TTD | Drug: D0VZ5X

Drug General Information
Drug ID	D0VZ5X
Former ID	DIB016394
Drug Name	BI-44370 TA
Synonyms	BI-44370; Calcitonin gene-related peptide antagonist (migraine), Boehringer Ingelheim
Indication	Migraine [ICD9: 346; ICD10:G43]		Phase 2	[522435]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1CN(C(=O)Nc2c1cccc2)C1CCN(CC1)C(=O)C[C@@H](C(=O)N1CCC(<br />CC1)N1CCOCC1)Cc1cc(c(c(c1)C)O)C
Target and Pathway
Target(s)	Calcitoningene-related peptide type 1 receptor	Target Info	Antagonist	[531309]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Vascular smooth muscle contraction
Reactome	G alpha (s) signalling events
Reactome	Calcitonin-like ligand receptors
WikiPathways	GPCRs, Class B Secretin-like
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522435	ClinicalTrials.gov (NCT00751803) BI 44370 TA in Acute Migraine Attack. U.S. National Institutes of Health.
Ref 531309	BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia. 2011 Apr;31(5):573-84.

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Drug Information