Drug Information

Drug General Information
Drug ID
D01DDN
Former ID
DNCL001886
Drug Name
SCH-900271
Drug Type
Small molecular drug
Indication Acute ischemic stroke [ICD9: 434.91; ICD10:I61-I63] Phase 2 [532808], [543156]
Company
Merck
Structure
Download
2D MOL
Formula
C14H16N2O4
InChI
InChI=1S/C14H16N2O4/c1-14(5-6-14)4-2-3-8-7-9(17)20-12-10(8)11(18)15-13(19)16-12/h7H,2-6H2,1H3,(H2,15,16,18,19)
InChIKey
ARJKMWXLIHZLQZ-UHFFFAOYSA-N
PubChem Compound ID
56950369
PubChem Substance ID
135657169, 140747647, 160673680, 160863695, 163642896, 198938039, 237652952, 243886620, 252166679
Target and Pathway
Target(s) Nicotinic acid receptor 1 Target Info Modulator [532808]
KEGG Pathway cAMP signaling pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
References
Ref 532808Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.
Ref 543156(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8469).
Ref 532808Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.

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