TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T40694	Polo-like kinase 1	D07POC	Erlotinib	Approved	176870	C22H23N3O4	393.4	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	D08CDI	Lapatinib	Approved	208908	C29H26ClFN4O4S	581.1	CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	D0E3TC	Staurosporine	Phase 2	44259	C28H26N4O3	466.5	C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC	IC50 = 129000 nM	Poor binder
T40694	Polo-like kinase 1	D0A5MC	MLN8054	Phase 1	11712649	C25H15ClF2N4O2	476.9	C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O	IC50 = 53000 nM	Poor binder
T40694	Polo-like kinase 1	D00PWQ	KENPAULLONE	Patented	3820	C16H11BrN2O	327.17	C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	D0Y3DN	Flavonoid derivative 4	Patented	5280343	C15H10O7	302.23	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O	IC50 = 64000 nM	Poor binder
T40694	Polo-like kinase 1	B0CZ6Y	Tert-Butyl 6-((2-Chloro-4-(Dimethylcarbamoyl)phenyl)amino)-2-(1-Methyl-1h-Pyrazol-4-Yl)-1h-Pyrrolo[3,2-C]pyridine-1-Carboxylate	Investigative	68310278	C25H27ClN6O3	495	CC(C)(C)OC(=O)N1C(=CC2=CN=C(C=C21)NC3=C(C=C(C=C3)C(=O)N(C)C)Cl)C4=CN(N=C4)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B0FY8K	2-(4-Methylanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379491	C19H16N4O	316.4	CC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=CC=CC=C4C3=N2	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B0HX8M	3-Methyl-4-(2-phenoxyacetamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide	Investigative	44406048	C15H14N4O3S	330.4	CC1=C2C(=C(SC2=NN1)C(=O)N)NC(=O)COC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B0ME5T	N-(2-Aminophenyl)-4-[[4-(3-bromoanilino)quinazolin-6-yl]oxymethyl]benzamide	Investigative	58191997	C28H22BrN5O2	540.4	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)COC3=CC4=C(C=C3)N=CN=C4NC5=CC(=CC=C5)Br	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B0N6VA	6-Phenyl-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amine	Investigative	10705154	C13H13N5	239.28	C1CNC2=NC=NC(=C2N=C1C3=CC=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B1A4EI	(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one	Investigative	9547398	C27H42O3	414.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3C[C@@H]([C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C)O	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B1VO9R	Calicoferol E	Investigative	5283685	C27H42O2	398.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B25LNI	2-(4-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379347	C18H13ClN4O	336.8	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B27PRM	(E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitrophenyl)acryloyl)benzoic acid	Investigative	24960018	C23H15BrFNO5S	516.299	C1=CC(=CC=C1CS/C(=C/C2=CC(=C(C=C2)F)[N+](=O)[O-])/C(=O)C3=CC=C(C=C3)C(=O)O)Br	IC50 ~ 50000 nM	Poor binder
T40694	Polo-like kinase 1	B2EX3Y	4-(1-Methylbenzimidazol-2-yl)-N-(4-methylphenyl)pyrimidin-2-amine	Investigative	60165994	C19H17N5	315.4	CC1=CC=C(C=C1)NC2=NC=CC(=N2)C3=NC4=CC=CC=C4N3C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B2U1YO	3,8,13,15,17,18-Hexazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929507	C12H8N6O	252.23	C1C2=C(C3=C(C=CC=N3)NC1=O)N4C(=NC=N4)N=C2	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B2VJY5	6-Phenyl-7,8-dihydro-9H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine	Investigative	10538870	C13H14N6	254.29	C1CNC2=NC(=NC(=C2N=C1C3=CC=CC=C3)N)N	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B31FCL	(+/-)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide	Investigative	51355713	C29H29F3N4O3	538.6	CC(C1=CC=CC=C1C(F)(F)F)OC2=C(C=CC(=C2)N3C=NC4=C3C=CC(=C4)OC5CCN(CC5)C)C(=O)N	IC50 = 87900 nM	Poor binder
