TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T27602	Cationic trypsinogen	D0K4FP	AZD-8165	Phase 1	44548240	C23H21ClFN7O4	513.9	CCC(=O)O[C@H](C1=CC=C(C=C1)F)C(=O)N2[C@@H](CC=N2)C(=O)NCC3=C(C=CC(=C3)Cl)N4C=NN=N4	IC50 = 86000 nM	Poor binder
T27602	Cationic trypsinogen	B04MPX	[5-[4-[Methyl(2-piperidin-4-ylethyl)carbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylate	Investigative	44315805	C36H58N10O6	726.9	CN(CCC1CCNCC1)C(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N	Ki = 126000 nM	Poor binder
T27602	Cationic trypsinogen	B0D4MI	(S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid 2-aminomethyl-benzylamide	Investigative	44344096	C22H28N4O2	380.5	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC=CC=C2)N)C(=O)NCC3=CC=CC=C3CN	Ki = 106000 nM	Poor binder
T27602	Cationic trypsinogen	B0E1OY	1beta,5beta-Bis[4-(4-guanidinophenylacetyl)piperazinocarbonyloxy]cyclooctane	Investigative	18397357	C36H50N10O6	718.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CC5=CC=C(C=C5)N=C(N)N	Ki = 82000 nM	Poor binder
T27602	Cationic trypsinogen	B0JM6L	1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(5-aminopentylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	18397370	C33H54N10O6	686.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCCCCN	Ki = 129000 nM	Poor binder
T27602	Cationic trypsinogen	B0MGZ7	N-[(S)-1-(1-Carbamimidoyl-piperidin-3-ylmethyl)-2-oxo-2-thiazol-2-yl-ethyl]-2-[(S)-2-isopropyl-3,6-dioxo-4-(3-phenyl-propyl)-piperazin-1-yl]-acetamide	Investigative	44318220	C30H41N7O4S	595.8	CC(C)[C@H]1C(=O)N(CC(=O)N1CC(=O)N[C@@H](CC2CCCN(C2)C(=N)N)C(=O)C3=NC=CS3)CCCC4=CC=CC=C4	IC50 = 74800 nM	Poor binder
T27602	Cationic trypsinogen	B0NBW2	1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-aminobenzylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	44316051	C35H50N10O6	706.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N	Ki = 126000 nM	Poor binder
T27602	Cationic trypsinogen	B0VOF7	N-[(S)-1-(1-Carbamimidoyl-piperidin-3-ylmethyl)-2-oxo-2-thiazol-2-yl-ethyl]-2-[2,5-dioxo-4-(3-phenyl-propyl)-piperazin-1-yl]-acetamide	Investigative	44462047	C27H35N7O4S	553.7	C1CC(CN(C1)C(=N)N)C[C@@H](C(=O)C2=NC=CS2)NC(=O)CN3CC(=O)N(CC3=O)CCCC4=CC=CC=C4	IC50 = 91200 nM	Poor binder
T27602	Cationic trypsinogen	B15JUI	(3Ar,6S,6aS)-4-methylsulfonyl-6-propan-2-yl-1-[2-(pyrrolidin-1-ylmethyl)-1,3-oxazole-4-carbonyl]-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride	Investigative	10322033	C19H29ClN4O5S	461	CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)C3=COC(=N3)CN4CCCC4)N(C1=O)S(=O)(=O)C.Cl	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	B1MDZ2	1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-piperidinylmethylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	44315643	C34H54N10O6	698.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5CCNCC5	Ki = 148000 nM	Poor binder
T27602	Cationic trypsinogen	B1SK6R	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-(1-methylpiperidin-4-yl)ethylcarbamoyl]piperazine-1-carboxylate	Investigative	44315788	C36H58N10O6	726.9	CN1CCC(CC1)CCNC(=O)N2CCN(CC2)C(=O)OC3CCCC(CCC3)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=C(C=C5)N=C(N)N	Ki = 110000 nM	Poor binder
T27602	Cationic trypsinogen	B23KMO	2-(2-Iodo-phenylamino)-7-trifluoromethyl-benzo[d][1,3]oxazin-4-one	Investigative	10071434	C15H8F3IN2O2	432.13	C1=CC=C(C(=C1)NC2=NC3=C(C=CC(=C3)C(F)(F)F)C(=O)O2)I	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	B24LAU	N-(Methoxycarbonyl)-L-valyl-N-((1S)-3,3,3-trifluoro-1-(1-methylethyl)-2-oxopropyl)-L-prolinamide	Investigative	9910174	C18H28F3N3O5	423.4	CC(C)[C@@H](C(=O)C(F)(F)F)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)OC	Ki = 66600 nM	Poor binder
