TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T55959	Dopamine transporter	D01UTL	Desipramine	Approved	2995	C18H22N2	266.4	CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31	IC50 = 50500 nM	Poor binder
T55959	Dopamine transporter	B09YKM	(2S,3S)-2-Biphenyl-4-yl-3,5,5-trimethylmorpholin-2-ol	Investigative	46837783	C19H23NO2	297.4	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC=C(C=C2)C3=CC=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	B0GBP4	2-(Benzhydrylsulfinylmethyl)-4-methoxy-6-methylpyrimidine	Investigative	137640164	C20H20N2O2S	352.5	CC1=CC(=NC(=N1)CS(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)OC	IC50 = 90500 nM	Poor binder
T55959	Dopamine transporter	B0IV1N	(R)-N-(Naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)methanesulfonamide	Investigative	45487762	C16H20N2O2S	304.4	CS(=O)(=O)N(CC1=CC2=CC=CC=C2C=C1)[C@@H]3CCNC3	IC50 ~ 68000 nM	Poor binder
T55959	Dopamine transporter	B0ON2P	Radafaxine	Investigative	9795056	C13H18ClNO2	255.74	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=CC=C2)Cl)O	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	B26CVM	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide	Investigative	743974	C16H19NO3S	305.4	CC1=CC(=C(C(=C1)C)NS(=O)(=O)C2=CC=C(C=C2)OC)C	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	B2F1KT	(cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one	Investigative	25258806	C21H27BrN2O3	435.4	COC1=C(C=C(C=C1)C2=NN(C(=O)[C@H]3[C@@H]2CC=CC3)CCCCCBr)OC	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	B2M0OR	6-Hydroxy-8-methyl-3-phenyl-8-aza-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester	Investigative	44322646	C16H19NO3	273.33	CN1C2C[C@@H](C1CC(=C2C(=O)OC)C3=CC=CC=C3)O	IC50 ~ 150000 nM	Poor binder
T55959	Dopamine transporter	B3SAG0	(2S,3S)-2-(4-Methoxyphenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837782	C14H21NO3	251.32	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC=C(C=C2)OC)O	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	B3Z8AN	2-(Benzhydrylsulfinylmethyl)-5-methylpyrimidine	Investigative	137645725	C19H18N2OS	322.4	CC1=CN=C(N=C1)CS(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 155700 nM	Poor binder
T55959	Dopamine transporter	B4ER7L	4-Hydroxy Duloxetine	Investigative	29981497	C18H19NO2S	313.4	CNCC[C@@H](C1=CC=CS1)OC2=CC=C(C3=CC=CC=C32)O	Ki = 130000 nM	Poor binder
T55959	Dopamine transporter	B5VWF6	Methyl 2-(4-chlorophenyl)cyclohex-1-enecarboxylate	Investigative	44429201	C14H15ClO2	250.72	COC(=O)C1=C(CCCC1)C2=CC=C(C=C2)Cl	Ki = 85000 nM	Poor binder
T55959	Dopamine transporter	B60AOI	(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one	Investigative	11044358	C16H18N2O3	286.33	COC1=C(C=C(C=C1)C2=NNC(=O)[C@H]3[C@@H]2CC=CC3)OC	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	B7UX3J	Methyl 3-(3-fluoro-4-methylphenyl)bicyclo[2.2.1]hept-2-ene-2-carboxylate	Investigative	44434887	C16H17FO2	260.3	CC1=C(C=C(C=C1)C2=C(C3CCC2C3)C(=O)OC)F	Ki = 56000 nM	Poor binder
