TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T17852	Phosphodiesterase 9	D01RCZ	B7673	Patented	2052828	C15H16N2OS2	304.4	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	D0A0ZU	AC1MOZOL	Patented	3403301	C16H18N2OS2	318.5	CCC(C)SC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	D0SG9Q	US9388139, 12	Patented	60194756	C20H20Cl2N2O2	391.3	CC(C)(C)C1=NN(C(C1)C2=C(C=C(C=C2)Cl)Cl)C3=CC=C(C=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T17852	Phosphodiesterase 9	D0SH7F	BC11-28	Patented	3257208	C25H19FN4	394.4	CC1=CC=CC=C1NC2=C3C(=CN(C3=NC=N2)C4=CC=C(C=C4)F)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	D0Z7YQ	AC1M1SP5	Patented	2155273	C16H18N2O2S2	334.5	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3OC)SCC2	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	B0A9ID	N-(4-Methoxybenzyl)-3-(cyclopentyloxy)-4-(difluoromethoxy)benzamide	Investigative	122193679	C21H23F2NO4	391.4	COC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC(F)F)OC3CCCC3	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	B0IL3G	Moracin C	Investigative	155248	C19H18O4	310.3	CC(=CCC1=C(C=C(C=C1O)C2=CC3=C(O2)C=C(C=C3)O)O)C	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	B0LMZ1	1-[4-Methoxy-3-(tetrahydropyran-4-yloxy)phenyl]butan-1-one	Investigative	23654252	C16H22O4	278.34	CCCC(=O)C1=CC(=C(C=C1)OC)OC2CCOCC2	IC50 ~ 50000 nM	Poor binder
T17852	Phosphodiesterase 9	B2DJ1U	N-(2-Chlorophenyl)-3-cyclopentyloxy-4-(difluoromethoxy)benzamide	Investigative	134129996	C19H18ClF2NO3	381.8	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	B48LUC	Chembl4206423	Investigative	145978345	C23H28N2O5S	444.5	CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N2CCC3=CC(=C(C=C3C2)OC4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	B5GSN2	Chembl4215772	Investigative	145974174	C25H26F3NO6	493.5	COC1=C(C=C2CN(C(CC2=C1)C(=O)OC)C(=O)C3=CC=C(C=C3)OC(F)(F)F)OC4CCCC4	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	B60LSR	1-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-1-quinolin-3-ylbutan-1-ol	Investigative	25179478	C25H24N2O3	400.5	CCCC(C1=CC(=C(C=C1)OC2=CC=CC=N2)OC)(C3=CC4=CC=CC=C4N=C3)O	IC50 ~ 50000 nM	Poor binder
T17852	Phosphodiesterase 9	B72YPD	(11R,15S)-5-Anilino-8-methyl-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one	Investigative	11988967	C30H28N6O	488.6	CN1C(=O)C2=C(N(N=C2N3C1=N[C@H]4[C@@H]3CCC4)CC5=CC=C(C=C5)C6=CC=CC=C6)NC7=CC=CC=C7	Ki ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	B8VUQ4	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130563	C17H16F2N2O3	334.32	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	B9FU3Y	(S)-1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidine-4(5H)-one	Investigative	46881198	C15H14ClF3N4O	358.74	C[C@@H](CC1=NC2C(C=NN2C3=CC=CC=C3Cl)C(=O)N1)C(F)(F)F	IC50 = 50000 nM	Poor binder
T17852	Phosphodiesterase 9	B9V3TH	N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide	Investigative	2409032	C23H24N4OS	404.5	CCN(CC)C(=O)C1=CC(=NC2=C1C(=NN2C3=CC=CC=C3C)C)C4=CC=CS4	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	BAN58F	(11R,15S)-5-Anilino-8-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methyl]-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one	Investigative	11989102	C24H22F3N7O	481.5	CN1C(=O)C2=C(N(N=C2N3C1=N[C@H]4[C@@H]3CCC4)CC5=CN=C(C=C5)C(F)(F)F)NC6=CC=CC=C6	Ki ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	BBX84M	4-(4-((8-(3-(Difluoromethoxy)phenyl)quinolin-6-yl)methoxy)phenyl)-2-methylbutan-2-ol	Investigative	46933992	C28H27F2NO3	463.5	CC(C)(CCC1=CC=C(C=C1)OCC2=CC(=C3C(=C2)C=CC=N3)C4=CC(=CC=C4)OC(F)F)O	IC50 ~ 55000 nM	Poor binder
T17852	Phosphodiesterase 9	BJA3Z5	4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one	Investigative	25179287	C25H22N2O3	398.5	CC(=O)CC(C1=CC(=C(C=C1)OC2=CC=CC=N2)OC)C3=CC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T17852	Phosphodiesterase 9	BO3YQ5	2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2155145	C16H18N2OS2	318.5	CCCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	BOF79I	(6Ar,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-(4-trifluoromethyl-benzyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one	Investigative	11989101	C25H23F3N6O	480.5	CN1C(=O)C2=C(N(N=C2N3C1=N[C@H]4[C@@H]3CCC4)CC5=CC=C(C=C5)C(F)(F)F)NC6=CC=CC=C6	Ki = 50000 nM	Poor binder
T17852	Phosphodiesterase 9	BR5L8O	2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2052838	C16H18N2OS2	318.5	CCCSC1=NC2=C(C(=O)N1C3=CC=C(C=C3)C)SCC2	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	BRHT84	3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione	Investigative	2802078	C15H9N3O2S	295.3	C1=CC=C(C=C1)N2C(=O)N=C3N(C2=O)C4=CC=CC=C4S3	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	BWDV57	Moracin M	Investigative	185848	C14H10O4	242.23	C1=CC2=C(C=C1O)OC(=C2)C3=CC(=CC(=C3)O)O	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	BX47WE	1-[4-(Difluoromethoxy)-3-(oxolan-3-yloxy)phenyl]-3-methylbutan-1-one	Investigative	25147798	C16H20F2O4	314.32	CC(C)CC(=O)C1=CC(=C(C=C1)OC(F)F)OC2CCOC2	IC50 ~ 50000 nM	Poor binder
T17852	Phosphodiesterase 9	BXLO05	3-Cyclopentyloxy-4-(difluoromethoxy)-N-pyridin-3-ylbenzamide	Investigative	134130328	C18H18F2N2O3	348.3	C1CCC(C1)OC2=C(C=CC(=C2)C(=O)NC3=CN=CC=C3)OC(F)F	IC50 ~ 100000 nM	Poor binder
T17852	Phosphodiesterase 9	BYVU78	N-(2-Chlorophenyl)-3(cyclopropylmethoxy)-4-(difluoromethoxy)benzamide	Investigative	134131162	C18H16ClF2NO3	367.8	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=CC=CC=C3Cl)OC(F)F	IC50 ~ 100000 nM	Poor binder