Drug General Information
Drug ID	D0G8TM
Former ID	DIB018061
Drug Name	(+)-5-(5-bromothiophen-3-yl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538966]
Structure		Download 2D MOL
Formula	C10H7BrO4S
InChI	InChI=1S/C10H7BrO4S/c1-10(5-2-8(11)16-4-5)7(12)3-6(15-10)9(13)14/h2-4H,1H3,(H,13,14)
InChIKey	WJDLYZAOTHNUJX-UHFFFAOYSA-N
PubChem Compound ID	11483496
PubChem Substance ID	16584953, 23618349, 42562390, 80293399, 103509957, 104085444, 135649821, 141075503, 229157469, 247762941
Target and Pathway
Target(s)	Nicotinic acid receptor 1	Target Info	Agonist	[527576]
KEGG Pathway	cAMP signaling pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538966	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1589).
Ref 527576	(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem. 2005 Jul 22;280(29):26649-52. Epub 2005 Jun 1.

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