TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T44818	Tryptophan 2,3-dioxygenase	D0J1HB	PF-06840003	Phase 1	23063810	C12H9FN2O2	232.21	C1C(C(=O)NC1=O)C2=CNC3=C2C=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B04GWJ	Diethyl 2-(2-oxo-1H-indol-3-ylidene)propanedioate	Investigative	336699	C15H15NO5	289.28	CCOC(=O)C(=C1C2=CC=CC=C2NC1=O)C(=O)OCC	IC50 = 71010 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B17YFB	3-(2H-1,2,3-Triazol-4-yl)benzonitrile	Investigative	11275256	C9H6N4	170.17	C1=CC(=CC(=C1)C2=NNN=C2)C#N	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B1W8HO	Chembl4160797	Investigative	142619919	C18H13ClFN3O	341.8	C1=CC2=C(C=C1F)C=C(N2)CN3C=NC=C3C4=C(C=CC(=C4)Cl)O	IC50 = 54400 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B3BO1Q	Chembl4281233	Investigative	145980819	C19H14N2O2	302.3	CC1=CC=CC=C1CN2C=NC3=C2C(=O)C4=CC=CC=C4C3=O	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B3G6EA	4-(3-Nitrophenyl)-1H-1,2,3-triazole	Investigative	21723626	C8H6N4O2	190.16	C1=CC(=CC(=C1)[N+](=O)[O-])C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B3M9EX	5-(3-Chlorophenyl)-1H-1,2,3-triazole	Investigative	6409664	C8H6ClN3	179.6	C1=CC(=CC(=C1)Cl)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B4CW5U	2-(2H-Triazol-4-yl)aniline	Investigative	19702149	C8H8N4	160.18	C1=CC=C(C(=C1)C2=NNN=C2)N	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B4FWK6	2-Chloro-4-(1H-1,2,3-triazol-4-yl)pyridine	Investigative	60156092	C7H5ClN4	180.59	C1=CN=C(C=C1C2=NNN=C2)Cl	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B4N7FZ	1H-1,2,3-Triazole, 5-(2-ethylphenyl)-	Investigative	22009901	C10H11N3	173.21	CCC1=CC=CC=C1C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B54MIS	Phenol, 2-(1H-1,2,3-triazol-5-yl)-	Investigative	135482065	C8H7N3O	161.16	C1=CC=C(C(=C1)C2=NNN=C2)O	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B5IBM8	4-Methyl-N'-(2-oxoindol-3-yl)benzenesulfonohydrazide	Investigative	236715	C15H13N3O3S	315.3	CC1=CC=C(C=C1)S(=O)(=O)N=NC2=C(NC3=CC=CC=C32)O	IC50 = 52900 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B74ZRV	Chembl4288429	Investigative	145990300	C20H14N2O4	346.3	COC(=O)C1=CC=CC(=C1)CN2C=NC3=C2C(=O)C4=CC=CC=C4C3=O	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B7LD5Z	4-(2,3-Dichlorophenyl)-1H-1,2,3-triazole	Investigative	60154726	C8H5Cl2N3	214.05	C1=CC(=C(C(=C1)Cl)Cl)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B7NAE9	4-(3-Methylphenyl)-1H-1,2,3-triazole	Investigative	6419227	C9H9N3	159.19	CC1=CC(=CC=C1)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B8ZY7M	3-[2-(4-Chlorophenyl)hydrazinyl]indol-2-one	Investigative	4190125	C14H10ClN3O	271.7	C1=CC=C2C(=C1)C(=C(N2)O)N=NC3=CC=C(C=C3)Cl	IC50 = 53380 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B9QU0A	Chembl4292907	Investigative	145988339	C24H17N3O2	379.4	CC1=CC=CC=C1CN2C3=C(C(=O)C4=CC=CC=C4C3=O)N=C2C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	B9T1RQ	1H-1,2,3-Triazole, 5-(3-ethylphenyl)-	Investigative	