TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T47941	Phosphodiesterase 4	D0U7GK	Thalidomide	Approved	5426	C13H10N2O4	258.23	C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O	IC50 > 500000 nM	Non binder
T47941	Phosphodiesterase 4	D0M3IN	Xanthine	Phase 1	1188	C5H4N4O2	152.11	C1=NC2=C(N1)C(=O)NC(=O)N2	Ki > 200000 nM	Non binder
T47941	Phosphodiesterase 4	B06BJK	3-(2-Methoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	17757114	C18H16N4O2S	352.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B0EPU3	Triazolothiadiazine, 11E	Investigative	17757138	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)C2=NN=C3N2N=C(CS3)C4=C(C=CC=C4OC)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B0F7ZT	Triazolothiadiazine, 10G	Investigative	17757150	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC(=C(C=C4)OC)OC	IC50 = 6900000 nM	Non binder
T47941	Phosphodiesterase 4	B0WI4T	4-[2-[[2-(Diethylamino)-6,7-dimethoxyquinazolin-4-yl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol;hydrochloride	Investigative	13408818	C23H31ClN4O5	479	CCN(CC)C1=NC2=CC(=C(C=C2C(=N1)NCC(C3=CC(=C(C=C3)O)CO)O)OC)OC.Cl	IC50 = 428000 nM	Non binder
T47941	Phosphodiesterase 4	B10LUT	Triazolothiadiazine, 10F	Investigative	17757144	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)OC)C2=NN3C(=NN=C3SC2)C4=C(C=CC(=C4)OC)OC	IC50 = 11900000 nM	Non binder
T47941	Phosphodiesterase 4	B15JFD	1H-Pyridazino(4,5-b)indol-1-one, 2,5-dihydro-4-(3,5-dimethyl-1H-pyrazol-1-yl)-, hydrazone, hydrochloride	Investigative	5488456	C15H16ClN7	329.79	CC1=CC(=NN1C2=NN=C(C3=C2NC4=CC=CC=C43)NN)C.Cl	IC50 = 348000 nM	Non binder
T47941	Phosphodiesterase 4	B15OJM	3-(2-Ethoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	17757163	C19H18N4O2S	366.4	CCOC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=CC=C(C=C4)OC	IC50 = 4500000 nM	Non binder
T47941	Phosphodiesterase 4	B1PEN9	Triazolothiadiazine, 7D	Investigative	17757127	C19H18N4O3S	382.4	COC1=CC=CC(=C1)C2=NN3C(=NN=C3SC2)C4=C(C(=CC=C4)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B23VNG	Triazolothiadiazine, 11F	Investigative	17757145	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(CS3)C4=C(C=CC=C4OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B2M5VG	3-(1-Methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-purin-7-yl)-propionic acid	Investigative	10378908	C12H16N4O4	280.28	CCCN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCC(=O)O	Ki > 200000 nM	Non binder
T47941	Phosphodiesterase 4	B2TL4H	6-(2,5-Dimethoxyphenyl)-3-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	662394	C19H18N4O3S	382.4	COC1=CC(=C(C=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC(=CC=C4)OC	IC50 = 12600000 nM	Non binder
T47941	Phosphodiesterase 4	B2UC9S	6-(2,5-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	3849553	C19H18N4O3S	382.4	COC1=CC(=C(C=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC	IC50 = 8900000 nM	Non binder
T47941	Phosphodiesterase 4	B2WX7Y	2,2'-Bi[1H-imidazole]-4-carbonitrile	Investigative	13663754	C7H5N5	159.15	C1=CN=C(N1)C2=NC=C(N2)C#N	IC50 = 339000 nM	Non binder
T47941	Phosphodiesterase 4	B39YUJ	Triazolothiadiazine, 9I	Investigative	44143467	C19H18N4O2S	366.4	CC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=C(C=C(C=C4)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B3V4RT	Triazolothiadiazine, 6F	Investigative	17757140	C19H18N4O3S	382.4	COC1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(CS3)C4=CC=CC=C4OC	IC50 = 19600000 nM	Non binder
