TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T19244	S-mephenytoin 4-hydroxylase	D00FGR	Miltefosine	Approved	3599	C21H46NO4P	407.6	CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D00YZD	Dolutegravir	Approved	54726191	C20H19F2N3O5	419.4	C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D01ZII	Chlorpromazine	Approved	2726	C17H19ClN2S	318.9	CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D03BLF	Triamcinolone	Approved	31307	C21H27FO6	394.4	C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)CCC4=CC(=O)C=C[C@@]43C)F)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D04NQI	Amodiaquine	Approved	2165	C20H22ClN3O	355.9	CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D04XGT	Benznidazole	Approved	31593	C12H12N4O3	260.25	C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D05CEU	Flunarizine	Approved	941361	C26H26F2N2	404.5	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D05EAM	Pentamidine	Approved	4735	C19H24N4O2	340.4	C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D06OIV	Tolbutamide	Approved	5505	C12H18N2O3S	270.35	CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C	Ki = 70000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D07ACT	Ceftriaxone	Approved	5479530	C18H18N8O7S3	554.6	CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\\OC)/C4=CSC(=N4)N)SC2)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D09SGV	Daclatasvir	Approved	25154714	C40H50N8O6	738.9	CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC	IC50 = 59500 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0C0SK	Pyrimethamine	Approved	4993	C12H13ClN4	248.71	CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl	Ki = 51500 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0C3SW	Lesinurad	Approved	53465279	C17H14BrN3O2S	404.3	C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O	IC50 = 78700 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0D1AL	Haloperidol	Approved	3559	C21H23ClFNO2	375.9	C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0D4YZ	PSI-7977	Approved	45375808	C22H29FN3O9P	529.5	C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3	IC50 = 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0I1FQ	Raltegravir	Approved	54671008	C20H21FN6O5	444.4	.	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0I2MK	Metoprolol	Approved	4171	C15H25NO3	267.36	CC(C)NCC(COC1=CC=C(C=C1)CCOC)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0K0TC	Sertraline	Approved	68617	C17H17Cl2N	306.2	CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0K9MY	Saxagliptin	Approved	11243969	C18H25N3O2	315.4	C1[C@@H]2C[C@@H]2N([C@@H]1C#N)C(=O)[C@H](C34CC5CC(C3)CC(C5)(C4)O)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0Q2PE	Norfloxacin	Approved	4539	C16H18FN3O3	319.33	CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0R0FE	Verapamil	Approved	2520	C27H38N2O4	454.6	CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0R1QE	Ibuprofen	Approved	3672	C13H18O2	206.28	CC(C)CC1=CC=C(C=C1)C(C)C(=O)O	Ki = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0Z3DY	Benzbromarone	Approved	2333	C17H12Br2O3	424.1	CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D06ZEO	BAY 1021189	Phase 3	54674461	C19H16F2N8O2	426.4	COC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=C(C=N3)F)CC4=CC=CC=C4F)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0SP5V	Setipiprant	Phase 3	49843471	C24H19FN2O3	402.4	C1CN(CC2=C1N(C3=C2C=C(C=C3)F)CC(=O)O)C(=O)C4=CC=CC5=CC=CC=C54	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0W9VW	TZP-101	Phase 2b	11526696	C30H39FN4O4	538.7	C[C@@H]1CN[C@H](C(=O)N([C@@H](C(=O)N[C@@H](C(=O)NCCCC2=CC=CC=C2O1)CC3=CC=C(C=C3)F)C)C)C4CC4	IC50 = 66000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D01DDN	SCH-900271	Phase 2	56950369	C14H16N2O4	276.29	CC1(CC1)CCCC2=CC(=O)OC3=C2C(=O)NC(=O)N3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D05UYQ	Camicinal	Phase 2	15984937	C25H33FN4O	424.6	C[C@H]1CN(CCN1)CC2=CC=C(C=C2)CC(=O)N3CCC(CC3)NC4=CC(=CC=C4)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D09WYL	GSK-557296	Phase 2	11634973	C30H38N4O4	518.6	CC[C@H](C)[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](C2=C(N=C(C=C2)C)C)C(=O)N3CCOCC3)C4CC5=CC=CC=C5C4	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0E0JO	GLPG-1837	Phase 2	117857370	C16H20N4O3S	348.4	CC1(CC2=C(C(O1)(C)C)SC(=C2C(=O)N)NC(=O)C3=CC=NN3)C	EC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0F6YM	VBP15	Phase 2	3035000	C22H28O4	356.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4(C3=CC[C@@]2([C@]1(C(=O)CO)O)C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0I4PW	APD371	Phase 2	60164925	C18H23N5O3	357.4	CC(C)(C)[C@@H](CO)NC(=O)C1=NN(C2=C1C[C@H]3[C@@H]2C3)C4=NC=C[N+](=C4)[O-]	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0M4TJ	Ralinepag	Phase 2	44219292	C23H26ClNO5	431.9	C1CC(CCC1COCC(=O)O)COC(=O)N(C2=CC=CC=C2)C3=CC=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0Q7NB	842166X	Phase 2	10253143	C18H17Cl2F3N4O2	449.3	C1COCCC1CNC(=O)C2=CN=C(N=C2C(F)(F)F)NC3=C(C=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0SG7B	GLPG-0634	Phase 2	49831257	C21H23N5O3S	425.5	C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5	IC50 ~ 70000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0W1US	PLECONARIL	Phase 2	1684	C18H18F3N3O3	381.3	CC1=CC(=CC(=C1OCCCC2=CC(=NO2)C)C)C3=NOC(=N3)C(F)(F)F	IC50 ~ 50118.72 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D03ISJ	BMS-863233	Phase 1/2	135564632	C14H12ClN3O2	289.71	.	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D03GNI	ISOQUINE	Phase 1	2166	C20H22ClN3O	355.9	CCN(CC)CC1=C(C=C(C=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O	IC50 = 75000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D03SQT	Q203	Phase 1	68234908	C29H28ClF3N4O2	557	CCC1=C(N2C=C(C=CC2=N1)Cl)C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0J1HB	PF-06840003	Phase 1	23063810	C12H9FN2O2	232.21	C1C(C(=O)NC1=O)C2=CNC3=C2C=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0LU9X	Tetra-hydro-oxazolopyridine derivative 3	Patented	74221950	C18H12ClF2N3O2	375.8	C1CN(CC2=C1OC(=N2)C3=NC=C(C=C3)F)C(=O)C4=CC(=CC(=C4)Cl)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0B7SP	GSK163090	Discontinued in Phase 2	11292933	C25H29N5O	415.5	CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCNC5=O	IC50 = 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0H9GQ	DOV-216303	Discontinued in Phase 2	9795276	C11H11Cl2N	228.11	C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl	IC50 = 99000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D03YPJ	SB 206553	Terminated	5163	C17H16N4O	292.33	CN1C=CC2=CC3=C(CCN3C(=O)NC4=CN=CC=C4)C=C21	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D07GIB	AZD5672	Terminated	11614352	C31H43F2N3O5S2	639.8	CCN(C1CCN(CC1)CC[C@H](C2CCN(CC2)S(=O)(=O)C)C3=CC(=CC(=C3)F)F)C(=O)CC4=CC=C(C=C4)S(=O)(=O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B01MJO	CID 71544946	Investigative	71544946	C28H25N3O6	499.5	C[C@H](C1=CC=CC=C1)N2C(=O)[C@@](OC2=O)(CC3=CC=CC=C3)C4=NN=C(O4)C5=CC(=CC(=C5)OC)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B01TPF	3-[7-Chloro-2-[(1-cyclopropyl-2-oxoimidazo[4,5-c]pyridin-3-yl)methyl]imidazo[1,2-a]pyridin-3-yl]propanoic acid	Investigative	118737720	C20H18ClN5O3	411.8	C1CC1N2C3=C(C=NC=C3)N(C2=O)CC4=C(N5C=CC(=CC5=N4)Cl)CCC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B03MNI	N'-[1-[2-(Dimethylamino)ethyl]-2-oxo-3,4-dihydroquinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664969	C18H24Cl2N4OS	415.4	CN(C)CCN1C(=O)CCC2=C1C=CC(=C2)N=C(C3=CC=CS3)N.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B04JSK	N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide	Investigative	44578955	C22H19ClN2O2	378.8	C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)NC(=O)CNC(=O)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B08UON	(2S)-N-(5-Tert-butyl-1,2-oxazol-3-yl)-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2-carboxamide	Investigative	67953837	C19H22F3N3O2	381.4	CC(C)(C)C1=CC(=NO1)NC(=O)[C@@H]2CCCN2C3=CC=C(C=C3)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B08VTN	(1S,2R,5S)-5-(4,7,8,12-Tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine	Investigative	24951733	C20H20F3N5	387.4	C1C[C@@H]([C@H](C[C@H]1N2CC3=C4N=CC=CN4N=C3C2)N)C5=CC(=C(C=C5F)F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B09XBP	(2S)-N-[5-[2-(6-Methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methyl-2-oxoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide	Investigative	118863011	C35H31N7O3	597.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)N(C(=O)C=C5)C)C6=CN=C(C=C6)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0BSM9	2-((R)-8-((R)-2-(4-Fluorophenyl)-N-methylpropanamido)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid	Investigative	45112038	C23H24FN3O3	409.5	C[C@H](C1=CC=C(C=C1)F)C(=O)N(C)[C@@H]2CCC3=C(C4=C(N3C2)N=CC=C4)CC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0G9IH	S-[2-[6-[[4-[3-(Dimethylamino)propoxy]phenyl]sulfonylamino]pyridin-3-yl]-2-oxoethyl] ethanethioate;hydrobromide	Investigative	24993935	C20H26BrN3O5S2	532.5	CC(=O)SCC(=O)C1=CN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)OCCCN(C)C.Br	EC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0KVO8	(4R)-4-(4-Cyanophenyl)-N-(2-hydroxyethyl)-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide	Investigative	90311190	C24H19F3N4O4	484.4	C1CC(=O)C2=C1N(C(=O)N([C@@H]2C3=CC=C(C=C3)C#N)C(=O)NCCO)C4=CC=CC(=C4)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0LD9Q	1-[5-(4-Methylpyridin-3-yl)-2,3-dihydroindol-1-yl]ethanone	Investigative	73603391	C16H16N2O	252.31	CC1=C(C=NC=C1)C2=CC3=C(C=C2)N(CC3)C(=O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0ME9H	CID 44125704	Investigative	44125704	C23H25ClN4O5	472.9	CC(C)OC1=C(C=C(C=N1)C2=NC(=NO2)C3=C4C(=CC=C3)C(NCCO4)CCCC(=O)O)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0MOF8	4-(2-(3-Chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one	Investigative	135681590	C25H25ClN6O2	477	CC1=CC(=CC2=C1N=C(N2)C3=C(C=CNC3=O)NCC(C4=CC(=CC=C4)Cl)O)C5=NCCN5C	IC50 = 91000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0QIZ3	(S)-3-(4-((2-(2,6-Dimethylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)methoxy)phenyl)hex-4-ynoic acid	Investigative	91809187	C27H25N3O3	439.5	CC#C[C@@H](CC(=O)O)C1=CC=C(C=C1)OCC2=CN3C(=NC(=N3)C4=C(C=CC=C4C)C)C=C2	IC50 ~ 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0R5OT	1-Propanol, 3-[(6-methoxy-1H-benzimidazol-2-yl)thio]-	Investigative	43388611	C11H14N2O2S	238.31	COC1=CC2=C(C=C1)N=C(N2)SCCCO	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0V5QJ	4-Fluoro-N-[2-[(2-fluoro-6,11-dihydrobenzo[c][1]benzoxepin-11-yl)methylamino]-2-oxoethyl]benzamide	Investigative	44579237	C24H20F2N2O3	422.4	C1C2=CC=CC=C2C(C3=C(O1)C=CC(=C3)F)CNC(=O)CNC(=O)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B0X4JZ	4-[[6-Ethyl-5-[[4-[(5R)-2-oxo-5-phenyl-3-(tetrahydro-2H-pyran-4-yl)imidazolidine-1-yl]piperidino]methyl]pyridine-2-yl]oxy]benzoic acid	Investigative	58835217	C34H40N4O5	584.7	CCC1=C(C=CC(=N1)OC2=CC=C(C=C2)C(=O)O)CN3CCC(CC3)N4[C@@H](CN(C4=O)C5CCOCC5)C6=CC=CC=C6	IC50 ~ 73000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B14FKW	(2S)-N-[5-[2-(2-Methoxypyridin-4-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methyl-2-oxoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide	Investigative	118863002	C35H31N7O3	597.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)N(C(=O)C=C5)C)C6=CC(=NC=C6)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B16BKM	(1R,2S,3R,5R)-3-[[2-[(2-Cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol	Investigative	117885766	C27H28N6O4	500.5	C1CC1OC2=NC=CC(=C2)NC3=NC=C(C(=N3)N[C@@H]4C[C@@H]([C@H]([C@H]4O)O)CO)C5=NC6=CC=CC=C6C=C5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B19KIV	(10S)-4-(1H-Indol-4-yl)-6-(4-methylsulfonyloxan-4-yl)-8,12-dioxa-1,3,5-triazatricyclo[8.4.0.02,7]tetradeca-2,4,6-triene	Investigative	78210287	C23H26N4O5S	470.5	CS(=O)(=O)C1(CCOCC1)C2=C3C(=NC(=N2)C4=C5C=CNC5=CC=C4)N6CCOC[C@H]6CO3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1A2VS	N-[4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide	Investigative	71811363	C19H19N3O	305.4	CCC(=O)NC1CCCC2=C1C=NC=C2C3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1BM3X	N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methyl-5-((1-methylpiperidin-4-yl)ethynyl)benzamide	Investigative	73670549	C31H42N4O3	518.7	CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CC4CCN(CC4)C	IC50 = 75660 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1CR7I	Rac-3-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy)phenyl)hex-4-ynoic acid	Investigative	53248846	C20H15F5O4	414.3	CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)OC(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1E0BF	3-[[4-(Dimethylamino)cyclohexyl]-ethylamino]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-[4-(2-methoxyethoxy)phenyl]-2-methylbenzamide	Investigative	73504705	C35H48N4O4	588.8	CCN(C1CCC(CC1)N(C)C)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)OCCOC	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1ENI2	4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide	Investigative	53311230	C27H26N4O3	454.5	C1CN2CCC1[C@@](C2)(C#CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)NCC5=NC=NC=C5)O	IC50 ~ 50118.72 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1HB7J	CID 49848896	Investigative	49848896	C33H32N6O5	592.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC(=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1HV0B	3-(4-Cyclohexylphenyl)-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069521	C30H34N6O3	526.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6CCCCC6	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1J6XH	(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(2-methylpyridin-3-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide	Investigative	118863042	C35H31N7O	565.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)C(=NC=C5)C)C6=C(N=CC=C6)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1K7XO	(1R)-1-[5-Methyl-2-[2-methyl-6-[(2R)-2-(1-methylbenzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]ethanol	Investigative	118423213	C21H23N7O	389.5	CC1=NC(=CC(=N1)N2C(=NC(=N2)C)[C@@H](C)O)C3C[C@H]3C4=NC5=CC=CC=C5N4C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1LWZ4	2-[(S)-[4-(Cyclopropylmethoxy)pyridin-2-yl]methylsulfinyl]-6-fluoro-1H-benzimidazole	Investigative	70693563	C17H16FN3O2S	345.4	C1CC1COC2=CC(=NC=C2)C[S@](=O)C3=NC4=C(N3)C=C(C=C4)F	Ki = 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1MW3P	N-[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(6-oxopyridazin-1-yl)acetamide	Investigative	44472610	C24H26N4O3	418.5	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)CN3C(=O)C=CC=N3)[C@@H](C4=CC=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1MYA6	(S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-((S)-1-methyl-2-oxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-5-yl)-acetic acid	Investigative	10224745	C24H24N4O4	432.5	CC1=CC(=NC(=N1)O[C@H](C(=O)O)[C@@]2(C3=CC=CC=C3N(C(=O)CN2)C)C4=CC=CC=C4)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1OF3Z	2-[(3S)-8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acid	Investigative	56603174	C23H23F3N4O3	460.4	C1CN(CCC12C[C@H](CO2)CC(=O)O)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1Q6RJ	Propan-2-yl 4-[5-fluoro-6-(2-methyl-6-methylsulfonylpyridin-3-yl)oxypyrimidin-4-yl]oxypiperidine-1-carboxylate	Investigative	118711211	C20H25FN4O6S	468.5	CC1=C(C=CC(=N1)S(=O)(=O)C)OC2=C(C(=NC=N2)OC3CCN(CC3)C(=O)OC(C)C)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1QAF7	2-[(3R)-8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acid	Investigative	56603175	C23H23F3N4O3	460.4	C1CN(CCC12C[C@@H](CO2)CC(=O)O)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1QF8P	N'-[1-[2-[(2S)-1-Methylpyrrolidin-2-yl]ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	53387025	C21H30Cl2N4S	441.5	CN1CCC[C@H]1CCN2CCCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1R5FG	2-Methyl-5-cyano-6-[3-[(benzylsulfonyl)carbamoyl]-1-azetidinyl]nicotinic acid ethyl ester	Investigative	15983546	C21H22N4O5S	442.5	CCOC(=O)C1=C(N=C(C(=C1)C#N)N2CC(C2)C(=O)NS(=O)(=O)CC3=CC=CC=C3)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1VT5J	2-(Ethylsulfanyl)-6-methoxy-1h-benzimidazole	Investigative	126266	C10H12N2OS	208.28	CCSC1=NC2=C(N1)C=C(C=C2)OC	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1WQ4F	1-Methyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-one	Investigative	25180109	C15H14N2O	238.28	CN1C(=O)CCC2=C1C=CC(=C2)C3=CN=CC=C3	IC50 = 125000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1XHI9	N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinoline-8-yl)acetamide	Investigative	71811365	C18H17N3O	291.3	CC(=O)NC1CCCC2=C1C=NC=C2C3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1XJ2F	CID 71580827	Investigative	71580827	C20H24BrN7O3	490.4	CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC(=C(N2)Br)C3=CC=C(C=C3)N=[N+]=[N-])NC(=O)OC	IC50 = 50500 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B1ZFE2	10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-6-methoxy-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Investigative	66898172	C18H22N4O2	326.4	COC1=CC2=C3C(=C1)C(=O)N(CCN3N=C2)[C@@H]4CN5CCC4CC5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B20HBC	3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid	Investigative	57387775	C31H29N7O4	563.