TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T53251	Histone-lysine N-methyltransferase EHMT2	D02HFD	Glutathione	Approved	124886	C10H17N3O6S	307.33	C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	D07BDD	BAM-002	Approved	65359	C20H32N6O12S2	612.6	C(CC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N)C(=O)NCC(=O)O)[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B01LJI	(2S)-2-Amino-5-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid	Investigative	56642706	C18H28IN7O5	549.4	CNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CN(CCC[C@@H](C(=O)O)N)CCI)O)O	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B0O9LD	5'-[(R)-1-Amino-2-cyclopropylethyl]-5'-deoxyadenosine	Investigative	132609264	C15H22N6O3	334.37	C1CC1C[C@H](C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	IC50 = 67200 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B10XUQ	(1S,4S,7S,9S)-4-(Hydroxymethyl)-9-[(1S,4S,7S,9S)-4-(hydroxymethyl)-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-trien-9-yl]-5-methyl-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dione	Investigative	46192085	C30H32N6O6	572.6	CN1[C@H](C(=O)N2[C@H](C1=O)C[C@@]3([C@H]2NC4=CC=CC=C43)[C@@]56C[C@H]7C(=O)N([C@H](C(=O)N7[C@@H]5NC8=CC=CC=C68)CO)C)CO	IC50 ~ 50000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B26QPW	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-[2-(2-pyrrolidin-1-ylethoxy)ethoxy]quinazolin-4-amine	Investigative	46901789	C29H47N7O3	541.7	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCOCCN5CCCC5	IC50 = 57000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B29ZVO	6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	Investigative	78357767	C23H35N5O2	413.6	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B2Y0HT	(2R,3S,4R,5R)-2-[2-Amino-3-(3,4-dimethoxyphenyl)propyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol	Investigative	90655766	C20H26N6O5	430.5	COC1=C(C=C(C=C1)CC(C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N)OC	IC50 = 157000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B3E1WA	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-pentyloxolane-3,4-diol	Investigative	86288827	C14H21N5O3	307.35	CCCCC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O	IC50 = 103000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B3SKQ1	6-Deoxy-5a,6-didehydrogliotoxin	Investigative	9883072	C13H12N2O3S2	308.4	CN1C(=O)[C@]23CC4=CC=CC=C4N2C(=O)[C@]1(SS3)CO	IC50 = 55000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B3V5TI	6,7-Dimethoxy-2-(4-methylpiperazin-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	Investigative	44605024	C21H32N6O2	400.5	CN1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OC)N4CCN(CC4)C	IC50 = 150000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B4ZO3K	6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)-7-[3-[methyl(propyl)amino]propoxy]quinazolin-4-amine	Investigative	46901621	C28H47N7O2	513.7	CCCN(C)CCCOC1=C(C=C2C(=C1)N=C(N=C2NC3CCN(CC3)C)N4CCCN(CC4)C)OC	IC50 = 51000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B59BFA	7-[5-(Dimethylamino)pentoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	Investigative	46901454	C28H47N7O2	513.7	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCCCCN(C)C	IC50 = 95000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B5W3VF	Chembl4283782	Investigative	89821586	C33H39N5O2	537.7	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCCC3)NC4CCN(CC4)CC5=CC=CC=C5)OCC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B7O9XY	(1S,3R,11R,14R)-14-(Hydroxymethyl)-3-[(1S,3R,11R,14R)-14-(hydroxymethyl)-15-methyl-13,16-dioxo-17-thia-10,12,15-triazapentacyclo[12.2.1.01,12.03,11.04,9]heptadeca-4,6,8-trien-3-yl]-15-methyl-17-thia-10,12,15-triazapentacyclo[12.2.1.01,12.03,11.04,9]heptadeca-4,6,8-triene-13,16-dione	Investigative	71717376	C30H28N6O6S2	632.7	CN1C(=O)[C@@]23C[C@]4([C@@H](N2C(=O)[C@]1(S3)CO)NC5=CC=CC=C54)[C@]67C[C@@]89C(=O)N([C@](S8)(C(=O)N9[C@H]6NC1=CC=CC=C71)CO)C	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B7WQU2	N-(4-((2-Amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide	Investigative	24858111	C27H23N7O	461.5	CC1=CC(=NC(=N1)N)NC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)NC4=CC=NC5=CC=CC=C54	IC50 = 59000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B80TXL	Ninhydrin	Investigative	10236	C9H6O4	178.14	C1=CC=C2C(=C1)C(=O)C(C2=O)(O)O	IC50 = 54000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B81UOK	Bisdethiobis(methylthio)gliotoxin	Investigative	194564	C15H20N2O4S2	356.5	CN1C(=O)[C@@]2(CC3=CC=C[C@@H]([C@H]3N2C(=O)[C@@]1(CO)SC)O)SC	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B87AFH	Chembl4281110	Investigative	145982395	C29H38N4O3	490.6	COC1CCN(CC1)C2=CC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC	IC50 ~ 50000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B8K7OX	7-[3-(4,4-Difluoropiperidin-1-yl)propoxy]-6-methoxy-2-(oxan-4-yl)-N-(1-propan-2-ylpiperidin-4-yl)quinazolin-4-amine	Investigative	72714644	C30H45F2N5O3	561.7	CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCC(CC4)(F)F)C5CCOCC5	IC50 ~ 