TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T16769 X-linked inhibitor of apoptosis protein D0R1CR L-Phenylalanine Approved 6140 C9H11NO2 165.19 C1=CC=C(C=C1)C[C@@H](C(=O)O)N IC50 = 80200 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B04HKV 4-Acetyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide Investigative 90060653 C33H32N4O4S 580.7 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC=C(C=C5)C(=O)C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B05MNR (2S)-N-(2-Benzoylphenyl)-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide Investigative 117886634 C31H34N4O4 526.6 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CC2=CC=CC=C21)C(=O)NC3=CC=CC=C3C(=O)C4=CC=CC=C4)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B0AZ8I (2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-8,9-difluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Investigative 73056901 C29H30BrF2N3O5 618.5 C[C@@H](C(=O)N[C@H]1C(=O)N(C2=C(C(=C(C=C2)F)F)OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B0B3YE (2S)-N-[(3S,4S)-1-(1,2-Benzoxazol-3-ylmethyl)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 72712342 C25H29N5O6S 527.6 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NOC4=CC=CC=C43)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B0NB9A 1-Acetyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-3,4-dihydro-2H-1,5-benzothiazepin-9-yl]piperidine-4-carboxamide Investigative 118586095 C32H39N5O3S 573.8 C[C@@H](C(=O)N[C@@H]1CN(C2=CC=CC(=C2SC1)NC(=O)C3CCN(CC3)C(=O)C)CC4=CC=CC5=CC=CC=C54)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B0U7NP 1-(6-Methylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone Investigative 71471946 C16H23N3O 273.37 C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)C IC50 = 51000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B0UX9S (2S)-2-(Methylamino)-N-[(3S)-5-[(2-methylsulfonyl-1,3-dihydroisoindol-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide Investigative 90060610 C23H28N4O5S 472.6 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=CC4=C3CN(C4)S(=O)(=O)C)NC IC50 = 53210 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B0Y8CE 3-Cyano-N-ethyl-4-[4-[[(2S,3S)-2-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]indazol-1-yl]benzamide Investigative 90060740 C32H33N7O4 579.6 CCNC(=O)C1=CC(=C(C=C1)N2C3=CC=CC(=C3C=N2)CN4C5=CC=CC=C5O[C@H]([C@@H](C4=O)NC(=O)[C@H](C)NC)C)C#N IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B17BLA (3S,8As)-6-[[(2S)-2-aminopropanoyl]amino]-5-oxo-N-phenyl-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride Investigative 45265687 C18H25ClN4O3 380.9 C[C@@H](C(=O)NC1CC[C@H]2CC[C@H](N2C1=O)C(=O)NC3=CC=CC=C3)N.Cl Ki ~ 100000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B1C8WY (2S)-2-Amino-N-[(3R)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide Investigative 90060665 C28H30BrN3O5 568.5 C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)N IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B1CO5T (2S)-N-[(3S,4S)-7-Cyano-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(ethylamino)propanamide Investigative 73425764 C31H35N5O5S 589.7 CCN[C@@H](C)C(=O)N[C@H]1[C@@H](N(C2=C(C=CC(=C2)C#N)N(C1=O)CC3=C(C=CC4=CC=CC=C43)C)C(=O)CS(=O)(=O)C)C IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B1E2KU (2S)-N-[(3S,4S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72712130 C29H35ClN4O6S 603.1 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC4=CC=CC=C43)OC)NC(=O)[C@H](C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B1R3HC (2S,3S)-2-Amino-N-((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-3-hydroxybutanamide hydrochloride Investigative 72712566 C26H29BrClN3O4 562.9 C[C@@H]([C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)N)O.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B1S3JT (2S)-N-[(3S)-5-Benzyl-1-(3-methylbutanoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72711020 C25H33ClN4O3 473 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC=C3)C(=O)CC(C)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B1SHL3 (2S)-N-(5-Benzyl-1,1,4-trioxo-2,3-dihydro-1lambda6,5-benzothiazepin-3-yl)-2-(methylamino)propanamide Investigative 73056593 C20H23N3O4S 401.5 C[C@@H](C(=O)NC1CS(=O)(=O)C2=CC=CC=C2N(C1=O)CC3=CC=CC=C3)NC IC50 ~ 54200 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B1SP9Y (2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,3'-oxetane]-3-yl]-2-(methylamino)propanamide Investigative 118586124 C27H28BrN3O5 554.4 C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13COC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B1TMJ6 (2S)-N-[(3S,4S)-1-[(7-Chloro-2-oxochromen-4-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73425989 C27H29ClN4O7S 589.1 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=CC(=O)OC4=C3C=CC(=C4)Cl)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B21SWQ (S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(7-phenylthiazolo[5,4-c]pyridin-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide Investigative 46884023 C28H35N5O2S 505.7 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(S3)C=NC=C4C5=CC=CC=C5)NC Ki = 73000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B28OTN (2S)-N-[(2S,3S)-5-[[2-Cyano-1-(2-cyanophenyl)indol-4-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide Investigative 90060675 C32H30N6O3 546.6 CCN[C@@H](C)C(=O)N[C@H]1[C@@H](OC2=CC=CC=C2N(C1=O)CC3=C4C=C(N(C4=CC=C3)C5=CC=CC=C5C#N)C#N)C IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B29EDT (1S)-N-(2,6-Difluorophenyl)-2-[(2S,3S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-3-phenylbutanoyl]-1,3-dihydroisoindole-1-carboxamide Investigative 73294887 C29H30F2N4O3 520.6 C[C@@H](C1=CC=CC=C1)[C@@H](C(=O)N2CC3=CC=CC=C3[C@H]2C(=O)NC4=C(C=CC=C4F)F)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B2CTK8 (2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-N-(2-phenylphenyl)-2,3-dihydroindole-2-carboxamide Investigative 117872952 C33H32N4O3 532.6 C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2[C@@H](CC3=CC=CC=C32)C(=O)NC4=CC=CC=C4C5=CC=CC=C5)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B2FG8H 1-(5-Fluoro-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone Investigative 71471949 C15H20FN3O 277.34 C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=CC(=C3)F IC50 = 130000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B2FIH5 (2S)-N-[(3S,4S)-1-[(7-Methoxy-2-oxochromen-4-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73427177 C28H32N4O8S 584.6 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=CC(=O)OC4=C3C=CC(=C4)OC)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B2IPM7 (S)-N-((S)-2-((S)-2-(4-(Benzo[d]isoxazol-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide Investigative 46884477 C26H33N5O3S 495.6 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=NOC5=CC=CC=C54)NC Ki = 120000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B2P8LY (2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxo-9-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73056915 C22H21F3N4O4 462.4 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=NOC4=CC=CC=C43)C(F)(F)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B2QD5S (2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-9-[4-(3-hydroxypropyl)piperazine-1-carbonyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73055136 C32H38BrN5O5 652.6 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=CC=C(C4=CC=CC=C34)Br)C(=O)N5CCN(CC5)CCCO)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B2TP9F (S)-N-((S)-2-((S)-2-(4-(Benzofuran-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide Investigative 46884476 C27H34N4O3S 494.7 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=COC5=CC=CC=C54)NC Ki = 100000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B2UI1E N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-8-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide Investigative 129012534 C30H33BrFN3O5 614.5 CCC(C(=O)N[C@@H]1C(=O)N(C2=C(C=C(C=C2)F)OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 ~ 50000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B36EFZ 4-Methoxy-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide Investigative 90060651 C32H32N4O4S 568.7 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC=C(C=C5)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B39QTD (S)-1-[(S)-3-Methyl-2-((S)-2-methylamino-propionylamino)-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid (2,6-difluoro-phenyl)-amide Investigative 117887617 C24H28F2N4O3 458.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CC2=CC=CC=C21)C(=O)NC3=C(C=CC=C3F)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B3QW1S (2R)-N-Benzhydryl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide Investigative 25241676 C27H36N4O3 464.6 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)NC(C2=CC=CC=C2)C3=CC=CC=C3)NC Ki ~ 56000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B3VT6Y (2S)-N-[(3S,4S)-5-(4-Acetylbenzoyl)-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 90082539 C38H35N7O4 653.7 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C3=CC=C(C=C3)C(=O)C)CC4=NN(C5=CC=CC=C54)C6=CC=CC=C6C#N)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B3X2IW (2S)-N-[(3S)-1-Acetyl-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72714287 C26H29ClN4O3 481 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)C(=O)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B3YD1Z (3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid Investigative 73057219 C26H27N3O6 477.5 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=CC=CC=C43)OC)C(=O)O)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B47KQO (3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid Investigative 73054593 C26H26BrN3O6 556.4 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)O)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B48SYE 3-[[6-Methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carbonyl]amino]propanoic acid Investigative 118586143 C29H32N4O7 548.6 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)NCCC(=O)O)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B4J9GQ N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]-6-oxoheptanamide Investigative 73058099 C31H36N4O4S 560.7 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)CCCCC(=O)C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B4P0SA N-(2-Hydroxyethyl)-6-methoxy-N-methyl-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxamide Investigative 118586168 C29H34N4O6 534.6 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)N(C)CCO)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B4QA6Y (2S)-N-[(3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 90060661 C25H27N3O4 433.5 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=CC=CC=C43)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B4R3JD (S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-isopropylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide Investigative 46883882 C26H38N4O2S 470.7 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C(C)C)NC Ki = 190000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B4U8AL (2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 90060659 C24H24BrN3O3 482.4 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=C(C4=CC=CC=C34)Br)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B4UZ8J (2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)-6-fluoroindazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide Investigative 90060671 C29H27FN6O3 526.6 CCN[C@@H](C)C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC(=C3)F)C5=CC=CC=C5C#N IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B50EOF 6-Methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxylic acid Investigative 73053728 C26H27N3O6 477.5 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)O)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B51HND (2S)-N-(2-Methoxyphenyl)-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide Investigative 117886657 C28H30N4O4 486.6 C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2[C@@H](CC3=CC=CC=C32)C(=O)NC4=CC=CC=C4OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B51UXN (2S)-2-(Methylamino)-N-[(3S)-1-[(4-methylnaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride Investigative 72712337 C26H30ClN3O2 452 CC1=CC=C(C2=CC=CC=C12)CN3C4=CC=CC=C4CC[C@@H](C3=O)NC(=O)[C@H](C)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B53IUD (2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(oxane-4-carbonyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 90082360 C35H37N7O4 619.7 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C3CCOCC3)CC4=NN(C5=CC=CC=C54)C6=CC=CC=C6C#N)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B57KTU (2S)-N-Benzyl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide Investigative 117870989 C25H32N4O3 436.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CC2=CC=CC=C21)C(=O)NCC3=CC=CC=C3)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B5EBT8 3-[[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carbonyl]amino]propanoic acid Investigative 73054852 C29H31BrN4O7 627.5 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)NCCC(=O)O)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B5JUX9 (2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-6-yl)propanamide Investigative 70980464 C11H15N5O2 249.27 C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)NC2)NC IC50 = 200000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B5KV1M (2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide Investigative 129012535 C29H28N6O3 508.6 CCN[C@@H](C)C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B5NRX7 (2S)-N-((1S)-2-((2S)-2-(4-(2-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide Investigative 46883923 C29H35ClN4O2S 539.1 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CC=CC=C5Cl)NC Ki = 160000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B5O8CT (1S)-N-(2,6-Difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 73295055 C25H30F2N4O3 472.