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=CN=C4)C5=CN=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B20JKR	4-(2-(3-Chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(1,4,5,6-tetrahydropyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one	Investigative	135681832	C25H25ClN6O2	477	CC1=CC(=CC2=C1N=C(N2)C3=C(C=CNC3=O)NCC(C4=CC(=CC=C4)Cl)O)C5=NCCCN5	IC50 = 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B20JYT	5-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]thiophene-2-carboxylic acid	Investigative	57387282	C30H28N6O5S	584.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC=C(S6)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B24FQB	(S)-3-((S)-1-(4-(1-Ethyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-(4-fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-1,3-oxazinan-2-one	Investigative	59635742	C29H33FN2O4	492.6	CCN1C=C(C=CC1=O)C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B24GFT	(4,4-Difluoropiperidin-1-yl)(1-isopropyl-5-((1-isopropylpiperidin-4-yl)oxy)-1H-indol-2-yl)methanone	Investigative	11619260	C25H35F2N3O2	447.6	CC(C)N1CCC(CC1)OC2=CC3=C(C=C2)N(C(=C3)C(=O)N4CCC(CC4)(F)F)C(C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B24VYX	Chembl4283853	Investigative	118261815	C22H27NO6	401.5	CC(C)[C@@H]1CC2=CC(=C(C=C2C3=CC(=O)C(=CN13)C(=O)O)OC)OCCCOC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B26ZAO	(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(6-methylpyridin-3-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide	Investigative	118862989	C35H31N7O	565.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)C(=NC=C5)C)C6=CN=C(C=C6)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B27RKI	N-(2-((3-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)-4-fluorobenzamide	Investigative	24900235	C22H18ClFN2O2	396.8	C1=CC=C(C=C1)C(C2=CC(=CC=C2)Cl)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B28LHJ	(17S,20R)-20-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,10,19-trioxo-2,5,8,11,18-pentazatetracyclo[20.2.2.25,8.212,15]triaconta-1(25),12,14,22(26),23,27-hexaene-17-carboxamide;2,2,2-trifluoroacetic acid	Investigative	71720404	C43H48F3N9O8S	908	C1CN2CCN1CC(=O)NC3=CC=C(C[C@H](C(=O)N[C@@H](CC4=CC=C(C=C4)NC(=O)C2)C(=O)NCC5=CC=C(C=C5)C(=N)N)NS(=O)(=O)CC6=CC=CC=C6)C=C3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2A0FE	8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one	Investigative	121313969	C24H28N4O5	452.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CCN(C4=O)C5=NN(C(=O)C=C5)C)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2AVH0	2-(3,4-Dimethoxyphenyl)-5-(3-methoxypropyl)benzofuran	Investigative	24764491	C20H22O4	326.4	COCCCC1=CC2=C(C=C1)OC(=C2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2B1EH	4-Fluoro-N-[2-oxo-2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylmethylamino)ethyl]benzamide	Investigative	44579236	C25H23FN2O2	402.5	C1CC2=CC=CC=C2C(C3=CC=CC=C31)CNC(=O)CNC(=O)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2CZK5	CID 57384750	Investigative	57384750	C32H31N7O5	593.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CN=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2HE4W	4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One	Investigative	118796358	C20H23N3O3	353.4	CN1C=C(C2=C(C1=O)C=NC=C2)C3=CC(=C(C(=C3)OC)CN(C)C)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2HX8R	(3-(4-(((3R,5S)-3,5-Dimethylpiperazin-1-yl)methyl)phenyl)pyridin-2-yl)(4-(4-fluorophenylamino)piperidin-1-yl)methanone	Investigative	16040587	C30H36FN5O	501.6	C[C@@H]1CN(C[C@@H](N1)C)CC2=CC=C(C=C2)C3=C(N=CC=C3)C(=O)N4CCC(CC4)NC5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2IX5R	(3R,4S)-N-(2-(3,5-Bis(trifluoromethyl)phenyl)propan-2-yl)-1-(1-acetylpiperidine-4-carbonyl)-4-(4-fluoro-2-methylphenyl)-N-methylpyrrolidine-3-carboxamide	Investigative	44433798	C32H36F7N3O3	643.6	CC1=C(C=CC(=C1)F)[C@H]2CN(C[C@@H]2C(=O)N(C)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)C4CCN(CC4)C(=O)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2M0VE	3-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	Investigative	57386783	C32H30N6O5	578.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC(=CC=C6)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2PD9C	2-Amino-N-[(1S)-1-[1-[(2R)-1-cyano-3-(2-hydroxyphenoxy)propan-2-yl]tetrazol-5-yl]-2-phenylmethoxyethyl]-2-methylpropanamide	Investigative	44454303	C24H29N7O4	479.5	CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C2=NN=NN2[C@H](CC#N)COC3=CC=CC=C3O)N	IC50 ~ 66000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2PI8M	Dibenzylideneacetone	Investigative	640180	C17H14O	234.29	C1=CC=C(C=C1)/C=C/C(=O)/C=C/C2=CC=CC=C2	IC50 = 67300 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2TX9Z	2-Bromo-N-[2-(2,6-dimethylpyridin-4-yl)propan-2-yl]-3,3-dimethylbutanamide	Investigative	4048115	C16H25BrN2O	341.29	CC1=CC(=CC(=N1)C)C(C)(C)NC(=O)C(C(C)(C)C)Br	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2V4JP	9-Fluoro-7-(5-fluoro-pyridin-3-yl)-1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline	Investigative	70977969	C16H12F2N4	298.29	CC1=NN=C2N1C3=C(CC2)C=C(C=C3F)C4=CC(=CN=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2W3GN	(6-Hydroxy-1,3-benzothiazol-2-yl)-(3-hydroxy-4-methylphenyl)methanone	Investigative	56847605	C15H11NO3S	285.3	CC1=C(C=C(C=C1)C(=O)C2=NC3=C(S2)C=C(C=C3)O)O	IC50 = 54000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2WPT6	2-(3-(1-(5-Hydroxypyridin-2-yl)-1H-pyrazol-4-yl)propanamido)cyclohex-1-enecarboxylicacid	Investigative	15986936	C18H20N4O4	356.4	C1CCC(=C(C1)C(=O)O)NC(=O)CCC2=CN(N=C2)C3=NC=C(C=C3)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2WSN5	4-[(4S)-2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]-3,4,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl]-3-methylsulfonylbenzonitrile	Investigative	77844826	C22H16F3N3O4S	475.4	CS(=O)(=O)C1=C(C=CC(=C1)C#N)[C@@H]2C3=C(CCC3=O)N(C(=O)N2)C4=CC=CC(=C4)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B2X3SV	1-[3-Fluoro-4-[4-(4-hydroxyphenyl)phenyl]phenyl]cyclopropane-1-carboxylic acid	Investigative	11609939	C22H17FO3	348.4	C1CC1(C2=CC(=C(C=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)O)F)C(=O)O	IC50 = 89000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B30CIV	(2S)-2-[6-Chloro-2-(4-chlorophenyl)-5-fluorobenzimidazol-1-yl]-N,2-dicyclohexylacetamide	Investigative	50938548	C27H30Cl2FN3O	502.4	C1CCC(CC1)[C@@H](C(=O)NC2CCCCC2)N3C4=CC(=C(C=C4N=C3C5=CC=C(C=C5)Cl)F)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B32JRY	Nav1.7-IN-3	Investigative	118112300	C17H20ClFN4O2S2	431	C1CC2(CCCN2C1)CNC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=NC=CS4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B34KOD	(1S)-1-(2,4-Difluorophenyl)-2-pyrazol-1-yl-1-(1,2,4-triazol-1-yl)ethanol	Investigative	76327922	C13H11F2N5O	291.26	C1=CN(N=C1)C[C@@](C2=C(C=C(C=C2)F)F)(N3C=NC=N3)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B35FQC	trans-4-((2S)-2-Cyclohexyl-2-(2-(2,4-dimethoxypyridin-3-yl)-5,6-difluoro-1H-benzo[d]imidazol-1-yl)acetamido)cyclohexanecarboxylic acid	Investigative	53317017	C29H34F2N4O5	556.6	COC1=NC(=C(C=C1)C2=NC3=CC(=C(C=C3N2[C@@H](C4CCCCC4)C(=O)NC5CCC(CC5)C(=O)O)F)F)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B37OFQ	CID 81689815	Investigative	81689815	C15H13FN6OS	344.4	CC1=NSC(=N1)C2=NN=C3N2CCN(C3)C(=O)C4=CC=C(C=C4)F	IC50 = 82000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B38SJF	2-[[3-[4-[[2-[[1-[3-[3-(Cyclohexylamino)propylamino]propyl]triazol-4-yl]methylamino]-6-methylpyrimidin-4-yl]amino]piperidin-1-yl]-3-oxopropyl]amino]acetic acid	Investigative	118965395	C30H51N11O3	613.8	CC1=CC(=NC(=N1)NCC2=CN(N=N2)CCCNCCCNC3CCCCC3)NC4CCN(CC4)C(=O)CCNCC(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B39OYV	(S)-6-(4-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-1,3-oxazinan-2-one	Investigative	59635648	C28H31FN2O4	478.6	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B39VFH	(2S)-N-[5-[2-(2-Methoxypyridin-4-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methylisoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide	Investigative	118863030	C35H31N7O2	581.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)C(=NC=C5)C)C6=CC(=NC=C6)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3BAM6	3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one	Investigative	135418940	C14H11F3N2OS	312.31	C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3DH6I	N'-[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-5-yl]furan-2-carboximidamide;dihydrochloride	Investigative	90664848	C19H22Cl2N4O	393.3	CN1CCC(=CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CO4)N.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3DP4G	Chembl4126548	Investigative	145960389	C20H21FN4O4	400.4	CC(C)COC(=O)[C@H](CN1C=CN=C1)NC(=O)C2=NOC(=C2)C3=CC=CC=C3F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3DZ2Q	Chembl4173133	Investigative	145952070	C12H16Cl2N2O	275.17	CCC1=C(C=NC=C1)C2=CC=C(O2)CN.Cl.Cl	IC50 = 59000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3ERV4	(1S,4S,5R,8R,13S,17S,18R)-24-Cyclohexyl-4,5,9,9,13,20,20-heptamethyl-10,16,23-trioxo-24-azahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosa-11,14-diene-11-carbonitrile	Investigative	122179416	C37H50N2O3	570.8	C[C@@]12CC[C@@H]3[C@@](C1=CC(=O)[C@@]45[C@]2(CC[C@@]6([C@H]4CC(CC6)(C)C)C(=O)N5C7CCCCC7)C)(C=C(C(=O)C3(C)C)C#N)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3J1DR	(S)-N-((3S,4S)-5-Acetyl-7-cyano-1-((2-methoxynaphthalen-1-yl)methyl)-4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride	Investigative	72714053	C29H32ClN5O4	550	C[C@H]1[C@@H](C(=O)N(C2=C(N1C(=O)C)C=C(C=C2)C#N)CC3=C(C=CC4=CC=CC=C43)OC)NC(=O)[C@H](C)NC.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3JAR7	4-[(2,4-Difluorophenyl)carbonyl]-1-[4-({3-[(2R)-2-methyl-1-pyrrolidinyl]propyl)oxy)phenyl]-2-piperazinone, formate salt	Investigative	24748995	C26H31F2N3O5	503.5	C[C@@H]1CCCN1CCCOC2=CC=C(C=C2)N3CCN(CC3=O)C(=O)C4=C(C=C(C=C4)F)F.C(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3NJH9	4-Amino-N-(3-hydroxy-propyl)-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	10861641	C18H20N4O3S	372.4	C1=CC=C(C=C1)N2C(=CC=N2)N(CCCO)S(=O)(=O)C3=CC=C(C=C3)N	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3PB6T	5-Methyl-3-[4-[[1-(6-methylpyridazin-3-yl)azetidin-3-yl]methoxy]phenyl]-1,2,4-oxadiazole	Investigative	54752774	C18H19N5O2	337.4	CC1=NN=C(C=C1)N2CC(C2)COC3=CC=C(C=C3)C4=NOC(=N4)C	IC50 ~ 50118.72 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3S0NM	N-[(2S)-3-[3-Chloro-4-(trifluoromethoxy)phenyl]-1-[(1-cyanocyclopropyl)amino]-1-oxopropan-2-yl]-2-methyltriazole-4-carboxamide	Investigative	129164668	C18H16ClF3N6O3	456.8	CN1N=CC(=N1)C(=O)N[C@@H](CC2=CC(=C(C=C2)OC(F)(F)F)Cl)C(=O)NC3(CC3)C#N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3SI9N	3-{(S)-1-[4-(1,4-Dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one	Investigative	42607222	C28H33N3O4	475.6	CC1=CC(=O)N(N=C1C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3TL6G	6-[(1S)-1-Hydroxy-2-[4-[(2R)-2-hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methoxypyridine-3-carbonitrile	Investigative	59568656	C24H28N4O5	452.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCN(CC3)C[C@@H](C4=NC=C(C(=C4)OC)C#N)O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3WP6F	3-(3-Thienyl)pyridine	Investigative	595254	C9H7NS	161.23	C1=CC(=CN=C1)C2=CSC=C2	IC50 = 96300 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3XD2W	N-(2-(Bis(4-methoxyphenyl)methylamino)-2-oxoethyl)-4-fluorobenzamide	Investigative	44578957	C24H23FN2O4	422.4	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3XR8I	2-[4-(2,4-Dichlorophenoxy)phenyl]-3H-quinazolin-4-one	Investigative	137658637	C20H12Cl2N2O2	383.2	C1=CC=C2C(=C1)C(=O)NC(=N2)C3=CC=C(C=C3)OC4=C(C=C(C=C4)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B3XS5F	(S)-6-(2-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one	Investigative	59635741	C28H31FN2O4	478.6	C[C@@H](C1=CC=C(C=C1)C2=CC(=O)N(C=C2)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B42KGS	(S)-6-(2-Hydroxyethyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)propyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	59635712	C27H30N2O4	446.5	CC[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)N3CC[C@](OC3=O)(CCO)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B49YJT	2-(2,4-Difluorophenyl)-1,1-difluoro-3-(tetrazol-1-yl)-1-[5-[4-(trifluoromethyl)phenyl]pyridin-2-yl]propan-2-ol	Investigative	53497481	C22H14F7N5O	497.4	C1=CC(=CC=C1C2=CN=C(C=C2)C(C(CN3C=NN=N3)(C4=C(C=C(C=C4)F)F)O)(F)F)C(F)(F)F	IC50 ~ 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4BA2Z	Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-	Investigative	16727109	C22H20ClFN2O6	462.9	CC1=C(N=C(O1)C2=CC=C(C=C2)Cl)COC3=CC(=C(C=C3)F)CN(CC(=O)O)C(=O)OC	IC50 ~ 150000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4E0LG	(3r,4r)-4-[4-Cyclopropyl-5-[3-(2-Methylpropyl)cyclobutyl]-1,2,4-Triazol-3-Yl]-N-(2,4-Dimethylphenyl)-1-Ethanoyl-Pyrrolidine-3-Carboxamide	Investigative	121345502	C28H39N5O2	477.6	CC1=CC(=C(C=C1)NC(=O)[C@H]2CN(C[C@@H]2C3=NN=C(N3C4CC4)C5CC(C5)CC(C)C)C(=O)C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4EXU2	(S)-4-(((R)-6-(2-Chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid	Investigative	89996234	C21H20ClFN4O5S	494.9	COC(=O)C1=C(NC(=N[C@H]1C2=C(C=C(C=C2)F)Cl)C3=NC=CS3)CN4CCOC[C@H]4C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4GNA9	(-)-Pantoprazole	Investigative	9908035	C16H15F2N3O4S	383.4	COC1=C(C(=NC=C1)C[S@](=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC	Ki = 64000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4GP2N	1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-3-[4-[4-(5-oxo-1,2-dihydropyrazol-3-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	57384236	C34H32N8O4	616.7	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC=C(C=C6)C7=CC(=O)NN7	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4L1YF	Tert-butyl 4-[[7-(2-fluoro-4-methylsulfonylphenyl)thieno[3,2-d]pyrimidin-4-yl]-methylamino]piperidine-1-carboxylate	Investigative	71471711	C24H29FN4O4S2	520.6	CC(C)(C)OC(=O)N1CCC(CC1)N(C)C2=NC=NC3=C2SC=C3C4=C(C=C(C=C4)S(=O)(=O)C)F	IC50 = 76850 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4N2FL	Chembl4227911	Investigative	145968879	C21H20N4O4	392.4	CC(C)OC(=O)[C@H](CN1C=CN=C1)NC(=O)C2=NOC3=C2C=CC4=CC=CC=C43	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4NG8J	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(11-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	127049204	C20H21F2N5O	385.4	CC1=NC2=C3CN(CC3=NN2C=C1)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4NK6U	(6S)-6-(2-Hydroxy-2-methylpropyl)-3-[(1S)-1-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]propyl]-6-phenyl-1,3-oxazinan-2-one	Investigative	59635774	C29H34N2O4	474.6	CC[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4O3SC	3-[[7-Chloro-3-(2-methylsulfonylethyl)imidazo[1,2-a]pyridin-2-yl]methyl]-1-cyclopropylimidazo[4,5-c]pyridin-2-one	Investigative	118737724	C20H20ClN5O3S	445.9	CS(=O)(=O)CCC1=C(N=C2N1C=CC(=C2)Cl)CN3C4=C(C=CN=C4)N(C3=O)C5CC5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4SUW3	4-[4-[2-Chloro-5-(trifluoromethoxy)phenyl]-2,6-dimethylphenoxy]butanoic acid	Investigative	134132142	C19H18ClF3O4	402.8	CC1=CC(=CC(=C1OCCCC(=O)O)C)C2=C(C=CC(=C2)OC(F)(F)F)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4UW7V	N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)isonicotinamide	Investigative	44579189	C21H18ClN3O2	379.8	