Drug Information

Drug General Information
Drug ID
D04ODO
Former ID
DIB005801
Drug Name
GSK-256073
Synonyms
GPCR agonists (hyperlipidemia), GSK; GSK-256073-A; HM74A receptor agonists (hyperlipidemia), GSK; G protein-coupled receptor agonists (hyperlipidemia), GSK
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Phase 2 [532371], [543157]
Company
GlaxoSmithKline plc
Structure
Download
2D MOL
Formula
C10H13ClN4O2
InChI
InChI=1S/C10H13ClN4O2/c1-2-3-4-5-15-7-6(12-9(11)13-7)8(16)14-10(15)17/h2-5H2,1H3,(H,12,13)(H,14,16,17)
InChIKey
CGAMDQCXAAOFSR-UHFFFAOYSA-N
PubChem Compound ID
46215799
PubChem Substance ID
125738600, 140735132, 162924772, 224102250, 228581179, 246256072, 252166680
Target and Pathway
Target(s) Nicotinic acid receptor 1 Target Info Agonist [532371], [532808]
KEGG Pathway cAMP signaling pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
References
Ref 532371GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2013 Nov;15(11):1013-21.
Ref 543157(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8470).
Ref 532371GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2013 Nov;15(11):1013-21.
Ref 532808Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.

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