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B5Q3DF (2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl)propanamide Investigative 70981492 C11H15N5O2 249.27 C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)CN2)NC IC50 = 55000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B5USN8 (2S)-N-[(3S)-1-Benzyl-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72712329 C21H26ClN3O2 387.9 C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B61BEO (1R)-6-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 90070355 C25H29ClF2N4O3 507 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@@H]1C(=O)NC3=C(C=CC=C3F)F)C=CC(=C2)Cl)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B62KFS (2S)-N-[(3R)-9-[[2-(2-Methoxyethoxy)acetyl]amino]-5-(naphthalen-1-ylmethyl)-3,4-dihydro-2H-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide Investigative 118586094 C29H36N4O4S 536.7 C[C@@H](C(=O)N[C@@H]1CN(C2=CC=CC(=C2SC1)NC(=O)COCCOC)CC3=CC=CC4=CC=CC=C43)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B69GCY (2S)-N-[(3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-1-(3-methylbutanoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72711026 C30H37ClN4O4 553.1 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=CC=CC=C43)OC)C(=O)CC(C)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B6P2ES Methyl 6-methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxylate Investigative 73058107 C27H29N3O6 491.5 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)OC)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B6R7QP (2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1'-methylsulfonyl-4-oxospiro[3H-1,5-benzoxazepine-2,4'-piperidine]-3-yl]-2-(methylamino)propanamide Investigative 118586228 C30H35BrN4O6S 659.6 C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCN(CC3)S(=O)(=O)C)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B6ZVY3 N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]pyridine-4-carboxamide Investigative 90060638 C30H29N5O3S 539.6 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC=NC=C5)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B70TXM (2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(1-methylindazol-3-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride Investigative 72712343 C26H33ClN6O5S 577.1 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NN(C4=CC=CC=C43)C)NC(=O)[C@H](C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B72FRA (1S)-N-(2,6-Difluorophenyl)-2-[(2S)-3,3-dimethyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 73295060 C26H32F2N4O3 486.6 C[C@@H](C(=O)N[C@H](C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)C(C)(C)C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B79MSQ (2S)-2-(Methylamino)-N-[(3S)-1-(naphthalen-1-ylmethyl)-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride Investigative 72712335 C25H28ClN3O2 438 C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7D2XB Formic acid;(2S)-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-(6-methylquinolin-5-yl)pyrrolidine-2-carboxamide Investigative 44182262 C23H31N5O3 425.5 CC[C@@H](C(=O)N1CCC[C@H]1C(=O)NC2=C(C=CC3=C2C=CC=N3)C)NC(=O)[C@H](C)NC Ki = 56130 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7DIS4 (2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-1-(quinolin-4-ylmethyl)-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide Investigative 73427183 C27H31N5O5S 537.6 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=CC=NC4=CC=CC=C34)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7FH5T (2S)-N-(1,3-Dimethyl-2-oxo-4H-pyrido[3,2-d]pyrimidin-6-yl)-2-(methylamino)propanamide Investigative 70980168 C13H19N5O2 277.32 C[C@@H](C(=O)NC1=NC2=C(C=C1)N(C(=O)N(C2)C)C)NC IC50 = 55000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7FVA5 (2S,4S)-1-[(2S)-2-[2-(Dimethylamino)propanoylamino]-3,3-dimethylbutanoyl]-4-phenoxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide Investigative 44396367 C32H44N4O4 548.7 CC(C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC2CCCC3=CC=CC=C23)OC4=CC=CC=C4)C(C)(C)C)N(C)C EC50 ~ 100000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7JH4N (5S,8S,10Ar)-N-benzhydryl-5-[[(2S)-3-(1H-indol-3-yl)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide Investigative 25173661 C40H48N6O4 676.8 CC(C)CC(=O)N1CC[C@H]2CC[C@H](N2C(=O)[C@H](C1)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC)C(=O)NC(C5=CC=CC=C5)C6=CC=CC=C6 Ki = 67300 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7JPK4 (S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(quinolin-4-yl)thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide Investigative 46884474 C28H35N5O2S 505.7 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=CC=NC5=CC=CC=C45)NC Ki = 75000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7LD0Y Nvp-cgm097 Investigative 53240420 C38H47ClN4O4 659.3 CC(C)OC1=C(C=C2CC(=O)N([C@H](C2=C1)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)N(C)CC5CCC(CC5)N6CCN(C(=O)C6)C)OC IC50 ~ 50000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7R6JM (2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride Investigative 72712132 C29H35ClN4O5S 587.1 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC4=CC=CC=C43)C)NC(=O)[C@H](C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7SUF8 (S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(pyridin-3-yl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide Investigative 46883921 C28H35N5O2S 505.7 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CN=CC=C5)NC Ki = 50000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7UCG9 (2S)-N-[(2S,3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide Investigative 118586173 C30H30N6O3 522.6 CCN[C@@H](C)C(=O)N[C@H]1[C@@H](OC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N)C IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B7UOM0 (2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride Investigative 72713609 C30H37ClN4O3 537.1 CC1=C(C2=CC=CC=C2C=C1)CN3C4=CC=CC=C4N(C[C@@H](C3=O)NC(=O)[C@H](C)NC)C(=O)CC(C)C.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B83VQI 2-((R)-3-Methyl-piperazin-1-yl)-1-(6-phenylamino-2,3-dihydro-indol-1-yl)-ethanone Investigative 86723980 C21H26N4O 350.5 C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)NC4=CC=CC=C4 IC50 = 79000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B83WCN (2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72713168 C25H29ClN4O5 501 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=NOC5=CC=CC=C54)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B87IOZ (2S)-N-[(3R)-5-[[2-(Difluoromethoxy)naphthalen-1-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Investigative 90060686 C29H31F2N3O5 539.6 C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=CC=CC=C54)OC(F)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B8C7EU (2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 73356962 C32H33ClN6O4 601.1 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=NN(C5=CC=CC=C54)C6=CC=CC=C6C#N)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B8DF3G (2S)-N-[(3S,4S)-5-Acetyl-4-methyl-1-[(3-methylquinolin-4-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73427080 C27H31N5O3 473.6 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C)CC3=C(C=NC4=CC=CC=C43)C)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B8IBD4 (2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-4-oxo-5-(2-phenylethyl)-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride Investigative 72711022 C26H35ClN4O3 487 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CCC3=CC=CC=C3)C(=O)CC(C)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B8TG3S (S)-N-((S)-2-((S)-2-(4-Benzylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide Investigative 46883883 C30H38N4O2S 518.7 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)CC5=CC=CC=C5)NC Ki = 150000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B8XPK2 (2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(1-methylindazol-3-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide Investigative 72712344 C26H32N6O5S 540.6 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NN(C4=CC=CC=C43)C)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9AEG0 (2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Investigative 118586164 C29H32BrN3O5 582.5 C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9AFE6 (2S)-2-(Methylamino)-N-[(3S)-2-oxo-1-(2-phenylethyl)-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride Investigative 72712331 C22H28ClN3O2 401.9 C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CCC3=CC=CC=C3)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9CBL2 (2S)-N-[(3S)-5-[(1-Ethyl-2-oxo-3H-indol-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73055432 C24H28N4O4 436.5 CCN1C(=O)CC2=C(C=CC=C21)CN3C4=CC=CC=C4OC[C@@H](C3=O)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9DVE8 (2S,3R)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide Investigative 90060723 C26H28BrN3O5 542.4 CC1=CC2=C(C=C1)N(C(=O)[C@H](CO2)NC(=O)[C@H]([C@@H](C)O)N)CC3=C(C=CC4=C3C=CC(=C4)Br)OC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9FIL0 (2S)-N-[(3S,4S)-7-Cyano-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73426205 C33H32N8O5S 652.7 C[C@H]1[C@@H](C(=O)N(C2=C(N1C(=O)CS(=O)(=O)C)C=C(C=C2)C#N)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9K3RF 5-[[(3S)-9-[2-Hydroxyethyl(methyl)carbamoyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]-6-methoxynaphthalene-2-carboxylic acid Investigative 73054857 C30H34N4O8 578.6 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)O)OC)C(=O)N(C)CCO)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9MB6Q (2S)-N-[(3S,4S)-1-[(5-Chloro-2-methoxyphenyl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73425995 C25H31ClN4O6S 551.1 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC(=C3)Cl)OC)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9RA7N (S)-N-((S)-2-((S)-2-(4-(4-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide Investigative 46883992 C29H35ClN4O2S 539.1 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CC=C(C=C5)Cl)NC Ki = 58000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9WA7J Afzelin Investigative 5316673 C21H20O10 432.4 C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC=C(C=C4)O)O)O)O IC50 ~ 100000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein B9ZPC8 (2S)-N-[(3S)-5-[(4-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73054591 C20H22ClN3O3 387.9 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=C(C=C3)Cl)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BA3O4D (2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(oxetan-3-ylamino)propanamide Investigative 73055732 C30H28N6O4 536.6 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC6COC6 IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BADF58 Smac AVPI Mimetic 3 Investigative 11280887 C19H26N4O3 358.4 C[C@@H](C(=O)N[C@H]1CC[C@@H]2CC[C@H](N2C1=O)C(=O)NCC3=CC=CC=C3)N Ki ~ 100000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BADP15 (2S)-N-[(3S,4S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 72712131 C29H34N4O6S 566.7 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC4=CC=CC=C43)OC)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BARB97 (3S,8Ar)-6-[[(2S)-2-aminopropanoyl]amino]-N-benzyl-5-oxo-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride Investigative 45263222 C19H27ClN4O3 394.9 C[C@@H](C(=O)NC1CC[C@@H]2CC[C@H](N2C1=O)C(=O)NCC3=CC=CC=C3)N.Cl Ki ~ 100000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BAU3Y4 1-(6-Isopropylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone Investigative 71471953 C18H27N3O 301.4 C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)C(C)C IC50 = 59000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BAV6G8 (2S)-2-(Methylamino)-N-[(3S)-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride Investigative 72712339 C26H30ClN3O2 452 CC1=C(C2=CC=CC=C2C=C1)CN3C4=CC=CC=C4CC[C@@H](C3=O)NC(=O)[C@H](C)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BAZV04 (2S)-N-[(3S)-5-[(6-Fluoro-1-methyl-2-oxoquinolin-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73055430 C24H25FN4O4 452.5 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC(=O)N(C4=C3C=C(C=C4)F)C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BB04AQ (1S)-N-(2,6-Difluorophenyl)-6-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 90070333 C25H29F3N4O3 490.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@H]1C(=O)NC3=C(C=CC=C3F)F)C=CC(=C2)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BB4AL9 (1R)-N-(2,6-Difluorophenyl)-6-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 90070354 C25H29F3N4O3 490.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@@H]1C(=O)NC3=C(C=CC=C3F)F)C=CC(=C2)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BB97XD 3,4,5-Trimethoxy-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide Investigative 73057823 C34H36N4O6S 628.7 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC(=C(C(=C5)OC)OC)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BB98PJ (S)-N-[(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(3-methyl-butyryl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride Investigative 72711028 C30H36BrClN4O4 632 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)CC(C)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BBP4Y6 (2S)-N-[(3S,4S)-1-[(6-Bromo-1,2-benzoxazol-3-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73425991 C25H28BrN5O6S 606.5 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NOC4=C3C=CC(=C4)Br)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BBRW91 (2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide Investigative 117870970 C21H24N4O3 380.4 C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2[C@@H](CC3=CC=CC=C32)C(=O)N)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BC15KN (2S)-N-[(5-Fluoro-2-methylphenyl)methyl]-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide Investigative 117872371 C26H33FN4O3 468.6 CC1=C(C=C(C=C1)F)CNC(=O)[C@@H]2CC3=CC=CC=C3N2C(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BC6YR1 (1S)-N-(2,6-Difluorophenyl)-2-[(2S,3S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]pentanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 73295053 C26H32F2N4O3 486.6 CC[C@H](C)[C@@H](C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BCG8E5 (3S)-5-[(6-Carboxy-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid Investigative 73054855 C27H27N3O8 521.5 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)O)OC)C(=O)O)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BCOX92 (2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(2-hydroxyethylamino)butanamide Investigative 73056601 C27H30BrN3O5 556.4 CC[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NCCO IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BD1J2B (2S)-2-(Methylamino)-N-[(3S)-4-oxo-5-[[2-(2,2,2-trifluoroethoxy)naphthalen-1-yl]methyl]spiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide Investigative 90060717 C30H32F3N3O5 571.6 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=CC=CC=C54)OCC(F)(F)F)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BDI4Y1 (2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2,2-dimethyl-4-oxo-3H-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide Investigative 90060685 C27H30BrN3O3S 556.5 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2SC1(C)C)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BDM21Y (2S)-2-(Methylamino)-N-[(3S)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide Investigative 73054588 C25H27N3O3 417.5 CC1=C(C2=CC=CC=C2C=C1)CN3C4=CC=CC=C4OC[C@@H](C3=O)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BDYU40 (3S,8As)-6-[[(2S)-2-aminopentanoyl]amino]-N-benzyl-5-oxo-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride Investigative 45263207 C21H31ClN4O3 422.9 CCC[C@@H](C(=O)NC1CC[C@H]2CC[C@H](N2C1=O)C(=O)NCC3=CC=CC=C3)N.Cl Ki ~ 100000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BE2Z4K (S)-N-(6-Amino-2-pyridyl)-2-aminopropanamide Investigative 91826683 C8H12N4O 180.21 C[C@@H](C(=O)NC1=CC=CC(=N1)N)N IC50 = 110000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BE9JM6 (1R)-N-(2,6-Difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide Investigative 90070352 C24H28F2N4O3 458.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CC2=CC=CC=C2[C@@H]1C(=O)NC3=C(C=CC=C3F)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BEAQ57 (2S)-N-[(2S,3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2,8-dimethyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73054024 C27H30BrN3O4 540.4 C[C@H]1[C@@H](C(=O)N(C2=C(O1)C=C(C=C2)C)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BF1HM6 (2S)-N-[(3S,4S)-5-Acetyl-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73425660 C28H32N4O3 472.6 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C)CC3=C(C=CC4=CC=CC=C43)C)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BF3YD9 Smac peptido-mimetic 12d Investigative 23646339 C22H34N4O3 402.5 CCC[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NCC2=CC=CC=C2)N Ki = 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BF5XW0 (2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(3-methylquinolin-4-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide Investigative 73427179 C28H33N5O5S 551.7 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=NC4=CC=CC=C43)C)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BFD13V (2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1-(2-methylsulfonylacetyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72711931 C28H32BrClN4O6S 668 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)CS(=O)(=O)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BFU10L (S)-N-((S)-2-((S)-2-(4-(3-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide Investigative 46883924 C29H35ClN4O2S 539.1 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CC(=CC=C5)Cl)NC Ki = 55000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BG2A8E N,N-Dimethyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-carboxamide Investigative 71472006 C18H26N4O2 330.4 C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)C(=O)N(C)C IC50 = 110000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BG3IK1 (2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Investigative 90060670 C32H32N6O4 564.6 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C5C=NN(C5=CC=C4)C6=CC=CC=C6C#N)NC IC50 ~ 53100 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BG3ZK1 6-Methoxy-N,N-dimethyl-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxamide Investigative 90060696 C28H32N4O5 504.6 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)C(=O)N(C)C)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BG4J7W (2S)-N-[(3S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72712558 C26H30ClN3O3 468 C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=CC=CC=C43)OC)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BG75YW (2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Investigative 72713169 C25H28N4O5 464.5 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=NOC5=CC=CC=C54)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BGH52F (2S)-2-(Methylamino)-N-[(3S)-1-(naphthalen-2-ylmethyl)-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride Investigative 72712333 C25H28ClN3O2 438 C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=CC4=CC=CC=C4C=C3)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BH6P2S (2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,1'-cyclopentane]-3-yl]-2-(methylamino)propanamide Investigative 118586161 C29H32BrN3O4 566.5 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BH7JT9 (S)-N-((S)-1-Cyclohexyl-2-((S)-2-(5-methyl-7-phenylthiazolo[5,4-d]pyrimidin-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide Investigative 46884084 C28H36N6O2S 520.7 CC1=NC(=C2C(=N1)SC(=N2)[C@@H]3CCCN3C(=O)[C@H](C4CCCCC4)NC(=O)[C@H](C)NC)C5=CC=CC=C5 Ki = 51000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BHD2I5 (2S)-N-[(3S)-5-[(3-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73054590 C20H22ClN3O3 387.9 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC(=CC=C3)Cl)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BHFE58 (2S)-N-[(3S)-1-Acetyl-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72711929 C27H30BrClN4O4 589.9 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BHW16K 3-Methyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]butanamide Investigative 90060635 C29H34N4O3S 518.7 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)CC(C)C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BI2HS0 (2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutyl)-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride Investigative 72714294 C29H37ClN4O2 509.1 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)CCC(C)C)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BI43NJ N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]-5-oxohexanamide Investigative 73057825 C30H34N4O4S 546.7 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)CCCC(=O)C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BI4Y7G (2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide Investigative 73056905 C29H31BrFN3O5 600.5 C[C@@H](C(=O)N[C@H]1C(=O)N(C2=C(C(=CC=C2)F)OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BI6X7Y (S)-N-((S)-3,3-Dimethyl-1-oxo-1-((S)-2-(4-(quinolin-4-yl)thiazol-2-yl)pyrrolidin-1-yl)butan-2-yl)-2-(methylamino)propanamide Investigative 46884475 C26H33N5O2S 479.6 C[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C2=NC(=CS2)C3=CC=NC4=CC=CC=C34)C(C)(C)C)NC Ki = 130000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BIA15Y (1S)-N-(2-Fluoro-6-methylphenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide Investigative 73294889 C25H31FN4O3 454.5 CC1=C(C(=CC=C1)F)NC(=O)[C@@H]2C3=CC=CC=C3CN2C(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BIN51D (3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid Investigative 73055134 