C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)NC(=O)CNC(=O)C3=CC=NC=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4VFW5	Isoquinoline N-oxide, 47	Investigative	25050394	C21H14ClF2N3O2S	445.9	CC1=C(SC=N1)C(=O)N(CC2=C[N+](=CC3=C2C=CC(=C3F)F)[O-])C4=CC(=CC=C4)Cl	EC50 = 55000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B4Y5QZ	Chembl4288001	Investigative	145990715	C21H19ClO5	386.8	CC#C[C@@H](CC(=O)O)C1=CC=C(C=C1)OC[C@H]2COC3=C(O2)C=C(C=C3)Cl	IC50 = 60500 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B53NHC	2-Chloro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	Investigative	57387028	C32H29ClN6O5	613.1	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC(=C(C=C6)C(=O)O)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B56MVW	4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]-N,N-dimethylbenzamide	Investigative	57384749	C34H35N7O4	605.7	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC=C(C=C6)C(=O)N(C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5A6XE	{1-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-phenyl]-1H-imidazol-2-yl}-[4-(3-fluoro-phenylamino)-piperidin-1-yl]-methanone	Investigative	16041292	C28H35FN6O	490.6	C[C@@H]1CN(C[C@@H](N1)C)CC2=CC=C(C=C2)N3C=CN=C3C(=O)N4CCC(CC4)NC5=CC(=CC=C5)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5AQ2J	(NE)-N-[(5-pyridin-3-ylfuran-2-yl)methylidene]hydroxylamine;(NZ)-N-[(5-pyridin-3-ylfuran-2-yl)methylidene]hydroxylamine	Investigative	56679632	C20H16N4O4	376.4	C1=CC(=CN=C1)C2=CC=C(O2)/C=N/O.C1=CC(=CN=C1)C2=CC=C(O2)/C=N\\O	IC50 = 141000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5C2RA	N'-[1-[2-[(2R)-1-Methylpyrrolidin-2-yl]ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	53392451	C21H30Cl2N4S	441.5	CN1CCC[C@@H]1CCN2CCCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5CEX2	(S)-(4,6-Dimethyl-pyrimidin-2-yloxy)-[(S)-2-oxo-5-phenyl-1-(2,4,6-trifluoro-benzyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-5-yl]-acetic acid	Investigative	10166543	C30H25F3N4O4	562.5	CC1=CC(=NC(=N1)O[C@H](C(=O)O)[C@@]2(C3=CC=CC=C3N(C(=O)CN2)CC4=C(C=C(C=C4F)F)F)C5=CC=CC=C5)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5DAZ9	4-Amino-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	10925491	C16H16N4O2S	328.4	CN(C1=CC=NN1C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N	IC50 = 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5I2BR	trans-4-((S)-2-(2-(4-Chlorophenyl)-5,6-difluoro-1H-benzo[d]imidazol-1-yl)-2-cyclohexylacetamido)cyclohexanecarboxylic acid	Investigative	53322279	C28H30ClF2N3O3	530	C1CCC(CC1)[C@@H](C(=O)NC2CCC(CC2)C(=O)O)N3C4=CC(=C(C=C4N=C3C5=CC=C(C=C5)Cl)F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5J4YU	4-[7-(5-{3-Cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl]butanoic acid	Investigative	44128987	C26H28N4O4	460.5	CC(C)OC1=C(C=C(C=C1)C2=NC(=NO2)C3=CC4=C(CCN(CC4)CCCC(=O)O)C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5JX8O	7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amine	Investigative	11719421	C28H31N5O	453.6	CC1=C(C(=CC=C1)C)C2=CC3=C(C(=C2)C)N=C(N=N3)NC4=CC=C(C=C4)OCCN5CCCC5	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5M1OX	6-Chloranyl-4-Phenyl-2-Piperidin-1-Yl-Quinoline-3-Carboxylic Acid	Investigative	71556223	C21H19ClN2O2	366.8	C1CCN(CC1)C2=NC3=C(C=C(C=C3)Cl)C(=C2C(=O)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B5S2RP	1-(2-(Benzyloxy)-5-bromobenzyl)-5-methyl-1H-pyrazole-3-carboxylic acid	Investigative	11235004	C19H17BrN2O3	401.3	CC1=CC(=NN1CC2=C(C=CC(=C2)Br)OCC3=CC=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B62VZQ	(2-(Pyridin-2-yl)quinolin-4-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone	Investigative	25179511	C24H26N4O	386.5	C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=NC4=CC=CC=C43)C5=CC=CC=N5	Ki = 76190 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B64PIB	CID 67453320	Investigative	67453320	C18H16FN5O	337.4	CC1=NC(=CC=C1)C2=NN=C3N2CCN(C3)C(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B67PWQ	(6S,9R,12R)-6-Cyclopropyl-21-fluoro-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trione	Investigative	11526745	C29H36F2N4O4	542.6	C[C@@H]1C(=O)N[C@@H](C(=O)NCCCC2=C(C=C(C=C2)F)OCCN[C@H](C(=O)N1C)C3CC3)CC4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B6AB5U	Methyl 2-[(S)-(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzimidazole-5-carboxylate	Investigative	70695688	C17H17N3O5S	375.4	COC1=C(C(=NC=C1)C[S@](=O)C2=NC3=C(N2)C=C(C=C3)C(=O)OC)OC	Ki = 64000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B6FTR9	2-(3,5-Difluorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (tetrahydro-pyran-4-ylmethyl)-amide	Investigative	10341839	C18H17F5N4O2	416.3	C1COCCC1CNC(=O)C2=CN=C(N=C2C(F)(F)F)NC3=CC(=CC(=C3)F)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B6FU5T	3-[(2R)-6-[3,4-Difluoro-6-(3-methoxycyclobutyl)oxypyridin-2-yl]-3,4-dihydro-2H-chromen-2-yl]propanoic acid	Investigative	134156727	C22H23F2NO5	419.4	COC1CC(C1)OC2=NC(=C(C(=C2)F)F)C3=CC4=C(C=C3)O[C@H](CC4)CCC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B6JFA5	2-[2-(3-Chlorobenzoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid	Investigative	11494768	C20H16ClFN2O3	386.8	C1CN(CC2=C1N(C3=C2C=C(C=C3)F)CC(=O)O)C(=O)C4=CC(=CC=C4)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B6L7QG	CID 44123747	Investigative	44123747	C22H25FN6O2	424.5	C[C@]1(CCCN(C1)C2=CC3=C(N2CC4=C(C=CC(=C4)F)C#N)C(=O)N(C(=O)N3C)C)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B6OZ2S	(R)-2-(7-(1-(4-Fluorophenyl)-N-methylcyclopentanecarboxamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid	Investigative	54580721	C27H29FN2O3	448.5	CN([C@@H]1CCC2=C(C3=CC=CC=C3N2C1)CC(=O)O)C(=O)C4(CCCC4)C5=CC=C(C=C5)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B6WBF0	N-(2,6-Dimethylbenzyl)-1,2-dimethyl-1H-pyrrolo[3,2-c]pyridin-4-amine	Investigative	46879432	C18H21N3	279.4	CC1=C(C(=CC=C1)C)CNC2=NC=CC3=C2C=C(N3C)C	IC50 = 66000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B6X5AF	4-[[2-[(5-Cyano-1,3-thiazol-2-yl)amino]pyridin-4-yl]methyl]-N-methylpiperazine-1-carboxamide	Investigative	5329333	C16H19N7OS	357.4	CNC(=O)N1CCN(CC1)CC2=CC(=NC=C2)NC3=NC=C(S3)C#N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B70IAP	6,7-Dihydro-4H-thieno[3,2-c]pyridin-5-yl-(2,4-dihydroxy-5-propan-2-ylphenyl)methanone	Investigative	134149366	C17H19NO3S	317.4	CC(C)C1=CC(=C(C=C1O)O)C(=O)N2CCC3=C(C2)C=CS3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B70THD	3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-carbonyl]-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoic acid	Investigative	44396541	C26H23FN4O4S	506.5	C1CN(CCC1C2=C(C=CC(=C2)CN)F)C(=O)C3=CC(=CC(=C3)C4=NC(=NO4)C5=CC=CS5)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B71JVL	4-[2-(2-Carboxyethyl)-3-[6-(3,5-diphenylphenoxy)hexyl]phenoxy]butanoic acid	Investigative	25192021	C37H40O6	580.7	C1=CC=C(C=C1)C2=CC(=CC(=C2)OCCCCCCC3=C(C(=CC=C3)OCCCC(=O)O)CCC(=O)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B76BHP	(5R)-5-[5-[(3,6-Dichloroquinolin-8-yl)amino]-2-fluorophenyl]-5-methyl-2,6-dihydro-1,4-oxazin-3-amine	Investigative	57520209	C20H17Cl2FN4O	419.3	C[C@]1(COCC(=N1)N)C2=C(C=CC(=C2)NC3=C4C(=CC(=C3)Cl)C=C(C=N4)Cl)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B78TDB	(2R,3S,5R)-5-(11-Methyl-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine	Investigative	127051045	C20H20F3N5O	403.4	CC1=NN2C3=C(CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=CC(=C(C=C5F)F)F)N)C=NC2=C1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B78XFR	Chembl4175429	Investigative	145951105	C10H14Cl2N2	233.13	CCC1=C(C=NC=C1)C#CCN.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B79GLA	(3R,4S)-N-(3,5-Bis(trifluoromethyl)benzyl)-1-(1-acetylpiperidine-4-carbonyl)-4-(4-fluoro-2-methylphenyl)-N-methylpyrrolidine-3-carboxamide	Investigative	44433797	C30H32F7N3O3	615.6	CC1=C(C=CC(=C1)F)[C@H]2CN(C[C@@H]2C(=O)N(C)CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)C4CCN(CC4)C(=O)C	IC50 = 69000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B7CG9Y	(S)-3-((S)-1-(4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	46865563	C28H30N4O3	470.6	C[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)N4CC[C@](OC4=O)(CC(C)(C)O)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B7E2NG	(1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol	Investigative	118462026	C26H28N6O3S	504.6	CC1=CC(=CC(=N1)C)NC2=NC=C(C(=N2)N[C@@H]3C[C@@H]([C@H]([C@H]3O)O)CO)C4=NC(=CS4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B7OVZ3	2-Phenyl-4-(piperidin-1-ylmethyl)-1H-benzimidazole	Investigative	70685176	C19H21N3	291.4	C1CCN(CC1)CC2=C3C(=CC=C2)NC(=N3)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B7Q1KM	N-Benzyl-N-hydroxy-2,2-dimethylbutanamide	Investigative	121439991	C13H19NO2	221.29	CCC(C)(C)C(=O)N(CC1=CC=CC=C1)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B7R1LT	9-Fluoro-1-methyl-7-(4-methyl-3-pyridyl)-4,5-dihydro[1,2,4]triazolo[4,3-a]quinoline	Investigative	66575743	C17H15FN4	294.33	CC1=C(C=NC=C1)C2=CC3=C(C(=C2)F)N4C(=NN=C4CC3)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B7RP0K	8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(4-morpholin-4-ylphenyl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136205833	C34H35N7O4	605.7	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=CC=C(C=C6)N7CCOCC7	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B7VZ5T	Chembl4127317	Investigative	122484585	C30H34N8O4	570.6	CC(C)N1C(=O)C2=CN=C(N=C2N(C1=O)C3=CC=CC(=C3)NC(=O)C=C)NC4=C(C=C(C=C4)N5CCN(CC5)C)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B7YHS4	3-[3-[4-(Methylsulfonylamino)styryl]-4-methoxy-5-tert-butylphenyl]-5-fluoro-2(1H)-pyridone	Investigative	67070065	C25H27FN2O4S	470.6	CC(C)(C)C1=CC(=CC(=C1OC)/C=C/C2=CC=C(C=C2)NS(=O)(=O)C)C3=CC(=CNC3=O)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B80GPO	Posaconazole	Investigative	468595	C37H42F2N8O4	700.8	CC[C@@H]([C@H](C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F	IC50 = 109000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B83KMA	CID 49847379	Investigative	49847379	C31H29N7O5	579.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CN=C(C=C5)C6=CC=C(C=C6)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B83KQA	Chembl4172462	Investigative	145949470	C11H14Cl2N2OS	293.2	COC1=C(C=NC=C1)C2=CC=C(S2)CN.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B89CRW	(4R)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide	Investigative	76322043	C24H26N4O2S	434.6	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)[C@@H]3CCC4=C3N=CS4)[C@@H](C5=CN=CC=C5)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B89KHR	CID 71225056	Investigative	71225056	C18H13F4N5O	391.3	C1CN2C(=NN=C2C3=NC(=CC=C3)C(F)(F)F)CN1C(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8A7MV	N'-[3-(1-Methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indol-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	56593712	C19H22Cl2N4S	409.4	CN1CCC(=CC1)C2=CNC3=C2C=CC(=C3)N=C(C4=CC=CS4)N.Cl.Cl	IC50 = 72700 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8B7WR	(3-Fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone	Investigative	74222036	C18H13F2N3O2	341.3	C1CN(CC2=C1OC(=N2)C3=NC=C(C=C3)F)C(=O)C4=CC(=CC=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8C1IH	(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(2-methylpyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide	Investigative	118862998	C34H30N8O	566.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)C(=NC=C5)C)C6=CN=C(N=C6)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8C4WI	Nicotinoyl guanidine, 29	Investigative	44473093	C28H32N6O5	532.6	CC1=CC2=C(O1)C=CC(=C2)NC(=N[C@H]3CCCCN(C3=O)CC(=O)N4CCCC4)NC(=O)C5=C[N+](=CC=C5)[O-]	IC50 = 122000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8DT6V	2-(1-Hydroxy-1-methylethyl)-5-[3-[3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridine-1(4H)-yl]phenyl]pyridine 1-oxide	Investigative	10297996	C26H24N4O4	456.5	CC(C)(C1=[N+](C=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=O)C4=C3N=CC=C4)C(=O)NC5CC5)[O-])O	IC50 = 59000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8E2AM	1-(5-(Pyridin-3-yl)thiophen-2-yl)ethan-1-one	Investigative	15778480	C11H9NOS	203.26	CC(=O)C1=CC=C(S1)C2=CN=CC=C2	IC50 = 98200 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8ID2W	Nvp-qav-680	Investigative	11508736	C18H18N2O4S	358.4	CC1=C(C2=C(N1CC3=CC=C(C=C3)S(=O)(=O)C)N=CC=C2)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8KO4A	4-[4-[8-[(3-Methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrazin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	Investigative	57387542	C31H28N6O4	548.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=CN=C4)C5=CC=C(C=C5)C6=CC=C(C=C6)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8MCI6	CID 49849123	Investigative	49849123	C34H32N8O3	600.7	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC=C(C=C6)C7=CC=NN7	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8MNA5	Chembl4165094	Investigative	145960338	C14H16Cl4N4S	414.2	C1=CN=CC(=C1C2=CN=CN=C2)C3=CC=C(S3)CN.Cl.Cl.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8OKW4	(S)-8-(1-Isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16679614	C20H27N3O2	341.4	C[C@H]1CNC(=O)C2=CC3=C(N12)C=CC(=C3)OC4CCN(CC4)C(C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8RT6L	CYP3cide	Investigative	71315139	C26H32N8	456.6	CC1=CC=C(C=C1)C2=C(C=NN2C)C3=NN(C4=C3C(=NC=N4)N5CC[C@@H](C5)N6CCCCC6)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8U1IE	CID 86274362	Investigative	86274362	C17H16FN5OS	357.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC=C(C=C3)F)C4=CSC(=N4)C	IC50 = 56000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8UTD4	CID 49847377	Investigative	49847377	C32H30N6O4	562.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=NC=C4)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8WOF9	4-Allyl-N-(3-hydroxy-propyl)-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	10938153	C21H23N3O3S	397.5	C=CCC1=CC=C(C=C1)S(=O)(=O)N(CCCO)C2=CC=NN2C3=CC=CC=C3	IC50 = 80000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8X4QN	(R)-2-(9-Chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid	Investigative	53362086	C24H23ClF3NO4	481.9	CC(C)OC1=C(C=C(C=C1)COC2=CC3=C(C=C2)N4CC[C@@H](C4=C3Cl)CC(=O)O)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8YID1	2,2,2-Trifluoro-1-[5-methyl-2-[2-methyl-6-[3-(1-methylbenzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]ethanol	Investigative	74767337	C21H21F3N8O	458.4	CC1=NC(=CC(=N1)N2CC(C2)C3=NC4=CC=CC=C4N3C)N5C(=NC(=N5)C)C(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B8Z5PV	6-((1R,2S)-2-Amino-cyclohexylamino)-4-(6-methyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide	Investigative	71626755	C17H23N7O	341.4	CC1=NC(=CC=C1)NC2=CC(=NN=C2C(=O)N)N[C@@H]3CCCC[C@@H]3N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B92CBY	3-(1H-Pyrazol-3-yl)pyridine	Investigative	7074967	C8H7N3	145.16	C1=CC(=CN=C1)C2=CC=NN2	Ki = 172000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B92YAB	N-({[(4-Chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-2-phenyl-acetamide	Investigative	44578954	C23H21ClN2O2	392.9	C1=CC=C(C=C1)CC(=O)NCC(=O)NC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B93VEY	(S)-4-((S)-2-Phenylbutyl)-4,5-dihydrooxazol-2-amine	Investigative	24963286	C13H18N2O	218.29	CC[C@@H](C[C@H]1COC(=N1)N)C2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B97VLB	1,5-Bis(3,5-dimethyl-4-hydroxyphenyl)-1,4-pentadien-3-one	Investigative	10829689	C21H22O3	322.4	CC1=CC(=CC(=C1O)C)/C=C/C(=O)/C=C/C2=CC(=C(C(=C2)C)O)C	IC50 = 62800 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B98UHN	N,N-Dimethyl(5-(pyridin-3-yl)furan-2-yl)methanamine	Investigative	11171679	C12H14N2O	202.25	CN(C)CC1=CC=C(O1)C2=CN=CC=C2	Ki = 111000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9A2BE	N-[(3R,5S)-1-(1-Benzofuran-3-carbonyl)-5-carbamoylpyrrolidin-3-yl]-2,5-diethylpyrazole-3-carboxamide	Investigative	76314530	C22H25N5O4	423.5	CCC1=NN(C(=C1)C(=O)N[C@@H]2C[C@H](N(C2)C(=O)C3=COC4=CC=CC=C43)C(=O)N)CC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9A4YR	CID 86274732	Investigative	86274732	C17H17FN6O2S	388.4	CC1=NSC(=N1)C2=NN=C3N2CCN([C@@H]3CCO)C(=O)C4=CC=C(C=C4)F	IC50 = 77000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9AR2N	3-(1-Ethyl-1H-imidazol-4-yl)pyridine	Investigative	11480732	C10H11N3	173.21	CCN1C=C(N=C1)C2=CN=CC=C2	IC50 = 75200 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9EHK2	3-{(S)-1-[4-(5-Fluoro-1-methyl-2-oxo-1,2-dihydro-pyridin-4-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one	Investigative	59635727	C28H31FN2O4	478.6	C[C@@H](C1=CC=C(C=C1)C2=CC(=O)N(C=C2F)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9FO2R	Chembl4203179	Investigative	124114343	C30H36F2N8	546.7	CCN1CCC(CC1)N2CCC3=C(C2)C=CC(=N3)NC4=NC=C(C(=N4)C5=CC6=C(C(=C5)F)N=C(N6C(C)C)C)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9FU8I	N-(4-Tert-Butylphenyl)-N'-hydroxyformamidine	Investigative	10313487	C11H16N2O	192.26	CC(C)(C)C1=CC=C(C=C1)N=CNO	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9GQ3C	CID 71580631	Investigative	71580631	C20H25N7O3	411.5	CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)N=[N+]=[N-])NC(=O)OC	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9NG7Q	Etaconazole	Investigative	91673	C14H15Cl2N3O2	328.2	CCC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9OY2X	(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(2-methylpyridin-4-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide	Investigative	118862990	C35H31N7O	565.