T40694	Polo-like kinase 1	B31SIO	6-(3-Methylphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine	Investigative	44450059	C14H15N5	253.3	CC1=CC(=CC=C1)C2=NC3=C(N=CN=C3NCC2)N	IC50 = 50000 nM	Poor binder
T40694	Polo-like kinase 1	B3LYC9	4-(1-Methylbenzimidazol-2-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine	Investigative	60166135	C22H22N6O	386.4	CN1C2=CC=CC=C2N=C1C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B3P9IK	4-Methoxy-N-methylbenzamide	Investigative	346031	C9H11NO2	165.19	CNC(=O)C1=CC=C(C=C1)OC	IC50 = 125000 nM	Poor binder
T40694	Polo-like kinase 1	B3ZQ9K	4-(4-Ethoxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379814	C19H17N5O2	347.4	CCOC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=C(C3=N2)N=CC=C4	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B45EMH	2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one	Investigative	21100709	C15H10O4	254.24	C1=CC=C2C(=C1)C(=O)/C(=C\\C3=CC(=C(C=C3)O)O)/O2	IC50 = 100000 nM	Poor binder
T40694	Polo-like kinase 1	B4AH7O	2-Anilino-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379344	C18H14N4O	302.3	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B4S6OA	2-(2-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379496	C18H13ClN4O	336.8	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=CC=C4Cl	IC50 = 73000 nM	Poor binder
T40694	Polo-like kinase 1	B4UK1A	(R)-3-(1-(2-Chloro-4-((2-hydroxyethylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45269507	C23H23ClN4O3S	471	C[C@H](C1=C(C=C(C=C1)CNCCO)Cl)OC2=C(SC(=C2)C3=CN=C4N3C=CC=C4)C(=O)N	EC50 = 184000 nM	Poor binder
T40694	Polo-like kinase 1	B4YXC8	7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol	Investigative	76335685	C24H33NO3	383.5	C[C@H]1CC[C@@]2([C@H]([C@]1(C)CC3=C4C(=CC(=C3O)OC)N=C(O4)C)CCC=C2C)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B5JKD1	N-(4-Chlorophenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine	Investigative	60165995	C18H14ClN5	335.8	CN1C2=CC=CC=C2N=C1C3=NC(=NC=C3)NC4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B5V6KY	Benzamide, 4-ethoxy-N-methyl-	Investigative	789021	C10H13NO2	179.22	CCOC1=CC=C(C=C1)C(=O)NC	IC50 = 64700 nM	Poor binder
T40694	Polo-like kinase 1	B5VG2J	9-Chloro-2-[[5-[3-(dimethylamino)propyl]pyridin-3-yl]amino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione	Investigative	46235770	C22H23ClN6S	439	CN(C)CCCC1=CC(=CN=C1)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)Cl	EC50 = 53000 nM	Poor binder
T40694	Polo-like kinase 1	B5WMG0	2-(Dimethylamino)-2-(2-ethylphenyl)-N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)acetamide	Investigative	101903000	C25H27N5O3S	477.6	CCC1=CC=CC=C1C(C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC(=CC=C4)S(=O)(=O)N)N(C)C	IC50 ~ 50000 nM	Poor binder
T40694	Polo-like kinase 1	B65OJD	(R)-3-(1-(4-((Tert-butylamino)methyl)-2-(difluoromethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45271099	C26H28F2N4O2S	498.6	C[C@H](C1=C(C=C(C=C1)CNC(C)(C)C)C(F)F)OC2=C(SC(=C2)C3=CN=C4N3C=CC=C4)C(=O)N	EC50 = 82000 nM	Poor binder
T40694	Polo-like kinase 1	B72QGA	2-(4-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379493	C18H13BrN4O	381.2	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=C(C=C4)Br	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B7O6YE	4-(4-Methoxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379812	C18H15N5O2	333.3	COC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=C(C3=N2)N=CC=C4	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B7SRD4	9-Chloro-2-[5-[3-(dimethylamino)propyl]-2-methylanilino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione	Investigative	56945171	C24H26ClN5S	452	CC1=C(C=C(C=C1)CCCN(C)C)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)Cl	EC50 = 64000 nM	Poor binder
