TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T87024	Amyloid beta A4 protein	D0A1PX	Flurbiprofen	Approved	3394	C15H13FO2	244.26	CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O	IC50 = 305000 nM	Non binder
T87024	Amyloid beta A4 protein	D05FGR	R-flurbiprofen	Phase 2	92337	C15H13FO2	244.26	C[C@H](C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O	IC50 = 280000 nM	Non binder
T87024	Amyloid beta A4 protein	B2X3SV	1-[3-Fluoro-4-[4-(4-hydroxyphenyl)phenyl]phenyl]cyclopropane-1-carboxylic acid	Investigative	11609939	C22H17FO3	348.4	C1CC1(C2=CC(=C(C=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)O)F)C(=O)O	IC50 = 409000 nM	Non binder
T87024	Amyloid beta A4 protein	B3QT6X	Phenethyl cinnamate	Investigative	5369459	C17H16O2	252.31	C1=CC=C(C=C1)CCOC(=O)/C=C/C2=CC=CC=C2	EC50 = 1040000 nM	Non binder
T87024	Amyloid beta A4 protein	B4JEO0	Brevione L	Investigative	127038083	C27H36O6	456.6	CC1=CC[C@H]2[C@]([C@]13CC4=C(O3)C(=C(OC4=O)C)C)(CC[C@@H]5[C@@]2([C@H](CC(=O)OC5(C)C)O)C)C	IC50 > 300000 nM	Non binder
T87024	Amyloid beta A4 protein	B5ZOG9	29-N-Demethylparaherquamide J	Investigative	127037726	C27H31N3O5	477.6	C[C@@H]1C[C@@]23C[C@@H]4[C@@](C[C@@]5(C4(C)C)C6=C(C7=C(C=C6)OC(C=CO7)(C)C)NC5=O)(CN2C1=O)NC3=O	EC50 > 300000 nM	Non binder
T87024	Amyloid beta A4 protein	B6E0ZK	N-[(1R,10S,13R)-13-[(5-Chlorothiophen-2-yl)sulfonylamino]-5-tricyclo[8.2.1.03,8]trideca-3(8),4,6-trienyl]-2-[[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]amino]acetamide	Investigative	89641711	C35H34ClN5O4S2	688.3	CN1C2=CC=CC=C2C(=N[C@@H](C1=O)NCC(=O)NC3=CC4=C(C[C@@H]5CC[C@H](C4)[C@@H]5NS(=O)(=O)C6=CC=C(S6)Cl)C=C3)C7=CC=CC=C7	IC50 = 800000 nM	Non binder
T87024	Amyloid beta A4 protein	B72EWU	6-[2-[[6-[2-(Dipyridin-2-ylamino)ethyl]pyridin-2-yl]amino]ethyl]-N-methylpyridin-2-amine	Investigative	58230686	C25H27N7	425.5	CNC1=CC=CC(=N1)CCNC2=CC=CC(=N2)CCN(C3=CC=CC=N3)C4=CC=CC=N4	IC50 = 240000 nM	Non binder
T87024	Amyloid beta A4 protein	B79YJB	3-[2,5-Bis(trifluoromethyl)phenyl]-N-[(1R,10S,13R)-13-[(5-chlorothiophen-2-yl)sulfonylamino]-5-tricyclo[8.2.1.03,8]trideca-3(8),4,6-trienyl]propanamide	Investigative	89641697	C28H25ClF6N2O3S2	651.1	C1C[C@@H]2CC3=C(C[C@H]1[C@H]2NS(=O)(=O)C4=CC=C(S4)Cl)C=CC(=C3)NC(=O)CCC5=C(C=CC(=C5)C(F)(F)F)C(F)(F)F	IC50 = 630000 nM	Non binder
