TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T51076 NT-3 growth factor receptor B1A9DU N-(1H-Imidazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137659623 C18H16N4OS 336.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=NC=CN3)C4=CC=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B3WJ9F N-(Pyrimidin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137659402 C19H16N4OS 348.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=NC=CC=N3)C4=CC=CS4 IC50 = 58440 nM Poor binder T51076 NT-3 growth factor receptor B51FNC 2-(2-Pyridin-3-ylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide Investigative 137652057 C21H18N4O 342.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=CC=N3)C4=CN=CC=C4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B5JDG2 N-[(1-Methylimidazol-2-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137638843 C19H18N4OS 350.4 CN1C=CN=C1CNC(=O)CN2C3=CC=CC=C3C=C2C4=CC=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B67IKH N-(1H-Benzimidazol-2-ylmethyl)-2-[5-fluoro-2-(1,3-oxazol-2-yl)indol-1-yl]acetamide Investigative 137657779 C21H16FN5O2 389.4 C1=CC=C2C(=C1)NC(=N2)CNC(=O)CN3C4=C(C=C(C=C4)F)C=C3C5=NC=CO5 IC50 = 68750 nM Poor binder T51076 NT-3 growth factor receptor B68DHG N-(Pyridin-4-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137642417 C20H17N3OS 347.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=NC=C3)C4=CC=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B6K0AZ 2-(2-Phenylpyrrolo[3,2-b]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide Investigative 137656463 C21H18N4O 342.4 C1=CC=C(C=C1)C2=CC3=C(N2CC(=O)NCC4=CC=CC=N4)C=CC=N3 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B78VZH N-(2-Pyridin-2-ylethyl)-2-thiophen-2-ylindole-1-carboxamide Investigative 137641283 C20H17N3OS 347.4 C1=CC=C2C(=C1)C=C(N2C(=O)NCCC3=CC=CC=N3)C4=CC=CS4 IC50 = 80270 nM Poor binder T51076 NT-3 growth factor receptor B8ACN9 2-(2-Pyridin-2-ylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide Investigative 137652242 C21H18N4O 342.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=CC=N3)C4=CC=CC=N4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B97SQF N-(1H-Benzimidazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 121272745 C22H18N4OS 386.5 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=NC4=CC=CC=C4N3)C5=CC=CS5 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B9K7ND N-[(2-Phenyl-1H-imidazol-5-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137649400 C24H20N4OS 412.5 C1=CC=C(C=C1)C2=NC=C(N2)CNC(=O)CN3C4=CC=CC=C4C=C3C5=CC=CS5 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B9LH7N N-(1,3-Thiazol-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137661074 C18H15N3OS2 353.5 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=NC=CS3)C4=CC=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B9PGB1 N-(Pyridin-3-ylmethyl)-2-(2-thien-2-yl-1H-indol-1-yl)acetamide Investigative 20907256 C20H17N3OS 347.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CN=CC=C3)C4=CC=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor B9QD5X N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-carboxamide Investigative 137644894 C20H17N3OS 347.4 C1=CC=C2C(=C1)C=C(N2CCNC(=O)C3=CC=CC=N3)C4=CC=CS4 IC50 = 80020 nM Poor binder T51076 NT-3 growth factor receptor BA4FR1 2-(6-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide Investigative 137650528 C22H18FN3O 359.4 C1=CC=C(C=C1)C2=CC3=C(N2CC(=O)NCC4=CC=CC=N4)C=C(C=C3)F IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BB65DH N-(Pyridin-2-ylmethyl)-2-thiophen-2-ylindole-1-carboxamide Investigative 137647123 C19H15N3OS 333.4 C1=CC=C2C(=C1)C=C(N2C(=O)NCC3=CC=CC=N3)C4=CC=CS4 IC50 = 81160 nM Poor binder T51076 NT-3 growth factor