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)C(=NC=C5)C)C6=CC(=NC=C6)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9SCY8	8-(1-Isopropylpiperidin-4-yloxy)-2-(pyridin-4-ylmethyl)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16678620	C25H30N4O2	418.5	CC(C)N1CCC(CC1)OC2=CC3=C(C=C2)N4CCN(C(=O)C4=C3)CC5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9TC2A	4-Amino-N-ethyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	11078396	C17H18N4O2S	342.4	CCN(C1=CC=NN1C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N	IC50 = 90000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9TD7C	N-Cyclopropyl-3-fluoro-4-methyl-5-[4-[(2-methyl-1,3-thiazol-4-yl)methylcarbamoyl]phenyl]benzamide	Investigative	44479933	C23H22FN3O2S	423.5	CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=CC=C(C=C3)C(=O)NCC4=CSC(=N4)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9UT1J	Chembl4227903	Investigative	145968399	C24H24F3N3O3	459.5	CC1=CN=C(C=C1)C2=CC(=CC(=C2)C(C)(C)O)C(=O)N[C@H](C)C3=C[N+](=C(C=C3)C(F)(F)F)[O-]	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9UXC8	1-Cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one	Investigative	6478034	C21H23N5O2	377.4	C1CC1N2C3=C(C=NC=C3)N(C2=O)CC4=NC5=CC=CC=C5N4CCCCO	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9VZR2	2-[(R)-[4-(Cyclopropylmethoxy)pyridin-2-yl]methylsulfinyl]-6-fluoro-1H-benzimidazole	Investigative	70697669	C17H16FN3O2S	345.4	C1CC1COC2=CC(=NC=C2)C[S@@](=O)C3=NC4=C(N3)C=C(C=C4)F	Ki = 93000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9W6RP	3,5-Dimethyl-N-[2-methyl-4-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]phenyl]-1,2-oxazole-4-carboxamide	Investigative	25265089	C22H30N4O2	382.5	C[C@H]1CCCN1[C@H]2CCN(C2)C3=CC(=C(C=C3)NC(=O)C4=C(ON=C4C)C)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9XVS4	2-[8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-3-yl]acetic acid	Investigative	56603118	C23H23F3N4O3	460.4	C1CN(CCC12CC(CO2)CC(=O)O)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	B9ZY2M	7-(2-Aminopyrimidin-5-yl)-1-[[(1R)-1-cyclopropyl-2,2,2-trifluoroethyl]amino]-5H-pyrido[4,3-b]indole-4-carboxamide	Investigative	42622934	C21H18F3N7O	441.4	C1CC1[C@H](C(F)(F)F)NC2=NC=C(C3=C2C4=C(N3)C=C(C=C4)C5=CN=C(N=C5)N)C(=O)N	IC50 ~ 75000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BA8KE7	4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]thiophene-2-carboxylic acid	Investigative	57387283	C30H28N6O5S	584.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CSC(=C6)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BAB30C	(2S)-2-(Methylamino)-N-[6-[2-(1-methylisoquinolin-6-yl)ethynyl]-5-[7-methyl-2-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]pyridin-2-yl]propanamide	Investigative	118863027	C33H30N8O	554.6	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)C(=NC=C5)C)C6=CN(N=C6)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BABC07	4-[(5-Methoxybenzimidazol-2-ylthio)methyl]benzoic acid	Investigative	672443	C16H14N2O3S	314.4	COC1=CC2=C(C=C1)N=C(N2)SCC3=CC=C(C=C3)C(=O)O	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BACM85	CID 44512094	Investigative	44512094	C27H31N3O4	461.6	C[C@@H](C1=CC=C(C=C1)C2=NN(C(=O)C=C2)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BANG04	2-((4'-Chlorobiphenyl-2-yl)methylsulfinyl)acetamide	Investigative	11855008	C15H14ClNO2S	307.8	C1=CC=C(C(=C1)CS(=O)CC(=O)N)C2=CC=C(C=C2)Cl	IC50 = 129000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BAT1S0	(4-Fluorophenyl)-[(8R)-8-methyl-3-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone	Investigative	122187067	C18H19FN6O2	370.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC=C(C=C3)F)C4=NC(=NO4)C(C)C	IC50 = 64000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BAY0D2	Nicotinoyl guanidine, 33	Investigative	44473097	C29H32N6O6	560.6	CC1=CC2=C(O1)C=CC(=C2)NC(=N[C@H]3CCCCN(C3=O)CC(=O)N4CCCC4)NC(=O)C5=CN=C(C=C5)C(=O)O	IC50 = 122000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BAZ27J	2-[(3R)-3-Aminopiperidin-1-yl]-3-[(2-chloro-5-fluorophenyl)methyl]-5-methyl-4-oxoimidazo[4,5-c]quinoline-7-carboxylic acid;hydrochloride	Investigative	71461809	C24H24Cl2FN5O3	520.4	CN1C2=C(C=CC(=C2)C(=O)O)C3=C(C1=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)Cl.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BB09ES	N'-(1-Piperidin-4-yl-3,4-dihydro-2H-quinolin-6-yl)thiophene-2-carboximidamide;dihydrochloride	Investigative	90665208	C19H26Cl2N4S	413.4	C1CC2=C(C=CC(=C2)N=C(C3=CC=CS3)N)N(C1)C4CCNCC4.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BB1X6S	4-(4-Fluorobenzoyl)-1-[4-(3-piperidin-1-ylpropoxy)phenyl]piperazin-2-one;formic acid	Investigative	24748805	C26H32FN3O5	485.5	C1CCN(CC1)CCCOC2=CC=C(C=C2)N3CCN(CC3=O)C(=O)C4=CC=C(C=C4)F.C(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BB8X6I	N-[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(4-oxoquinazolin-3-yl)acetamide	Investigative	44472591	C28H28N4O3	468.5	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)CN3C=NC4=CC=CC=C4C3=O)[C@@H](C5=CC=CC=C5)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BB92RQ	5-[[5-(4-Fluorophenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-phenyl-1,2,4-oxadiazole	Investigative	2088634	C23H16FN5OS	429.5	C1=CC=C(C=C1)C2=NOC(=N2)CSC3=NN=C(N3C4=CC=CC=C4)C5=CC=C(C=C5)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BBH1C6	2-Amino-6-Bromo-7-(Trifluoromethyl)-1,8-Naphthyridine-3-Carboxamide	Investigative	60202329	C10H6BrF3N4O	335.08	C1=C2C=C(C(=NC2=NC(=C1C(=O)N)N)C(F)(F)F)Br	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BBJ8G1	(R)-6-Methoxymethyl-3-{(S)-1-[4-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-ethyl}-6-phenyl-[1,3]oxazinan-2-one	Investigative	59635704	C26H28N2O4	432.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)N3CC[C@](OC3=O)(COC)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BBM7D8	6-((1R,2S)-2-Aminocyclohexylamino)-4-(6,7-dihydro-5H-cyclopenta[b]pyridin-2-ylamino)pyridazine-3-carboxamide	Investigative	71626971	C19H25N7O	367.4	C1CC[C@H]([C@H](C1)N)NC2=NN=C(C(=C2)NC3=NC4=C(CCC4)C=C3)C(=O)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BBOL80	(2S)-2-(Methylamino)-N-[5-[7-methyl-2-(2-methylpyrimidin-5-yl)imidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methyl-2-oxoquinolin-6-yl)ethynyl]pyridin-2-yl]propanamide	Investigative	118862996	C34H30N8O2	582.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)N(C(=O)C=C5)C)C6=CN=C(N=C6)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BBQ60U	2-[[4-[[(3-Fluorophenyl)-phenylcarbamoyl]oxymethyl]cyclohexyl]methoxy]acetic acid	Investigative	44234032	C23H26FNO5	415.5	C1CC(CCC1COCC(=O)O)COC(=O)N(C2=CC=CC=C2)C3=CC(=CC=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BBT8U5	2-[2-(3-Chlorobenzoyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid	Investigative	11610353	C20H17ClN2O3	368.8	C1CN(CC2=C1N(C3=CC=CC=C23)CC(=O)O)C(=O)C4=CC(=CC=C4)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BBW4R3	3-(4-Methyl-1,3-thiazol-2-yl)pyridine	Investigative	1201554	C9H8N2S	176.24	CC1=CSC(=N1)C2=CN=CC=C2	Ki = 51500 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BBYQ31	CID 25118804	Investigative	25118804	C22H34N2O3	374.5	CC(C)[C@H]1C2=C(CCN1C(=O)CNCC3(CCCCC3)O)C=C(C=C2)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BC01AB	(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-isopropyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	59635784	C30H36N2O4	488.6	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C(C)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BC0XB2	N-Methyl-pyrimidinone derivative, 11	Investigative	54712015	C20H24FN5O5	433.4	CC(C)(C1=NC(=C(C(=O)N1C)O)C(=O)NCC2=CC=C(C=C2)F)NC(=O)C(=O)N(C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BC0XP8	CID 68046989	Investigative	68046989	C24H25F3N4O3	474.5	C1COC2(CCN(CC2)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F)CC1CC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BC1OB7	4-Fluoro-N-(2-oxo-2-(phenyl(pyridazin-3-yl)methylamino)ethyl)benzamide	Investigative	44578960	C20H17FN4O2	364.4	C1=CC=C(C=C1)C(C2=NN=CC=C2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BC53VR	4-[(4R)-2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]-3,4,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl]benzonitrile	Investigative	77844774	C21H14F3N3O2	397.3	C1CC(=O)C2=C1N(C(=O)N[C@@H]2C3=CC=C(C=C3)C#N)C4=CC=CC(=C4)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BC6UQ0	DprE1-IN-1	Investigative	72792692	C18H21N5O3	355.4	CC1=CC2=C(C(=CN2CC3=C(C(=NC=N3)OC)C)C(=O)NCCO)N=C1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BC86WX	2-(2-Fluoro-4-chlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (tetrahydro-pyran-4-ylmethyl)amide	Investigative	16719649	C18H17ClF4N4O2	432.8	C1COCCC1CNC(=O)C2=CN=C(N=C2C(F)(F)F)NC3=C(C=C(C=C3)Cl)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BC9S8V	1-Naphthalenyl[4-(pentyloxy)-1-naphthalenyl]methanone	Investigative	9799417	C26H24O2	368.5	CCCCCOC1=CC=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43	IC50 = 80800 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BCD05L	[3-(Tert-Butylaminomethyl)-4-fluorophenyl](7-chloro-quinolin-4-yl)amine	Investigative	9820134	C20H21ClFN3	357.8	CC(C)(C)NCC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)F	IC50 = 52000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BCFK50	4-Methyl-5-[4-methyl-5-[3-[(2S,3R)-2-phenyl-5-azaspiro[2.4]heptan-5-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole	Investigative	121304458	C22H27N5OS	409.5	CC1=C(OC=N1)C2=NN=C(N2C)SCCCN3CC[C@]4(C3)C[C@H]4C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BCI1Z4	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069563	C28H26N8O4	538.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=CNC(=O)N=C6	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BCK0R6	4-[[2-[(5-Cyano-1,3-thiazol-2-yl)amino]-3-methylpyridin-4-yl]methyl]-N-methylpiperazine-1-carboxamide	Investigative	5329336	C17H21N7OS	371.5	CC1=C(C=CN=C1NC2=NC=C(S2)C#N)CN3CCN(CC3)C(=O)NC	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BCWI07	2-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	Investigative	57386784	C32H30N6O5	578.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC=CC=C6C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BCWO08	3-Phenylthiophene	Investigative	75473	C10H8S	160.24	C1=CC=C(C=C1)C2=CSC=C2	Ki = 112000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BCX6O3	N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)thiophene-3-carboxamide	Investigative	24897002	C20H17ClN2O2S	384.9	C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)NC(=O)CNC(=O)C3=CSC=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BD0G9O	(6S)-3-[(1S)-1-[4-(1-Ethyl-6-oxopyridazin-3-yl)phenyl]ethyl]-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	58109730	C28H33N3O4	475.6	CCN1C(=O)C=CC(=N1)C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BD1J2M	N-(6,8-Dimethylimidazo[1,2-a]pyrazin-2-yl)-4-(4-methylpiperazin-1-yl)benzamide	Investigative	137647660	C20H24N6O	364.4	CC1=CN2C=C(N=C2C(=N1)C)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BD9P1K	4-Amino-N-benzyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	10894740	C22H20N4O2S	404.5	C1=CC=C(C=C1)CN(C2=CC=NN2C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)N	IC50 = 55000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BD9V8Y	N-[7-[Acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-2-methylpyrazole-3-carboxamide	Investigative	46911060	C17H19N5O3S	373.4	CCN(C1=C2C(=C(C=C1)OC)N=C(S2)NC(=O)C3=CC=NN3C)C(=O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BDFA51	(S)-6-(2-Hydroxy-2-methyl-propyl)-3-((S)-1-{4-[1-(2-hydroxy-2-methyl-propyl)-2-oxo-1,2-dihydro-pyridin-4-yl]-phenyl}ethyl)-6-phenyl-[1,3]oxazinan-2-one	Investigative	44476983	C31H38N2O5	518.6	C[C@@H](C1=CC=C(C=C1)C2=CC(=O)N(C=C2)CC(C)(C)O)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BDGF26	Cyclopropyl-[5-methyl-2-[2-methyl-6-[3-(1-methylbenzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]methanol	Investigative	74767501	C23H26N8O	430.5	CC1=NC(=CC(=N1)N2CC(C2)C3=NC4=CC=CC=C4N3C)N5C(=NC(=N5)C)C(C6CC6)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BDH95Q	N-(2,6-Dimethylbenzyl)-6,7-dimethyl-5H-pyrrolo[3,2-d]pyrimidin-4-amine	Investigative	46879428	C17H20N4	280.37	CC1=C(C(=CC=C1)C)CNC2=NC=NC3=C2NC(=C3C)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BDI85R	4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One	Investigative	117072549	C20H23N3O3	353.4	CN1C=C(C2=C(C1=O)C=NC=C2)C3=C(C=C(C(=C3)OC)CN(C)C)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BDS46N	[4-Methyl-3-[[2-(methylsulfamoylamino)pyridin-4-yl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	24753786	C20H22N4O6S	446.5	CC1=C(C(=O)OC2=C1C=CC(=C2)OC(=O)N(C)C)CC3=CC(=NC=C3)NS(=O)(=O)NC	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BDS78A	2-[3-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-3,9-diazaspiro[5.5]undecan-9-yl]acetic acid	Investigative	137656391	C24H26F3N5O2	473.5	C1CN(CCC12CCN(CC2)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F)CC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BDSZ24	4-Fluoro-N-[2-[(5-methyl-6-oxo-11H-benzo[c][1]benzazepin-11-yl)methylamino]-2-oxoethyl]benzamide	Investigative	44579273	C25H22FN3O3	431.5	CN1C2=CC=CC=C2C(C3=CC=CC=C3C1=O)CNC(=O)CNC(=O)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BDW2V0	4-[6-[2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(tetrazol-1-yl)propyl]pyridin-3-yl]benzonitrile	Investigative	53497480	C22H14F4N6O	454.4	C1=CC(=CC=C1C#N)C2=CN=C(C=C2)C(C(CN3C=NN=N3)(C4=C(C=C(C=C4)F)F)O)(F)F	IC50 ~ 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BE26DB	1-[(2R)-2,3-Dihydroxypropyl]-3-[1-[[(1S,2S,4R)-spiro[bicyclo[2.2.1]heptane-3,1'-cyclopropane]-2-yl]methyl]piperidin-4-yl]benzimidazol-2-one;hydrochloride	Investigative	44189732	C25H36ClN3O3	462	C1C[C@@H]2C[C@H]1[C@@H](C23CC3)CN4CCC(CC4)N5C6=CC=CC=C6N(C5=O)C[C@H](CO)O.