TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T17967	Pyruvate dehydrogenase kinase 2	B1GTI8	9-Hydroxy-N-methyl-N-phenyl-9-(trifluoromethyl)fluorene-2-carboxamide	Investigative	59492551	C22H16F3NO2	383.4	CN(C1=CC=CC=C1)C(=O)C2=CC3=C(C=C2)C4=CC=CC=C4C3(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	B27UBY	2,7-Dichloro-9-(trifluoromethyl)fluoren-9-ol	Investigative	59492552	C14H7Cl2F3O	319.1	C1=CC2=C(C=C1Cl)C(C3=C2C=CC(=C3)Cl)(C(F)(F)F)O	IC50 = 56574 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	B2IYO9	9-Hydroxy-N-methoxy-N-methyl-9-(trifluoromethyl)fluorene-4-carboxamide	Investigative	59493176	C17H14F3NO3	337.29	CN(C(=O)C1=C2C3=CC=CC=C3C(C2=CC=C1)(C(F)(F)F)O)OC	IC50 ~ 100000 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	B2O6WQ	9-Hydroxy-N,N-dimethyl-9-(trifluoromethyl)fluorene-4-carboxamide	Investigative	59492887	C17H14F3NO2	321.29	CN(C)C(=O)C1=C2C3=CC=CC=C3C(C2=CC=C1)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	B3M4NT	N-[9-Hydroxy-9-(trifluoromethyl)fluoren-4-yl]acetamide	Investigative	59492622	C16H12F3NO2	307.27	CC(=O)NC1=CC=CC2=C1C3=CC=CC=C3C2(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	B72QXH	9-Hydroxy-9-(trifluoromethyl)fluorene-4-carboxylic acid	Investigative	59493085	C15H9F3O3	294.22	C1=CC=C2C(=C1)C3=C(C=CC=C3C2(C(F)(F)F)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	BK7FI9	9-Hydroxy-9-(trifluoromethyl)fluorene-3-carboxylic acid	Investigative	59493066	C15H9F3O3	294.22	C1=CC=C2C(=C1)C3=C(C2(C(F)(F)F)O)C=CC(=C3)C(=O)O	IC50 = 68593 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	BNB5F7	4-Ethoxy-9-(trifluoromethyl)fluoren-9-ol	Investigative	59492788	C16H13F3O2	294.27	CCOC1=CC=CC2=C1C3=CC=CC=C3C2(C(F)(F)F)O	IC50 = 66305 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	BPQ3S2	9-Hydroxy-9-(trifluoromethyl)fluorene-2-carboxylic acid	Investigative	59492712	C15H9F3O3	294.22	C1=CC=C2C(=C1)C3=C(C2(C(F)(F)F)O)C=C(C=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	BRUO25	9-Hydroxy-N,N-dimethyl-9-(trifluoromethyl)fluorene-3-carboxamide	Investigative	59492643	C17H14F3NO2	321.29	CN(C)C(=O)C1=CC2=C(C=C1)C(C3=CC=CC=C32)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T17967	Pyruvate dehydrogenase kinase 2	BUC1V5	4-(Methoxymethyl)-9-(trifluoromethyl)fluoren-9-ol	Investigative	59492530	C16H13F3O2	294.27	COCC1=C2C3=CC=CC=C3C(C2=CC=C1)(C(F)(F)F)O	IC50 = 67348 nM	Poor binder