TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T09022	Proteasome beta-10	B02TGL	(2S)-1-[(2S)-2-[(2-Azidoacetyl)amino]propanoyl]-N-[(2S)-1-[[(2S)-3-cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]-4,4-difluoropyrrolidine-2-carboxamide	Investigative	118709680	C28H43F2N7O6	611.7	CCCC[C@@H](C(=O)N[C@@H](CC1CCCCC1)C(=O)[C@]2(CO2)C)NC(=O)[C@@H]3CC(CN3C(=O)[C@H](C)NC(=O)CN=[N+]=[N-])(F)F	IC50 ~ 100000 nM	Poor binder
T09022	Proteasome beta-10	B1A7LQ	(2S)-1-[(2S)-2-[(2-Azidoacetyl)amino]propanoyl]-4,4-difluoro-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide	Investigative	118709679	C28H37F2N7O6	605.6	CCCC[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)[C@]2(CO2)C)NC(=O)[C@@H]3CC(CN3C(=O)[C@H](C)NC(=O)CN=[N+]=[N-])(F)F	IC50 ~ 100000 nM	Poor binder
T09022	Proteasome beta-10	B8HGC1	N-[(2R)-1-[[(2S)-3-(1H-Indol-3-yl)-1-[[(E,2S)-4-methylsulfonyl-1-phenylbut-3-en-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methyl-1H-indene-2-carboxamide	Investigative	101874278	C36H38N4O5S	638.8	CC1=C(CC2=CC=CC=C12)C(=O)N[C@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC5=CC=CC=C5)/C=C/S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T09022	Proteasome beta-10	BKUA70	(2S)-1-[(2S)-2-[(2-Azidoacetyl)amino]propanoyl]-N-[(2S)-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]pyrrolidine-2-carboxamide	Investigative	118709677	C28H39N7O6	569.7	CCCC[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)[C@]2(CO2)C)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)CN=[N+]=[N-]	IC50 ~ 100000 nM	Poor binder
T09022	Proteasome beta-10	BL8SA9	N-[(2R)-1-[[(2S)-1-[[(2S)-3-Cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methyl-1H-indene-2-carboxamide	Investigative	101874275	C37H44N4O5	624.8	CC1=C(CC2=CC=CC=C12)C(=O)N[C@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC5CCCCC5)C(=O)[C@]6(CO6)C	IC50 ~ 100000 nM	Poor binder
T09022	Proteasome beta-10	BNIY76	Chembl4278272	Investigative	145979576	C36H43N5O8	673.8	C[C@@H](C(=O)N[C@@H](C[C@]1(C2=CC=CC=C2NC1=O)O)C(=O)NC)NC(=O)[C@H](CC3=CC=C(C=C3)OCC4=CC=CC=C4)NC(=O)OC(C)(C)C	IC50 = 79000 nM	Poor binder
T09022	Proteasome beta-10	BOWY37	Chembl4281070	Investigative	145980811	C39H47N5O10	745.8	C[C@@H](C(=O)N[C@@H](C[C@]1(C2=CC=CC=C2NC1=O)O)C(=O)NCCC(=O)OC)NC(=O)[C@H](CC3=CC=C(C=C3)OCC4=CC=CC=C4)NC(=O)OC(C)(C)C	IC50 = 106000 nM	Poor binder
T09022	Proteasome beta-10	BP0Y6B	PR-924	Investigative	92135659	C37H38N4O5	618.7	CC1=C(CC2=CC=CC=C12)C(=O)N[C@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)[C@]6(CO6)C	IC50 ~ 100000 nM	Poor binder
T09022	Proteasome beta-10	BT61BF	N-[(2R)-1-[[(2S)-1-[[(2S)-3-Cyclohexyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methyl-1H-indene-2-carboxamide	Investigative	101874279	C36H45N3O6	615.8	CC1=C(CC2=CC=CC=C12)C(=O)N[C@H](C)C(=O)N[C@@H](CC3=CC=C(C=C3)OC)C(=O)N[C@@H](CC4CCCCC4)C(=O)[C@]5(CO5)C	IC50 ~ 100000 nM	Poor binder