Drug General Information
Drug ID	D09TGC
Former ID	DIB005273
Drug Name	MK-1903
Synonyms	Second-generation niacin receptor agonists (oral, atherosclerosis), Arena/Merck & Co
Drug Type	Small molecular drug
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Phase 2	[522585], [541104]
Company	Arena Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C8H8N2O2
InChI	InChI=1S/C8H8N2O2/c11-8(12)7-5-2-3-1-4(3)6(5)9-10-7/h3-4H,1-2H2,(H,9,10)(H,11,12)
InChIKey	CUTZNERBKDMLAP-UHFFFAOYSA-N
PubChem Compound ID	11607970
PubChem Substance ID	16710707, 76205306, 139755579, 160669365, 160867278, 178102410, 230399561, 244167602, 246096309
Target and Pathway
Target(s)	Nicotinic acid receptor 1	Target Info	Agonist	[532014], [532808]
KEGG Pathway	cAMP signaling pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522585	ClinicalTrials.gov (NCT00847197) A Study to Evaluate MK1903 in Patients With Dyslipidemia (MK1903-004). U.S. National Institutes of Health.
Ref 541104	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5785).
Ref 532014	Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci Transl Med. 2012 Aug 22;4(148):148ra115.
Ref 532808	Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.

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