Drug Information

Drug General Information
Drug ID
D0T2QL
Former ID
DIB019142
Drug Name
cinnamic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540182]
Structure
Download
2D MOL
Formula
C9H8O2
InChI
InChI=1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+
InChIKey
WBYWAXJHAXSJNI-VOTSOKGWSA-N
PubChem Compound ID
444539
PubChem Substance ID
3713, 12623, 74712, 98281, 491236, 583919, 588530, 607059, 3135953, 7890710, 10299545, 10507636, 11533177, 14717783, 15219201, 22394956, 24848120, 24890291, 24893022, 24900955, 24900956, 25823625, 26703239, 29203962, 29217737, 36887530, 37608491, 46516668, 48421995, 49759521, 49856504, 49955076, 53788561, 57404626, 57924781, 80708217, 85164956, 85246717, 87565486, 87565727, 88529734, 92297555, 93166038, 99450362, 103131880, 103198631, 104632365, 104667294, 115001552, 117544895
Target and Pathway
Target(s) phosphomevalonate kinase Target Info Inhibitor [531912]
Nicotinic acid receptor 1 Target Info Agonist [529913]
KEGG Pathway cAMP signaling pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
References
Ref 540182(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3203).
Ref 529913Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G). J Lipid Res. 2009 May;50(5):908-14.
Ref 531912Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. Biochem J. 1979 Jul 1;181(1):143-51.

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