TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T47941	Phosphodiesterase 4	D0E0SW	Enoximone	Approved	53708	C12H12N2O2S	248.3	CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)SC	IC50 ~ 150000 nM	Poor binder
T47941	Phosphodiesterase 4	D0R6TI	Inamrinone Lactate	Approved	3698	C10H9N3O	187.2	C1=CN=CC=C1C2=CNC(=O)C(=C2)N	IC50 = 101000 nM	Poor binder
T47941	Phosphodiesterase 4	D0DF2M	PMID28870136-Compound-48	Patented	2153	C7H8N4O2	180.16	CN1C2=C(C(=O)N(C1=O)C)NC=N2	Ki = 56800 nM	Poor binder
T47941	Phosphodiesterase 4	D00YPW	ZAPRINAST	Terminated	135399235	C13H13N5O2	271.27	.	IC50 = 53000 nM	Poor binder
T47941	Phosphodiesterase 4	B0TFY6	(4Ar,6R,7R,7aS)-6-[6-(benzylamino)-8-benzylsulfanylpurin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	14102485	C24H24N5O6PS	541.5	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3SCC5=CC=CC=C5)NCC6=CC=CC=C6)O)OP(=O)(O1)O	IC50 = 56000 nM	Poor binder
T47941	Phosphodiesterase 4	B17AGX	9-[(4Ar,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-8-amino-3H-purine-6-thione	Investigative	90662968	C10H12N5O6PS	361.27	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=S)N=CN4)N=C3N)O)OP(=O)(O1)O	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	B1B0UR	4-Spiro[1,3-benzodioxole-2,1'-cyclohexane]-5-ylpyrrolidin-2-one	Investigative	44298012	C16H19NO3	273.33	C1CCC2(CC1)OC3=C(O2)C=C(C=C3)C4CC(=O)NC4	Ki = 63900 nM	Poor binder
T47941	Phosphodiesterase 4	B1I4TE	5,6a(R),7,8,9,9a(S)-Hexahydro-2,5-dimethylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one	Investigative	10776762	C12H15N5O	245.28	CC1=NC2=C(N1)C(=O)N(C3=N[C@@H]4CCC[C@@H]4N23)C	IC50 = 82000 nM	Poor binder
T47941	Phosphodiesterase 4	B1I7CS	8-(4-Chlorophenylthio)-cAMP	Investigative	91636	C16H15ClN5O6PS	471.8	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3SC5=CC=C(C=C5)Cl)N)O)OP(=O)(O1)O	IC50 = 200000 nM	Poor binder
T47941	Phosphodiesterase 4	B1P2UB	3-Cyclopentyloxy-N-[(3,4-dimethoxyphenyl)methyl]-4-methoxybenzamide	Investigative	122193674	C22H27NO5	385.5	COC1=C(C=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC)OC3CCCC3)OC	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B1QK9R	9-[(4Ar,6R,7R,7aS)-2,7-dihydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3H-purine-6-thione	Investigative	21829707	C10H11N4O6PS	346.26	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3NC=NC4=S)O)OP(=O)(O1)O	IC50 = 53000 nM	Poor binder
T47941	Phosphodiesterase 4	B1SZC9	3-Cyclopentyloxy-4-(difluoromethoxy)-N-[(3,4-dimethoxyphenyl)methyl]benzamide	Investigative	122193752	C22H25F2NO5	421.4	COC1=C(C=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC(F)F)OC3CCCC3)OC	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B2JM1R	3-Butyl-1-(4-fluorophenyl)-6-phenyl-4,5-dihydropyrazolo[3,4-c]pyridin-7-one	Investigative	10594887	C22H22FN3O	363.4	CCCCC1=NN(C2=C1CCN(C2=O)C3=CC=CC=C3)C4=CC=C(C=C4)F	IC50 = 84700 nM	Poor binder
T47941	Phosphodiesterase 4	B2RH0L	1-(3-Chloro-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10650764	C29H33ClN2O8	573	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Cl)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B2VY4Q	(4Ar,6R,7R,7aS)-6-(6-amino-8-butylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662994	C14H20N5O6PS	417.38	CCCCSC1=NC2=C(N=CN=C2N1[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O)N	IC50 = 160000 nM	Poor binder
T47941	Phosphodiesterase 4	B2XTY8	3-(Cyclopropylmethoxy)-4-(difluoromethoxy)-N-[(3,4-dimethoxyphenyl)methyl]benzamide	Investigative	122193755	C21H23F2NO5	407.4	COC1=C(C=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC(F)F)OCC3CC3)OC	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B3EAM6	T 0156 Hydrochloride	Investigative	9852041	C31H30ClN5O7	620	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl	IC50 = 67000 nM	Poor binder
