TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T42392	Glutamate receptor AMPA 2	B0XUQ9	Chembl4206883	Investigative	145976409	C9H12N2O2S	212.27	CC1=CC2=C(C=C1)S(=O)(=O)NCN2C	EC50 = 403300 nM	Non binder
T42392	Glutamate receptor AMPA 2	B3HQE6	(+)-2-Amino-4-(4-hydroxy-1,2,5-oxadiazol-3-yl)butanoicAcid	Investigative	46238075	C6H9N3O4	187.15	C(CC(C(=O)O)N)C1=NONC1=O	EC50 = 489000 nM	Non binder
T42392	Glutamate receptor AMPA 2	B3T4OA	2-Amino-3-[3-hydroxy-5-(1-methyl-1H-tetrazol-5-yl)-isoxazol-4-yl]-propionic acid	Investigative	10658567	C8H10N6O4	254.2	CN1C(=NN=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	EC50 > 3000000 nM	Non binder
T42392	Glutamate receptor AMPA 2	B3Z4CI	(RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Investigative	11219775	C10H14N6O4	282.26	CCCN1N=C(N=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	EC50 = 830000 nM	Non binder
T42392	Glutamate receptor AMPA 2	B51ESM	(+)-2-Amino-5-(4-hydroxy-1,2,5-oxadiazol-3-yl)pentanoicAcid	Investigative	46238077	C7H11N3O4	201.18	C(CC1=NONC1=O)CC(C(=O)O)N	EC50 = 489778.82 nM	Non binder
T42392	Glutamate receptor AMPA 2	B5OZ7L	(3S,4As,6S,8aR)-6-[3-methoxy-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72543950	C18H24ClN5O4	409.9	COC1=C(C(=CC=C1)O[C@H]2CC[C@H]3CN[C@@H](C[C@H]3C2)C(=O)O)C4=NNN=N4.Cl	Ki = 252000 nM	Non binder
T42392	Glutamate receptor AMPA 2	B5ZSG4	(S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic acid	Investigative	10398361	C10H17NO4	215.25	CCC(=C(C[C@@H](C(=O)O)N)C(=O)O)CC	Ki = 280900 nM	Non binder
T42392	Glutamate receptor AMPA 2	B6NS7O	(3S,4Ar,6S,8aR)-6-(3-carboxyanilino)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Investigative	60023864	C17H22N2O4	318.4	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1NC3=CC=CC(=C3)C(=O)O)C(=O)O	Ki = 238000 nM	Non binder
T42392	Glutamate receptor AMPA 2	B7SB9O	(RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid	Investigative	16659202	C14H14N6O4	330.3	C1=CC=C(C=C1)CN2N=C(N=N2)C3=C(C(=O)NO3)CC(C(=O)O)N	EC50 > 3000000 nM	Non binder
T42392	Glutamate receptor AMPA 2	B7UB8A	(3S,4As,6S,8aR)-6-[5-phenoxy-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72544861	C23H26ClN5O4	471.9	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=C(C=CC(=C3)OC4=CC=CC=C4)C5=NNN=N5)C(=O)O.Cl	Ki = 335000 nM	Non binder
T42392	Glutamate receptor AMPA 2	B8WG9J	(3S,4As,6S,8aR)-6-(4-carboxyphenyl)sulfanyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Investigative	72546524	C17H21NO4S	335.4	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1SC3=CC=C(C=C3)C(=O)O)C(=O)O	Ki = 418000 nM	Non binder
T42392	Glutamate receptor AMPA 2	B95TLY	2-Amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid	Investigative	11818375	C10H14N6O4	282.26	CC(C)N1N=C(N=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	EC50 = 1000000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BH9O2D	(3S,4As,6S,8aR)-6-(2-carboxy-6-chlorophenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547536	C17H21Cl2NO5	390.3	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=C(C=CC=C3Cl)C(=O)O)C(=O)O.Cl	Ki = 1470000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BK8C6P	(1S,2S,6R,8S)-6-(Carboxymethyl)-3-oxo-7-oxa-4,12-diazatricyclo[6.4.0.02,6]dodec-9-ene-5-carboxylic acid	Investigative	71719873	C12H14N2O6	282.25	C1C=C[C@H]2[C@@H](N1)[C@@H]3C(=O)NC([C@@]3(O2)CC(=O)O)C(=O)O	Ki = 560000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BM2O9F	(3S,4As,6S,8aR)-6-(4-carboxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547033	C17H22ClNO5	355.8	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=CC=C(C=C3)C(=O)O)C(=O)O.Cl	Ki = 913000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BN6UO3	(3S,4Ar,6S,8aR)-6-[(2-carboxyphenyl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	73348020	C18H24ClNO4	353.8	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CC3=CC=CC=C3C(=O)O)C(=O)O.Cl	Ki = 29600000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BND0R8	(3S,4Ar,6S,8aR)-6-[(4-carboxyphenyl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	69972507	C18H24ClNO4	353.8	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CC3=CC=C(C=C3)C(=O)O)C(=O)O.Cl	Ki = 553000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BP05IL	(3S,4As,6S,8aR)-6-(2-carboxy-6-methylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547537	C18H24ClNO5	369.8	CC1=C(C(=CC=C1)C(=O)O)O[C@H]2CC[C@H]3CN[C@@H](C[C@H]3C2)C(=O)O.Cl	Ki = 818000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BPA3B1	(3S,4Ar,6S,8aR)-6-(4-carboxyanilino)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Investigative	72546282	C17H22N2O4	318.4	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1NC3=CC=C(C=C3)C(=O)O)C(=O)O	Ki = 1420000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BQ2K1N	(3S,4As,6S,8aR)-6-[2-fluoro-6-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72544417	C17H21ClFN5O3	397.8	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=C(C=CC=C3F)C4=NNN=N4)C(=O)O.Cl	Ki = 450000 nM	Non binder
T42392	Glutamate receptor AMPA 2	BT0Y7O	(R)-N-(2-Phenylpropyl)methanesulfonamide	Investigative	52945897	C10H15NO2S	213.3	C[C@@H](CNS(=O)(=O)C)C1=CC=CC=C1	EC50 = 1980000 nM	Non binder
T42392	Glutamate receptor AMPA 2	D09VYB	UBP-302	Investigative	6420161	C15H15N3O6	333.3	C1=CC=C(C(=C1)CN2C(=O)C=CN(C2=O)C[C@@H](C(=O)O)N)C(=O)O	IC50 > 300000 nM	Non binder