T47941	Phosphodiesterase 4	B3XZ9Y	Triazolothiadiazine, 7F	Investigative	17757141	C19H18N4O3S	382.4	COC1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(CS3)C4=CC(=CC=C4)OC	IC50 = 8000000 nM	Non binder
T47941	Phosphodiesterase 4	B48WTE	Triazolothiadiazine, 10H	Investigative	17757156	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC(=CC(=C4)OC)OC	IC50 = 12700000 nM	Non binder
T47941	Phosphodiesterase 4	B4T5BM	1-Methyl-3-propyl-7-[3-(dimethylamino)propyl]xanthine	Investigative	9971635	C14H23N5O2	293.36	CCCN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCCN(C)C	Ki > 200000 nM	Non binder
T47941	Phosphodiesterase 4	B50XPG	Triazolothiadiazine, 10K	Investigative	135750252	C18H16N4O3S	368.4	COC1=CC(=C(C=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4O	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B53AMD	Triazolothiadiazine, 10D	Investigative	17757130	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)OC)C2=NN3C(=NN=C3SC2)C4=C(C(=CC=C4)OC)OC	IC50 = 11900000 nM	Non binder
T47941	Phosphodiesterase 4	B5E4LV	Triazolothiadiazine, 11J	Investigative	17757165	C20H20N4O3S	396.5	CCOC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=C(C=CC=C4OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B5S1BX	4-[2-[[4-(Diethylamino)-6,7-dimethoxyquinazolin-2-yl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol;hydrochloride	Investigative	13408812	C23H31ClN4O5	479	CCN(CC)C1=NC(=NC2=CC(=C(C=C21)OC)OC)NCC(C3=CC(=C(C=C3)O)CO)O.Cl	IC50 = 339000 nM	Non binder
T47941	Phosphodiesterase 4	B5VR6A	Triazolothiadiazine, 11K	Investigative	135750253	C18H16N4O3S	368.4	COC1=C(C(=CC=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4O	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B6K3VN	Triazolothiadiazine, 8H	Investigative	17757154	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=CC(=C4)OC)OC	IC50 = 9500000 nM	Non binder
T47941	Phosphodiesterase 4	B71QCM	(8Br)-6,7-dimethoxy-3,3a,4,8b-tetrahydro-1H-indeno[2,1-b]pyrrol-2-one	Investigative	44281955	C13H15NO3	233.26	COC1=C(C=C2[C@H]3CC(=O)NC3CC2=C1)OC	IC50 = 800000 nM	Non binder
T47941	Phosphodiesterase 4	B74LNA	Triazolothiadiazine, 7H	Investigative	17757153	C19H18N4O3S	382.4	COC1=CC=CC(=C1)C2=NN3C(=NN=C3SC2)C4=CC(=CC(=C4)OC)OC	IC50 = 13400000 nM	Non binder
T47941	Phosphodiesterase 4	B75DEB	6-(4-Methoxyphenyl)-3-(2-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	935803	C18H16N4OS	336.4	CC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=CC=C(C=C4)OC	IC50 = 12500000 nM	Non binder
T47941	Phosphodiesterase 4	B7C2AP	3-(3,4-Dimethoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	3788138	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=C(C=C4)OC)OC	IC50 = 7500000 nM	Non binder
T47941	Phosphodiesterase 4	B7FSZ6	Triazolothiadiazine, 8E	Investigative	17757135	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=C(C=C(C=C4)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B7SN1C	Triazolothiadiazine, 10J	Investigative	17757164	C20H20N4O3S	396.5	CCOC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=C(C=CC(=C4)OC)OC	IC50 = 13400000 nM	Non binder
T47941	Phosphodiesterase 4	B7TL5R	Triazolothiadiazine, 7B	Investigative	17757119	C18H16N4O2S	352.4	COC1=CC=CC(=C1)C2=NN3C(=NN=C3SC2)C4=CC(=CC=C4)OC	IC50 = 12600000 nM	Non binder