T47941	Phosphodiesterase 4	B3L7JE	Triazolothiadiazine, 5K	Investigative	135750254	C18H16N4O3S	368.4	COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC=CC=C4O)OC	IC50 = 159000 nM	Poor binder
T47941	Phosphodiesterase 4	B43EAS	CCK antagonist synthetic 14	Investigative	14208192	C24H18N4O2	394.4	C1=CC=C(C=C1)C2=NC(C(=O)NC3=CC=CC=C32)NC(=O)C4=CC5=CC=CC=C5N4	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B49ESZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10508072	C29H33BrN2O8	617.5	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B4K0IJ	(4Ar,6R,7R,7aS)-6-[6-(ethylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	14102450	C12H16N5O6P	357.26	CCNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O	IC50 = 130000 nM	Poor binder
T47941	Phosphodiesterase 4	B4MB6W	(4Ar,6R,7R,7aS)-6-[6-amino-8-(4-bromophenyl)sulfanyl-purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	3010411	C16H15BrN5O6PS	516.299	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3SC5=CC=C(C=C5)Br)N)O)OP(=O)(O1)O	IC50 = 60000 nM	Poor binder
T47941	Phosphodiesterase 4	B59XAU	Triazolothiadiazine, 5E	Investigative	17757139	C20H20N4O4S	412.5	COC1=CC(=C(C=C1)C2=NN=C3N2N=C(CS3)C4=CC(=C(C=C4)OC)OC)OC	IC50 = 79000 nM	Poor binder
T47941	Phosphodiesterase 4	B5T6MB	4-N,4-N-Diethyl-6,7-dimethoxy-2-N-(2-phenylethyl)quinazoline-2,4-diamine	Investigative	13408793	C22H28N4O2	380.5	CCN(CC)C1=NC(=NC2=CC(=C(C=C21)OC)OC)NCCC3=CC=CC=C3	IC50 = 87000 nM	Poor binder
T47941	Phosphodiesterase 4	B5YPU0	N-Ethyl-N-[[4-[2-(tetrazol-2-yl)phenyl]phenyl]methyl]-[1,2,4]thiadiazolo[2,3-a]benzimidazol-2-amine	Investigative	44365068	C24H20N8S	452.5	CCN(CC1=CC=C(C=C1)C2=CC=CC=C2N3N=CN=N3)C4=NC5=NC6=CC=CC=C6N5S4	IC50 = 74000 nM	Poor binder
T47941	Phosphodiesterase 4	B5ZHN1	2-(1-Methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-purin-7-yl)-acetamide	Investigative	10355485	C11H15N5O3	265.27	CCCN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC(=O)N	Ki = 119000 nM	Poor binder
T47941	Phosphodiesterase 4	B68FIQ	8-OH-cAMP	Investigative	14212369	C10H12N5O7P	345.21	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4NC3=O)N)O)OP(=O)(O1)O	IC50 = 150000 nM	Poor binder
T47941	Phosphodiesterase 4	B6B7OU	1-(3-Dimethylamino-propyl)-3-propyl-3,7-dihydro-purine-2,6-dione	Investigative	9970847	C13H21N5O2	279.34	CCCN1C2=C(C(=O)N(C1=O)CCCN(C)C)NC=N2	Ki = 92000 nM	Poor binder
T47941	Phosphodiesterase 4	B6FLE7	N-[6-Chloro-9-(2-fluorophenyl)-12-oxo-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	Investigative	44209387	C26H18ClFN4O2	472.9	C1CN2C(=O)C(N=C(C3=CC(=CC1=C32)Cl)C4=CC=CC=C4F)NC(=O)C5=CC6=CC=CC=C6N5	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B6HBD1	1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]butan-1-one	Investigative	25178735	C16H22O4	278.34	CCCC(=O)C1=CC(=C(C=C1)OC2CCOCC2)OC	IC50 = 60000 nM	Poor binder
T47941	Phosphodiesterase 4	B6KC9P	Triazolothiadiazine, 5H	Investigative	17757158	C20H20N4O4S	412.5	COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=CC(=C4)OC)OC)OC	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	B6LH7G	Benzenesulfonamide, 3,4-dimethoxy-N-(2-cyanoethyl)-N-tetrahydrofurfuryl-	Investigative	551348	C16H22N2O5S	354.4	COC1=C(C=C(C=C1)S(=O)(=O)N(CCC#N)CC2CCCO2)OC	IC50 = 112000 nM	Poor binder
T47941	Phosphodiesterase 4	B6R2LU	(4Ar,6R,7R,7aS)-6-[6-(benzylamino)-8-bromopurin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662975	C17H17BrN5O6P	498.2	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3Br)NCC5=CC=CC=C5)O)OP(=O)(O1)O	IC50 = 61000 nM	Poor binder
T47941	Phosphodiesterase 4	B76DAZ	(3As,9bR)-7,8-dimethoxy-1,2,3a,4,5,9b-hexahydrobenzo[e]isoindol-3-one	Investigative	14537182	C14H17NO3	247.29	COC1=C(C=C2[C@@H]3CNC(=O)[C@H]3CCC2=C1)OC	IC50 = 138000 nM	Poor binder
