Drug Information

Drug General Information
Drug ID
D06KHX
Former ID
DIB005000
Drug Name
GPR109A agonists, Merck
Synonyms
Nicotinic acid receptor agonists (cardiovascular diseases); Nicotinic acid receptor agonists (cardiovascular diseases), Merck
Indication Cardiovascular disorder [ICD10:I00-I99] Investigative [532808]
Company
Merck & Co Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(=O)cc(c2c(o1)nc([nH]c2=O)OCC#CCC)CCCC1CC1
Target and Pathway
Target(s) Nicotinic acid receptor 1 Target Info Agonist [532808]
KEGG Pathway cAMP signaling pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
References
Ref 532808Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.
Ref 532808Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.

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