T47941	Phosphodiesterase 4	B81ZFW	6-[6-(3-Methoxyphenyl)-2,7-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-ylidene]-1-cyclohexa-2,4-dienone	Investigative	3244396	C17H14N4O2S	338.4	COC1=CC=CC(=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4O	IC50 = 14100000 nM	Non binder
T47941	Phosphodiesterase 4	B8JH1D	Triazolothiadiazine, 9G	Investigative	17757149	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=C(C=C4)OC)OC)OC	IC50 = 6700000 nM	Non binder
T47941	Phosphodiesterase 4	B8OKI0	Triazolothiadiazine, 6C	Investigative	17757123	C18H16N4O2S	352.4	COC1=CC=C(C=C1)C2=NN=C3N2N=C(CS3)C4=CC=CC=C4OC	IC50 = 14100000 nM	Non binder
T47941	Phosphodiesterase 4	B8WME4	Triazolothiadiazine, 11A	Investigative	17757116	C19H18N4O3S	382.4	COC1=C(C(=CC=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B8YM3T	Triazolothiadiazine, 9E	Investigative	17757136	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)C2=NN3C(=NN=C3SC2)C4=C(C=C(C=C4)OC)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	B94IJG	Triazolothiadiazine, 11C	Investigative	17757125	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN=C3N2N=C(CS3)C4=C(C=CC=C4OC)OC	IC50 = 19700000 nM	Non binder
T47941	Phosphodiesterase 4	B94MDF	3-(3-Methoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	4363048	C18H16N4O2S	352.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=CC=C4)OC	IC50 = 12600000 nM	Non binder
T47941	Phosphodiesterase 4	B9B0HS	4-(4-Butoxy-3-methoxy-phenyl)-pyrrolidin-2-one	Investigative	14537161	C15H21NO3	263.33	CCCCOC1=C(C=C(C=C1)C2CC(=O)NC2)OC	IC50 > 1000000 nM	Non binder
T47941	Phosphodiesterase 4	B9BR4Z	2-[[4-(Diethylamino)-6,7-dimethoxyquinazolin-2-yl]amino]-1-phenylethanol	Investigative	13408794	C22H28N4O3	396.5	CCN(CC)C1=NC(=NC2=CC(=C(C=C21)OC)OC)NCC(C3=CC=CC=C3)O	IC50 = 328000 nM	Non binder
T47941	Phosphodiesterase 4	B9DFL2	9-[(4Ar,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-chloro-7H-purin-8-one	Investigative	90662967	C10H10ClN4O7P	364.63	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=NC=N4)Cl)NC3=O)O)OP(=O)(O1)O	IC50 = 330000 nM	Non binder
T47941	Phosphodiesterase 4	B9U5EF	Triazolothiadiazine, 6H	Investigative	17757152	C19H18N4O3S	382.4	COC1=CC=CC=C1C2=NN3C(=NN=C3SC2)C4=CC(=CC(=C4)OC)OC	IC50 = 13400000 nM	Non binder
T47941	Phosphodiesterase 4	B9XZQ1	Triazolothiadiazine, 9D	Investigative	17757129	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)C2=NN3C(=NN=C3SC2)C4=C(C(=CC=C4)OC)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BB04SJ	3-(2-Methoxyphenyl)-6-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	17757113	C18H16N4O2S	352.4	COC1=CC=CC(=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC	IC50 = 12000000 nM	Non binder
T47941	Phosphodiesterase 4	BB7X3T	Triazolothiadiazine, 11I	Investigative	17757160	C19H18N4O2S	366.4	CC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=C(C=CC=C4OC)OC	IC50 = 14100000 nM	Non binder
T47941	Phosphodiesterase 4	BBE5I1	4-(3-Butoxy-phenyl)-pyrrolidin-2-one	Investigative	14537164	C14H19NO2	233.31	CCCCOC1=CC=CC(=C1)C2CC(=O)NC2	IC50 > 1000000 nM	Non binder
T47941	Phosphodiesterase 4	BC8IP3	6-(2,5-Dimethoxyphenyl)-3-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	3835979	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN=C3N2N=C(CS3)C4=C(C=CC(=C4)OC)OC	IC50 = 10100000 nM	Non binder