T47941	Phosphodiesterase 4	B76EBQ	8-Thiomethyl cyclic AMP	Investigative	10068047	C11H14N5O6PS	375.3	CSC1=NC2=C(N=CN=C2N1[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O)N	IC50 = 69000 nM	Poor binder
T47941	Phosphodiesterase 4	B7CDZ0	1-[3-Methoxy-4-(tetrahydropyran-4-yloxy)phenyl]pentan-1-one	Investigative	25178736	C17H24O4	292.4	CCCCC(=O)C1=CC(=C(C=C1)OC2CCOCC2)OC	IC50 = 71000 nM	Poor binder
T47941	Phosphodiesterase 4	B7GNV3	3-(Cyclopropylmethoxy)-N-[(3,4-dimethoxyphenyl)methyl]-4-methoxybenzamide	Investigative	122193676	C21H25NO5	371.4	COC1=C(C=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC)OCC3CC3)OC	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B7GR4Y	1-[3-Methoxy-4-(tetrahydrofuran-3-yloxy)phenyl]pentan-1-one	Investigative	25178738	C16H22O4	278.34	CCCCC(=O)C1=CC(=C(C=C1)OC2CCOC2)OC	IC50 = 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B7OP5V	(4Ar,6R,7R,7aS)-6-[8-benzylsulfanyl-6-(hexylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	14102471	C23H30N5O6PS	535.6	CCCCCCNC1=C2C(=NC=N1)N(C(=N2)SCC3=CC=CC=C3)[C@H]4[C@@H]([C@H]5[C@H](O4)COP(=O)(O5)O)O	IC50 = 56000 nM	Poor binder
T47941	Phosphodiesterase 4	B7VYU8	1-Methyl-3-propyl-7-(2-methoxyethyl)xanthine	Investigative	10333140	C12H18N4O3	266.3	CCCN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCOC	Ki = 72700 nM	Poor binder
T47941	Phosphodiesterase 4	B7YQ3I	(4Ar,6R,7R,7aS)-6-(6-benzylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662993	C17H17N4O6PS	436.4	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=CN=C4SCC5=CC=CC=C5)O)OP(=O)(O1)O	IC50 = 53000 nM	Poor binder
T47941	Phosphodiesterase 4	B7YXS3	4-[4-(2,3-Dimethylimidazol-3-ium-1-yl)benzoyl]-5-ethyl-1,3-dihydroimidazol-2-one	Investigative	13815995	C17H19N4O2+	311.36	CCC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)N3C=C[N+](=C3C)C	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B82FGU	(11R,15S)-4-(Cyclopentylmethyl)-8-methyl-1,3,5,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2(6),3,9-trien-7-one	Investigative	10663015	C17H23N5O	313.4	CN1C(=O)C2=C(N=C(N2)CC3CCCC3)N4C1=N[C@H]5[C@@H]4CCC5	IC50 = 57000 nM	Poor binder
T47941	Phosphodiesterase 4	B86APC	(4Ar,6R,7R,7aS)-6-(6-amino-8-propan-2-ylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662970	C13H18N5O6PS	403.35	CC(C)SC1=NC2=C(N=CN=C2N1[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O)N	IC50 = 56000 nM	Poor binder
T47941	Phosphodiesterase 4	B8C5LR	(4Ar,6R,7R,7aS)-6-[8-benzylsulfanyl-6-(methylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662973	C18H20N5O6PS	465.4	CNC1=C2C(=NC=N1)N(C(=N2)SCC3=CC=CC=C3)[C@H]4[C@@H]([C@H]5[C@H](O4)COP(=O)(O5)O)O	IC50 = 120000 nM	Poor binder
T47941	Phosphodiesterase 4	B8E7NX	2-Butyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	44323510	C14H15N3O	241.29	CCCCN1C(=O)C2=C(N1)C3=CC=CC=C3N=C2	IC50 = 90000 nM	Poor binder
T47941	Phosphodiesterase 4	B8L1EO	1-Benzoyl-4-(3,4-dimethoxy-phenyl)-pyrrolidin-2-one	Investigative	14537163	C19H19NO4	325.4	COC1=C(C=C(C=C1)C2CC(=O)N(C2)C(=O)C3=CC=CC=C3)OC	IC50 = 58000 nM	Poor binder
T47941	Phosphodiesterase 4	B8V7AK	N-Cyclopentyl-3,4-dimethoxybenzenesulfonamide	Investigative	16619271	C13H19NO4S	285.36	COC1=C(C=C(C=C1)S(=O)(=O)NC2CCCC2)OC	IC50 = 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B8XF2Q	Methyl 4-(3-chloro-4-methoxybenzylamino)-8-(2-hydroxyethyl)-7-methoxyquinazolin-6-yl(methyl)carbamate	Investigative	24810298	C22H25ClN4O5	460.9	CN(C1=C(C(=C2C(=C1)C(=NC=N2)NCC3=CC(=C(C=C3)OC)Cl)CCO)OC)C(=O)OC	IC50 = 84000 nM	Poor binder
T47941	Phosphodiesterase 4	B92BKO	1,3-Bis(cyclopropylmethyl)-7-methyl-8-[(phenylsulfonyl)amino]xanthine	Investigative	10252045	C20H23N5O4S	429.5	CN1C2=C(N=C1NS(=O)(=O)C3=CC=CC=C3)N(C(=O)N(C2=O)CC4CC4)CC5CC5	IC50 = 52000 nM	Poor binder
