TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T20514 Delta-aminolevulinic acid dehydratase B1W9KC 1-[[2-(Trifluoromethyl)phenyl]methyl]benzimidazole-5-carboxylic acid Investigative 71044558 C16H11F3N2O2 320.27 C1=CC=C(C(=C1)CN2C=NC3=C2C=CC(=C3)C(=O)O)C(F)(F)F IC50 = 145000 nM Poor binder T20514 Delta-aminolevulinic acid dehydratase B5UZ1S 1-(3-Methoxy-benzyl)-1H-benzoimidazole-5-c arboxylic acid Investigative 29296769 C16H14N2O3 282.29 COC1=CC=CC(=C1)CN2C=NC3=C2C=CC(=C3)C(=O)O IC50 = 156000 nM Poor binder T20514 Delta-aminolevulinic acid dehydratase BCU82S 1-[[3-(Trifluoromethyl)phenyl]methyl]benzimidazole-5-carboxylic acid Investigative 90643852 C16H11F3N2O2 320.27 C1=CC(=CC(=C1)C(F)(F)F)CN2C=NC3=C2C=CC(=C3)C(=O)O IC50 = 197000 nM Poor binder T20514 Delta-aminolevulinic acid dehydratase BI3S5M 1-[(4-Fluorophenyl)methyl]-2-oxo-3-(pyrimidin-2-ylmethyl)benzimidazole-5-carboxylic acid Investigative 50956414 C20H15FN4O3 378.4 C1=CN=C(N=C1)CN2C3=C(C=CC(=C3)C(=O)O)N(C2=O)CC4=CC=C(C=C4)F IC50 = 119000 nM Poor binder T20514 Delta-aminolevulinic acid dehydratase BM5K2L 1-[[4-(Trifluoromethyl)phenyl]methyl]benzimidazole-5-carboxylic acid Investigative 83413959 C16H11F3N2O2 320.27 C1=CC(=CC=C1CN2C=NC3=C2C=CC(=C3)C(=O)O)C(F)(F)F IC50 = 173000 nM Poor binder T20514 Delta-aminolevulinic acid dehydratase BO5L6N 4-(4-Bromophenyl)thiophene-2-carboxylic Acid Investigative 2757170 C11H7BrO2S 283.14 C1=CC(=CC=C1C2=CSC(=C2)C(=O)O)Br IC50 = 99700 nM Poor binder T20514 Delta-aminolevulinic acid dehydratase BQ3FW6 4-(4-Chlorophenyl)thiophene-2-carboxylic acid Investigative 2735808 C11H7ClO2S 238.69 C1=CC(=CC=C1C2=CSC(=C2)C(=O)O)Cl IC50 = 85300 nM Poor binder