receptor BDFK41 2-[2-(5-Methylfuran-2-yl)indol-1-yl]-N-(pyridin-2-ylmethyl)acetamide Investigative 137658125 C21H19N3O2 345.4 CC1=CC=C(O1)C2=CC3=CC=CC=C3N2CC(=O)NCC4=CC=CC=N4 IC50 = 73070 nM Poor binder T51076 NT-3 growth factor receptor BF9EA4 2-(2-Phenylpyrrolo[2,3-c]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide Investigative 137633567 C21H18N4O 342.4 C1=CC=C(C=C1)C2=CC3=C(N2CC(=O)NCC4=CC=CC=N4)C=NC=C3 IC50 = 51000 nM Poor binder T51076 NT-3 growth factor receptor BFC3I8 N-Methyl-N-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137658859 C21H19N3OS 361.5 CN(CC1=CC=CC=N1)C(=O)CN2C3=CC=CC=C3C=C2C4=CC=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BG5ZN2 N-(Pyridin-2-ylmethyl)-2-[2-(1,2-thiazol-3-yl)indol-1-yl]acetamide Investigative 137659789 C19H16N4OS 348.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=CC=N3)C4=NSC=C4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BKF8U2 2-(2-Phenylpyrrolo[3,2-c]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide Investigative 137655170 C21H18N4O 342.4 C1=CC=C(C=C1)C2=CC3=C(N2CC(=O)NCC4=CC=CC=N4)C=CN=C3 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BLSI07 N-(1H-Benzimidazol-2-ylmethyl)-2-[2-(1,3-oxazol-2-yl)indol-1-yl]acetamide Investigative 121272655 C21H17N5O2 371.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=NC4=CC=CC=C4N3)C5=NC=CO5 IC50 = 68160 nM Poor binder T51076 NT-3 growth factor receptor BM08KT N-(1H-Imidazol-5-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137632400 C18H16N4OS 336.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CN=CN3)C4=CC=CS4 IC50 = 120000 nM Poor binder T51076 NT-3 growth factor receptor BM6VF7 N-[(5-Phenyl-1H-imidazol-2-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137653271 C24H20N4OS 412.5 C1=CC=C(C=C1)C2=CN=C(N2)CNC(=O)CN3C4=CC=CC=C4C=C3C5=CC=CS5 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BM9N7I N-(Pyridin-2-ylmethyl)-2-[2-(1,3-thiazol-2-yl)indol-1-yl]acetamide Investigative 137638576 C19H16N4OS 348.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=CC=N3)C4=NC=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BN0GM1 2-[2-(1,3-Oxazol-2-yl)indol-1-yl]-N-(pyridin-2-ylmethyl)acetamide Investigative 137660998 C19H16N4O2 332.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=CC=N3)C4=NC=CO4 IC50 = 53490 nM Poor binder T51076 NT-3 growth factor receptor BQ40TL N-(Pyridin-2-ylmethyl)-2-[2-(1,3-thiazol-5-yl)indol-1-yl]acetamide Investigative 137640958 C19H16N4OS 348.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=CC=N3)C4=CN=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BS4EC8 2-(4-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide Investigative 137634804 C22H18FN3O 359.4 C1=CC=C(C=C1)C2=CC3=C(N2CC(=O)NCC4=CC=CC=N4)C=CC=C3F IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BS9Q0L N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-sulfonamide Investigative 137633612 C19H17N3O2S2 383.5 C1=CC=C2C(=C1)C=C(N2CCNS(=O)(=O)C3=CC=CC=N3)C4=CC=CS4 IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BU0NC8 N-(Imidazo[1,2-a]pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)acetamide Investigative 137657302 C22H18N4OS 386.5 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CN4C=CC=CC4=N3)C5=CC=CS5 IC50 = 71720 nM Poor binder T51076 NT-3 growth factor receptor BX1P0L 2-(5-Fluoro-2-phenylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide Investigative 137655709 C22H18FN3O 359.4 C1=CC=C(C=C1)C2=CC3=C(N2CC(=O)NCC4=CC=CC=N4)C=CC(=C3)F IC50 ~ 81010 nM Poor binder T51076 NT-3 growth factor receptor BXI4F2 N-(Pyridin-2-ylmethyl)-2-[2-(1,2-thiazol-5-yl)indol-1-yl]acetamide Investigative 137655675 C19H16N4OS 348.4 C1=CC=C2C(=C1)C=C(N2CC(=O)NCC3=CC=CC=N3)C4=CC=NS4 IC50 = 70240 nM Poor binder