TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T65200 Corticosteroid 11-beta-dehydrogenase 1 B1CJH7 (1S,5R)-1-(1,3-Benzothiazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127042478 C21H23NOS2 369.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CSC3=NC4=CC=CC=C4S3 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B2B9JY (1S,3As,5aS,6S,7R,9aS)-7-methyl-1-propan-2-yl-2,3,3a,4,5a,6,8,9-octahydro-1H-cyclopenta[c][1]benzofuran-6,7-diol Investigative 127027104 C15H26O3 254.36 CC(C)[C@@H]1CC[C@H]2[C@]13CC[C@@]([C@H]([C@H]3OC2)O)(C)O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B2EIO3 (1S,5R,8R)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-ol Investigative 127042784 C15H24O2 236.35 CC(C)C1=CC[C@@H]([C@]12CC[C@@](C=C2)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B2MWE9 4-[[2-[6-(4-Fluorophenyl)-1,1-dioxo-1,2,6-thiadiazinan-2-yl]acetyl]amino]adamantane-1-carboxamide Investigative 70683862 C22H29FN4O4S 464.6 C1CN(S(=O)(=O)N(C1)C2=CC=C(C=C2)F)CC(=O)NC3C4CC5CC3CC(C5)(C4)C(=O)N IC50 = 351000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B2UB3E (2S,3R,5'S,6'R)-5',6'-Dihydroxy-1'-methylspiro[1,2-dihydroindene-3,4'-cyclohexene]-2-carboxylic acid Investigative 127027408 C16H18O4 274.31 CC1=CC[C@]2([C@H](CC3=CC=CC=C32)C(=O)O)[C@@H]([C@@H]1O)O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B3JN5S 1-(1-Adamantyl)-3-[(1R,4S,5R,9R,10S,11S,13R,15R)-11,15-dihydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]urea Investigative 73356626 C30H46N2O3 482.7 C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2[C@H](C[C@@H](C3)C(=C)[C@H]4O)O)(C)NC(=O)NC56CC7CC(C5)CC(C7)C6 IC50 = 403700 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B3KD5S (1S,4'S,5R,6S)-4'-(Hydroxymethyl)-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,5'-cyclopentene]-2-one Investigative 127041837 C14H20O3 236.31 CC(C)C1=CC[C@@H]([C@]12CCC(=O)[C@@H]3[C@H]2O3)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B3TS9X (1S,5R)-N-[(3,5-Difluorophenyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide Investigative 127040565 C21H23F2NO2 359.4 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NCC3=CC(=CC(=C3)F)F IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B3X8UP (1S,5R)-1-(1,3-Benzothiazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127042102 C21H23NO3S2 401.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CS(=O)(=O)C3=NC4=CC=CC=C4S3 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B4JT9G (1S,5R)-1-(1,3-Benzoxazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127042477 C21H23NO2S 353.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CSC3=NC4=CC=CC=C4O3 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B4M3GI (1S,5R)-1-[(5-Hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127040906 C22H32N2OS3 436.7 CCCCCCSC1=NN=C(S1)SC[C@H]2CC=C([C@@]23CCC(=O)C=C3)C(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B4NR2X [(1S,5R)-8-Methyl-4-propan-2-ylspiro[4.5]deca-3,8-dien-1-yl]methanol Investigative 127040907 C15H24O 220.35 CC1=CC[C@]2(CC1)[C@H](CC=C2C(C)C)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B4TL1I Ethyl (1S,4S,5R,9S)-9-acetyloxy-8-methylidene-1-propan-2-ylspiro[4.5]decane-4-carboxylate Investigative 127026801 C19H30O4 322.4 CCOC(=O)[C@H]1CC[C@H]([C@]12CCC(=C)[C@H](C2)OC(=O)C)C(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B6VQW2 (1S,2S,2'S,5S,5'S,6S)-2'-(Hydroxymethyl)-2-methyl-5'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,1'-cyclopentane]-2-ol Investigative 127027103 C15H26O3 254.36 