T47941	Phosphodiesterase 4	BC9Z5P	Triazolothiadiazine, 11B	Investigative	17757121	C19H18N4O3S	382.4	COC1=C(C(=CC=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC(=CC=C4)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BCJX69	4-[2-Methoxy-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-butyric acid	Investigative	14537156	C15H19NO5	293.31	COC1=C(C=C(C=C1)C2CC(=O)NC2)OCCCC(=O)O	IC50 = 400000 nM	Non binder
T47941	Phosphodiesterase 4	BD6J9S	Triazolothiadiazine, 9K	Investigative	135750251	C18H16N4O3S	368.4	COC1=CC(=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4O)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BD7W0S	Triazolothiadiazine, 11H	Investigative	17757157	C20H20N4O4S	412.5	COC1=C(C(=CC=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC(=CC(=C4)OC)OC	IC50 = 19600000 nM	Non binder
T47941	Phosphodiesterase 4	BD96RW	Triazolothiadiazine, 7G	Investigative	17757148	C19H18N4O3S	382.4	COC1=C(C=C(C=C1)C2=NN=C3N2N=C(CS3)C4=CC(=CC=C4)OC)OC	IC50 = 9000000 nM	Non binder
T47941	Phosphodiesterase 4	BD9T8Q	3-(3,4-Dimethoxyphenyl)pyrrolidine;oxalic acid	Investigative	44282299	C14H19NO6	297.3	COC1=C(C=C(C=C1)C2CCNC2)OC.C(=O)(C(=O)O)O	IC50 > 1000000 nM	Non binder
T47941	Phosphodiesterase 4	BDO64U	Triazolothiadiazine, 9B	Investigative	17757120	C19H18N4O3S	382.4	COC1=CC(=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=CC=C4)OC)OC	IC50 = 14100000 nM	Non binder
T47941	Phosphodiesterase 4	BDOF07	2-Pyrrolidinone, 4-(3-hydroxy-4-methoxyphenyl)-	Investigative	10130484	C11H13NO3	207.23	COC1=C(C=C(C=C1)C2CC(=O)NC2)O	IC50 > 1000000 nM	Non binder
T47941	Phosphodiesterase 4	BE08SQ	3-[2-[[4-(Diethylamino)-6,7-dimethoxyquinazolin-2-yl]amino]-1-hydroxyethyl]phenol	Investigative	13408815	C22H28N4O4	412.5	CCN(CC)C1=NC(=NC2=CC(=C(C=C21)OC)OC)NCC(C3=CC(=CC=C3)O)O	IC50 = 295000 nM	Non binder
T47941	Phosphodiesterase 4	BEFY93	Triazolothiadiazine, 9C	Investigative	17757124	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN=C3N2N=C(CS3)C4=C(C=C(C=C4)OC)OC	IC50 = 13400000 nM	Non binder
T47941	Phosphodiesterase 4	BEI93Q	3,6-Bis(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	17757112	C18H16N4O2S	352.4	COC1=CC=CC=C1C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC	IC50 = 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BERQ35	Triazolothiadiazine, 8K	Investigative	135750250	C17H14N4O2S	338.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4O	IC50 = 8400000 nM	Non binder
T47941	Phosphodiesterase 4	BF4I2X	Triazolothiadiazine, 7J	Investigative	17757162	C19H18N4O2S	366.4	CCOC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=CC(=CC=C4)OC	IC50 = 11200000 nM	Non binder
T47941	Phosphodiesterase 4	BG0F1E	2-Butyl-N-[(4-phenylphenyl)methyl]thieno[3,2-d]pyrimidin-4-amine	Investigative	10690761	C23H23N3S	373.5	CCCCC1=NC2=C(C(=N1)NCC3=CC=C(C=C3)C4=CC=CC=C4)SC=C2	IC50 > 200000 nM	Non binder
T47941	Phosphodiesterase 4	BG18YE	(2,6-Dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-acetic acid	Investigative	10083549	C10H12N4O4	252.23	CCCN1C2=C(C(=O)N(C1=O)CC(=O)O)NC=N2	Ki > 200000 nM	Non binder
T47941	Phosphodiesterase 4	BG89HD	2-(2,6-Dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-acetamide	Investigative	10399896	C10H13N5O3	251.24	CCCN1C2=C(C(=O)N(C1=O)CC(=O)N)NC=N2	Ki > 200000 nM	Non binder
T47941	Phosphodiesterase 4	BHCR20	(1-Methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid	Investigative	10084247	C11H14N4O4	266.25	CCCN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)O	Ki > 200000 nM	Non binder
T47941	Phosphodiesterase 4	BHRI48	4-(3-Butoxy-4-methoxy-phenyl)-pyrrolidine-2-thione	Investigative	44281897	C15H21NO2S	279.4	CCCCOC1=C(C=CC(=C1)C2CC(=S)NC2)OC	IC50 = 500000 nM	Non binder