T27602	Cationic trypsinogen	B29YTW	2-(4-Fluoro-benzenesulfonylamino)-N-(1-formyl-3-methyl-butyl)-3-methyl-butyramide	Investigative	10861643	C17H25FN2O4S	372.5	CC(C)C[C@H](C=O)NC(=O)[C@H](C(C)C)NS(=O)(=O)C1=CC=C(C=C1)F	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	B2I3FS	(S)-1-((R)-3-Cyclohexyl-2-phenylmethanesulfonylamino-propionyl)-pyrrolidine-2-carboxylic acid (2-amino-5,6,7,8-tetrahydro-quinazolin-6-yl)-amide	Investigative	10281431	C29H40N6O4S	568.7	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NC3CCC4=NC(=NC=C4C3)N)NS(=O)(=O)CC5=CC=CC=C5	Ki ~ 68300 nM	Poor binder
T27602	Cationic trypsinogen	B2MIZ5	(3Ar,6S,6aS)-1-[1-(2,2-dimethylpropyl)azetidine-3-carbonyl]-4-methylsulfonyl-6-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride	Investigative	10455658	C19H34ClN3O4S	436	CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)C3CN(C3)CC(C)(C)C)N(C1=O)S(=O)(=O)C.Cl	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	B2XP8V	2-[3-(2,2-Difluoro-2-pyridin-2-yl-ethylamino)-2-oxo-6-trifluoromethyl-2H-pyrazin-1-yl]-N-(3-fluoro-pyridin-2-ylmethyl)-acetamide	Investigative	11733626	C20H16F6N6O2	486.4	C1=CC=NC(=C1)C(CNC2=NC=C(N(C2=O)CC(=O)NCC3=C(C=CC=N3)F)C(F)(F)F)(F)F	Ki = 136000 nM	Poor binder
T27602	Cationic trypsinogen	B3IWP7	{1-[1-(1-Formyl-4-guanidino-butylcarbamoyl)-2-methyl-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester	Investigative	14488962	C25H40N6O5	504.6	CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)OCC1=CC=CC=C1	IC50 = 81400 nM	Poor binder
T27602	Cationic trypsinogen	B41TDK	1,6-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,6-hexanedione	Investigative	44315832	C32H46N12O4	662.8	C1CN(CCN1C(=O)CCCCC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)C(=O)NCC4=CC=C(C=C4)N=C(N)N	Ki = 54000 nM	Poor binder
T27602	Cationic trypsinogen	B4D2JA	(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)pyrrolidine-2-carboxamide	Investigative	9872423	C29H41N5O4S	555.7	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=C(C3)C=NN4)NS(=O)(=O)CC5=CC=CC=C5	Ki ~ 68300 nM	Poor binder
T27602	Cationic trypsinogen	B4QWC8	N'-Hydroxy-4-[[[(6-methoxynaphthalen-2-yl)sulfonylamino]-(4-methylpiperidine-1-carbonyl)amino]methyl]benzenecarboximidamide	Investigative	10962439	C26H31N5O5S	525.6	CC1CCN(CC1)C(=O)N(CC2=CC=C(C=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=C(C=C3)C=C(C=C4)OC	Ki ~ 68000 nM	Poor binder
T27602	Cationic trypsinogen	B4VAC3	1,4-Bis[1,4-dioxo-4-(4-guanidinobenzylamino)butylaminomethyl]benzene	Investigative	44315846	C32H40N10O4	628.7	C1=CC(=CC=C1CNC(=O)CCC(=O)NCC2=CC=C(C=C2)N=C(N)N)CNC(=O)CCC(=O)NCC3=CC=C(C=C3)N=C(N)N	Ki = 146000 nM	Poor binder
T27602	Cationic trypsinogen	B5N1IW	(4-Benzhydryloxy-benzyl)-pyridin-4-yl-amine	Investigative	10021822	C25H22N2O	366.5	C1=CC=C(C=C1)C(C2=CC=CC=C2)OC3=CC=C(C=C3)CNC4=CC=NC=C4	Ki = 77000 nM	Poor binder
T27602	Cationic trypsinogen	B5OXS4	(2S)-1-[(2R)-2-Amino-3-(3,4-dichlorophenyl)propanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-ylmethyl)pyrrolidine-2-carboxamide	Investigative	10165649	C22H27Cl2N5O2	464.4	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC(=C(C=C2)Cl)Cl)N)C(=O)NCC3CCC4=C(C3)C=NN4	Ki ~ 68300 nM	Poor binder