T47941	Phosphodiesterase 4	B9D0SI	5-(1-Methyl-6-oxo-4,5-dihydropyridazin-3-yl)-1,3-dihydroindol-2-one	Investigative	10377117	C13H13N3O2	243.26	CN1C(=O)CCC(=N1)C2=CC3=C(C=C2)NC(=O)C3	Ki = 61400 nM	Poor binder
T47941	Phosphodiesterase 4	B9DTN4	1-(4-Methoxy-3-(tetrahydro-2H-pyran-4-yloxy)phenyl)butan-1-ol	Investigative	25181027	C16H24O4	280.36	CCCC(C1=CC(=C(C=C1)OC)OC2CCOCC2)O	IC50 = 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B9FK7T	9-[(2-Fluorophenyl)methyl]-6-piperidin-1-ylpurine;hydrochloride	Investigative	45260180	C17H19ClFN5	347.8	C1CCN(CC1)C2=NC=NC3=C2N=CN3CC4=CC=CC=C4F.Cl	IC50 = 121000 nM	Poor binder
T47941	Phosphodiesterase 4	B9K6NZ	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-5-chloro-2-naphthoic acid methyl ester	Investigative	10232923	C27H28BrClN2O6	591.9	COC1=C(C(=CC(=C1)C2=C3C=CC=C(C3=CC(=C2C(=O)OC)C(=O)N4CCN(CC4)CCO)Cl)Br)OC	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B9MY0H	1-(3,4,5-Trimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6,7-dimethoxy-2-naphthoic acid methyl ester	Investigative	10626842	C30H36N2O9	568.6	COC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)OC)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	B9WR4G	(4Ar,6R,7R,7aS)-6-[6-chloro-8-(diethylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662966	C14H19ClN5O6P	419.76	CCN(CC)C1=NC2=C(N1[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O)N=CN=C2Cl	IC50 = 80000 nM	Poor binder
T47941	Phosphodiesterase 4	BA36NO	(4Ar,6R,7R,7aS)-2-hydroxy-6-[6-(methylamino)purin-9-yl]-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	14803339	C11H14N5O6P	343.23	CNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	BAYF21	(4Ar,6R,7R,7aS)-6-[6-(butylamino)-8-methylsulfanylpurin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662969	C15H22N5O6PS	431.4	CCCCNC1=C2C(=NC=N1)N(C(=N2)SC)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O	IC50 = 53000 nM	Poor binder
T47941	Phosphodiesterase 4	BBDS62	2-Butyl-5-phenethyl-3,5-dihydro-2H-pyrazolo[4,3-c]quinoline-3-one	Investigative	44323270	C22H23N3O	345.4	CCCCN1C(=O)C2=CN(C3=CC=CC=C3C2=N1)CCC4=CC=CC=C4	IC50 = 160000 nM	Poor binder
T47941	Phosphodiesterase 4	BBEU89	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-2-naphthoic acid methyl ester	Investigative	10816641	C27H29BrN2O6	557.4	COC1=C(C(=CC(=C1)C2=C(C(=CC3=CC=CC=C32)C(=O)N4CCN(CC4)CCO)C(=O)OC)Br)OC	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BBJW34	(3S,4R)-4-[(4S)-4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-oxopyrrolidin-1-yl]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile	Investigative	44294027	C28H32N2O5	476.6	CC1([C@H]([C@@H](C2=C(O1)C=CC(=C2)C#N)N3C[C@@H](CC3=O)C4=CC(=C(C=C4)OC)OC5CCCC5)O)C	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BC40DN	6-Propyl-6,9-dihydro-5H-tetrazolo[5,1-i]purin-5-one	Investigative	135531470	C8H9N7O	219.2	CCCN1C2=C(C3=NN=NN3C1=O)NC=N2	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BC5UD4	(4Ar,6R,7R,7aS)-6-(6-amino-8-phenylsulfanylpurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662986	C16H16N5O6PS	437.4	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3SC5=CC=CC=C5)N)O)OP(=O)(O1)O	IC50 = 57000 nM	Poor binder
T47941	Phosphodiesterase 4	BD0ZI2	1H-Pyridazino(4,5-b)indol-1-one, 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2,5-dihydro-, methylhydrazone	Investigative	5487421	C16H17N7	307.35	CC1=CC(=NN1C2=NN=C(C3=C2NC4=CC=CC=C43)NNC)C	IC50 = 118000 nM	Poor binder
T47941	Phosphodiesterase 4	BD74SC	(4Ar,6R,7R,7aS)-6-(6,8-diaminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	169185	C10H13N6O6P	344.22	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3N)N)O)OP(=O)(O1)O	IC50 = 83000 nM	Poor binder
T47941	Phosphodiesterase 4	BD76NM	N-(6-Methoxy-12-oxo-9-phenyl-1,7,10-triazatricyclo[6.4.1.04,13]trideca-4,6,8(13),9-tetraen-11-yl)pyridine-3-carboxamide	Investigative	11373312	C23H19N5O3	413.4	COC1=NC2=C3C(=C1)CCN3C(=O)C(N=C2C4=CC=CC=C4)NC(=O)C5=CN=CC=C5	IC50 = 73000 nM	Poor binder