T47941	Phosphodiesterase 4	BI52DW	4-(4-Butoxy-phenyl)-pyrrolidin-2-one	Investigative	14537165	C14H19NO2	233.31	CCCCOC1=CC=C(C=C1)C2CC(=O)NC2	IC50 > 1000000 nM	Non binder
T47941	Phosphodiesterase 4	BJ5V3C	(4Ar,6R,7R,7aS)-6-(6-amino-8-pentylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90663007	C15H22N5O6PS	431.4	CCCCCSC1=NC2=C(N=CN=C2N1[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O)N	IC50 = 290000 nM	Non binder
T47941	Phosphodiesterase 4	BJQ7C4	Triazolothiadiazine, 11G	Investigative	17757151	C20H20N4O4S	412.5	COC1=C(C(=CC=C1)OC)C2=NN3C(=NN=C3SC2)C4=CC(=C(C=C4)OC)OC	IC50 = 14100000 nM	Non binder
T47941	Phosphodiesterase 4	BJY0R5	5-[2-[[4-(Diethylamino)-6,7-dimethoxyquinazolin-2-yl]amino]-1-hydroxyethyl]benzene-1,3-diol;hydrochloride	Investigative	13408814	C22H29ClN4O5	464.9	CCN(CC)C1=NC(=NC2=CC(=C(C=C21)OC)OC)NCC(C3=CC(=CC(=C3)O)O)O.Cl	IC50 = 432000 nM	Non binder
T47941	Phosphodiesterase 4	BK93XO	Triazolothiadiazine, 11D	Investigative	17757131	C20H20N4O4S	412.5	COC1=C(C(=CC=C1)OC)C2=NN3C(=NN=C3SC2)C4=C(C(=CC=C4)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BKRC52	Triazolothiadiazine, 6K	Investigative	135750249	C17H14N4O2S	338.4	COC1=CC=CC=C1C2=NN3C(=NN=C3SC2)C4=CC=CC=C4O	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BLAO89	3,6-Bis(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	662872	C18H16N4O2S	352.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=C(C=C4)OC	IC50 = 8400000 nM	Non binder
T47941	Phosphodiesterase 4	BM3SI5	6-(3-Methoxyphenyl)-3-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	4558271	C18H16N4O2S	352.4	COC1=CC=C(C=C1)C2=NN=C3N2N=C(CS3)C4=CC(=CC=C4)OC	IC50 = 8400000 nM	Non binder
T47941	Phosphodiesterase 4	BNM8Y6	Triazolothiadiazine, 10E	Investigative	17757137	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)OC)C2=NN3C(=NN=C3SC2)C4=C(C=C(C=C4)OC)OC	IC50 = 5300000 nM	Non binder
T47941	Phosphodiesterase 4	BO3K7G	Triazolothiadiazine, 6E	Investigative	17757133	C19H18N4O3S	382.4	COC1=CC(=C(C=C1)C2=NN=C3N2N=C(CS3)C4=CC=CC=C4OC)OC	IC50 = 19700000 nM	Non binder
T47941	Phosphodiesterase 4	BO53DT	Triazolothiadiazine, 6G	Investigative	17757147	C19H18N4O3S	382.4	COC1=C(C=C(C=C1)C2=NN=C3N2N=C(CS3)C4=CC=CC=C4OC)OC	IC50 = 8900000 nM	Non binder
T47941	Phosphodiesterase 4	BOC12L	Triazolothiadiazine, 7E	Investigative	17757134	C19H18N4O3S	382.4	COC1=CC(=C(C=C1)C2=NN=C3N2N=C(CS3)C4=CC(=CC=C4)OC)OC	IC50 = 13400000 nM	Non binder
T47941	Phosphodiesterase 4	BOH6R4	6-(2,4-Dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	17757115	C19H18N4O3S	382.4	COC1=CC(=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4OC)OC	IC50 = 15000000 nM	Non binder
T47941	Phosphodiesterase 4	BOU1S5	4-Phenyl-2-pyrrolidinone	Investigative	121397	C10H11NO	161.2	C1C(CNC1=O)C2=CC=CC=C2	IC50 > 1000000 nM	Non binder
T47941	Phosphodiesterase 4	BOXC91	2-[[2-(Diethylamino)-6,7-dimethoxyquinazolin-4-yl]amino]-1-phenylethanol	Investigative	13408798	C22H28N4O3	396.5	CCN(CC)C1=NC2=CC(=C(C=C2C(=N1)NCC(C3=CC=CC=C3)O)OC)OC	IC50 = 350000 nM	Non binder
T47941	Phosphodiesterase 4	BP6KY4	(4Ar,6R,7R,7aS)-6-(6-amino-8-propylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662971	C13H18N5O6PS	403.35	CCCSC1=NC2=C(N=CN=C2N1[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O)N	IC50 = 310000 nM	Non binder