T27602	Cationic trypsinogen	B5YD6I	N'-Hydroxy-4-[[(4-methylpiperidine-1-carbonyl)-(naphthalen-2-ylsulfonylamino)amino]methyl]benzenecarboximidamide	Investigative	11762766	C25H29N5O4S	495.6	CC1CCN(CC1)C(=O)N(CC2=CC=C(C=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 68000 nM	Poor binder
T27602	Cationic trypsinogen	B5YZ6B	2-(6-Methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-N-(1H-pyrrolo[3,2-b]pyridin-5-ylmethyl)-acetamide	Investigative	9931726	C23H24N6O2	416.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=NC3=C(C=C2)NC=C3)NCCC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	B61LFO	Ethyl 2-[(2E)-2-carbamimidoylimino-6-hydroxy-1,3-benzothiazol-3-yl]acetate	Investigative	70686249	C12H14N4O3S	294.33	CCOC(=O)CN\\1C2=C(C=C(C=C2)O)S/C1=N/C(=N)N	Ki = 198000 nM	Poor binder
T27602	Cationic trypsinogen	B62UFV	4-{2-(4-Amino-cyclohexyl)-2-[((6S,8aS)-4-oxo-2-phenylmethanesulfonyl-octahydro-pyrrolo[1,2-a]pyrazine-6-carbonyl)-amino]-acetyl}-5-methyl-thiazole-2-carboxylic acid	Investigative	76316955	C28H35N5O7S2	617.7	CC1=C(SC(=N1)C(=O)C(C2CCC(CC2)N)NC(=O)[C@@H]3CC[C@@H]4N3C(=O)CN(C4)S(=O)(=O)CC5=CC=CC=C5)C(=O)O	Ki = 65000 nM	Poor binder
T27602	Cationic trypsinogen	B65DTR	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(6-aminopyridin-3-yl)propanoyl]piperazine-1-carboxylate	Investigative	44315852	C35H50N10O6	706.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCC5=CN=C(C=C5)N	Ki = 156000 nM	Poor binder
T27602	Cationic trypsinogen	B6W0TS	Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate	Investigative	13192685	C26H42N6O5	518.6	CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1	IC50 = 163800 nM	Poor binder
T27602	Cationic trypsinogen	B6Z1CQ	[5-[4-[[4-(Aminomethyl)-1-bicyclo[2.2.2]octanyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(aminomethyl)-1-bicyclo[2.2.2]octanyl]methylcarbamoyl]piperazine-1-carboxylate	Investigative	44315391	C40H68N8O6	757	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC34CCC(CC3)(CC4)CN)OC(=O)N5CCN(CC5)C(=O)NCC67CCC(CC6)(CC7)CN	Ki = 95000 nM	Poor binder
T27602	Cationic trypsinogen	B75ANJ	(1R,3As,8bS)-1-(5-amino-5-iminopentyl)-7-[3-(diethylcarbamoyl)phenyl]-N-ethyl-2-oxo-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrole-3-carboxamide	Investigative	44290377	C30H39N5O3	517.7	CCNC(=O)N1[C@H]2CC3=C([C@@H]2[C@H](C1=O)CCCCC(=N)N)C=C(C=C3)C4=CC(=CC=C4)C(=O)N(CC)CC	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	B7O3FM	1beta,5beta-Bis[3-(4-guanidinobenzyl)ureidoacetoxy]cyclooctane	Investigative	44315758	C30H42N10O6	638.7	C1CC(CCCC(C1)OC(=O)CNC(=O)NCC2=CC=C(C=C2)N=C(N)N)OC(=O)CNC(=O)NCC3=CC=C(C=C3)N=C(N)N	Ki = 78000 nM	Poor binder
T27602	Cationic trypsinogen	B7PGD8	((R)-1-(3,4-Dichloro-benzyl)-2-oxo-2-{(S)-2-[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-ethyl)-carbamic acid tert-butyl ester	Investigative	10166622	C27H35Cl2N5O4	564.5	CC(C)(C)OC(=O)N[C@H](CC1=CC(=C(C=C1)Cl)Cl)C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=C(C3)C=NN4	Ki ~ 68300 nM	Poor binder
T27602	Cationic trypsinogen	B7R5UJ	1-{[5-(5-Chloro-2-thienyl)isoxazol-3-YL]methyl}-N-(1-isopropylpiperidin-4-YL)-1H-indole-2-carboxamide	Investigative	6540265	C25H27ClN4O2S	483	CC(C)N1CCC(CC1)NC(=O)C2=CC3=CC=CC=C3N2CC4=NOC(=C4)C5=CC=C(S5)Cl	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	B83JAT	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(3-piperidin-4-ylpropylcarbamoyl)piperazine-1-carboxylate	Investigative	44315641	C36H58N10O6	726.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCCC5CCNCC5	Ki = 80000 nM	Poor binder
