TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T15776	Pyruvate dehydrogenase kinase 1	D06SDP	Melanotetan II	Preclinical	6323491	C18H17ClO6	364.8	C[C@@H]1C[C@@H]2[C@H](O2)/C=C\\C=C\\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1	IC50 = 230000 nM	Non binder
T15776	Pyruvate dehydrogenase kinase 1	B5JCH6	[(1S,3Ar,6E,9S,9aR,10R,11aS)-6-[[tert-butyl(2-hydroxyethyl)amino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-10-yl] acetate	Investigative	24807809	C29H41NO9	547.6	CC(=O)O[C@@H]1C[C@]2([C@@H](CC[C@@H]2O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(CCO)C(C)(C)C)/C4=C(C3=O)O)COC)C)C	IC50 > 200000 nM	Non binder
T15776	Pyruvate dehydrogenase kinase 1	BEKU49	4-[4-(4-Methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol	Investigative	764764	C17H16N2O3	296.32	CC1=C(C(=NN1)C2=C(C=C(C=C2)O)O)C3=CC=C(C=C3)OC	IC50 = 648000 nM	Non binder
T15776	Pyruvate dehydrogenase kinase 1	BRE4P2	(1E,4S,4Ar,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-4a,5,6,6a,7,8,9,9a-octahydro-cyclopenta[5,6]naphtho[1,2-c]pyran-2,10(1H,4H)-dione	Investigative	11526786	C29H42N2O8	546.7	CC(=O)O[C@@H]1C[C@]2([C@@H](CC[C@@H]2O)C3=C1[C@]4([C@H](OC(=O)/C(=C/N(C)CCCN(C)C)/C4=C(C3=O)O)COC)C)C	IC50 > 200000 nM	Non binder
T15776	Pyruvate dehydrogenase kinase 1	BZ7W8L	Dichloroacetic acid	Investigative	6597	C2H2Cl2O2	128.94	C(C(=O)O)(Cl)Cl	IC50 = 1025000 nM	Non binder