TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T49507	Ephrin type-B receptor 4	D0YX2B	PMID28460551-Compound-2	Patented	5329102	C22H27FN4O2	398.5	CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)F)NC2=O)C	IC50 ~ 50000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B1J8DP	1-Isopropyl-3-(1-methyl-1H-indol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905221	C17H18N6	306.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)N(C=C4)C)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B1WJT8	Tert-Butyl {4-[4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]-2-Methoxyphenyl}carbamate	Investigative	24905150	C20H26N6O3	398.5	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)NC(=O)OC(C)(C)C)OC)N	IC50 ~ 50000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B1Z5LD	5-(4-Amino-3-(3-hydroxy-4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pentanenitrile	Investigative	24905329	C16H15FN6O	326.33	C1=CC(=C(C=C1C2=NN(C3=NC=NC(=C23)N)CCCCC#N)O)F	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B23SCK	5-[4-Amino-1-[(3R)-pyrrolidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-fluorophenol	Investigative	24905310	C15H15FN6O	314.32	C1CNC[C@@H]1N2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)F)O)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B2BMA6	1-Isopropyl-3-(pyrido[3,2-b]pyrazin-7-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905225	C15H14N8	306.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=NC=CN=C4N=C3)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B46VQO	1-(3-(8-(Piperidin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea	Investigative	46878686	C26H26F3N7O	509.5	C1CNCCC1CNC2=NC(=CN3C2=NC=C3)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(F)(F)F	IC50 = 50000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B4HX3I	1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905171	C12H13N7	255.28	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=CN=C3)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B4K5EC	3-(2-(Hydrazine)quinolin-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905228	C17H18N8	334.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)N=C(C=C4)NN)N	IC50 = 87000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B6NC3V	N-[4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamide	Investigative	24905161	C15H18N6O2S	346.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)NS(=O)(=O)C)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B73VJZ	3-(4-Bromo-3-(methoxymethoxy)phenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905336	C16H18BrN5O2	392.25	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)Br)OCOC)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B7ILR1	2-[4-Amino-3-(3-ethoxy-4-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethanol	Investigative	52940797	C16H19N5O3	329.35	CCOC1=C(C=CC(=C1)C2=NN(C3=NC=NC(=C23)N)CCO)OC	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B9DA2Y	N-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(trifluoromethyl)benzenesulfonamide	Investigative	46878690	C25H19F3N6O2S	524.5	C1=CC(=CC(=C1)NS(=O)(=O)C2=CC=CC(=C2)C(F)(F)F)C3=CN4C=CN=C4C(=N3)NCC5=CC=NC=C5	IC50 = 50000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B9QYC4	5-(4-Amino-1-((S)-pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenol	Investigative	24905311	C16H18N6O2	326.35	COC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)[C@@H]4CCNC4)O	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	B9SP2F	(3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)methanol	Investigative	24905344	C15H17N5O	283.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC(=C3)CO)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BB2S4A	2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one	Investigative	24905149	C28H23N7O2	489.5	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=NC=NC(=C5C(=N4)C6=CC(=CC=C6)O)N	IC50 ~ 50000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BB6J1Q	1-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)ethanone	Investigative	24905155	C16H17N5O	295.34	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)C(=O)C)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BB8J4R	3-(Benzo[c][1,2,5]oxadiazol-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905165	C14H13N7O	295.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=NON=C4C=C3)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BBWU45	6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one	Investigative	24905227	C19H18N6O	346.4	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC5=C(C=C4)NC(=O)C=C5)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BC23WJ	3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905246	C15H15N7	293.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=NC=CN4C=C3)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BD6QZ4	1-Cyclohexyl-3-(4-ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905298	C20H25N5O2	367.4	CCOC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)C4CCCCC4)OC	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BDH5W2	5-(4-Amino-1-((S)-1-aminopropan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905323	C14H15FN6O	302.31	C[C@@H](CN)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)F)O)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BDJU98	1-Isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905170	C13H14N6	254.29	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=CC=C3)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BDT2O1	1-Allyl-3-(4-ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905297	C17H19N5O2	325.4	CCOC1=C(C=C(C=C1)C2=NN(C3=NC=NC(=C23)N)CC=C)OC	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BE8O6C	N-[3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenyl]-methanesulfonamide	Investigative	24905159	C15H18N6O2S	346.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=CC=C3)NS(=O)(=O)C)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BH1FA3	6-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-4H-chromen-4-one	Investigative	24905234	C15H11N5O2	293.28	CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC=CC4=O)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BH1N4K	5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)pyridine-2-carbonitrile	Investigative	24905341	C14H13N7	279.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=C(C=C3)C#N)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BJ8H1L	5h-Thieno[2,3-c]pyran-3-carboxamide, 4,7-dihydro-5,5-dimethyl-2-[[(phenylamino)carbonyl]amino]-	Investigative	777124	C17H19N3O3S	345.4	CC1(CC2=C(CO1)SC(=C2C(=O)N)NC(=O)NC3=CC=CC=C3)C	IC50 = 76000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BJR40B	5-(4-Amino-1-((piperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905301	C17H19FN6O	342.4	C1CNCCC1CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)F)O)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BKX54B	1-(3-(8-(Benzylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea	Investigative	46878646	C27H21F3N6O	502.5	C1=CC=C(C=C1)CNC2=NC(=CN3C2=NC=C3)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(F)(F)F	IC50 = 50000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BOA45D	3-(4-Ethoxy-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905292	C14H15N5O2	285.3	CCOC1=C(C=C(C=C1)C2=C3C(=NC=NC3=NN2)N)OC	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BOVT82	5-(4-Amino-1-((piperidin-3-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol	Investigative	24905299	C17H19ClN6O	358.8	C1CC(CNC1)CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BXBH56	1-(4-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea	Investigative	46878784	C26H20F3N7O	503.5	C1=CC(=CC(=C1)NC(=O)NC2=CC=C(C=C2)C3=CN4C=CN=C4C(=N3)NCC5=CC=NC=C5)C(F)(F)F	IC50 = 50000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BXD89Y	2-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetonitrile	Investigative	24905166	C16H16N6	292.34	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)CC#N)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BXW73J	5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905308	C21H15FN6O2	402.4	C1=CC=C(C=C1)C2=C(OC=N2)CN3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)F)O)N	IC50 = 100000 nM	Poor binder
T49507	Ephrin type-B receptor 4	BY7MP5	5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one	Investigative	118723185	C21H19N3O4	377.4	COC1=CC(=CC(=C1OC)OC)C2=NC(=CNC2=O)C3=CNC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder