TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T53378	Carbonic anhydrase IV	D02PJA	Hydriodic acid iodine-125	Approved	24841	HI	127.912	I	Ki = 80000 nM	Poor binder
T53378	Carbonic anhydrase IV	D02URS	Potassium iodide	Approved	4875	IK	166.003	[K+].[I-]	Ki = 80000 nM	Poor binder
T53378	Carbonic anhydrase IV	D07CWD	Hydroxyurea	Approved	3657	CH4N2O2	76.055	C(=O)(N)NO	Ki = 113000 nM	Poor binder
T53378	Carbonic anhydrase IV	D0E9JM	Potassium Chloride	Approved	4873	ClK	74.55	[Cl-].[K+]	Ki = 90000 nM	Poor binder
T53378	Carbonic anhydrase IV	D0SC6I	Sodium benzoate	Phase 2/3	517055	C7H5NaO2	144.1	C1=CC=C(C=C1)C(=O)[O-].[Na+]	Ki = 74700 nM	Poor binder
T53378	Carbonic anhydrase IV	D0X2AU	Selenium compound 1	Patented	23427	C6H6O2Se	189.08	C1=CC=C(C=C1)[Se](=O)O	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	B1JOZ8	Bis(2-nitrophenyl) diselenide	Investigative	101424	C12H8N2O4Se2	402.1	C1=CC=C(C(=C1)[N+](=O)[O-])[Se][Se]C2=CC=CC=C2[N+](=O)[O-]	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	B36YTS	3-(4-Methoxyphenyl)-4-tosyl-3,4-dihydro-2H-1,4-benzoselenazine	Investigative	101564149	C22H21NO3SSe	458.4	CC1=CC=C(C=C1)S(=O)(=O)N2C(C[Se]C3=CC=CC=C32)C4=CC=C(C=C4)OC	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	B4NO8M	3-(4-Methoxyphenyl)-4-tosyl-6-chloro-3,4-dihydro-2H-1,4-benzoselenazine	Investigative	132547793	C22H20ClNO3SSe	492.9	CC1=CC=C(C=C1)S(=O)(=O)N2C(C[Se]C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)OC	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	B6K2SQ	5-[1-Hydroxy-2-[[2-hydroxy-2-(3-hydroxy-4-methoxyphenyl)ethyl]diselanyl]ethyl]-2-methoxyphenol	Investigative	137642864	C18H22O6Se2	492.3	COC1=C(C=C(C=C1)C(C[Se][Se]CC(C2=CC(=C(C=C2)OC)O)O)O)O	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	B72KYJ	Hydrofluoric acid	Investigative	14917	FH	20.006	F	Ki = 70000 nM	Poor binder
T53378	Carbonic anhydrase IV	B8D2BK	N-[(S)-1-[(Phenylseleno)methyl]-3-methylbutyl]-p-toluenesulfonamide	Investigative	102311866	C19H25NO2SSe	410.4	CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC(C)C)C[Se]C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	B8TDZ9	Spermine(hbbh)	Investigative	389642	C20H42N4O4	402.6	CC(C)(C)OC(=O)N(CCCCN(CCCN)C(=O)OC(C)(C)C)CCCN	Ki = 103000 nM	Poor binder
T53378	Carbonic anhydrase IV	B9Z6GL	Sulfamic acid	Investigative	5987	H3NO3S	97.1	NS(=O)(=O)O	Ki = 90000 nM	Poor binder
T53378	Carbonic anhydrase IV	BAB06K	1,1'-Selanediyldi(3-benzyloxypropan-2-ol)	Investigative	122386532	C20H26O4Se	409.4	C1=CC=C(C=C1)COCC(C[Se]CC(COCC2=CC=CC=C2)O)O	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BC6XN1	Hydrogen bromide	Investigative	260	BrH	80.91	Br	Ki = 90000 nM	Poor binder
T53378	Carbonic anhydrase IV	BF48BA	3-(4-Methoxyphenyl)-4-(2-nitrophenylsulfonyl)-6-chloro-3,4-dihydro-2H-1,4-benzoselenazine	Investigative	132547798	C21H17ClN2O5SSe	523.9	COC1=CC=C(C=C1)C2C[Se]C3=C(N2S(=O)(=O)C4=CC=CC=C4[N+](=O)[O-])C=C(C=C3)Cl	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BFNJ79	2-Hydroxycinnamic acid	Investigative	637540	C9H8O3	164.16	C1=CC=C(C(=C1)/C=C/C(=O)O)O	Ki = 62300 nM	Poor binder
T53378	Carbonic anhydrase IV	BG9IX6	1-Bromo-3,5-bis[(2,3-dibromo-4,5-dimethoxyphenyl)methyl]-2,4,6-trimethoxybenzene	Investigative	66573254	C27H27Br5O7	863	COC1=C(C(=C(C(=C1)CC2=C(C(=C(C(=C2OC)Br)OC)CC3=CC(=C(C(=C3Br)Br)OC)OC)OC)Br)Br)OC	Ki = 57610 nM	Poor binder
T53378	Carbonic anhydrase IV	BHGC36	4-Methyl-N-[(2S)-3-methyl-1-[(2S)-3-methyl-2-[(4-methylphenyl)sulfonylamino]butyl]selanylbutan-2-yl]benzenesulfonamide	Investigative	137643671	C24H36N2O4S2Se	559.7	CC1=CC=C(C=C1)S(=O)(=O)N[C@H](C[Se]C[C@H](C(C)C)NS(=O)(=O)C2=CC=C(C=C2)C)C(C)C	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BHIG92	2-[(2-Amino-4-methylphenyl)diselanyl]-5-methylaniline	Investigative	137634525	C14H16N2Se2	370.2	CC1=CC(=C(C=C1)[Se][Se]C2=C(C=C(C=C2)C)N)N	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BMG38O	Potassium fluoride	Investigative	522689	FK	58.097	[F-].[K+]	Ki = 70000 nM	Poor binder
T53378	Carbonic anhydrase IV	BMU5R0	1-{2-Fluoro-4-[(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-3-{[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl}thiourea	Investigative	44430524	C21H27FN6O9S4	654.7	CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)CNC(=S)NC4=C(C=C(C=C4)S(=O)(=O)NC5=NN=C(S5)S(=O)(=O)N)F)C	Ki = 89300 nM	Poor binder
T53378	Carbonic anhydrase IV	BN35LF	4-Methyl-N-[5-methyl-2-[[4-methyl-2-[(4-methylphenyl)sulfonylamino]phenyl]diselanyl]phenyl]benzenesulfonamide	Investigative	137639833	C28H28N2O4S2Se2	678.6	CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CC(=C2)C)[Se][Se]C3=C(C=C(C=C3)C)NS(=O)(=O)C4=CC=C(C=C4)C	Ki = 78900 nM	Poor binder
T53378	Carbonic anhydrase IV	BNK20S	(3,4-Diacetyloxy-2,5,6-tribromophenyl)methyl acetate	Investigative	57397836	C13H11Br3O6	502.93	CC(=O)OCC1=C(C(=C(C(=C1Br)Br)OC(=O)C)OC(=O)C)Br	Ki = 102400 nM	Poor binder
T53378	Carbonic anhydrase IV	BNKI43	2,3,6-Tribromo-4,5-dimethoxybenzyl alcohol	Investigative	57397664	C9H9Br3O3	404.88	COC1=C(C(=C(C(=C1Br)CO)Br)Br)OC	Ki = 104410 nM	Poor binder
T53378	Carbonic anhydrase IV	BP8KU1	Bis[2-hydroxy-3-(benzyloxy)propyl] perselenide	Investigative	102480165	C20H26O4Se2	488.4	C1=CC=C(C=C1)COCC(C[Se][Se]CC(COCC2=CC=CC=C2)O)O	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BQ9BT2	Sodium malate	Investigative	8736	C4H4Na2O5	178.05	C(C(C(=O)[O-])O)C(=O)[O-].[Na+].[Na+]	Ki = 53700 nM	Poor binder
T53378	Carbonic anhydrase IV	BR12TI	Potassium bromide	Investigative	253877	BrK	119	[K+].[Br-]	Ki = 90000 nM	Poor binder
T53378	Carbonic anhydrase IV	BS0KE1	2-(4-Hydroxyphenyl)benzo[b]selenophene-5,7-diol	Investigative	122226189	C14H10O3Se	305.2	C1=CC(=CC=C1C2=CC3=CC(=CC(=C3[Se]2)O)O)O	Ki = 56800 nM	Poor binder