T40694	Polo-like kinase 1	B7WZL1	5-Methoxy-8,13,17,18-tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929510	C15H12N4O2	280.28	COC1=CC2=C(C=C1)C3=C(CC(=O)N2)C=NC4=CC=NN43	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B92GIU	N-(2-Aminophenyl)-4-[[4-(3-ethynylanilino)quinazolin-6-yl]oxymethyl]benzamide	Investigative	58191965	C30H23N5O2	485.5	C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C(C=C3)OCC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	B9VCN0	2-(2-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379605	C18H13BrN4O	381.2	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=CC=C4Br	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BA8MW7	4-[2-(2-Hydroxyethoxy)-5-methyl-3-[4-(2H-tetrazol-5-yl)phenyl]phenyl]benzonitrile	Investigative	71524012	C23H19N5O2	397.4	CC1=CC(=C(C(=C1)C2=CC=C(C=C2)C3=NNN=N3)OCCO)C4=CC=C(C=C4)C#N	IC50 = 139000 nM	Poor binder
T40694	Polo-like kinase 1	BB0A7C	4-{5-[(1-Methylpiperidin-4-YL)oxy]-1H-benzimidazol-1-YL}-2-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}benzamide	Investigative	50990894	C29H29F3N4O3	538.6	C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(C=CC(=C2)N3C=NC4=C3C=CC(=C4)OC5CCN(CC5)C)C(=O)N	IC50 = 51300 nM	Poor binder
T40694	Polo-like kinase 1	BB6Y2U	3,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379342	C14H9N5O3	295.25	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=C(C=CC=N4)NC1=O	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BC06QB	4-(3-Chloro-4-hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	135929542	C17H12ClN5O2	353.8	C1C2=CN=C(N=C2C3=C(C=CC=N3)NC1=O)NC4=CC(=C(C=C4)O)Cl	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BC3K0L	Methyl 3-(piperidin-1-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate	Investigative	44405987	C13H17N3O2S	279.36	COC(=O)C1=CC2=C(NN=C2S1)CN3CCCCC3	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BC5S8Z	4-Methoxy-N-methylnaphthalene-1-carboxamide	Investigative	13433112	C13H13NO2	215.25	CNC(=O)C1=CC=C(C2=CC=CC=C21)OC	IC50 = 99000 nM	Poor binder
T40694	Polo-like kinase 1	BD2WL1	16-Phenyl-3,8,13,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929527	C19H13N5O	327.3	C1C2=C(C3=C(C=CC=N3)NC1=O)N4C(=CC(=N4)C5=CC=CC=C5)N=C2	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BD4G0L	4,8,15,17,19-Pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379340	C14H9N5O3	295.25	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=C(C=CN=C4)NC1=O	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BD58RS	8,15,17,19-Tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione	Investigative	45379202	C15H10N4O3	294.26	C1C2=CC3=C(NC(=O)NC3=O)N=C2C4=CC=CC=C4NC1=O	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BDK9R0	Calicoferol C	Investigative	10024683	C28H44O2	412.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@H]2O)C)[C@H](C)CCC(=C)C(C)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BDXT45	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	Investigative	11530963	C21H18N2O5	378.4	COC1=CC(=CC(=C1OC)OC)C2=C(C(=O)NC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BE87NL	2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379494	C20H18N4O2	346.4	CCOC1=CC=C(C=C1)NC2=NC=C3CC(=O)NC4=CC=CC=C4C3=N2	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BEG6C4	16-Phenyl-4,8,13,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929504	