T87024	Amyloid beta A4 protein	B7CE3S	2-(4-Benzo[1,3]dioxol-5-yl-3-fluoro-phenyl)-propionic acid	Investigative	11529378	C16H13FO4	288.27	CC(C1=CC(=C(C=C1)C2=CC3=C(C=C2)OCO3)F)C(=O)O	IC50 = 210000 nM	Non binder
T87024	Amyloid beta A4 protein	B7G2HW	Chembl4166279	Investigative	145955195	C19H22O4	314.4	COC1=C(C=C(C=C1)CCOC(=O)CCC2=CC=CC=C2)OC	EC50 = 274000 nM	Non binder
T87024	Amyloid beta A4 protein	BB6A4L	(1S,5R,7R,9S,11R)-2',2',5,10,10,13-Hexamethylspiro[3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane-11,9'-7H-[1,4]dioxepino[2,3-f]indole]-4,8',14-trione	Investigative	127037724	C28H33N3O5	491.6	C[C@@H]1C[C@@]23C[C@@H]4[C@@](C[C@@]5(C4(C)C)C6=CC7=C(C=C6NC5=O)OC=CC(O7)(C)C)(CN2C1=O)N(C3=O)C	EC50 > 300000 nM	Non binder
T87024	Amyloid beta A4 protein	BRAG46	Paraherquamide K	Investigative	127037725	C28H33N3O4	475.6	C[C@@H]1C[C@@]23C[C@@H]4[C@@](C[C@@]5(C4(C)C)C6=C(C7=C(C=C6)OC(C=C7)(C)C)NC5=O)(CN2C1=O)N(C3=O)C	IC50 > 300000 nM	Non binder
T87024	Amyloid beta A4 protein	BSE0U6	2,2-Dimethyl-2H-chromene-6-carboxylic acid	Investigative	5319235	C12H12O3	204.22	CC1(C=CC2=C(O1)C=CC(=C2)C(=O)O)C	EC50 = 251500 nM	Non binder
T87024	Amyloid beta A4 protein	BUC03A	(1'S,3R,5'R,7'S,9'S)-5',7,7,10',10',13'-Hexamethylspiro[1H-pyrano[2,3-g]indole-3,11'-3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane]-2,14'-dione	Investigative	127037733	C28H35N3O3	461.6	C[C@@H]1C[C@@]23C[C@@H]4[C@@](C[C@@]5(C4(C)C)C6=C(C7=C(C=C6)OC(C=C7)(C)C)NC5=O)(CN2C1)N(C3=O)C	IC50 = 203700 nM	Non binder
T87024	Amyloid beta A4 protein	BVOU54	N-Methyl-6-[2-[[6-[2-(pyridin-2-ylamino)ethyl]pyridin-2-yl]amino]ethyl]pyridin-2-amine	Investigative	58230640	C20H24N6	348.4	CNC1=CC=CC(=N1)CCNC2=CC=CC(=N2)CCNC3=CC=CC=N3	IC50 = 280000 nM	Non binder
T87024	Amyloid beta A4 protein	BZ70VP	3-Phenylpropionic acid, 2-phenylethyl ester	Investigative	520360	C17H18O2	254.32	C1=CC=C(C=C1)CCC(=O)OCCC2=CC=CC=C2	EC50 = 4536000 nM	Non binder
T87024	Amyloid beta A4 protein	D0R4FM	DIHYDROKAEMPFEROL	Investigative	122850	C15H12O6	288.25	C1=CC(=CC=C1[C@@H]2[C@H](C(=O)C3=C(C=C(C=C3O2)O)O)O)O	IC50 > 500000 nM	Non binder
T87024	Amyloid beta A4 protein	D0V9EN	3,4-Dihydroxycinnamic Acid	Investigative	689043	C9H8O4	180.16	C1=CC(=C(C=C1/C=C/C(=O)O)O)O	EC50 = 216000 nM	Non binder
T87024	Amyloid beta A4 protein	D0Y7HG	GALANGIN	Investigative	5281616	C15H10O5	270.24	C1=CC=C(C=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O	IC50 > 500000 nM	Non binder