C25H24BrN3O5 526.4 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=CC=C(C4=CC=CC=C34)Br)C(=O)O)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BITH41 (2S)-N-[(3S,4S)-5-Acetyl-1-[(5-bromo-2-methoxyphenyl)methyl]-7-cyano-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73425879 C25H28BrN5O4 542.4 C[C@H]1[C@@H](C(=O)N(C2=C(N1C(=O)C)C=C(C=C2)C#N)CC3=C(C=CC(=C3)Br)OC)NC(=O)[C@H](C)NC IC50 = 53050 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BJ4HI2 (2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-N-phenyl-2,3-dihydroindole-2-carboxamide Investigative 117872174 C27H28N4O3 456.5 C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)N2[C@@H](CC3=CC=CC=C32)C(=O)NC4=CC=CC=C4)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BJ85NB (2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73055138 C29H27N5O3 493.6 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=CN(C4=CC=C3)C5=CC=CC=C5C#N)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BJCV98 (S)-N-((S)-2-((S)-2-(4-(4-Fluoronaphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide Investigative 11497354 C28H33FN4O3S 524.7 C[C@@H](C(=O)N[C@@H](C1CCOCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=CC=C(C5=CC=CC=C54)F)NC Ki = 140000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BJF8I5 (2S)-N-Benzhydryl-1-[(2S)-3-methyl-2-[[(2R)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide Investigative 56666366 C27H36N4O3 464.6 C[C@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC(C2=CC=CC=C2)C3=CC=CC=C3)NC Ki ~ 56000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BJG83V (2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1-(4-nitrobenzoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72711484 C32H31BrClN5O6 697 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)C5=CC=C(C=C5)[N+](=O)[O-])NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BJR64G (2S)-2-(Methylamino)-N-[(3S)-4-oxo-5-propan-2-ylspiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide Investigative 90060715 C20H29N3O4 375.5 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)C(C)C)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BK02LQ (2S,3S)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide Investigative 90060699 C26H28BrN3O5 542.4 CC1=CC2=C(C=C1)N(C(=O)[C@H](CO2)NC(=O)[C@H]([C@H](C)O)N)CC3=C(C=CC4=C3C=CC(=C4)Br)OC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BK58GW (2S)-N-(1,3-Dimethyl-2-oxobenzimidazol-5-yl)-2-(methylamino)propanamide Investigative 89970323 C13H18N4O2 262.31 C[C@@H](C(=O)NC1=CC2=C(C=C1)N(C(=O)N2C)C)NC IC50 = 55000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BL30OR (2S,3S)-2-Amino-N-[(3R)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-3-hydroxybutanamide Investigative 118582223 C29H32BrN3O6 598.5 C[C@@H]([C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)N)O IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BL5RB6 (2R)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72712562 C26H29BrClN3O3 546.9 C[C@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BL68TM (1S)-7-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 90070353 C25H29ClF2N4O3 507 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@H]1C(=O)NC3=C(C=CC=C3F)F)C=C(C=C2)Cl)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BLO4C5 (2S,3S)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-3-hydroxybutanamide Investigative 118582222 C29H32BrN3O6 598.5 C[C@@H]([C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)N)O IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BLX4S3 Smac peptido-mimetic 12a Investigative 23646336 C20H30N4O3 374.5 CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)NCCC2=CC=CC=C2)NC(=O)CN Ki = 68000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BM0L3N (1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-hydroxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide Investigative 73294730 C23H26F2N4O4 460.5 C[C@H]([C@@H](C(=O)N1CC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC(=O)[C@H](C)NC)O IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BM4PK5 (1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-methoxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 73295228 C25H30F2N4O4 488.5 C[C@H]([C@@H](C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC(=O)[C@H](C)NC)OC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BME0D6 (2S)-2-Amino-N-[(3S)-4-oxo-5-propan-2-ylspiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide Investigative 118582224 C19H27N3O4 361.4 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)C(C)C)N IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BMK1Q7 (1S)-N-(2,6-Dichlorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 73295057 C25H30Cl2N4O3 505.4 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3Cl)Cl)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BMQ59X (1R)-2-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-naphthalen-1-yl-1,3-dihydroisoindole-1-carboxamide Investigative 73297144 C28H32N4O3 472.6 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CC2=CC=CC=C2[C@@H]1C(=O)NC3=CC=CC4=CC=CC=C43)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BMR54A (2S)-N-[(1S)-1-(Anilinocarbamoyl)-2-methyl-propyl]-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butyramide;formic acid Investigative 44176339 C20H33N5O3 391.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NNC1=CC=CC=C1)NC Ki = 65620 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BMX6D9 (3S,6S,8As)-6-[[(2S)-2-aminopentanoyl]amino]-N-benzyl-1,2,3,5,6,7,8,8a-octahydroindolizine-3-carboxamide Investigative 44590212 C21H32N4O2 372.5 CCC[C@@H](C(=O)N[C@H]1CC[C@H]2CC[C@H](N2C1)C(=O)NCC3=CC=CC=C3)N Ki ~ 100000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BN03AF Methanoic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]-N-[(2S)-1-oxidanylidene-1-(2-phenylhydrazinyl)propan-2-yl]butanamide Investigative 44176335 C18H29N5O3 363.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)NNC1=CC=CC=C1)NC Ki = 51790 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BN1XU9 3-Cyano-4-[4-[[(2S,3S)-2-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]indazol-1-yl]benzoic acid Investigative 90060674 C30H28N6O5 552.6 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2O1)CC3=C4C=NN(C4=CC=C3)C5=C(C=C(C=C5)C(=O)O)C#N)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BN35CM (1R)-7-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 90070358 C25H29ClF2N4O3 507 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@@H]1C(=O)NC3=C(C=CC=C3F)F)C=C(C=C2)Cl)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BO08LJ (S)-2-Methylamino-N-((S)-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride Investigative 72713605 C24H27ClN4O2 438.9 C[C@@H](C(=O)N[C@H]1CNC2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BO5ML4 (1R)-N-(2,6-Difluorophenyl)-7-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 90070335 C25H29F3N4O3 490.