T55959	Dopamine transporter	B8AMK4	(2-{5-[2-(5-Fluoro-2-methoxy-phenyl)-ethyl]-tetrahydro-furan-2-yl}-ethyl)-methyl-amine	Investigative	25258809	C16H24FNO2	281.37	CNCCC1CCC(O1)CCC2=C(C=CC(=C2)F)OC	Ki = 66988 nM	Poor binder
T55959	Dopamine transporter	B8M0AW	5-(Benzhydrylsulfinylmethyl)-4-propan-2-ylthiadiazole	Investigative	137646579	C19H20N2OS2	356.5	CC(C)C1=C(SN=N1)CS(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 69100 nM	Poor binder
T55959	Dopamine transporter	B94ZVL	Methyl 2-(3-aminophenyl)cyclopent-1-enecarboxylate	Investigative	44429198	C13H15NO2	217.26	COC(=O)C1=C(CCC1)C2=CC(=CC=C2)N	Ki = 121000 nM	Poor binder
T55959	Dopamine transporter	B9TC4K	5-((S)-3-Methylamino-1-thiophen-2-yl-propoxy)-naphthalen-2-ol	Investigative	10086952	C18H19NO2S	313.4	CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=C2C=CC(=C3)O	Ki = 163500 nM	Poor binder
T55959	Dopamine transporter	B9Z7FX	trans-2-Aminoethyl-5-(2''-methoxy-5''-fluorobenzyl)-tetrahydrofuran	Investigative	44590691	C14H20FNO2	253.31	COC1=C(C=C(C=C1)F)C[C@H]2CC[C@@H](O2)CCN	Ki = 51020 nM	Poor binder
T55959	Dopamine transporter	BBD3Y0	cis-2-Aminomethyl-5-(2''-methoxy-5''-fluorophenylmethyl)tetrahydrofuran	Investigative	11499666	C13H18FNO2	239.29	COC1=C(C=C(C=C1)F)C[C@@H]2CC[C@@H](O2)CN	Ki = 97180 nM	Poor binder
T55959	Dopamine transporter	BD8I5B	(-)-O-Methylcubebin	Investigative	59800034	C21H22O6	370.4	COC1[C@H]([C@@H](CO1)CC2=CC3=C(C=C2)OCO3)CC4=CC5=C(C=C4)OCO5	IC50 = 78600 nM	Poor binder
T55959	Dopamine transporter	BGH80W	3,5,5-Trimethyl-2-(pyridin-3-yl)morpholin-2-ol	Investigative	49799236	C12H18N2O2	222.28	CC1C(OCC(N1)(C)C)(C2=CN=CC=C2)O	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	BK3MR2	4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one	Investigative	22337182	C16H18N2O3	286.33	COC1=C(C=C(C=C1)C2=NNC(=O)C3C2CC=CC3)OC	Ki ~ 100000 nM	Poor binder
T55959	Dopamine transporter	BMH3O1	2-(Benzhydrylsulfinylmethyl)-4-methyl-1H-pyrimidin-6-one	Investigative	137653202	C19H18N2O2S	338.4	CC1=CC(=O)NC(=N1)CS(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 109000 nM	Poor binder
T55959	Dopamine transporter	BNEF42	Dimethyl phthalate	Investigative	8554	C10H10O4	194.18	COC(=O)C1=CC=CC=C1C(=O)OC	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	BO3D5E	4-(Benzhydrylsulfinylmethyl)-2,6-dimethylpyrimidine	Investigative	137658186	C20H20N2OS	336.5	CC1=CC(=NC(=N1)C)CS(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 82600 nM	Poor binder
T55959	Dopamine transporter	BP9U0D	(3S,4S)-Methyl 4-(3,4-dichlorophenyl)-1-methylpiperidine-3-carboxylate	Investigative	44429174	C14H17Cl2NO2	302.2	CN1CC[C@@H]([C@@H](C1)C(=O)OC)C2=CC(=C(C=C2)Cl)Cl	Ki = 59400 nM	Poor binder
T55959	Dopamine transporter	BPI13X	3-Biphenyl-2-yl-8-chloromethyl-8-methyl-8-azonia-bicyclo[3.2.1]oct-2-ene	Investigative	44405871	C21H23ClN+	324.9	C[N+]1(C2CCC1C=C(C2)C3=CC=CC=C3C4=CC=CC=C4)CCl	IC50 = 67000 nM	Poor binder