T27602	Cationic trypsinogen	B8YU1X	(S)-1-((R)-3-Cyclohexyl-2-phenylmethanesulfonylamino-propionyl)-pyrrolidine-2-carboxylic acid (2-amino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-amide	Investigative	10121049	C30H42N6O4S	582.8	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=NC(=NC=C4C3)N)NS(=O)(=O)CC5=CC=CC=C5	Ki ~ 68300 nM	Poor binder
T27602	Cationic trypsinogen	B9OBX0	2-Phenyl-1H-benzimidazole-5-carboxamidine	Investigative	11009950	C14H12N4	236.27	C1=CC=C(C=C1)C2=NC3=C(N2)C=C(C=C3)C(=N)N	Ki = 55000 nM	Poor binder
T27602	Cationic trypsinogen	B9WUT5	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(4-imidazol-1-ylbutanoyl)piperazine-1-carboxylate	Investigative	44315850	C34H50N10O6	694.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCCN5C=CN=C5	Ki = 158000 nM	Poor binder
T27602	Cationic trypsinogen	BA12DG	CID 10117543	Investigative	10117543	C25H29N5O4S	495.6	CC1CCN(CC1)C(=O)N(CC2=CC(=CC=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 68000 nM	Poor binder
T27602	Cationic trypsinogen	BA31GR	2-[6-Cyano-3-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-N-(3-fluoro-4-methyl-pyridin-2-ylmethyl)-acetamide	Investigative	9911960	C21H18F3N7O2	457.4	CC1=C(C(=NC=C1)CNC(=O)CN2C(=CN=C(C2=O)NCC(C3=CC=CC=N3)(F)F)C#N)F	Ki = 61000 nM	Poor binder
T27602	Cationic trypsinogen	BA5FN2	1beta,5beta-Bis[4-(4-amidinophenethylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	18397344	C38H54N10O6	746.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCCC3=CC=C(C=C3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5=CC=C(C=C5)C(=N)N	Ki = 66000 nM	Poor binder
T27602	Cationic trypsinogen	BASF42	N-Imidazo[1,2-a]pyridin-6-ylmethyl-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide	Investigative	9823195	C23H24N6O2	416.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=CN3C=CN=C3C=C2)NCCC4=CC=CC=C4	Ki = 100000 nM	Poor binder
T27602	Cationic trypsinogen	BBT7Q4	(3Ar,6S,6aS)-1-[5-[(cyclopropylamino)methyl]pyrazine-2-carbonyl]-4-methylsulfonyl-6-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride	Investigative	45261824	C19H28ClN5O4S	458	CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)C3=NC=C(N=C3)CNC4CC4)N(C1=O)S(=O)(=O)C.Cl	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BC7L3X	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-aminocyclohexyl)methylcarbamoyl]piperazine-1-carboxylate	Investigative	44315392	C35H56N10O6	712.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5CCC(CC5)N	Ki = 141000 nM	Poor binder
T27602	Cationic trypsinogen	BDCE35	Benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate	Investigative	14488960	C29H40N6O5	552.7	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCN=C(N)N)C=O)NC(=O)OCC2=CC=CC=C2	IC50 = 107100 nM	Poor binder
T27602	Cationic trypsinogen	BE4WD8	4-Methoxy-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamide	Investigative	10337666	C16H14N2O5S	346.4	CN(C1=NC2=CC=CC=C2C(=O)O1)S(=O)(=O)C3=CC=C(C=C3)OC	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BFGD03	1beta,5beta-Bis[4-[3-(1-amidino-4-piperidinyl)propionyl]piperazinocarbonyloxy]cyclooctane	Investigative	18397345	C36H62N10O6	730.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)CCC3CCN(CC3)C(=N)N)OC(=O)N4CCN(CC4)C(=O)CCC5CCN(CC5)C(=N)N	Ki = 171000 nM	Poor binder
T27602	Cationic trypsinogen	BFP02O	CID 10141502	Investigative	10141502	C25H29N5O4S	495.6	CC1CCCCN1C(=O)N(CC2=CC(=CC=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki = 67000 nM	Poor binder
