TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T26500	Histamine H4 receptor	D01UUD	Pitolisant	Phase 3	9948102	C17H26ClNO	295.8	C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl	Ki ~ 100000 nM	Poor binder
T26500	Histamine H4 receptor	B57MBZ	3-(1H-Imidazol-5-yl)propyl N-(3-phenoxypropyl)carbamate	Investigative	73347579	C16H21N3O3	303.36	C1=CC=C(C=C1)OCCCNC(=O)OCCCC2=CN=CN2	Ki ~ 100000 nM	Poor binder
T26500	Histamine H4 receptor	B9G7JR	3-(1H-Imidazol-5-yl)propyl N-(4-phenoxybutyl)carbamate	Investigative	73347580	C17H23N3O3	317.4	C1=CC=C(C=C1)OCCCCNC(=O)OCCCC2=CN=CN2	Ki ~ 100000 nM	Poor binder
T26500	Histamine H4 receptor	BA7O5P	(2R)-5beta-(4-Imidazolyl)-2,5-dihydrofuran-2beta-methanamine	Investigative	10820930	C8H11N3O	165.19	C1=C[C@H](O[C@H]1CN)C2=CN=CN2	EC50 = 75857.76 nM	Poor binder
T26500	Histamine H4 receptor	BCBH24	1H-Indol-2-yl-[4-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl]piperazin-1-yl]methanone	Investigative	57402471	C28H31N5O2	469.6	COC1=CC=C(C=C1)CN(CCN2CCN(CC2)C(=O)C3=CC4=CC=CC=C4N3)C5=CC=CC=N5	EC50 = 104712.85 nM	Poor binder
T26500	Histamine H4 receptor	BG0S4N	6-(4-Fluorophenyl)-7-methyl-4-(4-methylpiperazin-1-yl)pyrrolo[2,3-d]pyrimidin-2-amine	Investigative	71519499	C18H21FN6	340.4	CN1CCN(CC1)C2=NC(=NC3=C2C=C(N3C)C4=CC=C(C=C4)F)N	Ki = 67870 nM	Poor binder
T26500	Histamine H4 receptor	BJT04R	N-[(4-Methoxyphenyl)methyl]-2-(4-methylpiperazin-1-yl)-6-phenylpyrimidin-4-amine	Investigative	112936352	C23H27N5O	389.5	CN1CCN(CC1)C2=NC(=CC(=N2)NCC3=CC=C(C=C3)OC)C4=CC=CC=C4	Ki = 72443.6 nM	Poor binder
T26500	Histamine H4 receptor	BO3Y2C	6-(4-Fluorophenyl)-N,7-dimethyl-4-(4-methylpiperazin-1-yl)pyrrolo[2,3-d]pyrimidin-2-amine	Investigative	71519500	C19H23FN6	354.4	CNC1=NC2=C(C=C(N2C)C3=CC=C(C=C3)F)C(=N1)N4CCN(CC4)C	Ki ~ 100000 nM	Poor binder
T26500	Histamine H4 receptor	BP2LA6	1H-Indol-2-yl-[4-[2-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-methylamino]ethyl]piperazin-1-yl]methanone	Investigative	57402472	C31H38N6O2	526.7	CN(CCN1CCN(CC1)C(=O)C2=CC3=CC=CC=C3N2)CCN(CC4=CC=C(C=C4)OC)C5=CC=CC=N5	EC50 ~ 100000 nM	Poor binder
T26500	Histamine H4 receptor	BS9H6L	2-[2-(3H-Imidazol-4-yl)-ethyl]-pyridine	Investigative	11206058	C10H11N3	173.21	C1=CC=NC(=C1)CCC2=CN=CN2	EC50 = 58884.37 nM	Poor binder
T26500	Histamine H4 receptor	BU2D1Q	4-[4-(Dimethylamino)phenyl]-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-2-amine	Investigative	90645156	C16H23N7	313.4	CN1CCN(CC1)C2=NC(=NC(=N2)N)C3=CC=C(C=C3)N(C)C	Ki = 64490 nM	Poor binder
T26500	Histamine H4 receptor	BX67QY	(2S)-5beta-(4-Imidazolyl)-2,5-dihydrofuran-2alpha-methanamine	Investigative	10820929	C8H11N3O	165.19	C1=C[C@H](O[C@@H]1CN)C2=CN=CN2	EC50 = 85113.8 nM	Poor binder