Drug Information

Drug General Information
Drug ID
D09ZPN
Former ID
DIB006017
Drug Name
MK-6892
Synonyms
MK-6892; Nicotinic acid 1 receptor (GPR109A) agonists, Merck
Drug Type
Small molecular drug
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Investigative [541107]
Company
Merck Frosst Canada & Co
Structure
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2D MOL

3D MOL
Formula
C19H24N4O5
InChI
InChI=1S/C19H22N4O5/c1-19(2,18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8,10,24H,3-6,9H2,1-2H3,(H,21,27)(H,25,26)
InChIKey
CJHXBFSJXDUJHP-UHFFFAOYSA-N
PubChem Compound ID
73755154
Target and Pathway
Target(s) Nicotinic acid receptor 1 Target Info Agonist [532808]
KEGG Pathway cAMP signaling pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
References
Ref 541107(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5788).
Ref 532808Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.

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