T27602	Cationic trypsinogen	BG50PZ	1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(4-aminobutylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	22010099	C32H52N10O6	672.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCCCN	Ki = 132000 nM	Poor binder
T27602	Cationic trypsinogen	BG8FM0	1-{2-[(4-Chlorophenyl)amino]-2-oxoethyl}-N-(1-isopropylpiperidin-4-YL)-1H-indole-2-carboxamide	Investigative	6540268	C25H29ClN4O2	453	CC(C)N1CCC(CC1)NC(=O)C2=CC3=CC=CC=C3N2CC(=O)NC4=CC=C(C=C4)Cl	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BH3PB0	2-[3-(2,2-Difluoro-2-pyridin-2-yl-ethylamino)-6-methyl-2-oxo-2H-pyrazin-1-yl]-N-(3-fluoro-4-methyl-pyridin-2-ylmethyl)-acetamide	Investigative	447221	C21H21F3N6O2	446.4	CC1=C(C(=NC=C1)CNC(=O)CN2C(=CN=C(C2=O)NCC(C3=CC=CC=N3)(F)F)C)F	Ki = 118000 nM	Poor binder
T27602	Cationic trypsinogen	BHF84A	N-Imidazo[1,2-a]pyridin-7-ylmethyl-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide	Investigative	9844807	C23H24N6O2	416.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=CC3=NC=CN3C=C2)NCCC4=CC=CC=C4	Ki = 120000 nM	Poor binder
T27602	Cationic trypsinogen	BI34AP	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-pyridin-4-ylethylcarbamoyl)piperazine-1-carboxylate	Investigative	44315675	C35H50N10O6	706.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5=CC=NC=C5	Ki = 131000 nM	Poor binder
T27602	Cationic trypsinogen	BI75GR	N'-Hydroxy-4-[[(naphthalen-2-ylsulfonylamino)-(piperidine-1-carbonyl)amino]methyl]benzenecarboximidamide	Investigative	10906977	C24H27N5O4S	481.6	C1CCN(CC1)C(=O)N(CC2=CC=C(C=C2)/C(=N/O)/N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3	Ki ~ 68000 nM	Poor binder
T27602	Cationic trypsinogen	BI75RZ	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylate	Investigative	44315642	C35H56N10O6	712.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCC5CCNCC5	Ki = 121000 nM	Poor binder
T27602	Cationic trypsinogen	BI97QF	Chembl2332610	Investigative	71716976	C64H93N17O16S3	1452.7	C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N[C@@H](CSC3)C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N1)CCCN=C(N)N)NC(=O)[C@H](CO)N)C(=O)N[C@@H](CCCCN)C(=O)O)CC7=CC=C(C=C7)O	Ki ~ 120000 nM	Poor binder
T27602	Cationic trypsinogen	BIJ98M	4-Cyano-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamide	Investigative	15541224	C16H11N3O4S	341.3	CN(C1=NC2=CC=CC=C2C(=O)O1)S(=O)(=O)C3=CC=C(C=C3)C#N	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BILN94	2-Bromo-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamide	Investigative	15541220	C15H11BrN2O4S	395.2	CN(C1=NC2=CC=CC=C2C(=O)O1)S(=O)(=O)C3=CC=CC=C3Br	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BJ3RV5	1H-Indole-1-acetamide,N-(5-chloro-2-pyridinyl)-2-[[[1-(1-methylethyl)-4-piperidinyl]amino]carbonyl]-	Investigative	10095455	C24H28ClN5O2	454	CC(C)N1CCC(CC1)NC(=O)C2=CC3=CC=CC=C3N2CC(=O)NC4=NC=C(C=C4)Cl	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BJB5I0	1,7-Bis[4-(4-guanidinobenzylcarbamoyl)piperazino]-1,7-heptanedione	Investigative	44315831	C33H48N12O4	676.8	C1CN(CCN1C(=O)CCCCCC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)C(=O)NCC4=CC=C(C=C4)N=C(N)N	Ki = 52000 nM	Poor binder
T27602	Cationic trypsinogen	BKXL29	1,4-Bis[[2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene	Investigative	9872983	C30H36N6O6	576.6	C1=CC(=CC=C1CN)CNC(=O)CNC(=O)OCC2=CC=C(C=C2)COC(=O)NCC(=O)NCC3=CC=C(C=C3)CN	Ki = 84000 nM	Poor binder