C19H13N5O	327.3	C1C2=C(C3=C(C=CN=C3)NC1=O)N4C(=CC(=N4)C5=CC=CC=C5)N=C2	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BEO65U	6-(3-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine	Investigative	44450035	C13H12ClN5	273.72	C1CNC2=NC=NC(=C2N=C1C3=CC(=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BF32AR	Calicoferol B	Investigative	10047545	C27H44O3	416.6	CC1=C(C=C(C=C1)O)CC[C@@H]2[C@@H](CC[C@]3([C@H]2C[C@@H]([C@@H]3[C@H](C)CCCC(C)C)O)C)O	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BF4B7H	8,13,17,18-Tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one	Investigative	135929508	C14H10N4O	250.25	C1C2=C(C3=CC=CC=C3NC1=O)N4C(=CC=N4)N=C2	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BF9O4L	2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379492	C18H14N4O2	318.3	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=C(C=C4)O	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BG37WO	Astrogorgiadiol B	Investigative	5283727	C27H44O2	400.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@H]2O)C)[C@H](C)CCCC(C)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BG4R3Q	N-[(2,6-Dibromo-4-sulfamoylphenyl)carbamothioyl]benzamide	Investigative	134137232	C14H11Br2N3O3S2	493.2	C1=CC=C(C=C1)C(=O)NC(=S)NC2=C(C=C(C=C2Br)S(=O)(=O)N)Br	IC50 = 95000 nM	Poor binder
T40694	Polo-like kinase 1	BG63FT	6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amine	Investigative	10588346	C13H12ClN5	273.72	C1CNC2=NC=NC(=C2N=C1C3=CC=C(C=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BG87SE	15,17-Dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2,4,6,11,13(18)-hexaene-9,14,16-trione	Investigative	45379203	C17H14N4O3	322.32	CN1C2=C(C=C3CC(=O)NC4=CC=CC=C4C3=N2)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BG8TS9	N8-[(2S)-3,3-Dimethylbutan-2-yl]-N2-[2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyrido[3,4-d]pyrimidine-2,8-diamine	Investigative	73386882	C24H29N7O	431.5	C[C@@H](C(C)(C)C)NC1=NC=CC2=CN=C(N=C21)NC3=C(C=C(C=C3)C4=CN(N=C4)C)OC	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BHN9G3	(E)-3-[1-[4-(3-Ethynylanilino)quinazolin-6-yl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide	Investigative	58191961	C23H17N5O4S	459.5	C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C(C=C3)S(=O)(=O)N4C=CC(=C4)/C=C/C(=O)NO	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BHRM84	15,17-Dimethyl-4,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379341	C16H13N5O3	323.31	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)C=NC=C4)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BHV6I3	4-(1-Methylbenzimidazol-2-yl)-N-phenylpyrimidin-2-amine	Investigative	60165993	C18H15N5	301.3	CN1C2=CC=CC=C2N=C1C3=NC(=NC=C3)NC4=CC=CC=C4	IC50 = 60000 nM	Poor binder
T40694	Polo-like kinase 1	BI65QO	N-Methyl-1-naphthalenecarboxamide	Investigative	18839	C12H11NO	185.22	CNC(=O)C1=CC=CC2=CC=CC=C21	IC50 = 104000 nM	Poor binder
T40694	Polo-like kinase 1	BIX19Z	5-Methoxy-15,17-dimethyl-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379205	C18H16N4O4	352.3	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)C=CC(=C4)OC)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BJA83G	(7-Nitro-3-oxy-5-trifluoromethyl-benzothiazol-2-yl)-pyrrolidin-1-yl-methanone	Investigative	2779943	C13H10F3N3O4S	361.3	C1CCN(C1)C(=O)C2=[N+](C3=C(S2)C(=CC(=C3)C(F)(F)F)[N+](=O)[O-])[O-]	IC50 = 56000 nM	Poor binder