T47941	Phosphodiesterase 4	BDL9U3	1-Benzyl-3-(2-methylsulfinylphenyl)-7H-purine-2,6-dione	Investigative	44330971	C19H16N4O3S	380.4	CS(=O)C1=CC=CC=C1N2C3=C(C(=O)N(C2=O)CC4=CC=CC=C4)NC=N3	IC50 = 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BDM7C9	8-Hydrazinyl-3,4,6,7,16-pentazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),2,4,7,10,12,14-heptaene-5-carbohydrazide	Investigative	136035345	C12H11N9O	297.28	C1=CC=C2C(=C1)C3=C(N2)C4=NN=C(N4N=C3NN)C(=O)NN	IC50 = 121000 nM	Poor binder
T47941	Phosphodiesterase 4	BDW2H7	6-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	1499306	C19H18N4O3S	382.4	COC1=CC=C(C=C1)C2=NN=C3N2N=C(CS3)C4=CC(=C(C=C4)OC)OC	IC50 = 88900 nM	Poor binder
T47941	Phosphodiesterase 4	BE0ZK8	N-Ethyl-N-[[2-(tetrazol-2-yl)phenyl]methyl]-[1,2,4]thiadiazolo[2,3-a]benzimidazol-2-amine	Investigative	44365265	C18H16N8S	376.4	CCN(CC1=CC=CC=C1N2N=CN=N2)C3=NC4=NC5=CC=CC=C5N4S3	IC50 = 107000 nM	Poor binder
T47941	Phosphodiesterase 4	BE7JQ5	N-(13-Oxo-10-phenyl-1,11-diazatricyclo[7.4.1.05,14]tetradeca-5(14),6,8,10-tetraen-12-yl)-1H-indole-2-carboxamide	Investigative	44209388	C27H22N4O2	434.5	C1CC2=C3C(=CC=C2)C(=NC(C(=O)N3C1)NC(=O)C4=CC5=CC=CC=C5N4)C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BE96BG	4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one	Investigative	14537151	C18H19NO3	297.3	COC1=C(C=C(C=C1)C2CC(=O)NC2)OCC3=CC=CC=C3	IC50 = 96000 nM	Poor binder
T47941	Phosphodiesterase 4	BF80BX	(4Ar,6R,7R,7aS)-6-[6-amino-8-[(2-methylphenyl)methylsulfanyl]purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90663005	C18H20N5O6PS	465.4	CC1=CC=CC=C1CSC2=NC3=C(N=CN=C3N2[C@H]4[C@@H]([C@H]5[C@H](O4)COP(=O)(O5)O)O)N	IC50 = 77000 nM	Poor binder
T47941	Phosphodiesterase 4	BF9GX0	3-Methylxanthine	Investigative	70639	C6H6N4O2	166.14	CN1C2=C(C(=O)NC1=O)NC=N2	Ki = 156000 nM	Poor binder
T47941	Phosphodiesterase 4	BG2Q5R	1-Methyl-3-propyl-7-(2-ethoxyethyl)xanthine	Investigative	10085058	C13H20N4O3	280.32	CCCN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCOCC	Ki = 136000 nM	Poor binder
T47941	Phosphodiesterase 4	BH54BY	3-(1-Methyl-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-purin-7-yl)-propionamide	Investigative	10107643	C12H17N5O3	279.3	CCCN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCC(=O)N	Ki = 92400 nM	Poor binder
T47941	Phosphodiesterase 4	BH84YM	N-Butyl-9-[(2-fluorophenyl)methyl]purin-6-amine;hydrochloride	Investigative	45260248	C16H19ClFN5	335.81	CCCCNC1=C2C(=NC=N1)N(C=N2)CC3=CC=CC=C3F.Cl	IC50 = 53000 nM	Poor binder
T47941	Phosphodiesterase 4	BHV3J4	4-(3,4-Ethylenedioxyphenyl)-2-pyrrolidone	Investigative	20346768	C12H13NO3	219.24	C1COC2=C(O1)C=CC(=C2)C3CC(=O)NC3	Ki ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BI42VD	Methyl 7-[(2-methylpyridin-4-yl)methyl]-8-oxo-2-(pyrimidin-2-ylmethoxy)-5-(3,4,5-trimethoxyphenyl)-1,7-naphthyridine-6-carboxylate;hydrochloride	Investigative	45260805	C31H30ClN5O7	620	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)N=C(C=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl	IC50 = 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BIE5A4	(4Ar,6R,7R,7aS)-6-[6-amino-8-(pyridin-3-ylmethylsulfanyl)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90663006	C16H17N6O6PS	452.4	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3SCC5=CN=CC=C5)N)O)OP(=O)(O1)O	IC50 = 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BIVF85	2-Pyrrolidinone, 4-(3,4-dimethoxyphenyl)-	Investigative	11775680	C12H15NO3	221.25	COC1=C(C=C(C=C1)C2CC(=O)NC2)OC	IC50 = 53000 nM	Poor binder
T47941	Phosphodiesterase 4	BJ6SK7	4-Methyl-5-[4-(4-methylimidazol-1-yl)benzoyl]-1,3-dihydroimidazol-2-one	Investigative	13815975	C15H14N4O2	282.3	CC1=CN(C=N1)C2=CC=C(C=C2)C(=O)C3=C(NC(=O)N3)C	IC50 = 65000 nM	Poor binder