T27602	Cationic trypsinogen	BLWG35	1,4-Bis[methyl[1,4-dioxo-4-[4-(aminomethyl)benzylamino]butyl]aminomethyl]benzene	Investigative	44315608	C34H44N6O4	600.8	CN(CC1=CC=C(C=C1)CN(C)C(=O)CCC(=O)NCC2=CC=C(C=C2)CN)C(=O)CCC(=O)NCC3=CC=C(C=C3)CN	Ki = 162000 nM	Poor binder
T27602	Cationic trypsinogen	BLYO16	N-(1H-Indol-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide	Investigative	9801948	C24H25N5O2	415.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=CC3=C(C=C2)NC=C3)NCCC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BM14VC	2-[6-Chloro-3-(2,2-difluoro-2-pyridin-2-yl-ethylamino)-2-oxo-2H-pyrazin-1-yl]-N-(3-fluoro-4-methyl-pyridin-2-ylmethyl)-acetamide	Investigative	11762405	C20H18ClF3N6O2	466.8	CC1=C(C(=NC=C1)CNC(=O)CN2C(=CN=C(C2=O)NCC(C3=CC=CC=N3)(F)F)Cl)F	Ki = 80000 nM	Poor binder
T27602	Cationic trypsinogen	BM25DO	N-[(2S)-3-(1,3-Benzothiazol-2-yl)-1-[4-(2-hydroxyethyl)piperidin-1-yl]-1-oxopropan-2-yl]-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamide	Investigative	12047385	C27H34N4O4S2	542.7	CC1CC2=C(C(=CC=C2)S(=O)(=O)N[C@@H](CC3=NC4=CC=CC=C4S3)C(=O)N5CCC(CC5)CCO)NC1	Ki = 126000 nM	Poor binder
T27602	Cationic trypsinogen	BM6ND8	Chembl2332604	Investigative	71716975	C59H82N16O15S3	1351.6	C[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CSCC2=CC3=CC(=C2)CSC[C@@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N[C@@H](CSC3)C(=O)N5CCC[C@H]5C(=O)N6CCC[C@H]6C(=O)N1)CCCN=C(N)N)NC(=O)CN)C(=O)NCC(=O)O)CC7=CC=C(C=C7)O	Ki ~ 120000 nM	Poor binder
T27602	Cationic trypsinogen	BM9W8Q	N-(1H-Indol-6-ylmethyl)-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide	Investigative	9931673	C24H25N5O2	415.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=CC3=C(C=C2)C=CN3)NCCC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BMQ13O	2-[6-Methyl-2-oxo-3-(2-pyridin-2-yl-ethylamino)-2H-pyrazin-1-yl]-N-(1H-pyrrolo[2,3-c]pyridin-5-ylmethyl)-acetamide	Investigative	10093417	C22H23N7O2	417.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=NC=C3C(=C2)C=CN3)NCCC4=CC=CC=N4	Ki = 200000 nM	Poor binder
T27602	Cationic trypsinogen	BMTK54	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(5-imidazol-1-ylpentanoyl)piperazine-1-carboxylate	Investigative	44316065	C35H52N10O6	708.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCCCN5C=CN=C5	Ki = 144000 nM	Poor binder
T27602	Cationic trypsinogen	BN19PZ	1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(3-aminopropylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	22010100	C31H50N10O6	658.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCCCN	Ki = 138000 nM	Poor binder
T27602	Cationic trypsinogen	BN85OD	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(2-aminopyrimidin-5-yl)propanoyl]piperazine-1-carboxylate	Investigative	44315851	C34H49N11O6	707.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCC5=CN=C(N=C5)N	Ki = 165000 nM	Poor binder
T27602	Cationic trypsinogen	BNC1Q7	1,4-Bis[methyl[2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzene	Investigative	44316050	C32H40N6O6	604.7	CN(CC(=O)NCC1=CC=C(C=C1)CN)C(=O)OCC2=CC=C(C=C2)COC(=O)N(C)CC(=O)NCC3=CC=C(C=C3)CN	Ki = 50000 nM	Poor binder
T27602	Cationic trypsinogen	BNS8F1	1beta-[4-(4-Guanidinobenzylcarbamoyl)piperazinocarbonyloxy]-5beta-[4-(benzylcarbamoyl)piperazinocarbonyloxy]cyclooctane	Investigative	44315744	C35H49N9O6	691.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)NCC5=CC=CC=C5	Ki = 182000 nM	Poor binder