T40694	Polo-like kinase 1	BKE4L6	2-[2-(4-Fluorophenyl)imidazol-1-yl]-5,7,7-trimethyl-8-propan-2-ylpteridin-6-one	Investigative	58405755	C21H23FN6O	394.4	CC(C)N1C2=NC(=NC=C2N(C(=O)C1(C)C)C)N3C=CN=C3C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BL3M0G	2-(4-Nitroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one	Investigative	45379490	C18H13N5O3	347.3	C1C2=CN=C(N=C2C3=CC=CC=C3NC1=O)NC4=CC=C(C=C4)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BLJ03R	(R)-3-(1-(2-Chloro-4-((1-hydroxy-2-methylpropan-2-ylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45270344	C25H27ClN4O3S	499	C[C@H](C1=C(C=C(C=C1)CNC(C)(C)CO)Cl)OC2=C(SC(=C2)C3=CN=C4N3C=CC=C4)C(=O)N	EC50 = 120000 nM	Poor binder
T40694	Polo-like kinase 1	BOG2F9	(R)-3-(1-(2-Chloro-4-((cyclopentylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45269501	C26H27ClN4O2S	495	C[C@H](C1=C(C=C(C=C1)CNC2CCCC2)Cl)OC3=C(SC(=C3)C4=CN=C5N4C=CC=C5)C(=O)N	EC50 = 121000 nM	Poor binder
T40694	Polo-like kinase 1	BPH30Z	15,17-Dimethyl-3,8,15,17,19-pentazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379343	C16H13N5O3	323.31	CN1C2=C(C=C3CC(=O)NC4=C(C3=N2)N=CC=C4)C(=O)N(C1=O)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BPKW25	(R)-3-(1-(2-Chloro-4-((4-methylpiperazin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45273759	C26H28ClN5O2S	510.1	C[C@H](C1=C(C=C(C=C1)CN2CCN(CC2)C)Cl)OC3=C(SC(=C3)C4=CN=C5N4C=CC=C5)C(=O)N	EC50 = 120000 nM	Poor binder
T40694	Polo-like kinase 1	BPX05I	6-(3-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine	Investigative	44450033	C13H13ClN6	288.73	C1CNC2=NC(=NC(=C2N=C1C3=CC(=CC=C3)Cl)N)N	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BQLU06	6-(4-Methylphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine	Investigative	44450060	C14H15N5	253.3	CC1=CC=C(C=C1)C2=NC3=C(N=CN=C3NCC2)N	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BQS51E	Calicoferol A	Investigative	9547698	C27H40O2	396.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)/C=C/CC(C)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BQZH46	2-Pyrrolidin-1-yl-N-[3-(3-sulfamoylphenyl)-1H-indazol-5-yl]-2-thiophen-3-ylacetamide	Investigative	101902999	C23H23N5O3S2	481.6	C1CCN(C1)C(C2=CSC=C2)C(=O)NC3=CC4=C(C=C3)NN=C4C5=CC(=CC=C5)S(=O)(=O)N	IC50 ~ 50000 nM	Poor binder
T40694	Polo-like kinase 1	BR1BN6	4-(3-Hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	45379815	C17H13N5O2	319.32	C1C2=CN=C(N=C2C3=C(C=CC=N3)NC1=O)NC4=CC(=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BRA71K	6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine	Investigative	10732141	C13H13ClN6	288.73	C1CNC2=NC(=NC(=C2N=C1C3=CC=C(C=C3)Cl)N)N	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T40694	Polo-like kinase 1	BS40OC	3-Methyl-4-(thiophene-2-carboxamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide	Investigative	44406055	C12H10N4O2S2	306.4	CC1=C2C(=C(SC2=NN1)C(=O)N)NC(=O)C3=CC=CS3	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BSK3G0	4-(3-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide	Investigative	44405945	C14H11ClN4O2S	334.8	CC1=C2C(=C(SC2=NN1)C(=O)N)NC(=O)C3=CC(=CC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BSWL64	3,8,13,17,18-Pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929526	C13H9N5O	251.24	C1C2=C(C3=C(C=CC=N3)NC1=O)N4C(=CC=N4)N=C2	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BTH83N	CID 58405741	Investigative	58405741	C21H21FN6O2	408.4	CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3COC3)N4C=CN=C4C5=CC=C(C=C5)F)C	IC50 ~ 50000 nM	Poor binder
T40694	Polo-like kinase 1	BTZ3M4	9-Chloro-2-[5-[3-(dimethylamino)propyl]-2-methoxyanilino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione	Investigative	56945173	C24H26ClN5OS	468	CN(C)CCCC1=CC(=C(C=C1)OC)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)Cl	EC50 = 130000 nM	Poor binder
