TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T56510	Apoptosis regulator Bcl-xL	D0U3EP	Resveratrol	Phase 3	445154	C14H12O3	228.24	C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O	IC50 = 190000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	D03YSQ	SAR-405838	Phase 1	11512578	C29H35Cl2FN4O3	577.5	CC(C)(C)C[C@@H]1[C@]2([C@H]([C@@H](N1)C(=O)NCCN3CCOCC3)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O	IC50 ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B0Z2AS	4-((E)-(((E)-2-(Cyclohexylimino)-4-methylthiazol-3(2h)-yl)imino)methyl)benzene-1,2,3-triol	Investigative	135691163	C17H21N3O3S	347.4	CC1=CSC(=NC2CCCCC2)N1/N=C/C3=C(C(=C(C=C3)O)O)O	IC50 ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B13PRT	(2S)-3-(4-Bromophenyl)-N-(4-chloro-3-nitrophenyl)sulfonyl-2-[(5Z)-5-[[4-(4-nitrophenyl)phenyl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanamide	Investigative	118728693	C31H20BrClN4O8S3	788.1	C1=CC(=CC=C1C[C@@H](C(=O)NS(=O)(=O)C2=CC(=C(C=C2)Cl)[N+](=O)[O-])N3C(=O)/C(=C/C4=CC=C(C=C4)C5=CC=C(C=C5)[N+](=O)[O-])/SC3=S)Br	Ki = 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B1D4OI	2-[3-[(Z)-[5-(2-Methoxyphenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2-ylidene]methyl]phenoxy]acetic acid	Investigative	46223561	C28H22N2O5S	498.6	COC1=CC=CC=C1C2C=C(N=C3N2C(=O)/C(=C/C4=CC(=CC=C4)OCC(=O)O)/S3)C5=CC=CC=C5	IC50 = 72000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B1M7XA	6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[(2-methylpropanoylamino)methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamide	Investigative	127033347	C37H41Cl2N5O5S	738.7	CC1=CC(=CC(=C1Cl)C)OCCCC2=C(NC3=C2C=CC(=C3C4=C(N(N=C4C)C)C)Cl)C(=O)NS(=O)(=O)C5=CC=CC(=C5)CNC(=O)C(C)C	Ki ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B1RIB8	(4R,4As,6aR,6aS,6bR,8aR,12aR,14bR)-2,2,6a,6b,9,9,12a-heptamethyl-4-(3-methylbut-2-enoyloxy)-10-oxo-3,4,5,6,6a,7,8,8a,11,12,13,14b-dodecahydro-1H-picene-4a-carboxylic acid	Investigative	45269863	C35H52O5	552.8	CC(=CC(=O)O[C@@H]1CC(C[C@H]2[C@]1(CC[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CCC(=O)C5(C)C)C)C)C)C(=O)O)(C)C)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B1RJ6W	6-[8-(1,3-Benzothiazol-2-ylcarbamoyl)imidazo[1,2-a]pyridin-2-yl]pyridine-2-carboxylic acid	Investigative	90644937	C21H13N5O3S	415.4	C1=CC=C2C(=C1)N=C(S2)NC(=O)C3=CC=CN4C3=NC(=C4)C5=NC(=CC=C5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B1TIE8	(1S,2S,3R,6R,7R,10S,11S,12S)-2-[3-(3,4-Dihydroxyphenyl)propyl]tetracyclo[8.2.1.03,12.06,11]trideca-4,8-diene-7-carboxylic acid	Investigative	90645497	C23H26O4	366.4	C1[C@H]2C=C[C@H]([C@H]3[C@@H]2[C@H]4[C@@H]1[C@@H]([C@H]4C=C3)CCCC5=CC(=C(C=C5)O)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B2FEW3	2-[3-[(Z)-[11-(2-Methoxyphenyl)-13-oxo-5-phenylmethoxy-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2(7),3,5,16-pentaen-14-ylidene]methyl]phenoxy]acetic acid	Investigative	46223328	C37H30N2O6S	630.7	COC1=CC=CC=C1C2C3=C(C4=C(CC3)C=C(C=C4)OCC5=CC=CC=C5)N=C6N2C(=O)/C(=C/C7=CC(=CC=C7)OCC(=O)O)/S6	