Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32247 | Target Info | |||
| Target Name | Calcitonin receptor (CALCR) | ||||
| Synonyms | CT-R | ||||
| Target Type | Successful Target | ||||
| Gene Name | CALCR | ||||
| Biochemical Class | GPCR secretin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol hemisuccinate | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C | ||||
| InChI | 1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1 | ||||
| InChIKey | WLNARFZDISHUGS-MIXBDBMTSA-N | ||||
| PubChem Compound ID | 65082 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7TYN Calcitonin Receptor in complex with Gs and salmon calcitonin peptide | ||||||
| Method | Electron microscopy | Resolution | 2.60 Å | Mutation | Yes | [1] |
| PDB Sequence |
KPFLYVVGRK
46 KMMDAQYKCY56 DRMQQLPAYQ66 GEGPYCNRTW76 DGWLCWDDTP86 AGVLSYQFCP 96 DYFPDFDPSE106 KVTKYCDEKG116 VWFKHPENNR126 TWSNYTMCNA136 FTPEKLKNAY 146 VLYYLAIVGH156 SLSIFTLVIS166 LGIFVFFRSL176 GCQRVTLHKN186 MFLTYILNSM 196 IIIIHLVEVV206 PNGELVRRDP216 VSCKILHFFH226 QYMMACNYFW236 MLCEGIYLHT 246 LIVVAVFTEK256 QRLRWYYLLG266 WGFPLVPTTI276 HAITRAVYFN286 DNCWLSVETH 296 LLYIIHGPVM306 AALVVNFFFL316 LNIVRVLVTK326 MRETHEAESH336 MYLKAVKATM 346 ILVPLLGIQF356 VVFPWRPSNK366 MLGKIYDYVM376 HSLIHFQGFF386 VATIYCFCNN 396 EVQTTVKRQW406 AQF
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| PDB ID: 7TYO Calcitonin receptor in complex with Gs and human calcitonin peptide | ||||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
PFLYVVGRKK
47 MMDAQYKCYD57 RMQYCNRTWD77 GWLCWDDTPA87 GVLSYQFCPD97 YFPDFDPSEK 107 VTKYCDVWFK120 HPENNRTWSN130 YTMCNAFTPE140 KLKNAYVLYY150 LAIVGHSLSI 160 FTLVISLGIF170 VFFRSLGCQR180 VTLHKNMFLT190 YILNSMIIII200 HLVEVVPNGE 210 LVRRDPVSCK220 ILHFFHQYMM230 ACNYFWMLCE240 GIYLHTLIVV250 AVFTEKQRLR 260 WYYLLGWGFP270 LVPTTIHAIT280 RAVYFNDNCW290 LSVETHLLYI300 IHGPVMAALV 310 VNFFFLLNIV320 RVLVTKMRET330 HEAESHMYLK340 AVKATMILVP350 LLGIQFVVFP 360 WRPSNKMLGK370 IYDYVMHSLI380 HFQGFFVATI390 YCFCNNEVQT400 TVKRQWAQF |
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| PDB ID: 7TYW Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
PFLYVVGRKK
47 MMDAQYKCYD57 RMQQLPAYQG67 EGPYCNRTWD77 GWLCWDDTPA87 GVLSYQFCPD 97 YFPDFDPSEK107 VTKYCDEKGV117 WFKHPENNRT127 WSNYTMCNAF137 TPEKLKNAYV 147 LYYLAIVGHS157 LSIFTLVISL167 GIFVFFRSLG177 CQRVTLHKNM187 FLTYILNSMI 197 IIIHLVEVVP207 NGELVRRDPV217 SCKILHFFHQ227 YMMACNYFWM237 LCEGIYLHTL 247 IVVAVFTEKQ257 RLRWYYLLGW267 GFPLVPTTIH277 AITRAVYFND287 NCWLSVETHL 297 LYIIHGPVMA307 ALVVNFFFLL317 NIVRVLVTKM327 RETHEAESHM337 YLKAVKATMI 347 LVPLLGIQFV357 VFPWRPSNKM367 LGKIYDYVMH377 SLIHFQGFFV387 ATIYCFCNNE 397 VQTTVKRQWA407
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| PDB ID: 7TYY Human Amylin2 Receptor in complex with Gs and salmon calcitonin peptide | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
KPFLYVVGRK
46 KMMDAQYKCY56 DRMQQLPAYQ66 GEGPYCNRTW76 DGWLCWDDTP86 AGVLSYQFCP 96 DYFPDFDPSE106 KVTKYCDEKG116 VWFKHPENNR126 TWSNYTMCNA136 FTPEKLKNAY 146 VLYYLAIVGH156 SLSIFTLVIS166 LGIFVFFRSL176 GCQRVTLHKN186 MFLTYILNSM 196 IIIIHLVEVV206 PNGELVRRDP216 VSCKILHFFH226 QYMMACNYFW236 MLCEGIYLHT 246 LIVVAVFTEK256 QRLRWYYLLG266 WGFPLVPTTI276 HAITRAVYFN286 DNCWLSVETH 296 LLYIIHGPVM306 AALVVNFFFL316 LNIVRVLVTK326 MRETHEAESH336 MYLKAVKATM 346 ILVPLLGIQF356 VVFPWRPSNK366 MLGKIYDYVM376 HSLIHFQGFF386 VATIYCFCNN 396 EVQTTVKRQ
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A structural basis for amylin receptor phenotype. Science. 2022 Mar 25;375(6587):eabm9609. | ||||
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