T47941	Phosphodiesterase 4	BQ25FD	Sodium;2-[9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-aminopurin-8-yl]sulfanylacetate	Investigative	90662996	C12H13N5NaO8PS	441.29	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3SCC(=O)[O-])N)O)OP(=O)(O1)O.[Na+]	IC50 = 290000 nM	Non binder
T47941	Phosphodiesterase 4	BQ4CU7	(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol	Investigative	149784	C14H23N5O	277.37	CCCCCC[C@@H]([C@@H](C)O)N1C=NC2=C(N=CN=C21)N	Ki > 200000 nM	Non binder
T47941	Phosphodiesterase 4	BQ9IG2	7-Butyl-1-methyl-3-propyl-3,7-dihydro-purine-2,6-dione	Investigative	10400587	C13H20N4O2	264.32	CCCCN1C=NC2=C1C(=O)N(C(=O)N2CCC)C	Ki > 200000 nM	Non binder
T47941	Phosphodiesterase 4	BQM81I	3-[2-[[2-(Diethylamino)-6,7-dimethoxyquinazolin-4-yl]amino]-1-hydroxyethyl]phenol;hydrochloride	Investigative	13408820	C22H29ClN4O4	448.9	CCN(CC)C1=NC2=CC(=C(C=C2C(=N1)NCC(C3=CC(=CC=C3)O)O)OC)OC.Cl	IC50 = 610000 nM	Non binder
T47941	Phosphodiesterase 4	BQWD18	Triazolothiadiazine, 8D	Investigative	17757128	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=C(C(=CC=C4)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BSN62F	Triazolothiadiazine, 6I	Investigative	17757159	C18H16N4OS	336.4	CC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=CC=CC=C4OC	IC50 = 14100000 nM	Non binder
T47941	Phosphodiesterase 4	BT8E4Q	Triazolothiadiazine, 8F	Investigative	17757142	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=C(C=CC(=C4)OC)OC	IC50 = 1700000 nM	Non binder
T47941	Phosphodiesterase 4	BTBL39	7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoindol-3-one	Investigative	14537181	C14H17NO3	247.29	COC1=C(C=C2[C@@H]3CNC(=O)[C@@H]3CCC2=C1)OC	IC50 = 220000 nM	Non binder
T47941	Phosphodiesterase 4	BU1A8T	4-(3,4-Dimethoxy-phenyl)-2-oxo-pyrrolidine-3-carboxylic acid	Investigative	14537170	C13H15NO5	265.26	COC1=C(C=C(C=C1)C2CNC(=O)C2C(=O)O)OC	IC50 > 1000000 nM	Non binder
T47941	Phosphodiesterase 4	BUK5G4	Triazolothiadiazine, 6D	Investigative	17757126	C19H18N4O3S	382.4	COC1=CC=CC=C1C2=NN3C(=NN=C3SC2)C4=C(C(=CC=C4)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BVN3T6	Triazolothiadiazine, 6B	Investigative	17757118	C18H16N4O2S	352.4	COC1=CC=CC(=C1)C2=NN=C3N2N=C(CS3)C4=CC=CC=C4OC	IC50 = 13400000 nM	Non binder
T47941	Phosphodiesterase 4	BW8F9L	Triazolothiadiazine, 9F	Investigative	17757143	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(CS3)C4=C(C=C(C=C4)OC)OC	IC50 = 7500000 nM	Non binder
T47941	Phosphodiesterase 4	BW8H0D	Triazolothiadiazine, 9J	Investigative	44143468	C20H20N4O3S	396.5	CCOC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=C(C=C(C=C4)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BWI7B4	6-(2,5-Dimethoxyphenyl)-3-(2-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	3393127	C19H18N4O2S	366.4	CC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=C(C=CC(=C4)OC)OC	IC50 = 6300000 nM	Non binder
T47941	Phosphodiesterase 4	BX7QA5	Triazolothiadiazine, 7I	Investigative	17757175	C18H16N4OS	336.4	CC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=CC(=CC=C4)OC	IC50 = 3200000 nM	Non binder
T47941	Phosphodiesterase 4	BY0VQ2	Triazolothiadiazine, 9H	Investigative	17757155	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=CC(=C4)OC)OC)OC	IC50 > 20000000 nM	Non binder
T47941	Phosphodiesterase 4	BZR64N	Triazolothiadiazine, 6J	Investigative	17757161	C19H18N4O2S	366.4	CCOC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=CC=CC=C4OC	IC50 > 20000000 nM	Non binder