50000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B8VQ0F	(2S)-2-Amino-5-[[(2R,3S,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl-(2-iodoethyl)amino]pentanoic acid	Investigative	56642708	C24H32IN7O5	625.5	C1=CC=C(C=C1)CNC2=C3C(=NC=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CN(CCC[C@@H](C(=O)O)N)CCI)O)O	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	B8YU7O	7-[3-(Diethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	Investigative	46901457	C28H47N7O2	513.7	CCN(CC)CCCOC1=C(C=C2C(=C1)N=C(N=C2NC3CCN(CC3)C)N4CCCN(CC4)C)OC	IC50 = 52000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BB3FO8	Dehydrobis(methylthio)gliotoxin	Investigative	13989139	C15H18N2O4S2	354.4	CN1C(=O)[C@@]2(CC3=C(N2C(=O)[C@@]1(CO)SC)C(=CC=C3)O)SC	IC50 = 58000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BD3X9I	N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indazole-4-carboxamide	Investigative	67466175	C29H35N7O2	513.6	CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C)C	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BH06OY	7-[2-(Dimethylamino)ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	Investigative	46901285	C25H41N7O2	471.6	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCN(C)C	IC50 = 110000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BH48PI	N'-[2-[6-Methoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-[(1-methylpiperidin-4-yl)amino]quinazolin-7-yl]oxyethyl]-N,N,N'-trimethylethane-1,2-diamine	Investigative	46901935	C28H48N8O2	528.7	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCN(C)CCN(C)C	IC50 = 173000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BJR40Y	7-[4-(Dimethylamino)butoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	Investigative	46901453	C27H45N7O2	499.7	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCCCN(C)C	IC50 = 110000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BK51PI	(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(3-phenylpropyl)oxolane-3,4-diol	Investigative	90655765	C18H21N5O3	355.4	C1=CC=C(C=C1)CCC[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O	IC50 = 190000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BKZ52X	(1R,4R,7R,9R)-4-(Hydroxymethyl)-9-[(1R,4R,7R,9R)-4-(hydroxymethyl)-5-methyl-3,6-dioxo-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-trien-9-yl]-5-methyl-2,5,16-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-10,12,14-triene-3,6-dione	Investigative	46192084	C30H32N6O6	572.6	CN1[C@@H](C(=O)N2[C@@H](C1=O)C[C@]3([C@@H]2NC4=CC=CC=C43)[C@]56C[C@@H]7C(=O)N([C@@H](C(=O)N7[C@H]5NC8=CC=CC=C68)CO)C)CO	IC50 ~ 50000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BLA4S9	N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide	Investigative	54596764	C31H39N7O2	541.7	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BQ5LJ1	Cysteamine	Investigative	6058	C2H7NS	77.15	C(CS)N	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BRP8M5	7-(5-Aminopentoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	Investigative	46901787	C26H43N7O2	485.7	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCCCCN	IC50 = 110000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BT49KQ	(2R,3S,4R,5R)-2-[(2S)-2-Amino-3-cyclobutylpropyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol	Investigative	137640823	C16H24N6O3	348.4	C1CC(C1)C[C@@H](C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	IC50 = 169000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BV61WA	1-((2-(1H-Indol-3-yl)ethyl)amino)-3-(9H-carbazol-9-yl)-propan-2-ol	Investigative	16451230	C25H25N3O	383.5	C1=CC=C2C(=C1)C(=CN2)CCNCC(CN3C4=CC=CC=C4C5=CC=CC=C53)O	IC50 ~ 150000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BVM1C8	7-[3-(Dimethylamino)propoxy]-6-Methoxy-2-(4-Methyl-1,4-Diazepan-1-Yl)-N-(1-Methylpiperidin-4-Yl)quinazolin-4-Amine	Investigative	44251522	C26H43N7O2	485.7	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C)OC)OCCCN(C)C	IC50 = 57000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BW86ZU	Bis(dethio)-10a-methylthio-3a-deoxy-3,3a-didehydrogliotoxin	Investigative	57333568	C14H16N2O3S	292.36	CN1C(=C)C(=O)N2[C@@H]3[C@H](C=CC=C3C[C@]2(C1=O)SC)O	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BWR6L0	(2R,3S,4R,5R)-2-[(2S)-2-Amino-3-cyclopentylpropyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol	Investigative	137643972	C17H26N6O3	362.4	C1CCC(C1)C[C@@H](C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)O)N	IC50 = 191300 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	BY94KF	6-Methoxy-7-[3-(methylamino)propoxy]-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine	Investigative	46901456	C25H41N7O2	471.6	CNCCCOC1=C(C=C2C(=C1)N=C(N=C2NC3CCN(CC3)C)N4CCCN(CC4)C)OC	IC50 = 120000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	D02TVQ	GSK343	Investigative	71268957	C31H39N7O2	541.7	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C	IC50 ~ 100000 nM	Poor binder
T53251	Histone-lysine N-methyltransferase EHMT2	D0L5LN	ANTHRAQUINONE	Investigative	6780	C14H8O2	208.21	C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2=O	IC50 ~ 100000 nM	Poor binder