T55959	Dopamine transporter	BPUA81	5-(Benzhydrylsulfinylmethyl)-3-methyl-1,2,4-oxadiazole	Investigative	137641359	C17H16N2O2S	312.4	CC1=NOC(=N1)CS(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 56700 nM	Poor binder
T55959	Dopamine transporter	BQ85RH	Methyl biphenyl-2-carboxylate	Investigative	9920766	C14H12O2	212.24	COC(=O)C1=CC=CC=C1C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	BS8XE2	(2-(3,4-Dichlorophenyl)cyclopent-1-enyl)(pyrrolidin-1-yl)methanone	Investigative	44443875	C16H17Cl2NO	310.2	C1CCN(C1)C(=O)C2=C(CCC2)C3=CC(=C(C=C3)Cl)Cl	Ki = 58000 nM	Poor binder
T55959	Dopamine transporter	BSU5R7	Methyl 3-(4-nitrophenyl)-7-aza-bicyclo[2.2.1]hept-2-ene-2-carboxylate	Investigative	23661668	C14H14N2O4	274.27	COC(=O)C1=C(C2CCC1N2)C3=CC=C(C=C3)[N+](=O)[O-]	Ki = 67900 nM	Poor binder
T55959	Dopamine transporter	BT4A9G	2-(5-Bromo-pentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one	Investigative	22337167	C21H27BrN2O3	435.4	COC1=C(C=C(C=C1)C2=NN(C(=O)C3C2CC=CC3)CCCCCBr)OC	Ki ~ 100000 nM	Poor binder
T55959	Dopamine transporter	BV2UL1	3,5,5-Trimethyl-2-(pyridin-2-yl)morpholin-2-ol	Investigative	49799237	C12H18N2O2	222.28	CC1C(OCC(N1)(C)C)(C2=CC=CC=N2)O	IC50 ~ 100000 nM	Poor binder
T55959	Dopamine transporter	BVJ7L3	Methyl 2-(4-methoxyphenyl)cyclopent-1-enecarboxylate	Investigative	44429193	C14H16O3	232.27	COC1=CC=C(C=C1)C2=C(CCC2)C(=O)OC	Ki = 140000 nM	Poor binder
T55959	Dopamine transporter	BW42MI	US9085531, 4-(3,5-dimethyl-isoxazol-4-yl	Investigative	118796715	C15H18N2O	242.32	CC1=C(C(=NO1)C)C2CN(CC3=CC=CC=C23)C	Ki = 128000 nM	Poor binder
T55959	Dopamine transporter	BWE36C	4-(Benzhydrylsulfinylmethyl)pyridine	Investigative	137650031	C19H17NOS	307.4	C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC3=CC=NC=C3	IC50 = 63500 nM	Poor binder
T55959	Dopamine transporter	BX4NW6	(1R,4S,8R,10S,13R,18R,21R,27S,30S,33S)-30-(4-Aminobutyl)-18-[[(2S)-2-[[2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-8-hydroxy-27-[(4-hydroxyphenyl)methyl]-4-(1H-imidazol-5-ylmethyl)-33-(2-methylpropyl)-2,5,11,19,22,25,28,31,34-nonaoxo-15,16,37,38-tetrathia-3,6,12,20,23,26,29,32,35-nonazatricyclo[19.14.4.06,10]nonatriacontane-13-carboxylic acid	Investigative	44584916	C57H85N17O17S4	1408.7	CC(C)C[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC3=CC=C(C=C3)O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]4C[C@H](CN4C(=O)[C@@H](NC2=O)CC5=CN=CN5)O)C(=O)O)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CC(=O)N)N	IC50 = 199526.23 nM	Poor binder
T55959	Dopamine transporter	BX9E3U	2-(3,4-Dichlorophenyl)-N,N-diethylcyclopent-1-enecarboxamide	Investigative	44443877	C16H19Cl2NO	312.2	CCN(CC)C(=O)C1=C(CCC1)C2=CC(=C(C=C2)Cl)Cl	Ki = 94000 nM	Poor binder
T55959	Dopamine transporter	BY0ZG5	5-(Benzhydrylsulfinylmethyl)-2-methoxy-2,3-dihydro-1,3,4-thiadiazole	Investigative	137646374	C17H18N2O2S2	346.5	COC1NN=C(S1)CS(=O)C(C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 107600 nM	Poor binder