TTD | Drug: D0V9VG

Drug General Information
Drug ID	D0V9VG
Former ID	DIB014941
Drug Name	BMS-927711
Drug Type	Small molecular drug
Indication	Migraine [ICD9: 346; ICD10:G43]		Phase 2	[523614]
Company	Labrys Biologics
Structure		Download 2D MOL 3D MOL
Formula	C28H28F2N6O3
Canonical SMILES	N[C@H]1[C@@H](CC[C@@H](OC(=O)N2CCC(CC2)N3C(=O)Nc4ncccc3<br />4)c5ncccc15)c6cccc(F)c6F
InChI	1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1
InChIKey	KRNAOFGYEFKHPB-ANJVHQHFSA-N
PubChem Compound ID	51049968
Target and Pathway
Target(s)	Calcitoningene-related peptide type 1 receptor	Target Info	Antagonist	[532462]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Vascular smooth muscle contraction
Reactome	G alpha (s) signalling events
Reactome	Calcitonin-like ligand receptors
WikiPathways	GPCRs, Class B Secretin-like
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 523614	ClinicalTrials.gov (NCT01430442) Dose Ranging Study of a Drug for the Treatment of Acute Migraine. U.S. National Institutes of Health.
Ref 532462	BMS-927711 for the acute treatment of migraine: a double-blind, randomized, placebo controlled, dose-ranging trial. Cephalalgia. 2014 Feb;34(2):114-25.

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Drug Information