T47941	Phosphodiesterase 4	BJT9F1	6-(3,4-Dimethoxyphenyl)-3-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	3435529	C19H18N4O3S	382.4	COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=CC=C4)OC)OC	IC50 = 126000 nM	Poor binder
T47941	Phosphodiesterase 4	BJV0C5	3-(2,6-Dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-propionamide	Investigative	9993017	C11H15N5O3	265.27	CCCN1C2=C(C(=O)N(C1=O)CCC(=O)N)NC=N2	Ki = 56300 nM	Poor binder
T47941	Phosphodiesterase 4	BK96LG	9-[(2-Fluorophenyl)methyl]-N,8-dimethylpurin-6-amine;methanesulfonic acid	Investigative	44294818	C15H18FN5O3S	367.4	CC1=NC2=C(N=CN=C2N1CC3=CC=CC=C3F)NC.CS(=O)(=O)O	IC50 = 54000 nM	Poor binder
T47941	Phosphodiesterase 4	BKVA57	Methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(2-pyridin-2-ylethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate;hydrochloride	Investigative	45264635	C33H33ClN4O7	633.1	CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCCC4=CC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	BL4DP8	N-Benzyl-2-piperidin-1-ylthieno[3,2-d]pyrimidin-4-amine	Investigative	44352624	C18H20N4S	324.4	C1CCN(CC1)C2=NC3=C(C(=N2)NCC4=CC=CC=C4)SC=C3	IC50 = 65000 nM	Poor binder
T47941	Phosphodiesterase 4	BL6FI5	8-Benzylthio-N-butyl cyclic AMP	Investigative	13388130	C21H26N5O6PS	507.5	CCCCNC1=C2C(=NC=N1)N(C(=N2)SCC3=CC=CC=C3)[C@H]4[C@@H]([C@H]5[C@H](O4)COP(=O)(O5)O)O	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	BL6IY3	4-Propyl-7,8-dihydro-1H-imidazo[2,1-f]purin-5-one	Investigative	135442775	C10H13N5O	219.24	CCCN1C2=NC=NC2=C3NCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BLOV35	4-(1,3-Benzodioxol-5-yl)pyrrolidin-2-one	Investigative	659516	C11H11NO3	205.21	C1C(CNC1=O)C2=CC3=C(C=C2)OCO3	Ki ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BM5HL9	8-(Ethylthio)adenosine 3',5'-phosphoric acid	Investigative	11857713	C12H16N5O6PS	389.33	CCSC1=NC2=C(N=CN=C2N1[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O)N	IC50 = 77000 nM	Poor binder
T47941	Phosphodiesterase 4	BM76XR	N-Benzyl-N-butyl-[1,2,4]thiadiazolo[2,3-a]benzimidazol-2-amine	Investigative	44365050	C19H20N4S	336.5	CCCCN(CC1=CC=CC=C1)C2=NC3=NC4=CC=CC=C4N3S2	IC50 = 90000 nM	Poor binder
T47941	Phosphodiesterase 4	BMIV96	4-Propyl-7,8,9,10-tetrahydropyrimido[2,1-f]purin-5-one	Investigative	135528334	C11H15N5O	233.27	CCCN1C2=NC=NC2=C3NCCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BN1V2I	(4Ar,6R,7R,7aS)-6-[6-(butylamino)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	13606768	C14H20N5O6P	385.31	CCCCNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O	IC50 = 67000 nM	Poor binder
T47941	Phosphodiesterase 4	BN4D0M	2-[6-[3-(3,4-Dimethoxyphenyl)-6-oxopyridazin-1-yl]hexyl]guanidine	Investigative	11372218	C19H27N5O3	373.4	COC1=C(C=C(C=C1)C2=NN(C(=O)C=C2)CCCCCCN=C(N)N)OC	IC50 = 60000 nM	Poor binder
T47941	Phosphodiesterase 4	BN9H1E	1-(4-Fluorophenyl)-6-(4-methoxyphenyl)-3-propyl-4,5-dihydropyrazolo[3,4-c]pyridin-7-one	Investigative	10619709	C22H22FN3O2	379.4	CCCC1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)OC)C4=CC=C(C=C4)F	IC50 = 84900 nM	Poor binder
T47941	Phosphodiesterase 4	BNR46T	(4Ar,6R,7R,7aS)-6-(8-amino-6-chloropurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90663003	C10H11ClN5O6P	363.65	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=C(C(=NC=N4)Cl)N=C3N)O)OP(=O)(O1)O	IC50 = 170000 nM	Poor binder
T47941	Phosphodiesterase 4	BNX7R1	1-Methyl-3-propyl-7-[2-(dimethylamino)ethyl]xanthine	Investigative	10085014	C13H21N5O2	279.34	CCCN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCN(C)C	Ki = 53000 nM	Poor binder
T47941	Phosphodiesterase 4	BNYR43	6-Methylthioinosine-3',5'-cyclic monophosphate	Investigative	90662984	C11H13N4O6PS	360.29	CSC1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O	IC50 = 80000 nM	Poor binder