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BE27TD	2-[(1S,18S,21E,28S,29S,30S)-30-[(2S,4S,5R,6S)-5-(Dimethylamino)-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-52-hydroxy-18-[(1R)-1-hydroxyethyl]-9-methoxy-21-(1-methoxyethylidene)-16,19,26,31,42,46-hexaoxo-32,43,54-trioxa-3,13,23,49-tetrathia-7,17,20,27,45,51,52,55,56,57-decazadecacyclo[26.16.6.229,40.12,5.112,15.122,25.138,41.147,50.06,11.034,39]heptapentaconta-2(57),4,6,8,10,12(56),14,22(55),24,34(39),35,37,40,47,50-pentadecaen-8-yl]-N-(3-morpholin-4-ylpropyl)-1,3-thiazole-4-carboxamide	Investigative	44475943	C66H72N14O18S5	1509.7	C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@H]2[C@@H]3[C@H]4C5=NC(=CS5)C(=O)N[C@@H](COC(=O)C6=C(CO3)C7=C(COC2=O)C=CC=C7N6O)C8=NC(=CS8)C9=NC(=C(C=C9C1=NC(=CS1)C(=O)N[C@H](C(=O)N/C(=C(\\C)/OC)/C1=NC(=CS1)C(=O)N4)[C@@H](C)O)OC)C1=NC(=CS1)C(=O)NCCCN1CCOCC1)(C)O)N(C)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BE2M8Y	(R)-8-(3-(2-Methylpyrrolidin-1-yl)propoxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16122898	C19H25N3O2	327.4	C[C@@H]1CCCN1CCCOC2=CC3=C(C=C2)N4CCNC(=O)C4=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BE5CA0	N-[6-(2-Chlorophenyl)-5-(4-chlorophenyl)-2-(2-hydroxy-2-methylpropanoyl)furo[2,3-b]pyridin-3-yl]-2-hydroxyacetamide	Investigative	10028888	C25H20Cl2N2O5	499.3	CC(C)(C(=O)C1=C(C2=CC(=C(N=C2O1)C3=CC=CC=C3Cl)C4=CC=C(C=C4)Cl)NC(=O)CO)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BE7U0L	4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carbonyl)-amino]phenyl}piperidine-1-carbonyl)-cis-cyclohexanecarboxylic Acid	Investigative	25118654	C30H30F3N3O5	569.6	C1CC(CCC1C(=O)N2CCC(CC2)C3=CC=C(C=C3)NC(=O)C4=C(OC(=N4)C5=CC=CC=C5)C(F)(F)F)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BEJ91S	CCS(=O)(=O)CCc1c(CN2C(=O)N(C3CC3)c4ccncc24)nc5cc(Cl)ccn15	Investigative	118737725	C21H22ClN5O3S	459.9	CCS(=O)(=O)CCC1=C(N=C2N1C=CC(=C2)Cl)CN3C4=C(C=CN=C4)N(C3=O)C5CC5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BEOP15	(4-Fluoro-3-hydroxyphenyl)-(6-hydroxy-1,3-benzothiazol-2-yl)methanone	Investigative	56929249	C14H8FNO3S	289.28	C1=CC(=C(C=C1C(=O)C2=NC3=C(S2)C=C(C=C3)O)O)F	IC50 = 54000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BER28W	(2S,3S,11Bs)-3-butyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine	Investigative	44431744	C19H30N2O2	318.5	CCCC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1N)OC)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BF15WM	(R)-2-(7-(1-(4-Fluorophenyl)-N-methylcyclobutanecarboxamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid	Investigative	53248760	C26H27FN2O3	434.5	CN([C@@H]1CCC2=C(C3=CC=CC=C3N2C1)CC(=O)O)C(=O)C4(CCC4)C5=CC=C(C=C5)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BF5CY9	Chembl4126331	Investigative	145962320	C22H24N4O4	408.4	CC1=CC(=CC(=C1C#CC(C)(C)CC(=O)O)C)N2CCOC3=NC=NC(=C3C2=O)N	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BF5SK4	N-[(5-Methylpyrimidin-2-yl)methyl]-6-phenyl-2-pyridin-2-ylpyrimidin-4-amine	Investigative	5201490	C21H18N6	354.4	CC1=CN=C(N=C1)CNC2=NC(=NC(=C2)C3=CC=CC=C3)C4=CC=CC=N4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BF6E4Z	4-(Methanesulfonylmethyl)-2-phenyl-6-(pyrrolidin-1-yl)pyrimidine	Investigative	1476707	C16H19N3O2S	317.4	CS(=O)(=O)CC1=CC(=NC(=N1)C2=CC=CC=C2)N3CCCC3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BF6PJ5	(E)-Ethyl 3-(6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)acrylate	Investigative	71164844	C20H17F4N5O3	451.4	CCOC(=O)/C=C/C1=CN=C(C=C1)C(C(CN2C=NN=N2)(C3=C(C=C(C=C3)F)F)O)(F)F	IC50 = 75000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BF9GD7	N-(Diphenylmethyl)-2-[(4-fluorophenyl)formamido]acetamide	Investigative	18104758	C22H19FN2O2	362.4	C1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BFAJ70	3-{(S)-1-[4-(1,5-Dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one	Investigative	42605499	C28H33N3O4	475.6	CC1=CC(=NN(C1=O)C)C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BFKS31	3-[4-(1H-Indazol-6-yl)phenyl]-1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	57384237	C32H30N8O3	574.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC7=C(C=C6)C=NN7	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BFNV93	2-Fluoro-N-[3-fluoro-4-[5-(4-morpholin-4-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide	Investigative	57663655	C23H25F2N5O3	457.5	C1COCCN1CCCCNC2=NN=C(O2)C3=C(C=C(C=C3)NC(=O)C4=CC=CC=C4F)F	IC50 = 51000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BFOA25	(2S)-N-[5-[2-(6-Methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl]-6-[2-(1-methylisoquinolin-6-yl)ethynyl]pyridin-2-yl]-2-(methylamino)propanamide	Investigative	118863000	C35H31N7O2	581.7	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC5=C(C=C4)C(=NC=C5)C)C6=CN=C(C=C6)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BFWX86	4-[[6-Methyl-5-[[4-[(5R)-2-oxo-5-(3-chlorophenyl)-3-(tetrahydro-2H-pyran-4-yl)imidazolidine-1-yl]piperidino]methyl]pyridine-2-yl]oxy]benzoic acid	Investigative	58834906	C33H37ClN4O5	605.1	CC1=C(C=CC(=N1)OC2=CC=C(C=C2)C(=O)O)CN3CCC(CC3)N4[C@@H](CN(C4=O)C5CCOCC5)C6=CC(=CC=C6)Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BG2C4P	Spiro[9h-fluorene-9,4'-imidazolidine]-2',5'-dione	Investigative	234512	C15H10N2O2	250.25	C1=CC=C2C(=C1)C3=CC=CC=C3C24C(=O)NC(=O)N4	Ki = 125000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BG2FO3	(Rac)-N-(4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide	Investigative	89846366	C20H21N3O	319.4	CC(C)C(=O)NC1CCCC2=C1C=NC=C2C3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BG2S3U	(S)-7-Bromo-2-(cyclopropylmethyl)-8-(1-isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	52948255	C24H32BrN3O2	474.4	C[C@H]1CN(C(=O)C2=CC3=CC(=C(C=C3N12)Br)OC4CCN(CC4)C(C)C)CC5CC5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BGER45	1-(4-((3S,4R)-3-(3-(2-(3,5-Bis(trifluoromethyl)phenyl)propan-2-yl)-1,2,4-oxadiazol-5-yl)-4-(4-fluoro-2-methylphenyl)pyrrolidine-1-carbonyl)piperidin-1-yl)ethanone	Investigative	44433802	C32H33F7N4O3	654.6	CC1=C(C=CC(=C1)F)[C@@H]2CN(C[C@H]2C3=NC(=NO3)C(C)(C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C(=O)C5CCN(CC5)C(=O)C	IC50 = 89000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BGF19N	N-(4-Methylphenyl)-N'-hydroxyformamidine	Investigative	13163256	C8H10N2O	150.18	CC1=CC=C(C=C1)N=CNO	IC50 = 79000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BGI0F1	(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	44476893	C28H32N2O4	460.6	C[C@@H](C1=CC=C(C=C1)C2=CC(=O)N(C=C2)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BGIP98	10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-6-fluoro-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Investigative	66898814	C17H19FN4O	314.36	C1CN2CCC1[C@@H](C2)N3CCN4C5=C(C=C(C=C5C3=O)F)C=N4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BGLC41	4-[(4R)-3-Methylsulfonyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidin-4-yl]benzonitrile	Investigative	77844825	C22H16F3N3O4S	475.4	CS(=O)(=O)N1[C@@H](C2=C(CCC2=O)N(C1=O)C3=CC=CC(=C3)C(F)(F)F)C4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BGQ7T4	(R)-8-(1-Isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16679612	C20H27N3O2	341.4	C[C@@H]1CNC(=O)C2=CC3=C(N12)C=CC(=C3)OC4CCN(CC4)C(C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BGU01Q	SSTR5 antagonist 2 (TFA)	Investigative	138377584	C34H36F4N2O7	660.7	CCOC1=CC(=CC(=C1C2=CC=C(C=C2)F)OCC)CN3CCC4(CC3)CC(=O)N(C4)C5=CC=C(C=C5)C(=O)O.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BGX38E	1-[[6-(Dimethylamino)-5-methyl-pyrimidin-4-yl]methyl]-N-(2-hydroxyethyl)-6-methoxy-pyrrolo[3,2-b]pyridine-3-carboxamide	Investigative	90467162	C19H24N6O3	384.4	CC1=C(N=CN=C1N(C)C)CN2C=C(C3=C2C=C(C=N3)OC)C(=O)NCCO	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BH12CO	N-(2-((2-Chloro-9H-thioxanthen-9-yl)methylamino)-2-oxoethyl)-4-fluorobenzamide	Investigative	44579235	C23H18ClFN2O2S	440.9	C1=CC=C2C(=C1)C(C3=C(S2)C=CC(=C3)Cl)CNC(=O)CNC(=O)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BH4G9F	2-(4-Fluorobenzyl)-8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16678616	C26H30FN3O2	435.5	CC(C)N1CCC(CC1)OC2=CC3=C(C=C2)N4CCN(C(=O)C4=C3)CC5=CC=C(C=C5)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BH59SQ	2-[4-[4-[6-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]-1H-benzimidazol-2-yl]phenyl]cyclohexyl]acetic acid	Investigative	71812623	C32H27F3N4O4	588.6	C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)C3=NC4=C(N3)C=C(C=C4)NC(=O)C5=C(OC(=N5)C6=CC=CC=C6)C(F)(F)F	EC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BH7OJ2	6-(Pyridin-3-yl)-3,4-dihydroquinolin-2(1H)-one	Investigative	13728862	C14H12N2O	224.26	C1CC(=O)NC2=C1C=C(C=C2)C3=CN=CC=C3	IC50 = 58900 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHA64M	CID 71621803	Investigative	71621803	C31H20F4N6O2	584.5	C1=CC(=CC=C1COC2=CC=C(C=C2)C#CC3=CN=C(C=C3)C(C(CN4C=NN=N4)(C5=C(C=C(C=C5)F)F)O)(F)F)C#N	IC50 = 138000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHF7T6	8-(1-Isopropylpiperidin-4-yloxy)-2-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16679707	C20H27N3O2	341.4	CC(C)N1CCC(CC1)OC2=CC3=C(C=C2)N4CCN(C(=O)C4=C3)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHF7W1	Carbamic acid, N-(4-hydroxybutyl)-, 2-(5-((1S)-1-((2-amino-2-methyl-1-oxopropyl)amino)-2-(phenylmethoxy)ethyl)-1H-tetrazol-1-yl)ethyl ester	Investigative	23649669	C21H33N7O5	463.5	CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C2=NN=NN2CCOC(=O)NCCCCO)N	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHFA03	CID 49848895	Investigative	49848895	C32H30N6O5	578.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC=C(C=C6)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHTI42	2-(2-(4-((Dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)-5-((5-methoxypyridin-2-yl)methoxy)pyridazin-3(2H)-one	Investigative	71714121	C23H26N4O4	422.5	CC1=C(C=CC(=C1)CN(C)C)C(=O)CN2C(=O)C=C(C=N2)OCC3=NC=C(C=C3)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHU65C	CID 49849122	Investigative	49849122	C33H29F3N6O4	630.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=NC(=C4)C(F)(F)F)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHUR59	2-Methoxy-N-[(3R)-1-methyl-3-phenylpiperidin-3-yl]-6-methylsulfanyl-4-(trifluoromethyl)benzamide	Investigative	46850264	C22H25F3N2O2S	438.5	CN1CCC[C@](C1)(C2=CC=CC=C2)NC(=O)C3=C(C=C(C=C3SC)C(F)(F)F)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHX15E	Chembl4227117	Investigative	145968371	C21H22N4O4	394.4	CC(C)OC(=O)[C@H](CN1C=CN=C1)NC(=O)C2=NOC3=C2CCC4=CC=CC=C43	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BHXW01	N-[(8R)-4-(4-Cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide	Investigative	89846958	C19H19N3O	305.4	CCC(=O)N[C@@H]1CCCC2=C1C=NC=C2C3=CC=C(C=C3)C#N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BI3O2G	CID 49848897	Investigative	49848897	C33H32N6O5	592.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BI6RQ4	N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)-3-phenylpropanamide	Investigative	44578914	C24H23ClN2O2	406.9	C1=CC=C(C=C1)CCC(=O)NCC(=O)NC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BI9LA7	5-[(3,5-Dichlorophenoxy)methyl]-4-pyrazoline-3-one	Investigative	45102767	C10H8Cl2N2O2	259.089	C1=C(C=C(C=C1Cl)Cl)OCC2=CC(=O)NN2	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BIQS65	N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)cyclopentanecarboxamide	Investigative	44579190	C21H23ClN2O2	370.9	C1CCC(C1)C(=O)NCC(=O)NC(C2=CC=CC=C2)C3=CC=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BIT36P	Chembl4229237	Investigative	42603033	C23H21ClF3N3O3	479.9	C[C@H](C1=C[N+](=C(C=C1)C(F)(F)F)[O-])NC(=O)C2=CC(=CC(=C2)C3=NC=C(C=C3)Cl)C(C)(C)O	IC50 = 82000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BIY06M	N-(2,6-Dimethylbenzyl)-1,2-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine	Investigative	46879430	C17H20N4	280.37	CC1=C(C(=CC=C1)C)CNC2=NC=CC3=C2N=C(N3C)C	IC50 = 68000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJ35GN	(4R)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-methyl-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide	Investigative	76322044	C25H28N4O2S	448.6	CC1=NC2=C(S1)CC[C@H]2C(=O)NC3=CC=C(C=C3)C[C@@H]4CC[C@@H](N4)[C@@H](C5=CN=CC=C5)O	IC50 = 67200 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJ3B2V	N-(11-Oxo-2-phenylbenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl)methanesulfonamide	Investigative	15981007	C21H16N2O3S	376.4	CS(=O)(=O)NC1=CC2=C(C=C1)C=CC3=C(C2=O)C=C(C=N3)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJ3OM6	N-(2-Fluoroethyl)-1-((6-methoxy-5-methylpyrimidin-4-yl)methyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide	Investigative	72792633	C18H20FN5O2	357.4	CC1=CC2=C(C(=CN2CC3=C(C(=NC=N3)OC)C)C(=O)NCCF)N=C1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJ53QF	4-Fluoro-N-(2-oxo-2-(phenyl(3-(trifluoromethyl)phenyl)methylamino)ethyl)benzamide	Investigative	24899995	C23H18F4N2O2	430.4	C1=CC=C(C=C1)C(C2=CC(=CC=C2)C(F)(F)F)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJ65KB	3-Chloro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	Investigative	57386785	C32H29ClN6O5	613.1	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJ6LI7	(1S)-1-[5-Methyl-2-[2-methyl-6-[(2R)-2-(1-methylbenzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]ethanol	Investigative	118423208	C21H23N7O	389.5	CC1=NC(=CC(=N1)N2C(=NC(=N2)C)[C@H](C)O)C3C[C@H]3C4=NC5=CC=CC=C5N4C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJ7Y3X	9-(1-Isopropyl-piperidin-4-yloxy)-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indol-1-one	Investigative	16679701	C20H27N3O2	341.4	CC(C)N1CCC(CC1)OC2=CC3=C(C=C2)N4CCCNC(=O)C4=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJ9CU6	CID 76310313	Investigative	76310313	C20H18N2O3	334.4	CC1=NC=C(O1)C2=CC=C(C=C2)[C@@H]3[C@H]([C@H]3C(=O)NO)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJCN58	4-Fluoro-N-(2-oxo-2-(phenyl(m-tolyl)methylamino)ethyl)benzamide	Investigative	24900236	C23H21FN2O2	376.4	CC1=CC(=CC=C1)C(C2=CC=CC=C2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJER35	2-(4-Bromophenyl)-3,4-Dihydroquinazolin-4-One	Investigative	135421564	C14H9BrN2O	301.14	C1=CC=C2C(=C1)C(=O)NC(=N2)C3=CC=C(C=C3)Br	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJK7B6	6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(cyclopropylmethyl)pyridine-3-carboxamide	Investigative	21914667	C21H22FN3O2	367.4	CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=NC=C(C=C3)C(=O)NCC4CC4	IC50 = 63095.73 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BJNP01	1-(4-Benzyl-2-oxo-1,2-dihydro-quinolin-3-yl)-pyridinium	Investigative	44403288	C21H17N2O+	313.4	C1=CC=C(C=C1)CC2=C(C(=O)NC3=CC=CC=C32)[N+]4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BK0VJ8	(R)-2-(Cyclopropylmethyl)-8-(1-isopropylpiperidin-4-yloxy)-3-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	46945057	C24H33N3O2	395.5	C[C@@H]1CN2C3=C(C=C(C=C3)OC4CCN(CC4)C(C)C)C=C2C(=O)N1CC5CC5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BK60IH	4-[4-[4-(1-Cyclobutylpiperidin-4-yl)oxyphenyl]-3-oxopiperazine-1-carbonyl]benzonitrile;formic acid	Investigative	24749961	C28H32N4O5	504.6	C1CC(C1)N2CCC(CC2)OC3=CC=C(C=C3)N4CCN(CC4=O)C(=O)C5=CC=C(C=C5)C#N.C(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BK73DX	Desethylamodiaquine	Investigative	122068	C18H18ClN3O	327.8	CCNCC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O	IC50 = 58000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BKD64H	(4S)-4-(4-Cyano-2-methylsulfonylphenyl)-N-methyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide	Investigative	77844945	C24H19F3N4O5S	532.5	CNC(=O)N1[C@@H](C2=C(CCC2=O)N(C1=O)C3=CC=CC(=C3)C(F)(F)F)C4=C(C=C(C=C4)C#N)S(=O)(=O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BKE7A3	N-((3r,5s)-1-(Benzofuran-3-Carbonyl)-5-(Ethylcarbamoyl)pyrrolidin-3-Yl)-3-Ethyl-1-Methyl-1h-Pyrazole-5-Carboxamide	Investigative	72725792	C23H27N5O4	437.5	CCC1=NN(C(=C1)C(=O)N[C@@H]2C[C@H](N(C2)C(=O)C3=COC4=CC=CC=C43)C(=O)NCC)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BKNO32	Chembl4177457	Investigative	72950813	C19H18ClN5O3S	431.9	CS(=O)(=O)C1=NN(C2=C1C=CN=C2)CC3=NC4=C(N3CC5COC5)C=CC(=C4)Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BL0JX6	2-(2-Aminothiazol-4-yl)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)acetamide	Investigative	44472590	C23H26N4O2S	422.5	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)[C@@H](C4=CC=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BL65DR	(1S,2R,5S)-5-(12-Cyclopropyl-1,4,8,10,11-pentazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine	Investigative	127052638	C22H23F3N6	428.5	C1C[C@@H]([C@H](C[C@H]1N2CC3=C(C2)N4C(=NN=C4N=C3)C5CC5)N)C6=CC(=C(C=C6F)F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BL8R5J	Chembl4176506	Investigative	145974556	C15H16Cl3N3O	360.7	C1=CN=CC=C1C2=C(C=NC=C2)C3=CC=C(O3)CN.Cl.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLF2V0	JTZ-951 HCl	Investigative	67049587	C17H17ClN4O4	376.8	C1=CC=C(C=C1)CCC2=CC(=O)C(=C3N2NC=N3)C(=O)NCC(=O)O.