T53378	Carbonic anhydrase IV	BS58HU	N1,N3-Bis(2-(2,2,2-trifluoroacetamido)ethyl)-propane-1,3-diaminium trifluoroacetate	Investigative	46899573	C11H18F6N4O2	352.28	C(CNCCNC(=O)C(F)(F)F)CNCCNC(=O)C(F)(F)F	Ki = 108000 nM	Poor binder
T53378	Carbonic anhydrase IV	BTFJ40	9-(4-Methylphenyl)sulfonyl-2,3,3a,9a-tetrahydrofuro[3,2-b][1,4]benzoselenazine	Investigative	137661006	C17H17NO3SSe	394.4	CC1=CC=C(C=C1)S(=O)(=O)N2C3C(CCO3)[Se]C4=CC=CC=C42	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BUZ9G2	1,2,5-Tribromo-3,4-dimethoxybenzene	Investigative	57399336	C8H7Br3O2	374.85	COC1=C(C(=C(C=C1Br)Br)Br)OC	Ki = 163360 nM	Poor binder
T53378	Carbonic anhydrase IV	BV0I2K	N1,N12-Bis(trifluoroacetyl)-N4,N8-bis(t-butoxycarbonyl)spermine	Investigative	389641	C24H40F6N4O6	594.6	CC(C)(C)OC(=O)N(CCCCN(CCCNC(=O)C(F)(F)F)C(=O)OC(C)(C)C)CCCNC(=O)C(F)(F)F	Ki = 104000 nM	Poor binder
T53378	Carbonic anhydrase IV	BX3M4O	2-(4-Hydroxyphenyl)-4,6-dichlorobenzo[b]selenophene-5,7-diol	Investigative	122226187	C14H8Cl2O3Se	374.1	C1=CC(=CC=C1C2=CC3=C(C(=C(C(=C3[Se]2)O)Cl)O)Cl)O	Ki = 52400 nM	Poor binder
T53378	Carbonic anhydrase IV	BXK3N0	1-(Phenylseleno)-3-(benzyloxy)-2-propanol	Investigative	11034581	C16H18O2Se	321.3	C1=CC=C(C=C1)COCC(C[Se]C2=CC=CC=C2)O	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BYC75Q	4-[(3,4-Dimethoxyphenyl)methyl]-1,2-dimethoxybenzene	Investigative	284045	C17H20O4	288.34	COC1=C(C=C(C=C1)CC2=CC(=C(C=C2)OC)OC)OC	Ki = 145120 nM	Poor binder
T53378	Carbonic anhydrase IV	BYG5E7	1-(Phenylseleno)-2-propanol	Investigative	11183499	C9H12OSe	215.16	CC(C[Se]C1=CC=CC=C1)O	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BYL4J9	3-(4-Methoxyphenyl)-4-(2-nitrophenyl)sulfonyl-2,3-dihydro-1,4-benzoselenazine	Investigative	137650698	C21H18N2O5SSe	489.4	COC1=CC=C(C=C1)C2C[Se]C3=CC=CC=C3N2S(=O)(=O)C4=CC=CC=C4[N+](=O)[O-]	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	BZ4MK5	Bis[(S)-2-(tosylamino)-3-phenylpropyl] perselenide	Investigative	102151151	C32H36N2O4S2Se2	734.7	CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC=CC=C2)C[Se][Se]C[C@H](CC3=CC=CC=C3)NS(=O)(=O)C4=CC=C(C=C4)C	Ki ~ 100000 nM	Poor binder
T53378	Carbonic anhydrase IV	D09WVV	N1-(2-aminoethyl)ethane-1,2-diamine	Investigative	8111	C4H13N3	103.17	C(CNCCN)N	Ki = 116000 nM	Poor binder
T53378	Carbonic anhydrase IV	D0C7LR	LLZ16406	Investigative	313	ClH	36.46	Cl	Ki = 90000 nM	Poor binder
T53378	Carbonic anhydrase IV	D0G6OW	Sodium 2,3,5,6-tetrafluorobenzoate	Investigative	23675285	C7HF4NaO2	216.06	C1=C(C(=C(C(=C1F)F)C(=O)[O-])F)F.[Na+]	Ki = 74500 nM	Poor binder
T53378	Carbonic anhydrase IV	D0LU4S	7-butoxy-2H-chromen-2-one	Investigative	156219	C13H14O3	218.25	CCCCOC1=CC2=C(C=C1)C=CC(=O)O2	Ki = 61200 nM	Poor binder