEVFARF340 GSAIAPLGDL350 DQDGFNDIAI 360 AAPYGGEDKK370 GIVYIFNGRS380 TGLNAVPSQI390 LEGQWAARSM400 PPSFGYSMKG 410 ATDIDKNGYP420 DLIVGAFGVD430 RAILYRARPV440 ITVNAGLEVY450 PSILNQDNKT 460 CSLPGTALKV470 SCFNVRFCLK480 ADGKGVLPRK490 LNFQVELLLD500 KLKQKGAIRR 510 ALFLYSRSPS520 HSKNMTISRG530 GLMQCEELIA540 YLRDESEFRD550 KLTPITIFME 560 YRLDYRTAAD570 TTGLQPILNQ580 FTPANISRQA590 HILLDCGEDN600 VCKPKLEVSV 610 DSDQKKIYIG620 DDNPLTLIVK630 AQNQGEGAYE640 AELIVSIPLQ650 ADFIGVVRNN 660 EALARLSCAF670 KTENQTRQVV680 CDLGNPMKAG690 TQLLAGLRFS700 VHQQSEMDTS 710 VKFDLQIQSS720 NLFDKVSPVV730 SHKVDLAVLA740 AVEIRGVSSP750 DHVFLPIPNW 760 EHKENPETEE770 DVGPVVQHIY780 ELRNNGPSSF790 SKAMLHLQWP800 YKYNNNTLLY 810 ILHYDIDGPM820 NCTSDMEINP830 LRIKIHTLGC874 GVAQCLKIVC884 QVGRLDRGKS 894 AILYVKSLLW904 TETFMNKENQ914 NHSYSLKSSA924 SFNVIEFPYK934 NLPIEDITNS 944 TLVTTNVTWG954
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel Pure alphaVbeta3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations. doi:10.1021/acsptsci.9b00041. | ||||
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