Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T47492 Target Info
Target Name Neutrophil cytosol factor 1 (NCF1)
Synonyms SH3PXD1A; SH3 and PX domain-containing protein 1A; P47-phox; P47(phox) NAD(P)H oxidase; Nox-organizing protein 2; Nox organizer 2; Neutrophil NADPH oxidase factor 1; NOXO2; NCF-47K; NCF-1; 47 kDa neutrophil oxidase factor; 47 kDa autosomal chronic granulomatous disease protein
Target Type Literature-reported Target
Gene Name NCF1
UniProt ID
NCF1_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 4 (TRAF4) Interacting Protein Interacting Protein Info
UniProt ID
TRAF4_HUMAN 
Synonyms CART1; MLN62; RNF83
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Yeast two hybrid [2]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Neutrophil cytosol factor 2 (NCF2) Interacting Protein Interacting Protein Info
UniProt ID
NCF2_HUMAN 
Synonyms NCF.2; NOXA2; P67.PHOX; P67PHOX
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-crystal Structure [4]
3 Far Western [5]
4 Protein-peptide [6]
5 Reconstituted Complex [5]
6 Reconstituted Complex [7]
7 Yeast two hybrid [2]
References  Top
REF 1 Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. J Biol Chem. 2002 Aug 2;277(31):28051-7.
REF 2 TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. Eur J Immunol. 2005 Aug;35(8):2477-85.
REF 3 Activation state-dependent interaction between Galphai and p67phox. Mol Cell Biol. 2006 Jul;26(13):5190-200.
REF 4 Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p. EMBO J. 2002 Aug 15;21(16):4268-76.
REF 5 Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10650-4.
REF 6 Mapping of functional domains in the p22(phox) subunit of flavocytochrome b(559) participating in the assembly of the NADPH oxidase complex by "peptide walking". J Biol Chem. 2002 Mar 8;277(10):8421-32.
REF 7 Rac1 disrupts p67phox/p40phox binding: a novel role for Rac in NADPH oxidase activation. Biochem Biophys Res Commun. 1999 Sep 16;263(1):118-22.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.