CC(C)[C@@H]1CC[C@@H]([C@]12CC[C@]([C@@H]3[C@H]2O3)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B71JGK (1S,5R,8S,9S)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,9-diol Investigative 127039859 C15H26O3 254.36 CC(C)C1=CC[C@@H]([C@]12CC[C@]([C@H](C2)O)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B72EIW Ethyl (1S,4S,5S)-8-methylidene-1-propan-2-ylspiro[4.5]dec-9-ene-4-carboxylate Investigative 127026799 C17H26O2 262.4 CCOC(=O)[C@H]1CC[C@H]([C@@]12CCC(=C)C=C2)C(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B8LH4K 1,1-Dioxo-2-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]-1,2-benzothiazol-3-one Investigative 127040901 C21H23NO4S 385.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C(=O)C4=CC=CC=C4S3(=O)=O IC50 = 341000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B8WE3K (1S,5R)-8-Oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxylic acid Investigative 127038555 C14H18O3 234.29 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 B9E2OB (1S,5R)-1-[(1-Phenyltetrazol-5-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127038197 C21H24N4O3S 412.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CS(=O)(=O)C3=NN=NN3C4=CC=CC=C4 IC50 = 245000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BA24OC 4-Methoxy-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]benzenesulfonamide Investigative 127041808 C24H30N4O4S 470.6 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C=C(N=N3)CNS(=O)(=O)C4=CC=C(C=C4)OC IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BBP19D 2-[[(1S,5R)-8-Oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]isoindole-1,3-dione Investigative 127037875 C22H23NO3 349.4 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C(=O)C4=CC=CC=C4C3=O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BBX95U (1S,5R)-1-[[Tert-butyl(dimethyl)silyl]oxymethyl]-8-methyl-4-propan-2-ylspiro[4.5]deca-3,8-dien-10-one Investigative 127041220 C21H36O2Si 348.6 CC1=CC(=O)[C@]2(CC1)[C@H](CC=C2C(C)C)CO[Si](C)(C)C(C)(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BBZ1W8 (1S,5R)-1-[(1-Phenyltetrazol-5-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127040904 C21H24N4OS 380.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CSC3=NN=NN3C4=CC=CC=C4 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BC1W0F Ethyl (1S,5R,7S)-7-acetyloxy-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxylate Investigative 127042783 C18H24O5 320.4 CCOC(=O)[C@H]1CC=C([C@@]12C[C@@H](C(=O)C=C2)OC(=O)C)C(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BC85ON Ethyl (1S,4S,5S,7S,8R)-7-acetyloxy-8-hydroxy-1-propan-2-ylspiro[4.5]dec-9-ene-4-carboxylate Investigative 127026800 C18H28O5 324.4 CCOC(=O)[C@H]1CC[C@H]([C@@]12C[C@@H]([C@@H](C=C2)O)OC(=O)C)C(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BD2Y5M (1S,5R,8R)-1-[[Tert-butyl(dimethyl)silyl]oxymethyl]-8-hydroxy-8-methyl-4-propan-2-ylspiro[4.5]deca-3,9-dien-2-one Investigative 127041838 C21H36O3Si 364.6 CC(C)C1=CC(=O)[C@@H]([C@]12CC[C@@](C=C2)(C)O)CO[Si](C)(C)C(C)(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BD41TJ (1S,4S,5S,8R,10R)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]decane-8,10-diol Investigative 127027115 C15H28O3 256.38 CC(C)[C@@H]1CC[C@@H]([C@]12CC[C@@](C[C@H]2O)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BD48EW (1S,5R)-1-(Hydroxymethyl)-4-phenylspiro[4.5]deca-3,9-dien-8-one Investigative 127037847 C17H18O2 254.32 C1C[C@@]2(C=CC1=O)[C@H](CC=C2C3=CC=CC=C3)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BD80EU Ethyl (1S,5R)-4-methylidene-8-oxospiro[4.5]dec-9-ene-1-carboxylate Investigative 127038235 C14H18O3 234.29 CCOC(=O)[C@H]1CCC(=C)[C@@]12CCC(=O)C=C2 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BE1U2M (1S,5R)-1-(Naphthalen-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127040903 C24H26OS 362.