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLK05J	Schembl21666383	Investigative	44479934	C21H23FN2O3	370.4	CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=CC=C(C=C3)C(=O)NCCOC	IC50 = 63095.73 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLM68U	Methyl 2-[(R)-(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-3H-benzimidazole-5-carboxylate	Investigative	70691455	C17H17N3O5S	375.4	COC1=C(C(=NC=C1)C[S@@](=O)C2=NC3=C(N2)C=C(C=C3)C(=O)OC)OC	Ki = 140000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLQK90	DprE1-IN-2	Investigative	90467014	C19H24N6O2	368.4	CC1=CC2=C(C(=CN2CC3=C(C(=NC=N3)N(C)C)C)C(=O)NCCO)N=C1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLR7A1	2-((Pyridin-2-ylmethyl)thio)-1H-benzo[d]imidazole	Investigative	683949	C13H11N3S	241.31	C1=CC=C2C(=C1)NC(=N2)SCC3=CC=CC=N3	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLS18O	cis-2,6-Dimethyl-4-(6-(5-(1-methylcyclopropoxy)-1H-indazol-3-yl)pyrimidin-4-yl)morpholine	Investigative	78319901	C21H25N5O2	379.5	C[C@@H]1CN(C[C@@H](O1)C)C2=NC=NC(=C2)C3=NNC4=C3C=C(C=C4)OC5(CC5)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLSU13	Amodiaquine HCl	Investigative	16051921	C20H23Cl2N3O	392.3	CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.Cl	IC50 = 62000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLUE24	Abelcet	Investigative	118705500	C47H73NO17	924.1	C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLWN62	5-(3-Cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d]pyrimidine-4,7-dione	Investigative	51346919	C14H14F2N2O3	296.27	C1CC1CCCC2=CC(=O)OC3=C2C(=O)NC(=N3)C(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BLYJ59	(6R)-6-(3-Hydroxypropyl)-3-[(1S)-1-[4-(1-methyl-6-oxopyridazin-3-yl)phenyl]ethyl]-6-phenyl-1,3-oxazinan-2-one	Investigative	73427552	C26H29N3O4	447.5	C[C@@H](C1=CC=C(C=C1)C2=NN(C(=O)C=C2)C)N3CC[C@](OC3=O)(CCCO)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM0JA4	N-({[(4-Chloro-phenyl)-phenyl-methyl]-carbamoyl}-methyl)-acetamide	Investigative	44579191	C17H17ClN2O2	316.8	CC(=O)NCC(=O)NC(C1=CC=CC=C1)C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM1F0Z	2-[2-(4-Ethylsulfonyl-2-methylphenyl)-4-(trifluoromethyl)phenoxy]acetic acid	Investigative	53359023	C18H17F3O5S	402.4	CCS(=O)(=O)C1=CC(=C(C=C1)C2=C(C=CC(=C2)C(F)(F)F)OCC(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM1T2J	N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((1r,4r)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide	Investigative	73670548	C35H51N5O4	605.8	CCN(C1CCC(CC1)N(C)CCOC)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CCN4CCOCC4	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM56JK	[2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid sodium salt	Investigative	50901657	C29H31N2NaO5	510.6	CCN(CC1=C(C=CC(=C1)C2=CN=C(C=C2)OCC)C3=C(C=CC(=C3)CC(=O)[O-])OC)C(=O)C4CC4.[Na+]	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM5DW8	2-[8-Fluoro-2-[2-(1H-indol-3-yl)acetyl]-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid	Investigative	71733911	C23H20FN3O3	405.4	C1CN(CC2=C1N(C3=C2C=C(C=C3)F)CC(=O)O)C(=O)CC4=CNC5=CC=CC=C54	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM6FD8	8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(2-oxoazetidin-1-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069522	C27H27N7O4	513.5	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)N6CCC6=O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM7ZW8	2,5-Bis(3,5-di-tert-butyl-4-hydroxybenzylidene)cyclopentanone	Investigative	10791993	C35H48O3	516.799	CC(C1=CC(=CC(=C1O)C(C)(C)C)/C=C\\2/C(=O)/C(=C/C3=CC(=C(C(=C3)C(C)(C)C)O)C(C)(C)C)/CC2)(C)C	IC50 = 55000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM8H3E	1-[5-Methyl-2-[2-methyl-6-[3-(1-methylbenzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]propan-1-ol	Investigative	74767418	C22H26N8O	418.5	CCC(C1=NC(=NN1C2=CC(=NC(=N2)C)N3CC(C3)C4=NC5=CC=CC=C5N4C)C)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM95EQ	Chembl4128835	Investigative	145960490	C24H28Cl2N2O2	447.4	C[C@H](C1=CC=CC2=CC=CC=C21)N[C@H]3CCN(C3)C4=CC=C(C=C4)CC(=O)O.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BM9N7G	1-[5-Methyl-2-[2-methyl-6-[(2R)-2-(1-methylbenzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]propan-1-ol	Investigative	118423215	C22H25N7O	403.5	CCC(C1=NC(=NN1C2=NC(=NC(=C2)C3C[C@H]3C4=NC5=CC=CC=C5N4C)C)C)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BMH21S	(S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine	Investigative	56835991	C10H11FN2O	194.21	CC1=C(C=CC=C1F)[C@H]2COC(=N2)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BMK09X	2-[5-Fluoro-2-methyl-3-(1-oxo-2-propan-2-ylisoquinolin-4-yl)indol-1-yl]acetic acid	Investigative	57505249	C23H21FN2O3	392.4	CC1=C(C2=C(N1CC(=O)O)C=CC(=C2)F)C3=CN(C(=O)C4=CC=CC=C43)C(C)C	IC50 = 55000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BMPR42	(S)-3-((S)-1-(4-(1-Ethyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	59635683	C29H34N2O4	474.6	CCN1C=CC(=CC1=O)C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BMU4R1	2-[2-[(5-Acetyl-2-methoxyphenyl)methylsulfanyl]-5-fluorobenzimidazol-1-yl]acetic acid	Investigative	11682521	C19H17FN2O4S	388.4	CC(=O)C1=CC(=C(C=C1)OC)CSC2=NC3=C(N2CC(=O)O)C=CC(=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BMZ8E7	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-pyrazol-1-ylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069524	C27H26N8O3	510.5	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)N6C=CC=N6	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BN04HS	Dimethyl({[5-(pyridin-3-yl)thiophen-2-yl]methyl})amine	Investigative	11310529	C12H14N2S	218.32	CN(C)CC1=CC=C(S1)C2=CN=CC=C2	Ki = 103000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BN0T6U	CID 44517795	Investigative	44517795	C22H15F3N4O5	472.4	C1CN(C2=C1C=C(C=C2)C3=NOC(=N3)C4=CC(=CC(=C4)C#N)OC(F)(F)F)C(=O)CCC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BN1A7L	Pyridine, 3-(1-methyl-1H-imidazol-4-yl)-	Investigative	11344157	C9H9N3	159.19	CN1C=C(N=C1)C2=CN=CC=C2	IC50 = 79500 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BN31PD	1-(8-((1S,2S)-2-Hydroxy-2,3-dihydro-1H-inden-1-ylamino)-2,3-dimethylimidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one	Investigative	44583663	C23H22N4O2	386.4	CC1=C(N2C=C(C=C(C2=N1)N[C@@H]3[C@H](CC4=CC=CC=C34)O)N5C=CC=CC5=O)C	IC50 = 97000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BN6SC4	CID 49849002	Investigative	49849002	C31H28N6O4	548.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=NC=C4)C5=CC=C(C=C5)C6=CC=C(C=C6)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BN8D4L	1-[({2-[(1S)-1-Cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoethyl}amino)methyl]cyclohexanol	Investigative	25067546	C24H36N2O2	384.6	C1CCC(CC1)[C@H]2C3=CC=CC=C3CCN2C(=O)CNCC4(CCCCC4)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BN9Q8L	Methyl N-[(2S)-1-[(2S)-2-[5-chloro-4-[4-[4-[5-chloro-2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate	Investigative	53251325	C40H48Cl2N8O6	807.8	CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC(=C(N2)Cl)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=C(NC(=N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)Cl)NC(=O)OC	IC50 = 81600 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BNI9Y2	Chembl4127941	Investigative	145962388	C19H19FN4O4	386.4	CC(C)OC(=O)[C@H](CN1C=CN=C1)NC(=O)C2=NOC(=C2)C3=CC=CC=C3F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BNK8Z1	Furanyl analog 2	Investigative	9940105	C38H42F3N5O6	721.8	C1CN([C@@H](CN1CC2=CC=C(O2)C3=CC=CC=C3)C(=O)NCC(F)(F)F)C[C@H](C[C@@H](CC4=CN=CC=C4)C(=O)N[C@@H]5[C@@H](COC6=CC=CC=C56)O)O	IC50 = 83900 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BNLG57	7-Methoxy-4-trifluoromethylcoumarin-3-acetic acid	Investigative	9839359	C13H9F3O5	302.2	COC1=CC2=C(C=C1)C(=C(C(=O)O2)CC(=O)O)C(F)(F)F	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BNQM63	N-(2-((4-Chlorophenyl)(phenyl)methylamino)-2-oxoethyl)-4-fluorobenzamide	Investigative	24899993	C22H18ClFN2O2	396.8	C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BNR5J4	1,3-Bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione	Investigative	2187415	C20H20N2O3	336.4	C1C(=O)N(C(=O)N(C1=O)CCC2=CC=CC=C2)CCC3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BNZ3F9	4-Fluoro-N-(2-oxo-2-(phenyl(pyrimidin-2-yl)methylamino)ethyl)benzamide	Investigative	44578961	C20H17FN4O2	364.4	C1=CC=C(C=C1)C(C2=NC=CC=N2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO0M6F	4-(2-(3-Chlorophenyl)-2-hydroxyethylamino)-3-(4-methyl-6-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one	Investigative	135681833	C25H25ClN6O2	477	CC1CN=C(N1)C2=CC3=C(C(=C2)C)N=C(N3)C4=C(C=CNC4=O)NCC(C5=CC(=CC=C5)Cl)O	IC50 = 67000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO2X3C	N-(2-Hydroxyethyl)-6-methoxy-1-[(6-methoxy-5-methyl-pyrimidin-4-yl)methyl]pyrrolo[3,2-b]pyridine-3-carboxamide	Investigative	90467159	C18H21N5O4	371.4	CC1=C(N=CN=C1OC)CN2C=C(C3=C2C=C(C=N3)OC)C(=O)NCCO	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO31WG	Hydroxyethylamine derivative, 4	Investigative	44143257	C31H34F4N4O3	586.6	CCNC1=CC(=C(C(=C1)N2CCCC2=O)F)C(=O)N[C@@H](CC3=CC=CC=C3)[C@@H](CNCC4=CC(=CC=C4)C(F)(F)F)O	IC50 = 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO3HW7	N~1~-[(10S)-2-{[(4-Fluorophenyl)methyl]carbamoyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl]-N~1~,N~2~,N~2~-trimethylethanediamide	Investigative	54716246	C22H26FN5O5	459.5	CN(C)C(=O)C(=O)N(C)[C@H]1CCCCN2C1=NC(=C(C2=O)O)C(=O)NCC3=CC=C(C=C3)F	IC50 = 75000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO69JK	2-(2-Hydroxyethyl)-8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16678725	C21H29N3O3	371.5	CC(C)N1CCC(CC1)OC2=CC3=C(C=C2)N4CCN(C(=O)C4=C3)CCO	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO69VC	Vibegron	Investigative	44472635	C26H28N4O3	444.5	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)[C@@H]3CCC4=NC=CC(=O)N34)[C@@H](C5=CC=CC=C5)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO6MY0	1-(5-Isoquinolin-4-yl-2,3-dihydroindol-1-yl)propan-1-one	Investigative	73603344	C20H18N2O	302.4	CCC(=O)N1CCC2=C1C=CC(=C2)C3=CN=CC4=CC=CC=C43	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO7T8N	2-(3-Chloro-2-fluoroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide	Investigative	10071498	C18H17ClF4N4O2	432.8	C1COCCC1CNC(=O)C2=CN=C(N=C2C(F)(F)F)NC3=C(C(=CC=C3)Cl)F	IC50 = 75000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO8E6H	1-[(2-Chloroquinolin-3-Yl)methyl]-6-Fluoro-5-Methyl-3-(2-Oxo-1,2-Dihydropyridin-3-Yl)-1h-Indole-2-Carboxylic Acid	Investigative	25226377	C25H17ClFN3O3	461.9	CC1=CC2=C(C=C1F)N(C(=C2C3=CC=CNC3=O)C(=O)O)CC4=CC5=CC=CC=C5N=C4Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO8Y6E	6-(4-((S)-1-((S)-6-(2-Hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)nicotinamide	Investigative	58109674	C28H31N3O4	473.6	C[C@@H](C1=CC=C(C=C1)C2=NC=C(C=C2)C(=O)N)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BO9F4X	5-Chloro-4-[[(8R)-6,6-dimethyl-2,3,5,7-tetrahydro-1H-pyrrolizin-8-yl]methylamino]-2-fluoro-N-(1,3-thiazol-2-yl)benzenesulfonamide	Investigative	91666645	C19H24ClFN4O2S2	459	CC1(C[C@]2(CCCN2C1)CNC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=NC=CS4)F)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BOA4K8	(S)-3-((S)-1-(4-(1-Ethyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	59635800	C29H34N2O4	474.6	CCN1C=C(C=CC1=O)C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BOFD26	2-(2,4-Difluorophenyl)-1,1-difluoro-1-[5-(6-fluoropyridin-3-yl)pyridin-2-yl]-3-(tetrazol-1-yl)propan-2-ol	Investigative	71143726	C20H13F5N6O	448.3	C1=CC(=C(C=C1F)F)C(CN2C=NN=N2)(C(C3=NC=C(C=C3)C4=CN=C(C=C4)F)(F)F)O	IC50 = 81000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BOI6P9	N-Tert-butyl isoquine	Investigative	10316203	C20H22ClN3O	355.9	CC(C)(C)NCC1=C(C=C(C=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O	IC50 ~ 90000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BON3M1	[2-(5-Fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-phenylmethanone	Investigative	74221949	C18H14FN3O2	323.3	C1CN(CC2=C1OC(=N2)C3=NC=C(C=C3)F)C(=O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BOS9P8	(R)-6-(3-Hydroxypropyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	59635752	C27H30N2O4	446.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)N3CC[C@](OC3=O)(CCCO)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BOY54G	4-Fluoro-N-(2-oxo-2-(phenyl(o-tolyl)methylamino)ethyl)benzamide	Investigative	44579232	C23H21FN2O2	376.4	CC1=CC=CC=C1C(C2=CC=CC=C2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BP4JD9	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-(4-phenylphenyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069494	C30H28N6O3	520.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=CC=CC=C6	IC50 = 65000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BP7S5J	3-[4-[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069523	C28H28N8O5	556.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=NOC(=N6)COC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BPE7O1	4-[3-Oxo-4-[4-(3-piperidin-1-ylpropoxy)phenyl]piperazine-1-carbonyl]benzonitrile;hydrochloride	Investigative	24749608	C26H31ClN4O3	483	C1CCN(CC1)CCCOC2=CC=C(C=C2)N3CCN(CC3=O)C(=O)C4=CC=C(C=C4)C#N.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BPF14T	4-Fluoro-N-(2-oxo-2-(phenyl(thiazol-2-yl)methylamino)ethyl)benzamide	Investigative	44579234	C19H16FN3O2S	369.4	C1=CC=C(C=C1)C(C2=NC=CS2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BPN5S3	4-Methyl-5-[2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one	Investigative	57331668	C23H25N7O3	447.5	CC1=C(C=CC2=C1COC2=O)CCN3CCN(CC3)C(=O)CC4=CN=C(C=C4)N5C=NN=N5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BPQC67	8-[(3-Methylpyridin-2-yl)methyl]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069531	C27H25N7O4	511.5	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=CC=NO6	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BPX7B6	(S)-6-(2-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-1,3-oxazinan-2-one	Investigative	59635764	C28H31FN2O4	478.6	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQ42IC	4-(Methanesulfonylmethyl)-2-(pyridin-4-yl)-6-(pyrrolidin-1-yl)pyrimidine	Investigative	3811929	C15H18N4O2S	318.4	CS(=O)(=O)CC1=CC(=NC(=N1)C2=CC=NC=C2)N3CCCC3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQ59CW	N-(2-(Bis(3-fluorophenyl)methylamino)-2-oxoethyl)-4-fluorobenzamide	Investigative	24743795	C22H17F3N2O2	398.4	C1=CC(=CC(=C1)F)C(C2=CC(=CC=C2)F)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQ9I7D	1-[[6-(Difluoromethoxy)-5-methylpyrimidin-4-yl]methyl]-N-(2-hydroxyethyl)-6-methylpyrrolo[3,2-b]pyridine-3-carboxamide	Investigative	90467156	C18H19F2N5O3	391.4	CC1=CC2=C(C(=CN2CC3=C(C(=NC=N3)OC(F)F)C)C(=O)NCCO)N=C1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQ9O1W	CID 49849008	Investigative	49849008	C32H30N6O4	562.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=CN=C4)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQCX45	(1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diol	Investigative	118453722	C26H28N6O3	472.5	CC1=CC(=CC(=N1)C)NC2=NC=C(C(=N2)N[C@@H]3C[C@@H]([C@H]([C@H]3O)O)CO)C4=NC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQD29S	4-[(2-Cyclobutylimidazo[4,5-b]pyrazin-3-yl)methyl]-8-fluoro-1H-quinolin-2-one	Investigative	25211805	C19H16FN5O	349.4	C1CC(C1)C2=NC3=NC=CN=C3N2CC4=CC(=O)NC5=C4C=CC=C5F	EC50 ~ 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQF9K3	3-Methyl-4-[4-[1-(3-methylpyrazin-2-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	Investigative	57387540	C33H32N6O4	576.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=CN=C4C)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQS96L	3-[4-(1,3-Benzothiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069450	C31H27N7O3S	577.7	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=CC7=C(C=C6)SC=N7	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQV18F	cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate	Investigative	3114841	C14H15Cl2N3O5S	408.3	CS(=O)(=O)OCC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BQX5G3	4-Amino-N-butyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	11046887	C19H22N4O2S	370.5	CCCCN(C1=CC=NN1C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BR49IX	N-(2,6-Dimethyl-phenyl)-2-{4-[(R)-2-hydroxy-3-(2-methyl-benzothiazol-5-yloxy)-propyl]-piperazin-1-yl}-acetamide	Investigative	10457343	C25H32N4O3S	468.6	CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)C[C@H](COC3=CC4=C(C=C3)SC(=N4)C)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BR53FA	CID 49849007	Investigative	49849007	C32H29FN6O5	596.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BR5XI3	(4R)-2-Amino-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-cyclopenta[d][1,3]thiazole-4-carboxamide	Investigative	76336500	C25H28N4O2S	448.6	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)[C@@H]3CCC4=C3N=C(S4)N)[C@@H](C5=CC=CC=C5)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BR74FA	3-Methyl-4-[5-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decan-3-yl]pyridin-2-yl]benzoic acid	Investigative	136069453	C31H29N7O5	579.