T27602	Cationic trypsinogen	BOL1D0	{1-[1-(5-Amino-1-formyl-pentylcarbamoyl)-3-methyl-butylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester	Investigative	14488964	C26H42N4O5	490.6	CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1	IC50 = 195700 nM	Poor binder
T27602	Cationic trypsinogen	BP7ZM6	2-[6-Methyl-2-oxo-3-(2-pyridin-2-yl-ethylamino)-2H-pyrazin-1-yl]-N-(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-acetamide	Investigative	10070588	C22H23N7O2	417.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=CN=C3C(=C2)C=CN3)NCCC4=CC=CC=N4	Ki = 140000 nM	Poor binder
T27602	Cationic trypsinogen	BPC7D8	2-Carboxyindole 17	Investigative	20801160	C26H28ClN3OS	466	CC(C)N1CCC(CC1)NC(=O)C2=CC3=CC=CC=C3N2CC4=CC5=C(S4)C=C(C=C5)Cl	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BR1T4G	1,4-Bis[1,5-dioxo-5-(4-guanidinobenzylamino)pentylaminomethyl]benzene	Investigative	44315743	C34H44N10O4	656.8	C1=CC(=CC=C1CNC(=O)CCCC(=O)NCC2=CC=C(C=C2)N=C(N)N)CNC(=O)CCCC(=O)NCC3=CC=C(C=C3)N=C(N)N	Ki = 70000 nM	Poor binder
T27602	Cationic trypsinogen	BR2TD5	(2S)-1-[(2R)-2-Amino-3-(3,4-dichlorophenyl)propanoyl]-N-[(2-amino-5,6,7,8-tetrahydroquinazolin-6-yl)methyl]pyrrolidine-2-carboxamide	Investigative	10166616	C23H28Cl2N6O2	491.4	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC(=C(C=C2)Cl)Cl)N)C(=O)NCC3CCC4=NC(=NC=C4C3)N	Ki ~ 68300 nM	Poor binder
T27602	Cationic trypsinogen	BR8HJ7	[(R)-2-{(S)-2-[(2-Amino-5,6,7,8-tetrahydro-quinazolin-6-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-(3,4-dichloro-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester	Investigative	10303947	C28H36Cl2N6O4	591.5	CC(C)(C)OC(=O)N[C@H](CC1=CC(=C(C=C1)Cl)Cl)C(=O)N2CCC[C@H]2C(=O)NCC3CCC4=NC(=NC=C4C3)N	Ki ~ 68300 nM	Poor binder
T27602	Cationic trypsinogen	BRMO41	4-Amino-1-(4-benzyloxy-benzyl)-pyridinium	Investigative	9838954	C19H19N2O+	291.4	C1=CC=C(C=C1)COC2=CC=C(C=C2)C[N+]3=CC=C(C=C3)N	Ki = 77000 nM	Poor binder
T27602	Cationic trypsinogen	BRV7C5	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(6-imidazol-1-ylhexanoyl)piperazine-1-carboxylate	Investigative	44316026	C36H54N10O6	722.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCCCCN5C=CN=C5	Ki = 171000 nM	Poor binder
T27602	Cationic trypsinogen	BS08XC	3-[(1R,3As,8bS)-1-(5-amino-5-iminopentyl)-2-oxo-3-(5-phenylpentyl)-1,3a,4,8b-tetrahydroindeno[2,1-b]pyrrol-7-yl]-N,N-diethylbenzamide	Investigative	44290518	C38H48N4O2	592.8	CCN(CC)C(=O)C1=CC=CC(=C1)C2=CC3=C(C[C@H]4[C@H]3[C@H](C(=O)N4CCCCCC5=CC=CC=C5)CCCCC(=N)N)C=C2	IC50 ~ 50000 nM	Poor binder
T27602	Cationic trypsinogen	BSE39M	CGH-1484A free base	Investigative	9962561	C41H56FN7O6S2	826.1	CC1(CC2=C(C(=CC(=C2)CCC(=O)N3CCN(CC3)CC(=O)N4CCOCC4)S(=O)(=O)N[C@@H](CC5=NC6=CC=CC=C6S5)C(=O)N7CCC(CC7)CCF)NC1)C	Ki = 153000 nM	Poor binder
T27602	Cationic trypsinogen	BSH8O2	N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(6-methyl-2,8-dioxo-2,3,4,8-tetrahydro-1H-[1,7]naphthyridin-7-yl)-acetamide	Investigative	15454127	C18H21N5O3	355.4	CC1=CC2=C(C(=O)N1CC(=O)NCC3=C(N=C(C=C3)N)C)NC(=O)CC2	Ki = 101000 nM	Poor binder
T27602	Cationic trypsinogen	BSTG05	1,4-Bis[1,3-dioxo-3-(4-guanidinobenzylamino)propylaminomethyl]benzene	Investigative	44315610	C30H36N10O4	600.7	C1=CC(=CC=C1CNC(=O)CC(=O)NCC2=CC=C(C=C2)N=C(N)N)CNC(=O)CC(=O)NCC3=CC=C(C=C3)N=C(N)N	Ki = 73000 nM	Poor binder