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CSC3=CC4=CC=CC=C4C=C3 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BFR89N Ethyl (1S,4S,5R,9S)-9-acetyloxy-8-oxo-1-propan-2-ylspiro[4.5]decane-4-carboxylate Investigative 127039204 C18H28O5 324.4 CCOC(=O)[C@H]1CC[C@H]([C@]12CCC(=O)[C@H](C2)OC(=O)C)C(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BFS07P (1S)-1-(Hydroxymethyl)-4-propan-2-ylspiro[4.5]dec-3-en-8-one Investigative 127042786 C14H22O2 222.32 CC(C)C1=CC[C@@H](C12CCC(=O)CC2)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BGN89W Ethyl (1S,4S,5S)-8-oxo-1-propan-2-ylspiro[4.5]dec-9-ene-4-carboxylate Investigative 127042638 C16H24O3 264.36 CCOC(=O)[C@H]1CC[C@H]([C@@]12CCC(=O)C=C2)C(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BH65DA (2S,2'S,3R,3'R,4'S)-2',3'-Dihydroxy-4'-methylspiro[1,2-dihydroindene-3,1'-cyclohexane]-2-carboxylic acid Investigative 127027409 C16H20O4 276.33 C[C@H]1CC[C@]2([C@H](CC3=CC=CC=C32)C(=O)O)[C@@H]([C@@H]1O)O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BI2G8U (1R,9S,12S,13S,14R)-14-Methyl-11-oxatetracyclo[7.7.0.01,12.02,7]hexadeca-2,4,6-triene-13,14-diol Investigative 127027406 C16H20O3 260.329 C[C@]1(CC[C@@]23[C@H](CC4=CC=CC=C42)CO[C@@H]3[C@@H]1O)O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BJ5A3N (2S,3R)-2-(Hydroxymethyl)spiro[1,2-dihydroindene-3,4'-cyclohex-2-ene]-1'-one Investigative 127038877 C15H16O2 228.29 C1C[C@@]2(C=CC1=O)[C@H](CC3=CC=CC=C23)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BK3QL1 (1S,2R,2'S,5S,5'S,6S)-2'-(Hydroxymethyl)-2-methyl-5'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,1'-cyclopentane]-2-ol Investigative 127038549 C15H26O3 254.36 CC(C)[C@@H]1CC[C@@H]([C@]12CC[C@@]([C@@H]3[C@H]2O3)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BLF19H (3Ar,5aR,9aR)-1-propan-2-yl-3,3a,5a,6,8,9-hexahydrocyclopenta[c][1]benzofuran-4,7-dione Investigative 127042785 C14H18O3 234.29 CC(C)C1=CC[C@@H]2[C@]13CCC(=O)C[C@H]3OC2=O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BLG94Z (1S,5R)-1-(Hydroxymethyl)-4-(phenylmethoxymethyl)spiro[4.5]deca-3,9-dien-8-one Investigative 127041221 C19H22O3 298.4 C1C[C@@]2(C=CC1=O)[C@H](CC=C2COCC3=CC=CC=C3)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BLHU59 (1S,5R,8R,9S)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,9-diol Investigative 127038201 C15H26O3 254.36 CC(C)C1=CC[C@@H]([C@]12CC[C@@]([C@H](C2)O)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BLW7J3 (1S,5R)-8-Oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide Investigative 127039230 C14H19NO2 233.31 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)N IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BLY1I2 (1S,5R)-8-Oxo-4-propan-2-yl-N-(2-thiophen-2-ylethyl)spiro[4.5]deca-3,9-diene-1-carboxamide Investigative 127040566 C20H25NO2S 343.