Drug Information

Drug General Information
Drug ID
D07NDW
Former ID
DIB019627
Drug Name
compound 9n
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529657], [541114]
Structure
Download
2D MOL
Formula
C26H28N4O2
InChI
InChI=1S/C26H28N4O2/c1-17(2)20-10-12-21(13-11-20)24-15-28-30-19(4)23(14-27-25(24)30)26(31)29-18(3)16-32-22-8-6-5-7-9-22/h5-15,17-18H,16H2,1-4H3,(H,29,31)/t18-/m1/s1
InChIKey
DJSWNINDPRRCLC-GOSISDBHSA-N
PubChem Compound ID
25101223
PubChem Substance ID
56420949, 103626015, 104112324, 178102420
Target and Pathway
Target(s) Nicotinic acid receptor 1 Target Info Modulator (allosteric modulator) [529657]
KEGG Pathway cAMP signaling pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
References
Ref 529657Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4948-51.
Ref 541114(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5795).
Ref 529657Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4948-51.

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