T27602	Cationic trypsinogen	BT4GK7	2-(6-Methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-N-(1H-pyrrolo[2,3-c]pyridin-5-ylmethyl)-acetamide	Investigative	44379112	C23H24N6O2	416.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=NC=C3C(=C2)C=CN3)NCCC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BTC93D	1,4-Bis[[2-oxo-2-(4-guanidinobenzylamino)ethyl]carbamoyloxymethyl]benzene	Investigative	44315844	C30H36N10O6	632.7	C1=CC(=CC=C1CNC(=O)CNC(=O)OCC2=CC=C(C=C2)COC(=O)NCC(=O)NCC3=CC=C(C=C3)N=C(N)N)N=C(N)N	Ki = 56000 nM	Poor binder
T27602	Cationic trypsinogen	BV0YT5	(2S)-1-[(2R)-2-(Benzylsulfonylamino)-3-cyclohexylpropanoyl]-N-(4,5,6,7-tetrahydro-1H-indazol-5-yl)pyrrolidine-2-carboxamide	Investigative	10209142	C28H39N5O4S	541.7	C1CCC(CC1)C[C@H](C(=O)N2CCC[C@H]2C(=O)NC3CCC4=C(C3)C=NN4)NS(=O)(=O)CC5=CC=CC=C5	Ki ~ 68300 nM	Poor binder
T27602	Cationic trypsinogen	BW17DK	{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester	Investigative	44337899	C24H38N6O4	474.6	CC(C)(C)OC(=O)N[C@@H](CN1CCC[C@H]1C(=O)NC(CCCN=C(N)N)C=O)C2=CC=CC=C2	IC50 = 64000 nM	Poor binder
T27602	Cationic trypsinogen	BW32UP	2-(6-Methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-N-(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-acetamide	Investigative	44379037	C23H24N6O2	416.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=CN=C3C(=C2)C=CN3)NCCC4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BWF0I1	2-{(S)-2-[((S)-1-{(S)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-3-methyl-butyryl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyryl}-benzooxazole-5-carboxylic acid amide	Investigative	9962331	C37H39ClN6O9S	779.3	CC(C)[C@@H](C(=O)C1=NC2=C(O1)C=CC(=C2)C(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C(C)C)NC(=O)C4=CC=C(C=C4)C(=O)NS(=O)(=O)C5=CC=C(C=C5)Cl	Ki ~ 50000 nM	Poor binder
T27602	Cationic trypsinogen	BX5US3	2-(6-Methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-N-(2-methyl-pyridin-3-ylmethyl)-acetamide	Investigative	10905246	C22H25N5O2	391.5	CC1=CN=C(C(=O)N1CC(=O)NCC2=C(N=CC=C2)C)NCCC3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BXO6V7	N-(2-Aminomethyl-benzyl)-2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide	Investigative	44344083	C23H26N4O4S	454.5	CC1=CC=C(C(=O)N1CC(=O)NCC2=CC=CC=C2CN)NS(=O)(=O)CC3=CC=CC=C3	Ki = 67000 nM	Poor binder
T27602	Cationic trypsinogen	BY0H5N	N-Methyl-4-nitro-N-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-benzenesulfonamide	Investigative	15541223	C15H11N3O6S	361.3	CN(C1=NC2=CC=CC=C2C(=O)O1)S(=O)(=O)C3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T27602	Cationic trypsinogen	BY3B4R	1,4-Bis[[3-oxo-3-(4-guanidinobenzylamino)propyl]carbamoyloxymethyl]benzene	Investigative	44315843	C32H40N10O6	660.7	C1=CC(=CC=C1CNC(=O)CCNC(=O)OCC2=CC=C(C=C2)COC(=O)NCCC(=O)NCC3=CC=C(C=C3)N=C(N)N)N=C(N)N	Ki = 72000 nM	Poor binder
T27602	Cationic trypsinogen	BYVP36	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(pyridin-4-ylamino)propanoyl]piperazine-1-carboxylate	Investigative	44316015	C35H50N10O6	706.8	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCNC5=CC=NC=C5	Ki = 111000 nM	Poor binder
T27602	Cationic trypsinogen	BZ8Q2B	[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(3-pyridin-4-ylsulfanylpropanoyl)piperazine-1-carboxylate	Investigative	44315912	C35H49N9O6S	723.9	C1CC(CCCC(C1)OC(=O)N2CCN(CC2)C(=O)NCC3=CC=C(C=C3)N=C(N)N)OC(=O)N4CCN(CC4)C(=O)CCSC5=CC=NC=C5	Ki = 156000 nM	Poor binder
T27602	Cationic trypsinogen	D0O1DU	D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide	Investigative	25011732	C21H24ClN3O2	385.9	C1C[C@H](N(C1)C(=O)[C@@H](CC2=CC=CC=C2)N)C(=O)NCC3=CC(=CC=C3)Cl	Ki = 89000 nM	Poor binder