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NCCC3=CC=CS3 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BMY86X (2S,3R)-6'-Oxospiro[1,2-dihydroindene-3,3'-cyclohexene]-2-carboxylic acid Investigative 127041801 C15H14O3 242.27 C1C[C@@]2(C=CC1=O)[C@H](CC3=CC=CC=C23)C(=O)O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BO5SU0 (4S,5R)-1-Methyl-4-(hydroxymethyl)spiro[4.5]deca-1,6-diene-8-one Investigative 102528497 C12H16O2 192.25 CC1=CC[C@@H]([C@]12CCC(=O)C=C2)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BO6G1Q (1'S,2S,3R,6'S)-2-(Hydroxymethyl)spiro[1,2-dihydroindene-3,5'-7-oxabicyclo[4.1.0]heptane]-2'-one Investigative 127027407 C15H16O3 244.28 C1C[C@]2([C@H](CC3=CC=CC=C32)CO)[C@H]4[C@@H](C1=O)O4 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BP95MG Tert-butyl-[(1S,4R,4'S,6S)-4'-[[tert-butyl(dimethyl)silyl]oxymethyl]-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-4,5'-cyclopentene]-1-yl]oxy-dimethylsilane Investigative 127042637 C26H50O3Si2 466.8 CC(C)C1=CC[C@@H]([C@]12CC[C@@]3([C@H](C2)O3)O[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BP9A6R (4S,5R)-1-Isopropyl-4-(hydroxymethyl)spiro[4.5]deca-1,6-diene-8-one Investigative 72793118 C14H20O2 220.31 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BPEA36 Tert-butyl N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]carbamate Investigative 127041809 C22H32N4O3 400.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C=C(N=N3)CNC(=O)OC(C)(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BPKR17 4-Amino-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]-N-pyrimidin-2-ylbenzenesulfonamide Investigative 127040902 C27H31N7O3S 533.6 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C=C(N=N3)CN(C4=NC=CC=N4)S(=O)(=O)C5=CC=C(C=C5)N IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BPW9O3 (1S,5R)-4-[2-[Tert-butyl(dimethyl)silyl]oxyethyl]-1-(hydroxymethyl)spiro[4.5]deca-3,9-dien-8-one Investigative 127041222 C19H32O3Si 336.5 CC(C)(C)[Si](C)(C)OCCC1=CC[C@@H]([C@]12CCC(=O)C=C2)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BQF9E5 Ethyl (1S,4S,5S,7S)-7-acetyloxy-8-methylidene-9-oxo-1-propan-2-ylspiro[4.5]decane-4-carboxylate Investigative 127039211 C19H28O5 336.4 CCOC(=O)[C@H]1CC[C@H]([C@@]12C[C@@H](C(=C)C(=O)C2)OC(=O)C)C(C)C IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BQN87Y (1S,3As,5aR,7R,9aS)-7-methyl-1-propan-2-yl-2,3,3a,4,5a,6,8,9-octahydro-1H-cyclopenta[c][1]benzofuran-7-ol Investigative 127038533 C15H26O2 238.37 CC(C)[C@@H]1CC[C@H]2[C@]13CC[C@@](C[C@H]3OC2)(C)O IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BQP59Y (1S,2S,4'S,5R,6S)-4'-(Hydroxymethyl)-2-methyl-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,5'-cyclopentene]-2-ol Investigative 127041839 C15H24O3 252.35 CC(C)C1=CC[C@@H]([C@]12CC[C@]([C@@H]3[C@H]2O3)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BS7B1M (1S,4S,5S,8R,9S)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]decane-8,9-diol Investigative 127042440 C15H28O3 256.38 CC(C)[C@@H]1CC[C@@H]([C@]12CC[C@@]([C@H](C2)O)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BT0A3N (1S,5R)-1-(1,3-Benzoxazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127042101 C21H23NO4S 385.5 CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CS(=O)(=O)C3=NC4=CC=CC=C4O3 IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BU35BD [(1S,5R)-8,8-Dimethoxy-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methanol Investigative 127042782 C16H26O3 266.38 CC(C)C1=CC[C@@H]([C@]12CCC(C=C2)(OC)OC)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BU6V5J (1S,5R,8R,10R)-1-(Hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,10-diol Investigative 127042636 C15H26O3 254.36 CC(C)C1=CC[C@@H]([C@]12CC[C@@](C[C@H]2O)(C)O)CO IC50 > 1000000 nM Non binder T65200 Corticosteroid 11-beta-dehydrogenase 1 BXTI57 (1S,5R)-1-(Ethoxymethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one Investigative 127041223 C16H24O2 248.36 CCOC[C@H]1CC=C([C@@]12CCC(=O)C=C2)C(C)C IC50 > 1000000 nM Non binder