60156091	C10H11N3	173.21	CCC1=CC(=CC=C1)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BA1YE3	Chembl4165309	Investigative	142619909	C18H13F2N3O	325.3	C1=CC2=C(C=C1F)C=C(N2)CN3C=NC=C3C4=C(C=CC(=C4)F)O	IC50 = 84000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BAE3J2	Chembl4294515	Investigative	145994224	C13H13NO4	247.25	CC(=O)CC(=O)CC1(C2=CC=CC=C2NC1=O)O	IC50 = 56120 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BAO70I	4-(5-Chloro-2-methylphenyl)-1H-1,2,3-triazole	Investigative	60154724	C9H8ClN3	193.63	CC1=C(C=C(C=C1)Cl)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BB0K8N	4-(2,5-Dichlorophenyl)-1H-1,2,3-triazole	Investigative	60154725	C8H5Cl2N3	214.05	C1=CC(=C(C=C1Cl)C2=NNN=C2)Cl	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BE5AZ6	2-Bromo-4-(2H-triazol-4-yl)pyridine	Investigative	60156093	C7H5BrN4	225.05	C1=CN=C(C=C1C2=NNN=C2)Br	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BFOU13	7-Chloro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indole	Investigative	53391725	C15H11ClN2	254.71	C1=CC2=C(C(=C1)Cl)NC=C2/C=C/C3=CN=CC=C3	IC50 ~ 50000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BG8IR3	3-(1H-1,2,3-Triazol-4-yl)phenol	Investigative	9815283	C8H7N3O	161.16	C1=CC(=CC(=C1)O)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BGD4F8	1H-1,2,3-Triazole, 5-(3-fluorophenyl)-	Investigative	71458329	C8H6FN3	163.15	C1=CC(=CC(=C1)F)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BGW59A	4-(2-Methoxyphenyl)-1h-1,2,3-triazole	Investigative	9877511	C9H9N3O	175.19	COC1=CC=CC=C1C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BLI5N0	4-(2-Fluorophenyl)-1h-1,2,3-triazole	Investigative	9920462	C8H6FN3	163.15	C1=CC=C(C(=C1)C2=NNN=C2)F	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BLNX70	4-(4-Fluorophenyl)-1H-1,2,3-triazole	Investigative	9877471	C8H6FN3	163.15	C1=CC(=CC=C1C2=NNN=C2)F	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BN20SB	Chembl4290045	Investigative	145987994	C11H8ClNO2	221.64	CC(=O)/C=C\\1/C2=C(C=CC(=C2)Cl)NC1=O	IC50 = 54690 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BN7O8R	4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide	Investigative	135424953	C9H7ClFN5O2	271.63	C1=CC(=C(C=C1N=C(C2=NON=C2N)NO)Cl)F	IC50 = 70000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BO0A7R	beta-3-Oxindolylalanine	Investigative	13393248	C11H12N2O3	220.22	C1=CC=C2C(=C1)C(C(=O)N2)C[C@@H](C(=O)O)N	IC50 = 60220 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BO5S7W	4-[2-(Trifluoromethyl)phenyl]-2H-triazole	Investigative	11694196	C9H6F3N3	213.16	C1=CC=C(C(=C1)C2=NNN=C2)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BOA6E7	4-(3-Bromophenyl)-1H-1,2,3-triazole	Investigative	6400901	C8H6BrN3	224.06	C1=CC(=CC(=C1)Br)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BOP1K9	Chembl4250771	Investigative	145985603	C23H15N3O3	381.4	CC1=CC=CC=C1NC(=O)C2=C3C=CC=CN3C4=C2C(=O)C5=C(C4=O)N=CC=C5	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BP6LK4	