Target Interacting Protein Information
Target General Information | Top | ||||
---|---|---|---|---|---|
Target ID | T15776 | Target Info | |||
Target Name | Pyruvate dehydrogenase kinase 1 (PDHK1) | ||||
Synonyms | Pyruvate dehydrogenase kinase isoform 1; Pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial; PDHK1; PDH kinase 1 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | PDK1 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Kinases | [+] 1 Kinases | + | |||
Interacting Target Name | Pyruvate dehydrogenase kinase 2 (PDHK2) | Literature-reported Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PDKII; PDK2; PDH kinase 2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [1] | |||
2 | Affinity Capture-MS | [2] | |||
3 | Affinity Capture-MS | [3] | |||
4 | Reconstituted Complex | [4] | |||
Oxidoreductases | [+] 1 Oxidoreductases | + | |||
Interacting Protein Name | Pyruvate dehydrogenase E1 alpha 1 subunit (PDHA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | PDHA; PDHAD; PDHCE1A; PHE1A | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-MS | [2] | |||
2 | Biochemical Activity | [5] | |||
3 | Reconstituted Complex | [6] | |||
4 | Reconstituted Complex | [5] |
References | Top | ||||
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REF 1 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
REF 2 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. | ||||
REF 3 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23. | ||||
REF 4 | Formation of functional heterodimers by isozymes 1 and 2 of pyruvate dehydrogenase kinase. Biochim Biophys Acta. 2003 Feb 21;1645(2):183-92. | ||||
REF 5 | Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell. 2011 Dec 23;44(6):864-77. | ||||
REF 6 | Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol Cell. 2014 Feb 20;53(4):534-48. |
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