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CN=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BR7XT3	(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(2-methylpyrimidin-5-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	58109240	C27H31N3O3	445.6	CC1=NC=C(C=N1)C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BR8NM0	3-[(5-Cyclopropyl-1,2-oxazol-3-yl)methylamino]adamantan-1-ol	Investigative	137651899	C17H24N2O2	288.4	C1CC1C2=CC(=NO2)CNC34CC5CC(C3)CC(C5)(C4)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BR9W1C	N-(9-Ethyl-9H-carbazol-3-yl)-2-{4-[(R)-2-hydroxy-3-(2-methyl-benzothiazol-5-yloxy)-propyl]-piperazin-1-yl}-acetamide	Investigative	10415353	C31H35N5O3S	557.7	CCN1C2=C(C=C(C=C2)NC(=O)CN3CCN(CC3)C[C@H](COC4=CC5=C(C=C4)SC(=N5)C)O)C6=CC=CC=C61	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BRA50S	Chembl4164781	Investigative	145958087	C9H12Cl2N2	219.11	CC1=NC=C(C=C1)C#CCN.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BRBX35	1(4H)-Pyrimidineacetamide, N-(2-(diethylamino)ethyl)-2-(((4-fluorophenyl)methyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)-4-oxo-N-((4'-(trifluoromethyl)(1,1'-biphenyl)-4-yl)methyl)-	Investigative	10417440	C38H40F4N6O2S	720.8	CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)CN3C=C(C(=O)N=C3SCC4=CC=C(C=C4)F)CC5=CN(N=C5)C	IC50 = 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BRFX94	4-Amino-N-(3-methyl-butyl)-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	10045582	C20H24N4O2S	384.5	CC(C)CCN(C1=CC=NN1C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N	IC50 = 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BRY3F1	4-(5-Chloro-2-hydroxy-phenyl)-3-[3-((R)-diethyl-amino)-2-hydroxy-propylsulfanyl]-6-trifluoromethyl-1H-quinolin-2-one	Investigative	11272006	C23H24ClF3N2O3S	501	CCN(CC)C[C@H](CSC1=C(C2=C(C=CC(=C2)C(F)(F)F)NC1=O)C3=C(C=CC(=C3)Cl)O)O	IC50 = 50680 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BS3U4D	(6S)-N-[4-[[(2S,5R)-5-[(R)-Hydroxy(pyridin-3-yl)methyl]pyrrolidin-2-yl]methyl]phenyl]-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-6-carboxamide	Investigative	70792359	C24H27N5O2	417.5	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)[C@@H]3CCC4=CC=NN34)[C@@H](C5=CN=CC=C5)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BS4V5K	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,7,8,9,12-pentazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	24798754	C18H18F2N6O	372.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C5N=CC=NN5N=C4C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BS59EU	4-Fluoro-N-(2-oxo-2-(phenyl(p-tolyl)methylamino)ethyl)benzamide	Investigative	44579233	C23H21FN2O2	376.4	CC1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BS6B3J	2-[8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-2-yl]acetic acid	Investigative	56603353	C23H23F3N4O3	460.4	C1CC2(CCN(CC2)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F)OC1CC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BS7I5D	Chembl4246655	Investigative	145984299	C26H29N5O2S2	507.7	C1C[C@H](N(C1)S(=O)(=O)C2=CN=CC3=CC=CC=C32)CCN4CCN(CC4)C5=NSC6=CC=CC=C65	IC50 = 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BS7YV4	(S)-N-((3S,4S)-5-Acetyl-7-cyano-4-methyl-1-((2-methylnaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1, 4]diazepin-3-yl)-2-(methylamino)propanamide hydrochloride	Investigative	72714057	C29H32ClN5O3	534	C[C@H]1[C@@H](C(=O)N(C2=C(N1C(=O)C)C=C(C=C2)C#N)CC3=C(C=CC4=CC=CC=C43)C)NC(=O)[C@H](C)NC.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BS91AU	10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Investigative	49843532	C17H20N4O	296.37	C1CN2CCC1[C@@H](C2)N3CCN4C5=C(C=CC=C5C3=O)C=N4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BSG15N	Chembl4162449	Investigative	145958967	C11H14Cl2N2O2	277.14	COC1=C(C=NC=C1)C2=CC=C(O2)CN.Cl.Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BSK39J	Chembl4224936	Investigative	10223809	C24H21NO6	419.4	CCOC1=C2C(=C(C3=CC=CC=C31)OCC)C(=O)N(C2=O)C4=CC=C(C=C4)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BSN8D2	6-Chloro-4-phenyl-2-propan-2-ylquinoline-3-carboxylic acid	Investigative	71556166	C19H16ClNO2	325.8	CC(C)C1=NC2=C(C=C(C=C2)Cl)C(=C1C(=O)O)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BSR43T	Schembl20719106	Investigative	49850345	C21H18N2O4	362.4	CC(C)C1(C(=O)NC(=O)O1)C2=CC=C(NC2=O)C3=CC4=CC=CC=C4C=C3	IC50 ~ 50118.72 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BSXF58	6-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(5-fluoro-6-methylpyridin-2-yl)amino]pyridazine-3-carboxamide	Investigative	71626895	C17H22FN7O	359.4	CC1=C(C=CC(=N1)NC2=CC(=NN=C2C(=O)N)N[C@@H]3CCCC[C@@H]3N)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BSXW86	CID 49849120	Investigative	49849120	C33H32N6O4	576.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=NC(=C4)C)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT1NK2	SB 271046 Hydrochloride	Investigative	6918455	C20H23Cl2N3O3S2	488.5	CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)NC3=CC(=C(C=C3)OC)N4CCNCC4.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT50NK	Hydroxy ethylamine (HEA), 15	Investigative	25190493	C29H40N6O4S	568.7	CCNC1=CC(=CC(=C1)C(=O)N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CN(N=C3)CC)O)N4CCCCS4(=O)=O	IC50 ~ 89000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT5V2F	CID 56603301	Investigative	56603301	C24H25F3N4O3	474.5	C1CC2(CCN(CC2)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F)OCC1CC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT6ED3	3-(2-Thienyl)pyridine	Investigative	595145	C9H7NS	161.23	C1=CC(=CN=C1)C2=CC=CS2	IC50 = 99200 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT6QD3	(4S)-4-(4-Cyano-2-methylsulfonylphenyl)-N-ethyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide	Investigative	77844946	C25H21F3N4O5S	546.5	CCNC(=O)N1[C@@H](C2=C(CCC2=O)N(C1=O)C3=CC=CC(=C3)C(F)(F)F)C4=C(C=C(C=C4)C#N)S(=O)(=O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT7HU3	(2R)-N-(4-Methoxyphenyl)-2-(pyridin-3-yloxymethyl)piperazine-1-carboxamide;hydrochloride	Investigative	90643570	C18H23ClN4O3	378.9	COC1=CC=C(C=C1)NC(=O)N2CCNC[C@@H]2COC3=CN=CC=C3.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT7ZL8	(S)-7-Bromo-8-(1-isopropylpiperidin-4-yloxy)-4-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	52944579	C20H26BrN3O2	420.3	C[C@H]1CNC(=O)C2=CC3=CC(=C(C=C3N12)Br)OC4CCN(CC4)C(C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT9E6B	4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]furan-2-carboxylic acid	Investigative	70688210	C30H28N6O6	568.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=COC(=C6)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BT9Q0V	(S)-6-(4-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)ethyl)-1,3-oxazinan-2-one	Investigative	44512034	C27H30FN3O4	479.5	C[C@@H](C1=CC=C(C=C1)C2=NN(C(=O)C=C2)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BTG81V	(R)-2-(3-(1-(4-Hydroxyphenyl)-5-methyl-1H-pyrazol-4-yl)-2-methylpropanamido)cyclohex-1-enecarboxylic acid	Investigative	44586212	C21H25N3O4	383.4	CC1=C(C=NN1C2=CC=C(C=C2)O)C[C@@H](C)C(=O)NC3=C(CCCC3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BTPD92	4-Fluoro-N-(2-oxo-2-(1-phenylpropylamino)ethyl)benzamide	Investigative	44578958	C18H19FN2O2	314.4	CCC(C1=CC=CC=C1)NC(=O)CNC(=O)C2=CC=C(C=C2)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BTSL94	(19S,22R)-22-(Benzylsulfonylamino)-N-[(4-carbamimidoylphenyl)methyl]-3,12,21-trioxo-2,6,9,13,20-pentazatetracyclo[22.2.2.26,9.214,17]dotriaconta-1(27),14(30),15,17(29),24(28),25-hexaene-19-carboxamide;2,2,2-trifluoroacetic acid	Investigative	71716137	C45H52F3N9O8S	936	C1CN2CCN(CCC(=O)NC3=CC=C(C[C@H](NC(=O)[C@@H](CC4=CC=C(C=C4)NC1=O)NS(=O)(=O)CC5=CC=CC=C5)C(=O)NCC6=CC=C(C=C6)C(=N)N)C=C3)CC2.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BTZ6W5	3-[4-(2,4-Dimethyl-1,3-thiazol-5-yl)phenyl]-8-[(3-methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069532	C29H29N7O3S	555.7	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=C(N=C(S6)C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU1G2C	[4-Methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	24753607	C21H23N3O6S	445.5	CC1=C(C(=O)OC2=C1C=CC(=C2)OC(=O)N(C)C)CC3=CC(=CC=C3)NS(=O)(=O)NC	IC50 = 96000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU28ZY	N-Methyl-N-[(1-methylpyrrol-2-yl)methyl]adamantane-1-carboxamide	Investigative	23583191	C18H26N2O	286.4	CN1C=CC=C1CN(C)C(=O)C23CC4CC(C2)CC(C4)C3	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU2A0E	(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(6-methylpyridazin-3-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	58109250	C27H31N3O3	445.6	CC1=NN=C(C=C1)C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU2WQ4	2-(3-Hydroxy-4-methoxyphenyl)quinazoline-4(3H)-one	Investigative	136044076	C15H12N2O3	268.27	COC1=C(C=C(C=C1)C2=NC3=CC=CC=C3C(=O)N2)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU32JF	4-[[1-[(3-Fluoro-4-methylphenyl)sulfonyl-methylamino]cyclopropanecarbonyl]amino]adamantane-1-carboxamide	Investigative	127039139	C23H30FN3O4S	463.6	CC1=C(C=C(C=C1)S(=O)(=O)N(C)C2(CC2)C(=O)NC3C4CC5CC3CC(C5)(C4)C(=O)N)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU3H8O	6-{[(1r,2s)-2-Aminocyclohexyl]amino}-4-[(5,6-Dimethylpyridin-2-Yl)amino]pyridazine-3-Carboxamide	Investigative	71626896	C18H25N7O	355.4	CC1=C(N=C(C=C1)NC2=CC(=NN=C2C(=O)N)N[C@@H]3CCCC[C@@H]3N)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU48HQ	4-Fluoro-N-(2-((4-methoxyphenyl)(phenyl)methylamino)-2-oxoethyl)benzamide	Investigative	24649020	C23H21FN2O3	392.4	COC1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU64BZ	5-(Pyridin-3-yl)thiophene-2-carbaldehyde	Investigative	10899427	C10H7NOS	189.24	C1=CC(=CN=C1)C2=CC=C(S2)C=O	IC50 = 55200 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU69BC	3-(3-(2-(Benzyloxy)-5-chlorophenyl)pyridin-2-yl)benzoic acid	Investigative	11235389	C25H18ClNO3	415.9	C1=CC=C(C=C1)COC2=C(C=C(C=C2)Cl)C3=C(N=CC=C3)C4=CC(=CC=C4)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU6MQ1	(1R)-1-[5-Methyl-2-[2-methyl-6-[3-(1-methylbenzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]ethanol	Investigative	74767262	C21H24N8O	404.5	CC1=NC(=CC(=N1)N2CC(C2)C3=NC4=CC=CC=C4N3C)N5C(=NC(=N5)C)[C@@H](C)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BU9MQ1	6-[1-[(2R,3S)-2-Propyl-3-[4-(trifluoromethyl)phenoxy]-1-[4-(trifluoromethyl)pyridine-3-carbonyl]piperidine-3-carbonyl]piperidin-4-yl]oxypyridine-2-carboxylic acid	Investigative	127046727	C34H34F6N4O6	708.6	CCC[C@@H]1[C@@](CCCN1C(=O)C2=C(C=CN=C2)C(F)(F)F)(C(=O)N3CCC(CC3)OC4=CC=CC(=N4)C(=O)O)OC5=CC=C(C=C5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BUI18M	3-(4-Methylthiophen-3-yl)pyridine	Investigative	11378800	C10H9NS	175.25	CC1=CSC=C1C2=CN=CC=C2	Ki = 61500 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BUK7O2	6-[(6-Fluoroquinolin-4-yl)methyl]-5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-methyl-1-(2-methylpropyl)-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione	Investigative	16102853	C26H27FN4O4S	510.6	CC(C)CN1C2=C(C(=C(S2)CC3=C4C=C(C=CC4=NC=C3)F)C(=O)N5CC[C@H](C5)O)C(=O)N(C1=O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BUKO19	(1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-methoxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol	Investigative	117885912	C25H26N6O4	474.5	COC1=NC=CC(=C1)NC2=NC=C(C(=N2)N[C@@H]3C[C@@H]([C@H]([C@H]3O)O)CO)C4=NC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BUKO52	2-[[(2R)-2-Hydroxypropyl]amino]-1-[(1S)-8-methoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl]ethanone	Investigative	25118805	C21H26N2O3	354.4	C[C@H](CNCC(=O)N1CCC2=C([C@@H]1C3=CC=CC=C3)C(=CC=C2)OC)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BUPM21	4-Amino-N-isopropyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	11100382	C18H20N4O2S	356.4	CC(C)N(C1=CC=NN1C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N	IC50 = 80000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BUQ1X3	4-[[(3S)-1-(4-Chlorophenyl)-2-oxo-3-methylpyrrolidine-3-yl]amino]benzhydroximic acid	Investigative	118733374	C18H18ClN3O3	359.8	C[C@@]1(CCN(C1=O)C2=CC=C(C=C2)Cl)NC3=CC=C(C=C3)C(=O)NO	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BUQT10	[(1S,2S,4S)-4-[(4-Chlorophenyl)methylamino]-2-(2-methylphenyl)cyclohexyl]-(3,3-diphenylazetidin-1-yl)methanone	Investigative	76331595	C36H37ClN2O	549.1	CC1=CC=CC=C1[C@H]2C[C@H](CC[C@@H]2C(=O)N3CC(C3)(C4=CC=CC=C4)C5=CC=CC=C5)NCC6=CC=C(C=C6)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BUQY47	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	127050762	C20H21F2N5O	385.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BV1BL8	2,6-Difluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamide	Investigative	56929159	C14H8F2N2O3S	322.29	C1=CC2=C(C=C1O)SC(=N2)NC(=O)C3=C(C=CC(=C3F)O)F	IC50 = 54000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BV5Y1D	6-Methyl-2-(pyridin-2-ylmethylsulfanyl)-1H-benzimidazole	Investigative	3012527	C14H13N3S	255.34	CC1=CC2=C(C=C1)N=C(N2)SCC3=CC=CC=N3	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BV68RP	Cyclopropanecarboxylic acid, 2-(3'-(3-((cyclopropylamino)carbonyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)-3-fluoro(1,1'-biphenyl)-4-yl)-, (1R,2R)-	Investigative	11755033	C28H22FN3O4	483.5	C1CC1NC(=O)C2=CN(C3=C(C2=O)C=CC=N3)C4=CC=CC(=C4)C5=CC(=C(C=C5)[C@@H]6C[C@H]6C(=O)O)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BV8IP4	(1S,8R)-4-[(4-Chlorophenyl)carbamoylamino]-11-methyl-5-thia-11-azatricyclo[6.2.1.02,6]undeca-2(6),3-diene-3-carboxamide;hydrochloride	Investigative	137655508	C18H20Cl2N4O2S	427.3	CN1[C@@H]2CC[C@H]1C3=C(C2)SC(=C3C(=O)N)NC(=O)NC4=CC=C(C=C4)Cl.Cl	IC50 = 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BV90BY	2-Amino-N-[(1S)-1-[1-[(2R)-1-cyano-3-pyridin-2-yloxypropan-2-yl]tetrazol-5-yl]-2-phenylmethoxyethyl]-2-methylpropanamide	Investigative	25022640	C23H28N8O3	464.5	CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C2=NN=NN2[C@H](CC#N)COC3=CC=CC=N3)N	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BVDB94	4-(3-Amino-propyl)-N-(3-hydroxy-propyl)-N-(2-phenyl-2H-pyrazol-3-yl)-benzenesulfonamide	Investigative	11732429	C21H26N4O3S	414.5	C1=CC=C(C=C1)N2C(=CC=N2)N(CCCO)S(=O)(=O)C3=CC=C(C=C3)CCCN	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BVFH15	2-[4-[(2,4-Difluorophenyl)methoxy]phenyl]-3H-quinazolin-4-one	Investigative	137645181	C21H14F2N2O2	364.3	C1=CC=C2C(=C1)C(=O)NC(=N2)C3=CC=C(C=C3)OCC4=C(C=C(C=C4)F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BVI65R	4-[2-(4-{[(2r,3s)-2-Propyl-1-{[4-(Trifluoromethyl)pyridin-3-Yl]carbonyl}-3-{[5-(Trifluoromethyl)thiophen-3-Yl]oxy}piperidin-3-Yl]carbonyl}piperazin-1-Yl)phenoxy]butanoic Acid	Investigative	59648133	C35H38F6N4O6S	756.8	CCC[C@@H]1[C@@](CCCN1C(=O)C2=C(C=CN=C2)C(F)(F)F)(C(=O)N3CCN(CC3)C4=CC=CC=C4OCCCC(=O)O)OC5=CSC(=C5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BVRL26	Chembl4239823	Investigative	118626089	C27H30N4O2S2	506.7	C1C[C@H](N(C1)S(=O)(=O)C2=CN=CC3=CC=CC=C32)CCN4CCN(CC4)C5=C6C=CSC6=CC=C5	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BVU0G3	(R)-2-(7-(2-(4-Fluorophenyl)-N-methylacetamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid	Investigative	54583706	C23H23FN2O3	394.4	CN([C@@H]1CCC2=C(C3=CC=CC=C3N2C1)CC(=O)O)C(=O)CC4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BVW19Y	10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-1,3,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13)-triene-2,9-dione	Investigative	69937257	C17H20N4O2	312.37	C1CN2CCC1[C@@H](C2)N3CCN4C5=C(C3=O)C=CC=C5NC4=O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BVY3E4	3-(1-(4-Chlorophenylcarbamoyl)-3-phenylpiperidin-3-yl)propanoic acid	Investigative	42646199	C21H23ClN2O3	386.9	C1CC(CN(C1)C(=O)NC2=CC=C(C=C2)Cl)(CCC(=O)O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BW02DJ	(2S)-2-(Methylamino)-N-[5-[7-methyl-2-(2-methylpyridin-4-yl)imidazo[1,2-a]pyridin-3-yl]-6-(2-phenylethynyl)pyridin-2-yl]propanamide	Investigative	118863016	C31H28N6O	500.6	CC1=CC2=NC(=C(N2C=C1)C3=C(N=C(C=C3)NC(=O)[C@H](C)NC)C#CC4=CC=CC=C4)C5=CC(=NC=C5)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BW02DT	4-Chloro-N-(2-((4-chlorophenyl)(phenyl)methylamino)-2-oxoethyl)benzamide	Investigative	44593648	C22H18Cl2N2O2	413.3	C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)NC(=O)CNC(=O)C3=CC=C(C=C3)Cl	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BW26EV	CID 73670174	Investigative	73670174	C25H26N6O3S	490.6	CC1=NC=CC(=C1)NC2=NC=C(C(=N2)N[C@@H]3C[C@@H]([C@H]([C@H]3O)O)CO)C4=NC(=CS4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BW2O0H	(1S,2R,5S)-5-(11-Methyl-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine	Investigative	68658979	C21H22F3N5	401.4	CC1=NN2C3=C(CN(C3)[C@H]4CC[C@@H]([C@H](C4)N)C5=CC(=C(C=C5F)F)F)C=NC2=C1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BW51OQ	Acetamide,N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-[(2R)-2-(methoxymethyl)-1-pyrrolidinyl]-4-pyrimidinyl]-	Investigative	24812771	C17H24N6O2	344.4	CC1=CC(=NN1C2=NC(=CC(=N2)N3CCC[C@@H]3COC)NC(=O)C)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BW72EP	2-(4-{[2-(3-Chlorophenyl)-2-hydroxyethyl]amino}-2-oxo-1,2-dihydropyridin-3-yl)-N,4-dimethyl-1H-1,3-benzodiazole-6-carboximidamide	Investigative	135681730	C23H23ClN6O2	450.9	CC1=CC(=CC2=C1N=C(N2)C3=C(C=CNC3=O)NCC(C4=CC(=CC=C4)Cl)O)C(=NC)N	IC50 = 76000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BW7D9E	(E)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(3-(2,2,2-trifluoroethoxy)prop-1-enyl)pyridin-2-yl) propan-2-ol	Investigative	71476986	C20H16F7N5O2	491.4	C1=CC(=C(C=C1F)F)C(CN2C=NN=N2)(C(C3=NC=C(C=C3)/C=C/COCC(F)(F)F)(F)F)O	IC50 = 145000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BW7ZA5	4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzamide	Investigative	57384482	C32H31N7O4	577.