2-Fluoro-4-(1H-1,2,3-triazol-4-yl)pyridine	Investigative	60156094	C7H5FN4	164.14	C1=CN=C(C=C1C2=NNN=C2)F	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BPEA19	Chembl4248088	Investigative	145983122	C22H13N3O3	367.4	C1=CC=C(C=C1)NC(=O)C2=C3C=CC=CN3C4=C2C(=O)C5=C(C4=O)C=CC=N5	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BQ6KS2	Chembl4239450	Investigative	145982993	C23H12KN3O5	449.5	C1=CC2=C(C3=C(N2C=C1)C(=O)C4=C(C3=O)N=CC=C4)C(=O)NC5=CC=CC(=C5)C(=O)[O-].[K+]	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BQD8E4	Chembl4291850	Investigative	145986692	C19H12N2O4	332.3	C1=CC=C2C(=C1)C(=O)C3=C(C2=O)N(C=N3)CC4=CC(=CC=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BQR9N3	3-(1H-1,2,3-Triazol-5-yl)aniline	Investigative	9964175	C8H8N4	160.18	C1=CC(=CC(=C1)N)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BR3VJ6	4-(3-(Trifluoromethyl)phenyl)-1H-1,2,3-triazole	Investigative	9899225	C9H6F3N3	213.16	C1=CC(=CC(=C1)C(F)(F)F)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BS29XC	Chembl4286924	Investigative	24741909	C18H18N2O3	310.3	C1=CC=C(C=C1)COC(=O)NCCC2C3=CC=CC=C3NC2=O	IC50 = 58330 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BT6UI7	5-(2-Bromophenyl)-1H-1,2,3-triazole	Investigative	9920916	C8H6BrN3	224.06	C1=CC=C(C(=C1)C2=NNN=C2)Br	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BU0V7M	4-Chloro-2-(1H-1,2,3-triazol-4-yl)phenol	Investigative	135981331	C8H6ClN3O	195.6	C1=CC(=C(C=C1Cl)C2=NNN=C2)O	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BW60DY	Chembl4285062	Investigative	145992186	C23H14ClN3O2	399.8	C1=CC=C2C(=C1)C(=O)C3=C(C2=O)N(C(=N3)C4=CC=NC=C4)CC5=CC(=CC=C5)Cl	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BXVB20	Chembl4277781	Investigative	145985633	C18H11ClN2O2	322.7	C1=CC=C2C(=C1)C(=O)C3=C(C2=O)N(C=N3)CC4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BYA0H9	Chembl4237632	Investigative	145984936	C23H15N3O3	381.4	CC1=CC=CC=C1NC(=O)C2=C3C=CC=CN3C4=C2C(=O)C5=C(C4=O)C=CC=N5	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BYQ9X2	Chembl4279220	Investigative	145979858	C13H14N2O4	262.26	CC(=O)N[C@@H](CC1C2=CC=CC=C2NC1=O)C(=O)O	IC50 = 83470 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BZBI03	5-(2-Methylphenyl)-1H-1,2,3-triazole	Investigative	9812842	C9H9N3	159.19	CC1=CC=CC=C1C2=NNN=C2	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BZBP73	1H-1,2,3-Triazole, 5-(2-chlorophenyl)-	Investigative	9964258	C8H6ClN3	179.6	C1=CC=C(C(=C1)C2=NNN=C2)Cl	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	BZSF78	4-(2H-Triazol-4-yl)-2-(trifluoromethyl)pyridine	Investigative	60156095	C8H5F3N4	214.15	C1=CN=C(C=C1C2=NNN=C2)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	D01HST	amg-1	Investigative	1085108	C20H16N4O3S2	424.5	CC1=CC=C(C=C1)C2=CSC3=NN=C(N23)SCC(=O)NC4=CC5=C(C=C4)OCO5	IC50 ~ 62500 nM	Poor binder
T44818	Tryptophan 2,3-dioxygenase	D0O3IE	5-phenyl-1H-1,2,3-triazole	Investigative	137153	C8H7N3	145.16	C1=CC=C(C=C1)C2=NNN=C2	IC50 ~ 100000 nM	Poor binder