Drug Information

Drug General Information
Drug ID
D0WQ5S
Former ID
DCL001029
Drug Name
U-99363E
Synonyms
U 99363; U 99363E; U-99363; N-(1-benzylpiperidin-4-yl)-3-ethoxy-N-methylpyridin-2-amine; 3-Ethoxy-N-methyl-N-(1-(phenylmethyl)-4-piperidinyl)-2-pyridinylamine
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Preclinical [536463]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C20H27N3O
Canonical SMILES
CCOC1=C(N=CC=C1)N(C)C2CCN(CC2)CC3=CC=CC=C3
InChI
1S/C20H27N3O/c1-3-24-19-10-7-13-21-20(19)22(2)18-11-14-23(15-12-18)16-17-8-5-4-6-9-17/h4-10,13,18H,3,11-12,14-16H2,1-2H3
InChIKey
VNSBZWKWQFCKGO-UHFFFAOYSA-N
CAS Number
CAS 188989-96-0
PubChem Compound ID
133107
PubChem Substance ID
10243301, 14850770, 29311102, 57344392, 75713190, 104379017, 125693917, 129500976, 134339454, 135089419, 162805633, 196399562, 225047053, 233020536
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Binder [536463]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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