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=CC=C(C=C6)C(=O)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BWE2Z6	2-(Cyclopropylmethyl)-8-(1-isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	52941269	C23H31N3O2	381.5	CC(C)N1CCC(CC1)OC2=CC3=C(C=C2)N4CCN(C(=O)C4=C3)CC5CC5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BWG0D7	MK-3697	Investigative	46190695	C23H21N5O3S	447.5	CC1=CC(=CN=C1)C2=NC=C(C(=C2)C(=O)NCC3=NC(=C(C=C3)OC)OC)C4=NC=CS4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BWJ9Y1	3-(3-Methyl-1H-imidazol-4-yl)-pyridine	Investigative	44388606	C9H10N3+	160.2	C[N+]1=CNC=C1C2=CN=CC=C2	IC50 = 79500 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BWN2Z7	(1R)-2-[2-(1-Hydroxycyclohexylmethylamino)acetyl]-1,2,3,4-tetrahydro-1-isopropyl-6-methoxyisoquinoline	Investigative	122182156	C22H34N2O3	374.5	CC(C)[C@@H]1C2=C(CCN1C(=O)CNCC3(CCCCC3)O)C=C(C=C2)OC	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BWO4I3	4-[(2-Cyclobutylimidazo[4,5-b]pyrazin-3-yl)methyl]-7,8-difluoro-1H-quinolin-2-one	Investigative	25211910	C19H15F2N5O	367.4	C1CC(C1)C2=NC3=NC=CN=C3N2CC4=CC(=O)NC5=C4C=CC(=C5F)F	EC50 ~ 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BWQS62	Chembl4276719	Investigative	25099235	C21H23N3O3S2	429.6	CCCCC1=CC=CC=C1NCC2=CC=C(S2)C(=O)NC3=NC(=CS3)CC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BWRC87	10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Investigative	69937236	C18H21N3O	295.4	C1CN2CCC1[C@@H](C2)N3CCN4C=CC5=C4C(=CC=C5)C3=O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BX02OC	2-Fluoro-N-[3-methoxy-4-[5-(3-piperidin-1-ylpropylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide	Investigative	23624283	C24H28FN5O3	453.5	COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=C2F)C3=NN=C(O3)NCCCN4CCCCC4	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BX27NK	Methyl N-[(2S)-1-[(2S)-2-[5-fluoro-4-[4-[4-[5-fluoro-2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate	Investigative	70694560	C40H48F2N8O6	774.9	CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC(=C(N2)F)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=C(NC(=N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)F)NC(=O)OC	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BX2HM6	(S)-3-((S)-1-(4-(1-Ethyl-5-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	44625775	C30H36N2O4	488.6	CCN1C=C(C=C(C1=O)C)C2=CC=C(C=C2)[C@H](C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BX4KC9	Oteseconazole	Investigative	77050711	C23H16F7N5O2	527.4	C1=CC(=CC=C1C2=CN=C(C=C2)C([C@](CN3C=NN=N3)(C4=C(C=C(C=C4)F)F)O)(F)F)OCC(F)(F)F	IC50 = 99000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BX5WF4	4-{4-Ethyl-5-[(4-methoxybenzyl)thio]-4H-1,2,4-triazol-3-yl}pyridine	Investigative	936091	C17H18N4OS	326.4	CCN1C(=NN=C1SCC2=CC=C(C=C2)OC)C3=CC=NC=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BX6D8T	8-(1-Isopropylpiperidin-4-yloxy)-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16679518	C19H25N3O2	327.4	CC(C)N1CCC(CC1)OC2=CC3=C(C=C2)N4CCNC(=O)C4=C3	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BX9K7D	CID 16041411	Investigative	16041411	C32H36N4O4S	572.7	C1CN(CCC1N2[C@@H](CN(C2=O)C3CCOCC3)C4=CC=CC=C4)CC5=CN=C(C=C5)SC6=CC=C(C=C6)C(=O)O	IC50 ~ 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BXEL43	2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide	Investigative	71571306	C13H12ClN3O3S	325.77	COC1=C(C=C(C=C1)Cl)C2=CC(=O)NC(=S)N2CC(=O)N	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BXJ01W	N-(2,2-Difluoroethyl)-1-[(6-methoxy-5-methyl-pyrimidin-4-yl)methyl]-6-methyl-pyrrolo[3,2-b]pyridine-3-carboxamide	Investigative	90467013	C18H19F2N5O2	375.4	CC1=CC2=C(C(=CN2CC3=C(C(=NC=N3)OC)C)C(=O)NCC(F)F)N=C1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BXJ6E3	2-(3-Methoxy-4-hydroxyphenyl)quinazoline-4(3H)-one	Investigative	136632047	C15H12N2O3	268.27	COC1=C(C=CC(=C1)C2=NC3=CC=CC=C3C(=O)N2)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BXM1U6	9-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-9-azaspiro[5.5]undecane-3-carboxylic acid	Investigative	56603115	C23H23F3N4O3	460.4	C1CC2(CCN(CC2)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F)OCC1C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BXS3A1	(S)-1,1,1-Trifluoro-3-((S)-3-(3-(1,1,2,2-tetrafluoroethoxy)phenyl)-8-(3-(trifluoromethoxy)phenyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)propan-2-ol	Investigative	17754437	C26H19F10NO4	599.4	C1[C@@H](N(C2=CC=CC(=C2O1)C3=CC(=CC=C3)OC(F)(F)F)C[C@@H](C(F)(F)F)O)C4=CC(=CC=C4)OC(C(F)F)(F)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BXSI29	Etrasimod	Investigative	44623998	C26H26F3NO3	457.5	C1CCC(C1)C2=C(C=C(C=C2)COC3=CC4=C(C=C3)NC5=C4CC[C@@H]5CC(=O)O)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BXU37S	2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile	Investigative	108137	C17H15N3O	277.32	CC1=C(N2C=CC=C(C2=N1)OCC3=CC=CC=C3)CC#N	IC50 = 54000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BY19IU	4-Fluoro-N-(2-oxo-2-(phenyl(pyridin-4-yl)methylamino)ethyl)benzamide	Investigative	44578959	C21H18FN3O2	363.4	C1=CC=C(C=C1)C(C2=CC=NC=C2)NC(=O)CNC(=O)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BY3E6Q	2-[({4-[2-(Trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid	Investigative	25138295	C20H19F3N2O3	392.4	C1CN(CCC1C2=CC=CC=C2C(F)(F)F)C(=O)NC3=CC=CC=C3C(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BY4Q9R	N'-[1-[2-(Dimethylamino)ethyl]-3,4-dihydro-2H-quinolin-6-yl]thiophene-2-carboximidamide;dihydrochloride	Investigative	90664721	C18H26Cl2N4S	401.4	CN(C)CCN1CCCC2=C1C=CC(=C2)N=C(C3=CC=CS3)N.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BY6T3U	4-[(6-Methoxy-1H-1,3-benzodiazol-2-YL)sulfanyl]butanoic acid	Investigative	20115797	C12H14N2O3S	266.32	COC1=CC2=C(C=C1)N=C(N2)SCCCC(=O)O	IC50 = 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BY8VW7	3-Methyl-4-[4-[8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1-pyrimidin-2-yl-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	Investigative	57387541	C32H30N6O4	562.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC=CC=N4)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYB34A	10-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-6-chloro-1,2,10-triazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-one	Investigative	69937162	C17H19ClN4O	330.8	C1CN2CCC1[C@@H](C2)N3CCN4C5=C(C=C(C=C5C3=O)Cl)C=N4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYI37J	CID 53482945	Investigative	53482945	C17H14FN5O	323.32	C1CN2C(=NN=C2C3=CC=CC=N3)CN1C(=O)C4=CC=C(C=C4)F	IC50 = 66000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYIJ39	2-[[3-[1-(4-Hydroxyphenyl)-5-methylpyrazol-4-yl]-2-methylpropanoyl]amino]cyclohexene-1-carboxylic acid	Investigative	15986929	C21H25N3O4	383.4	CC1=C(C=NN1C2=CC=C(C=C2)O)CC(C)C(=O)NC3=C(CCCC3)C(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYKA08	5-(4-Butoxy-phenyl)-1H-imidazole	Investigative	11275964	C13H16N2O	216.28	CCCCOC1=CC=C(C=C1)C2=CN=CN2	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYO9F4	3-[2-[5-(3-Chloro-4-propan-2-yloxyphenyl)-1,3,4-thiadiazol-2-yl]-3-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]propanoic acid	Investigative	49848557	C21H24ClN5O3S	462	CC1=C2CN(CCC2=NN1C3=NN=C(S3)C4=CC(=C(C=C4)OC(C)C)Cl)CCC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYT46D	(S)-8-(1-Isopropylpiperidin-4-yloxy)-3-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16679616	C20H27N3O2	341.4	C[C@H]1CN2C3=C(C=C(C=C3)OC4CCN(CC4)C(C)C)C=C2C(=O)N1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYVD12	(4S)-4-(4-Fluorophenyl)-N-[5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]-2-methylphenyl]-1-methyl-2-oxo-3,4-dihydropyridine-5-carboxamide	Investigative	59377559	C27H28FN5O6	537.5	CC1=C(C=C(C=C1)N2C(=O)N(C(=O)C=N2)C[C@H](COC)O)NC(=O)C3=CN(C(=O)C[C@H]3C4=CC=C(C=C4)F)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYW2A5	CID 73669500	Investigative	73669500	C25H27N5O3S	477.6	CC1=CC(=CC(=N1)C)NC2=NC=C(C(=C2)N[C@@H]3C[C@@H]([C@H]([C@H]3O)O)CO)C4=NC5=CC=CC=C5S4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BYW32O	4-(7-(2,6-Dimethylbenzylamino)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-5-yl)morpholin-3-one	Investigative	46879552	C22H26N4O2	378.5	CC1=C(C(=CC=C1)C)CNC2=C3C(=CC(=N2)N4CCOCC4=O)C(=C(N3)C)C	IC50 = 61000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ0NR9	2-((R)-7-((R)-2-(4-Fluorophenyl)-N-methylpropanamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid	Investigative	53248845	C24H25FN2O3	408.5	C[C@H](C1=CC=C(C=C1)F)C(=O)N(C)[C@@H]2CCC3=C(C4=CC=CC=C4N3C2)CC(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ0X8I	2-(4-(Prop-2-ynyloxy)phenyl)quinazolin-4(3h)-one	Investigative	136982007	C17H12N2O2	276.29	C#CCOC1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=O)N2	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ2OK6	CID 57519510	Investigative	57519510	C28H26N8O	490.6	CC1=NC=C(C=C1)C2=NN(C=N2)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC(=CC=C5)N6CCOCC6	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ2TK0	N'-[3-[4-(Methylamino)cyclohexyl]-1H-indol-5-yl]thiophene-2-carboximidamide;hydrochloride	Investigative	57385793	C20H25ClN4S	389	CNC1CCC(CC1)C2=CNC3=C2C=C(C=C3)N=C(C4=CC=CS4)N.Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ42VK	8-[(3-Methylpyridin-2-yl)methyl]-1-(4-oxo-1H-pyrimidin-6-yl)-3-[4-[4-(1H-pyrazol-5-yl)phenyl]phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136205832	C33H30N8O3	586.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=CC=C(C=C6)C7=CC=NN7	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ4KF0	3-[[2-[(Methylaminosulfonyl)amino]-3-fluoropyridin-4-yl]methyl]-4-methyl-7-[(pyrimidin-2-yl)oxy]-2H-1-benzopyran-2-one	Investigative	16719221	C21H18FN5O5S	471.5	CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F	IC50 = 60000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ4OU7	N-[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-2-(2-oxopyrimidin-1-yl)acetamide	Investigative	44472612	C24H26N4O3	418.5	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)NC(=O)CN3C=CC=NC3=O)[C@@H](C4=CC=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ5U1C	CID 49847378	Investigative	49847378	C33H32N6O4	576.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=NC(=NC=C4)C)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ75BX	N-(2-Methylphenyl)-N'-hydroxyformamidine	Investigative	20763606	C8H10N2O	150.18	CC1=CC=CC=C1N=CNO	IC50 = 77000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ75JB	(1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-propan-2-yloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diol	Investigative	117885758	C27H30N6O4	502.6	CC(C)OC1=NC=CC(=C1)NC2=NC=C(C(=N2)N[C@@H]3C[C@@H]([C@H]([C@H]3O)O)CO)C4=NC5=CC=CC=C5C=C4	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ78AN	6-Chloranyl-2-Methyl-4-Phenyl-Quinoline-3-Carboxylic Acid	Investigative	626798	C17H12ClNO2	297.7	CC1=C(C(=C2C=C(C=CC2=N1)Cl)C3=CC=CC=C3)C(=O)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ8ME3	Bicyclic pyrimidinone, (R)-22b	Investigative	54709839	C19H24FN5O5S	453.5	CN(C)S(=O)(=O)N(C)[C@@H]1CCCN2C1=NC(=C(C2=O)O)C(=O)NCC3=CC=C(C=C3)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZ9SY7	2-[(8R)-8-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl]acetic acid	Investigative	51003549	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C3=C(N2C1)N=CC=C3)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZB74R	(R)-(+)-Pantoprazole	Investigative	11181988	C16H15F2N3O4S	383.4	COC1=C(C(=NC=C1)C[S@@](=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC	Ki = 145000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZD59V	Fevipiprant	Investigative	23582412	C19H17F3N2O4S	426.4	CC1=C(C2=C(N1CC3=C(C=C(C=C3)S(=O)(=O)C)C(F)(F)F)N=CC=C2)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZDT08	(4R)-4-(4-Cyanophenyl)-N-(2-hydroxy-2-methylpropyl)-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-6,7-dihydro-4H-cyclopenta[d]pyrimidine-3-carboxamide	Investigative	77844888	C26H23F3N4O4	512.5	CC(C)(CNC(=O)N1[C@@H](C2=C(CCC2=O)N(C1=O)C3=CC=CC(=C3)C(F)(F)F)C4=CC=C(C=C4)C#N)O	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZJ5U3	4-Amino-N-(2-phenyl-2H-pyrazol-3-yl)-N-propyl-benzenesulfonamide	Investigative	10861208	C18H20N4O2S	356.4	CCCN(C1=CC=NN1C2=CC=CC=C2)S(=O)(=O)C3=CC=C(C=C3)N	IC50 = 55000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZQ23F	2-[5-Methyl-2-[2-methyl-6-[(2R)-2-(1-methylbenzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl]-1,2,4-triazol-3-yl]propan-2-ol	Investigative	118423217	C22H25N7O	403.5	CC1=NC(=CC(=N1)N2C(=NC(=N2)C)C(C)(C)O)C3C[C@H]3C4=NC5=CC=CC=C5N4C	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZU96N	(R)-8-(1-Isopropylpiperidin-4-yloxy)-3-methyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one	Investigative	16679617	C20H27N3O2	341.4	C[C@@H]1CN2C3=C(C=C(C=C3)OC4CCN(CC4)C(C)C)C=C2C(=O)N1	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	BZWC49	6-Fluoro-2-methyl-3-[(3R,9sS)-octahydro-8-[2-[5-(1H-tetrazol-1-yl)-2-pyridinyl]acetyl]pyrazino[2.1=c][1.4]oxazin-3-yl]benzonitrile	Investigative	71603917	C23H23FN8O2	462.5	CC1=C(C=CC(=C1C#N)F)[C@@H]2CN3CCN(C[C@H]3CO2)C(=O)CC4=NC=C(C=C4)N5C=NN=N5	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D00AEX	2-Hexyloxy-5-imidazol-1-yl-pyridine	Investigative	44341439	C14H19N3O	245.32	CCCCCCOC1=NC=C(C=C1)N2C=CN=C2	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D00EMF	SB 242084	Investigative	3644637	C21H19ClN4O2	394.9	CC1=CC2=C(C=C1Cl)N(CC2)C(=O)NC3=CN=C(C=C3)OC4=C(N=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D00XDG	5-amino-2-phenyl-oxazole-4-carboxylic acid amide	Investigative	11708263	C10H9N3O2	203.2	C1=CC=C(C=C1)C2=NC(=C(O2)N)C(=O)N	IC50 ~ 50000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D05NWH	SB 228357	Investigative	443390	C22H17F4N3O2	431.4	COC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC(=CC(=C3)C4=CN=CC=C4)F)C(F)(F)F	IC50 = 82000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D05XGR	SB-214111	Investigative	6918647	C18H22BrN3O3S	440.4	CN1CCN(CC1)C2=C(C=CC(=C2)NS(=O)(=O)C3=CC=C(C=C3)Br)OC	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D06TRS	3-(3-methylthiophen-2-yl)pyridine	Investigative	23646069	C10H9NS	175.25	CC1=C(SC=C1)C2=CN=CC=C2	IC50 = 93100 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0BU8W	BMS pyrazole inhibitor 7f	Investigative	44219611	C23H18F3N7O2S	513.5	C[C@@H](C(=O)NCC1=CC(=CC=C1)N2C(=CC(=N2)C(F)(F)F)C3=NN=C(O3)C4=C5C(=CC=C4)N=CS5)N	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0DY5G	SB 221284	Investigative	443389	C16H14F3N3OS	353.4	CSC1=C(C=C2C(=C1)CCN2C(=O)NC3=CN=CC=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0G9WP	5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one	Investigative	18407230	C14H11NO	209.24	C1CC(=O)C2=C1C=C(C=C2)C3=CN=CC=C3	IC50 = 123000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0H1OK	TG-100435	Investigative	11562302	C26H25Cl2N5O	494.4	CC1=CC(=CC2=C1N=C(N=N2)NC3=CC=C(C=C3)OCCN4CCCC4)C5=C(C=CC=C5Cl)Cl	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0IM5E	Desethyl isoquine	Investigative	11450263	C18H18ClN3O	327.8	CCNCC1=C(C=C(C=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O	IC50 ~ 100000 nM	Poor binder
T19244	S-mephenytoin 4-hydroxylase	D0K4LS	Go-Y026	Investigative	10691533	C21H22O7	386.4	COC1=CC(=CC(=C1O)OC)/C=C/C(=O)/C=C/C2=CC(=C(C(=C2)OC)O)OC	IC50 = 59000 nM	Poor binder