T40694	Polo-like kinase 1	BUE5R6	5-Methoxy-8,13,15,17,18-pentazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2(7),3,5,12,14,16-heptaen-9-one	Investigative	135929506	C14H11N5O2	281.27	COC1=CC2=C(C=C1)C3=C(CC(=O)N2)C=NC4=NC=NN34	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BULB17	5-Methoxy-8,15,17,19-tetrazatetracyclo[9.8.0.02,7.013,18]nonadeca-1(19),2(7),3,5,11,13(18)-hexaene-9,14,16-trione	Investigative	45379204	C16H12N4O4	324.29	COC1=CC2=C(C=C1)C3=NC4=C(C=C3CC(=O)N2)C(=O)NC(=O)N4	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BV9WQ8	N-(4-Ethoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine	Investigative	60166136	C20H19N5O	345.4	CCOC1=CC=C(C=C1)NC2=NC=CC(=N2)C3=NC4=CC=CC=C4N3C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BVT45D	Methyl 3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylate	Investigative	44405982	C8H8N2O2S	196.23	CC1=C2C=C(SC2=NN1)C(=O)OC	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BVW47M	1,3-Dimethyl-7-(1-methylbenzimidazol-2-yl)pyrido[2,3-d]pyrimidine-2,4-dione	Investigative	60165992	C17H15N5O2	321.33	CN1C2=CC=CC=C2N=C1C3=NC4=C(C=C3)C(=O)N(C(=O)N4C)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BWJ84K	4-(4-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide	Investigative	44405946	C14H11ClN4O2S	334.8	CC1=C2C(=C(SC2=NN1)C(=O)N)NC(=O)C3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BX0D7J	Rel-Astrogorgol F	Investigative	54764923	C27H42O2	398.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@@H]2O)C)[C@H](C)/C=C/CC(C)C	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BXB35V	4-(4-Hydroxyanilino)-3,5,10,15-tetrazatricyclo[9.4.0.02,7]pentadeca-1(11),2,4,6,12,14-hexaen-9-one	Investigative	135929541	C17H13N5O2	319.32	C1C2=CN=C(N=C2C3=C(C=CC=N3)NC1=O)NC4=CC=C(C=C4)O	IC50 = 55000 nM	Poor binder
T40694	Polo-like kinase 1	BY1LI3	4-[2-Amino-5-[4-[(dimethylamino)methyl]thiophen-2-yl]pyridin-3-yl]-2-[(Z,2S)-5,5,5-trifluoropent-3-en-2-yl]oxybenzamide	Investigative	57387301	C24H25F3N4O2S	490.5	C[C@@H](/C=C\\C(F)(F)F)OC1=C(C=CC(=C1)C2=C(N=CC(=C2)C3=CC(=CS3)CN(C)C)N)C(=O)N	IC50 ~ 50000 nM	Poor binder
T40694	Polo-like kinase 1	BY1X8G	16-Phenyl-8,13,17,18-tetrazatetracyclo[9.7.0.02,7.014,18]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one	Investigative	135929509	C20H14N4O	326.4	C1C2=C(C3=CC=CC=C3NC1=O)N4C(=CC(=N4)C5=CC=CC=C5)N=C2	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BY3UW7	(R)-3-(1-(2-Chloro-4-((isopropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide	Investigative	45269500	C24H25ClN4O2S	469	C[C@H](C1=C(C=C(C=C1)CNC(C)C)Cl)OC2=C(SC(=C2)C3=CN=C4N3C=CC=C4)C(=O)N	EC50 = 68000 nM	Poor binder
T40694	Polo-like kinase 1	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BY89EO	3-[(E)-[3-[(E)-2-Pyridin-4-ylethenyl]indazol-6-ylidene]methyl]-1H-indol-2-ol	Investigative	135932346	C23H16N4O	364.4	C1=CC=C2C(=C1)C(=C(N2)O)/C=C/3\\C=CC4=C(N=NC4=C3)/C=C/C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T40694	Polo-like kinase 1	BYB0C2	24-Exomethylenecalicoferol E	Investigative	10047202	C28H42O2	410.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)CCC(=C)C(C)C	IC50 = 100000 nM	Poor binder
T40694	Polo-like kinase 1	BYW4L1	9-Chloro-2-[3-chloro-5-[3-(dimethylamino)propyl]anilino]-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione	Investigative	56945271	C23H23Cl2N5S	472.4	CN(C)CCCC1=CC(=CC(=C1)Cl)NC2=NC=C3CC(=S)NC4=C(C3=N2)C=CC(=C4)Cl	EC50 = 150000 nM	Poor binder
T40694	Polo-like kinase 1	BZR76B	Norlichexanthone	Investigative	5281657	C14H10O5	258.23	CC1=CC(=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O	IC50 = 75700 nM	Poor binder