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@@H]1C(=O)NC3=C(C=CC=C3F)F)C=C(C=C2)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BOS19I (2S)-2-(Methylamino)-N-[(3S)-3-methyl-2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl]propanamide Investigative 70980028 C12H17N5O2 263.3 C[C@H]1C(=O)NC2=C(N1)N=C(C=C2)NC(=O)[C@H](C)NC IC50 = 55000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BOW01N (2S)-N-[(3S,4S)-1-(1,2-Benzoxazol-3-ylmethyl)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 73352496 C25H30ClN5O6S 564.1 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NOC4=CC=CC=C43)NC(=O)[C@H](C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BP02YB N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide Investigative 73058103 C31H30N4O3S 538.7 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5=CC=CC=C5)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BP0J3I (1S)-2-[(2S)-2-Cyclopentyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(2,6-difluorophenyl)-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 73295404 C27H32F2N4O3 498.6 C[C@@H](C(=O)N[C@@H](C1CCCC1)C(=O)N2CCC3=CC=CC=C3[C@H]2C(=O)NC4=C(C=CC=C4F)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BP6T7Y (2S)-N-Benzhydryl-1-[(2R)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide Investigative 25241691 C27H36N4O3 464.6 C[C@@H](C(=O)N[C@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC(C2=CC=CC=C2)C3=CC=CC=C3)NC Ki ~ 56000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BP8N0H (2S)-N-[(3S)-5-[(2-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73054589 C20H22ClN3O3 387.9 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3Cl)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BPI2M6 (S)-N-((S)-3,3-Dimethyl-1-((S)-2-(4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-2-(methylamino)propanamide Investigative 46884410 C27H34N4O2S 478.7 C[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C2=NC(=CS2)C3=CC=CC4=CC=CC=C43)C(C)(C)C)NC Ki = 68000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BPQZ07 (2S)-1-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide Investigative 117871469 C18H26N4O3 346.4 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CC2=CC=CC=C21)C(=O)N)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BPT34E (2S)-N-(2,6-Difluorophenyl)-3,3-dimethyl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2H-indole-2-carboxamide Investigative 73442923 C26H32F2N4O3 486.6 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](C(C2=CC=CC=C21)(C)C)C(=O)NC3=C(C=CC=C3F)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BPZ81V (2S)-N-[(5-Fluoro-2-methylphenyl)methyl]-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide Investigative 117871180 C29H31FN4O3 502.6 CC1=C(C=C(C=C1)F)CNC(=O)[C@@H]2CC3=CC=CC=C3N2C(=O)[C@H](C4=CC=CC=C4)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BQ3HE5 (2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-9-[4-(2-hydroxyethyl)piperazine-1-carbonyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73055135 C31H36BrN5O5 638.6 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=CC=C(C4=CC=CC=C34)Br)C(=O)N5CCN(CC5)CCO)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BR2N6T 1-Methyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]piperidine-4-carboxamide Investigative 90060632 C31H37N5O3S 559.7 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)NC(=O)C5CCN(CC5)C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BREB57 (2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide Investigative 72712133 C29H34N4O5S 550.7 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=C(C=CC4=CC=CC=C43)C)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BRN4J1 (1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-methoxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide Investigative 90070334 C24H28F2N4O4 474.5 C[C@H]([C@@H](C(=O)N1CC2=CC=CC=C2[C@H]1C(=O)NC3=C(C=CC=C3F)F)NC(=O)[C@H](C)NC)OC IC50 = 51740 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BRS9F8 (2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(2-hydroxyethylamino)propanamide Investigative 73057217 C30H34BrN3O6 612.5 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NCCO IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BRT79A (2S)-N-[(3S)-5-[[6-Bromo-1-(2-cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide Investigative 90060741 C29H27BrN6O3 587.5 CCN[C@@H](C)C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC(=C3)Br)C5=CC=CC=C5C#N IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BS3Z5X 1-(4-Chloro-3,3-dimethyl-2H-indol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone Investigative 71472008 C17H24ClN3O 321.8 C[C@@H]1CN(CCN1)CC(=O)N2CC(C3=C2C=CC=C3Cl)(C)C IC50 = 150000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BS9N7U (1S)-N-(2,6-Difluorophenyl)-7-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide Investigative 90070337 C25H29F3N4O3 490.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CCC2=C([C@H]1C(=O)NC3=C(C=CC=C3F)F)C=C(C=C2)F)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BS9TM1 N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide Investigative 129012532 C30H33BrFN3O5 614.5 CCC(C(=O)N[C@H]1C(=O)N(C2=C(C(=CC=C2)F)OC13CCOCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BSC76E (2S)-N-[(2S,3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,3'-oxolane]-3-yl]-2-(methylamino)propanamide Investigative 90060712 C28H30BrN3O5 568.5 C[C@@H](C(=O)N[C@H]1C(=O)N(C2=CC=CC=C2O[C@@]13CCOC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BSDP36 (2S)-N-(3-Benzyl-2-oxo-1H-imidazo[4,5-b]pyridin-5-yl)-2-(methylamino)propanamide Investigative 71003452 C17H19N5O2 325.4 C[C@@H](C(=O)NC1=NC2=C(C=C1)NC(=O)N2CC3=CC=CC=C3)NC IC50 = 200000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BSGZ13 (2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride Investigative 72714289 C29H35ClN4O3 523.1 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)C(=O)CC(C)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BSNR67 (S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-phenylthiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide Investigative 46884409 C25H34N4O2S 454.6 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=CC=CC=C4)NC Ki = 190000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BST6W7 (2S)-2-(Methylamino)-N-[1,1,4-trioxo-5-(4-phenylbutyl)-2,3-dihydro-1lambda6,5-benzothiazepin-3-yl]propanamide Investigative 73056595 C23H29N3O4S 443.6 C[C@@H](C(=O)NC1CS(=O)(=O)C2=CC=CC=C2N(C1=O)CCCCC3=CC=CC=C3)NC IC50 ~ 54200 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BSZ0U2 (2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72712345 C32H34ClN7O5S 664.2 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC(=O)[C@H](C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BT8QD1 (3S,6S,10As)-N-[(S)-[1-[4-[4-[4-[4-[(S)-[[(3S,6S,10aS)-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carbonyl]amino]-phenylmethyl]triazol-1-yl]butyl]phenyl]butyl]triazol-4-yl]-phenylmethyl]-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide Investigative 24754961 C80H94N16O8 1407.7 CC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H]3CCCC[C@H]4CC[C@H](N4C3=O)C(=O)N[C@@H](C5=CC=CC=C5)C6=CN(N=N6)CCCCC7=CC=C(C=C7)CCCCN8C=C(N=N8)[C@H](C9=CC=CC=C9)NC(=O)[C@@H]1CC[C@H]2N1C(=O)[C@H](CCCC2)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)C IC50 ~ 50000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BUE72Y (2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(2-hydroxyethylamino)propanamide