T47941	Phosphodiesterase 4	BO4HU9	N-[(3R)-1-(2-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indol-3-yl]-1H-indole-2-carboxamide	Investigative	10455790	C26H19FN4O2	438.5	C1CN2C(=O)[C@@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4F)NC(=O)C5=CC6=CC=CC=C6N5	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BP59VY	4-Methyl-5-[4-(2,4,5-trimethylimidazol-1-yl)benzoyl]-1,3-dihydroimidazol-2-one	Investigative	13815976	C17H18N4O2	310.35	CC1=C(NC(=O)N1)C(=O)C2=CC=C(C=C2)N3C(=C(N=C3C)C)C	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BP8WY4	Tocladesine	Investigative	100299	C10H11ClN5O6P	363.65	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3Cl)N)O)OP(=O)(O1)O	IC50 = 59000 nM	Poor binder
T47941	Phosphodiesterase 4	BP9VK2	3-(1-Benzyl-2,6-dioxo-7H-purin-3-yl)benzoic acid	Investigative	44330913	C19H14N4O4	362.3	C1=CC=C(C=C1)CN2C(=O)C3=C(N=CN3)N(C2=O)C4=CC=CC(=C4)C(=O)O	IC50 = 110000 nM	Poor binder
T47941	Phosphodiesterase 4	BPC5O6	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-ethoxy-7-methoxy-2-naphthoic acid methyl ester	Investigative	10579873	C30H35BrN2O8	631.5	CCOC1=CC2=CC(=C(C(=C2C=C1OC)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BQW05F	1-Benzyl-3-(3-methylsulfinylphenyl)-7H-purine-2,6-dione	Investigative	2822879	C19H16N4O3S	380.4	CS(=O)C1=CC=CC(=C1)N2C3=C(C(=O)N(C2=O)CC4=CC=CC=C4)NC=N3	IC50 = 56000 nM	Poor binder
T47941	Phosphodiesterase 4	BQX3W5	(4Ar,6R,7R,7aS)-6-[6-(butylamino)-8-[(4-chlorophenyl)methylsulfanyl]purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	90662990	C21H25ClN5O6PS	541.9	CCCCNC1=C2C(=NC=N1)N(C(=N2)SCC3=CC=C(C=C3)Cl)[C@H]4[C@@H]([C@H]5[C@H](O4)COP(=O)(O5)O)O	IC50 = 75000 nM	Poor binder
T47941	Phosphodiesterase 4	BR86WU	3,4-Dimethoxy-N-methylsulfonyl-N-(pyridin-3-ylmethyl)benzenesulfonamide	Investigative	44322857	C15H18N2O6S2	386.4	COC1=C(C=C(C=C1)S(=O)(=O)N(CC2=CN=CC=C2)S(=O)(=O)C)OC	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	BS0Y3E	3-Ethylxanthine	Investigative	350737	C7H8N4O2	180.16	CCN1C2=C(C(=O)NC1=O)NC=N2	Ki = 63000 nM	Poor binder
T47941	Phosphodiesterase 4	BS4MT6	4-Propyl-8,9,10,11-tetrahydro-7H-[1,3]diazepino[2,1-f]purin-5-one	Investigative	135456675	C12H17N5O	247.3	CCCN1C2=NC=NC2=C3NCCCCN3C1=O	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BS59GH	8-S-Benzyl cyclic AMP	Investigative	94432	C17H18N5O6PS	451.4	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C4=NC=NC(=C4N=C3SCC5=CC=CC=C5)N)O)OP(=O)(O1)O	IC50 = 53000 nM	Poor binder
T47941	Phosphodiesterase 4	BS9BC0	4-Ethyl-5-[2-methyl-4-(2-methylimidazol-1-yl)benzoyl]-1,3-dihydroimidazol-2-one	Investigative	13815984	C17H18N4O2	310.35	CCC1=C(NC(=O)N1)C(=O)C2=C(C=C(C=C2)N3C=CN=C3C)C	IC50 = 73000 nM	Poor binder
T47941	Phosphodiesterase 4	BSK4L9	4-(2-Methoxy-4-pentanoylphenoxy)piperidine-1-carboxylic Acidtert-Butyl Ester	Investigative	25178733	C22H33NO5	391.5	CCCCC(=O)C1=CC(=C(C=C1)OC2CCN(CC2)C(=O)OC(C)(C)C)OC	IC50 = 93000 nM	Poor binder
T47941	Phosphodiesterase 4	BT5XB3	1-(6-Chloro-9H-purin-9-yl)-1-deoxy-beta-D-ribofuranose 3,5-phosphoric acid	Investigative	12922953	C10H10ClN4O6P	348.63	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=CN=C4Cl)O)OP(=O)(O1)O	IC50 = 77000 nM	Poor binder
T47941	Phosphodiesterase 4	BTWJ31	1,3-Bis(cyclopropylmethyl)-7-[[4-(trifluoromethyl)phenyl]sulfonyl]-8-aminoxanthine	Investigative	10096810	C20H20F3N5O4S	483.5	C1CC1CN2C3=C(C(=O)N(C2=O)CC4CC4)N(C(=N3)N)S(=O)(=O)C5=CC=C(C=C5)C(F)(F)F	IC50 = 54000 nM	Poor binder
