Target Validation Information
TTD ID	T60366
Target Name	Ornithine decarboxylase (ODC1)
Type of Target	Successful
Drug Potency against Target		Drug Info	Ki = 2200???000 nM	[4]
		Drug Info	IC50 = 39 nM	[3]
	3-(Aminooxy)propan-1-amine hydrochloride	Drug Info	IC50 = 35 nM	[3]
	3-methoxy-4-hydroxylonchocarpin	Drug Info	IC50 = 3600 nM	[1]
	4-hydroxylonchocarpin	Drug Info	IC50 = 4700 nM	[1]
	LONCHOCARPUSONE	Drug Info	IC50 = 2600 nM	[1]
	ZAPOTIN	Drug Info	IC50 = 3400 nM	[2]
References
REF 1	New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.
REF 2	Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.
REF 3	Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6.
REF 4	A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathog. 2010 Nov 24;6(11):e1001204.

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