Investigative 90060578 C29H28N6O4 524.6 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N)NCCO IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BV25KB (2S)-N-[5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-(2-methoxyethyl)-2-methyl-4-oxo-3H-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 118586166 C29H34BrN3O5 584.5 C[C@@H](C(=O)NC1C(=O)N(C2=CC=CC=C2OC1(C)CCOC)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BVL51G (2S)-N-[(3S)-5-[(2-Methoxyphenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 90060664 C21H25N3O4 383.4 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BVP34Y 4-({[(S)-9-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-7-((S)-2-methylamino-propionylamino)-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocycloheptene-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester Investigative 73054853 C35H35BrN4O7 703.6 C[C@@H](C(=O)N[C@H]1COC2=C(C=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)C(=O)NCC5=CC=C(C=C5)C(=O)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BW1XJ9 (2S)-N-[(3S,9S,12S,18S,24S,27S)-9,24-Dibenzyl-18-[[(2S)-2-(methylamino)propanoyl]amino]-2,8,11,17,23,26-hexaoxo-1,7,10,16,22,25-hexazatricyclo[25.3.0.012,16]triacontan-3-yl]-2-(methylamino)propanamide Investigative 46888403 C46H66N10O8 887.1 C[C@@H](C(=O)N[C@H]1CCCNC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C1=O)CC4=CC=CC=C4)NC(=O)[C@H](C)NC)CC5=CC=CC=C5)NC IC50 = 53900 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BW4DQ2 (2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-7-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73054296 C26H25BrF3N3O4 580.4 C[C@@H](C(=O)N[C@H]1COC2=C(C=C(C=C2)C(F)(F)F)N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BW8VT4 1-(6-Fluoroindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone Investigative 71471950 C15H20FN3O 277.34 C[C@@H]1CN(CCN1)CC(=O)N2CCC3=C2C=C(C=C3)F IC50 = 51000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BWB92O (2S)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(ethylamino)propanamide;hydrochloride Investigative 72712768 C27H31BrClN3O3 560.9 CCN[C@@H](C)C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BWD3M0 (2S)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride Investigative 72712560 C26H29BrClN3O3 546.9 C[C@@H](C(=O)N[C@H]1CCC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BWK7Y5 (2S)-N-[(3R)-9-Amino-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide Investigative 73058101 C24H26N4O2S 434.6 C[C@@H](C(=O)N[C@H]1CSC2=C(C=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)N)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BX04QZ 2-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-phenyl-1,3-dihydroisoindole-1-carboxamide Investigative 73296972 C24H30N4O3 422.5 C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N1CC2=CC=CC=C2C1C(=O)NC3=CC=CC=C3)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BX0ER3 (2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 72712346 C32H33N7O5S 627.7 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)CS(=O)(=O)C)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BX1CK2 (2S)-2-(Methylamino)-N-[(3S)-1-methyl-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride Investigative 72714292 C25H29ClN4O2 453 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)CC3=CC=CC4=CC=CC=C43)C)NC.Cl IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BXF7I6 (2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-(1-naphthalen-1-ylethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride Investigative 72711024 C30H37ClN4O3 537.1 C[C@@H](C(=O)N[C@H]1CN(C2=CC=CC=C2N(C1=O)C(C)C3=CC=CC4=CC=CC=C43)C(=O)CC(C)C)NC.Cl IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BXH4S6 (2S)-N-[(3S,4S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-5-(2-methoxyacetyl)-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 90089029 C29H33BrN4O5 597.5 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)COC)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC(=O)[C@H](C)NC IC50 = 50260 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BXQD72 (2S)-N-[(3S,4S)-5-Acetyl-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Investigative 73425656 C31H31N7O3 549.6 C[C@H]1[C@@H](C(=O)N(C2=CC=CC=C2N1C(=O)C)CC3=NN(C4=CC=CC=C43)C5=CC=CC=C5C#N)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BXYW79 (2S)-2-Amino-N-[(3S)-5-[[1-(2-cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide Investigative 90060606 C27H24N6O3 480.5 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N)N IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BY1XS0 (S)-2-Amino-N-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[D]azepin-1-YL)propanamide Investigative 44178407 C14H19N3O2 261.32 C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2CCN(C1=O)C)N IC50 ~ 54200 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BY7Q3N (2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-[(2-hydroxy-2-methylpropyl)amino]propanamide Investigative 90060724 C31H32N6O4 552.6 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C4C=NN(C4=CC=C3)C5=CC=CC=C5C#N)NCC(C)(C)O IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BYK54J (S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(pyridin-4-yl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide Investigative 46883922 C28H35N5O2S 505.7 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC4=C(C=CC=C4S3)C5=CC=NC=C5)NC Ki = 60000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BZ98KP (2S)-N-(5-Benzyl-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl)-2-(methylamino)propanamide Investigative 73056591 C20H23N3O2S 369.5 C[C@@H](C(=O)NC1CSC2=CC=CC=C2N(C1=O)CC3=CC=CC=C3)NC IC50 ~ 54200 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BZD7K3 (2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,1'-cyclohexane]-3-yl]-2-(methylamino)propanamide Investigative 73056304 C30H34BrN3O4 580.5 C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2OC13CCCCC3)CC4=C(C=CC5=C4C=CC(=C5)Br)OC)NC IC50 = 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BZP97N (S)-N-[(S)-9-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-2-methylamino-propionamide trifluoroacetate Investigative 72712770 C27H27BrF3N3O6 626.4 C[C@@H](C(=O)N[C@H]1COC2=CC=CC=C2N(C1=O)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC.C(=O)(C(F)(F)F)O IC50 ~ 54000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BZWE03 N-{(1s)-1-Cyclohexyl-2-[(2s)-2-(4-Naphthalen-1-Yl-1,3-Thiazol-2-Yl)pyrrolidin-1-Yl]-2-Oxoethyl}-N~2~-Methyl-L-Alaninamide Investigative 44820626 C29H36N4O2S 504.7 C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C4=CC=CC5=CC=CC=C54)NC Ki = 68000 nM Poor binder T16769 X-linked inhibitor of apoptosis protein BZX1T5 (2S)-N-[(2S,3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-methyl-4-oxo-7-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide Investigative 73054298 C27H27BrF3N3O4 594.4 C[C@H]1[C@@H](C(=O)N(C2=C(O1)C=CC(=C2)C(F)(F)F)CC3=C(C=CC4=C3C=CC(=C4)Br)OC)NC(=O)[C@H](C)NC IC50 ~ 54800 nM Poor binder T16769 X-linked inhibitor of apoptosis protein D0G3TK KAEMPFEROL Investigative 5280863 C15H10O6 286.24 C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O IC50 ~ 100000 nM Poor binder