T47941	Phosphodiesterase 4	BUG1C3	(4Ar,6R,7R,7aS)-6-[6,8-bis(methylsulfanyl)purin-9-yl]-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol	Investigative	21829362	C12H15N4O6PS2	406.4	CSC1=NC=NC2=C1N=C(N2[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O)SC	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	BUMH09	6-(3,4-Dimethoxyphenyl)-3-(2-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	3829988	C19H18N4O2S	366.4	CC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=CC(=C(C=C4)OC)OC	IC50 = 141000 nM	Poor binder
T47941	Phosphodiesterase 4	BURX95	N,N-Diethyladenosine 3',5'-phosphoric acid	Investigative	14803281	C14H20N5O6P	385.31	CCN(CC)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)O)O	IC50 = 67000 nM	Poor binder
T47941	Phosphodiesterase 4	BUY8C7	3-(2,6-Dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl)-propionic acid	Investigative	10061430	C11H14N4O4	266.25	CCCN1C2=C(C(=O)N(C1=O)CCC(=O)O)NC=N2	Ki = 60000 nM	Poor binder
T47941	Phosphodiesterase 4	BV8A6B	1-(3-Bromo-4,5-dimethoxyphenyl)-3-[[4-(2-hydroxyethyl)piperazino]carbonyl]-6-methoxy-2-naphthoic acid methyl ester	Investigative	10674875	C28H31BrN2O7	587.5	COC1=CC2=CC(=C(C(=C2C=C1)C3=CC(=C(C(=C3)Br)OC)OC)C(=O)OC)C(=O)N4CCN(CC4)CCO	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BW5P2I	1,3-Bis(cyclopropylmethyl)-7-(3,4,5-trimethoxybenzyl)-8-[[(4-methoxyphenyl)sulfonyl]amino]xanthine	Investigative	11764545	C30H35N5O8S	625.7	COC1=CC=C(C=C1)S(=O)(=O)NC2=NC3=C(N2CC4=CC(=C(C(=C4)OC)OC)OC)C(=O)N(C(=O)N3CC5CC5)CC6CC6	IC50 = 56000 nM	Poor binder
T47941	Phosphodiesterase 4	BX3FA2	3,6-Bis(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	3492181	C20H20N4O4S	412.5	COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=C(C=C4)OC)OC)OC	IC50 = 177000 nM	Poor binder
T47941	Phosphodiesterase 4	BX6E1G	N-[(11R)-6-Nitro-12-oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]isoquinoline-3-carboxamide	Investigative	10695964	C27H19N5O4	477.5	C1CN2C(=O)[C@@H](N=C(C3=CC(=CC1=C32)[N+](=O)[O-])C4=CC=CC=C4)NC(=O)C5=CC6=CC=CC=C6C=N5	IC50 ~ 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BXD6H7	Triazolothiadiazine, 5D	Investigative	17757132	C20H20N4O4S	412.5	COC1=C(C=C(C=C1)C2=NN3C(=NN=C3SC2)C4=C(C(=CC=C4)OC)OC)OC	IC50 = 112000 nM	Poor binder
T47941	Phosphodiesterase 4	BXL2C9	N-[(11S)-12-Oxo-9-phenyl-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7,9-tetraen-11-yl]-1H-indole-2-carboxamide	Investigative	11742876	C26H20N4O2	420.5	C1CN2C(=O)[C@H](N=C(C3=CC=CC1=C32)C4=CC=CC=C4)NC(=O)C5=CC6=CC=CC=C6N5	IC50 = 100000 nM	Poor binder
T47941	Phosphodiesterase 4	BYD3N9	Benzenesulfonamide, 3,4-dimethoxy-N-(2-cyanoethyl)-	Investigative	608456	C11H14N2O4S	270.31	COC1=C(C=C(C=C1)S(=O)(=O)NCCC#N)OC	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	BZ1RM7	N-Benzyl-2-(piperidinomethyl)thieno[3,2-d]pyrimidine-4-amine	Investigative	10759471	C19H22N4S	338.5	C1CCN(CC1)CC2=NC3=C(C(=N2)NCC4=CC=CC=C4)SC=C3	IC50 = 65000 nM	Poor binder
T47941	Phosphodiesterase 4	BZK5U3	6-(3,4-Dimethoxyphenyl)-3-(2-ethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	17757166	C20H20N4O3S	396.5	CCOC1=CC=CC=C1C2=NN=C3N2N=C(CS3)C4=CC(=C(C=C4)OC)OC	IC50 = 50000 nM	Poor binder
T47941	Phosphodiesterase 4	BZO26T	1-(4-Methoxy-3-(tetrahydrofuran-3-yloxy)phenyl)butan-1-ol	Investigative	25178111	C15H22O4	266.33	CCCC(C1=CC(=C(C=C1)OC)OC2CCOC2)O	IC50 = 100000 nM	Poor binder
T47941	Phosphodiesterase 4	D0A2WH	1-Butyl-3,7-dihydro-purine-2,6-dione	Investigative	14969715	C9H12N4O2	208.22	CCCCN1C(=O)C2=C(NC1=O)N=CN2	Ki = 71100 nM	Poor binder
T47941	Phosphodiesterase 4	D0F1AS	1-METHYLXANTHINE	Investigative	80220	C6H6N4O2	166.14	CN1C(=O)C2=C(NC1=O)N=CN2	Ki = 163000 nM	Poor binder
T47941	Phosphodiesterase 4	D0M5NU	N6 benzyl-cAMP	Investigative	161733	C17H18N5O6P	419.3	C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)NCC5=CC=CC=C5)O)OP(=O)(O1)O	IC50 = 130000 nM	Poor binder
T47941	Phosphodiesterase 4	D0S4JI	9-BENZYL-9H-ADENINE	Investigative	20262	C12H11N5	225.25	C1=CC=C(C=C1)CN2C=NC3=C(N=CN=C32)N	IC50 = 160000 nM	Poor binder