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B2MSV9	1-(2-Ethoxyphenyl)-2-[3-methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)-4H-pyrazol-4-yl]ethane-1,2-dione	Investigative	118734789	C23H19N3O4S	433.5	CCOC1=CC=CC=C1C(=O)C(=O)C2C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B34SQW	2-[3-[4-(Dimethylamino)phenyl]-5-hydroxyphenyl]-4-[(2-ethoxyphenyl)diazenyl]-5-methyl-1H-pyrazol-3-one	Investigative	136934823	C26H27N5O3	457.5	CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=CC(=CC(=C3)C4=CC=C(C=C4)N(C)C)O)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B3LXJ5	N-[4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-(3-phenyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl)benzamide	Investigative	16109084	C38H42N6O6S2	742.9	CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCC5(CC4)CC(=NO5)C6=CC=CC=C6)[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B3PX0O	(1S,2S,3R,6R,7R,10S,11S,12S)-2-[3-(4-Hydroxyphenyl)propyl]tetracyclo[8.2.1.03,12.06,11]trideca-4,8-diene-7-carboxylic acid	Investigative	90645494	C23H26O3	350.4	C1[C@H]2C=C[C@H]([C@H]3[C@@H]2[C@H]4[C@@H]1[C@@H]([C@H]4C=C3)CCCC5=CC=C(C=C5)O)C(=O)O	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B46DLU	2-(3-((Z)-((E)-9-(3-Fluorobenzylidene)-5-(3-fluorophenyl)-3-oxo-3,5,6,7,8,9-hexahydro-2H-thiazolo[2,3-b]quinazolin-2-ylidene)methyl)-phenoxy)acetic Acid	Investigative	46223560	C32H24F2N2O4S	570.6	C1C/C(=C\\C2=CC(=CC=C2)F)/C3=C(C1)C(N4C(=O)/C(=C/C5=CC(=CC=C5)OCC(=O)O)/SC4=N3)C6=CC(=CC=C6)F	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B4P0AX	(2R,3R,3As,9bS)-N-((S)-1-benzylpyrrolidin-3-yl)-1-(cyclohexylmethyl)-3-(hydroxymethyl)-6-oxo-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide	Investigative	44574951	C30H40N4O3	504.7	C1CCC(CC1)CN2[C@H]3[C@H](CN4C3=CC=CC4=O)[C@H]([C@@H]2C(=O)N[C@H]5CCN(C5)CC6=CC=CC=C6)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B4VWZ9	1-O-[alpha-L-(Rhamnopyranosyl]-23-acetoxyimberbic acid 29-methyl ester	Investigative	45270689	C39H62O10	690.9	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@@H]([C@@]([C@H]3[C@]2([C@H]4CC=C5[C@H]6C[C@](CC[C@@]6(CC[C@]5([C@@]4(CC3)C)C)C)(C)C(=O)OC)C)(C)COC(=O)C)O)O)O)O	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B5DX7R	4-[2-(2-Ethoxyphenyl)acetyl]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-4H-pyrazol-3-one	Investigative	118734788	C23H21N3O3S	419.5	CCOC1=CC=CC=C1CC(=O)C2C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B6BND7	N-[5-(Benzylcarbamoyl)furan-2-yl]sulfonyl-6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamide	Investigative	127031601	C38H37Cl2N5O6S	762.7	CC1=CC(=CC(=C1Cl)C)OCCCC2=C(NC3=C2C=CC(=C3C4=C(N(N=C4C)C)C)Cl)C(=O)NS(=O)(=O)C5=CC=C(O5)C(=O)NCC6=CC=CC=C6	Ki ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B6JE8C	2-[3-[(Z)-[8-Methoxy-11-(2-methoxyphenyl)-13-oxo-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-14-ylidene]methyl]phenoxy]acetic acid	Investigative	46887075	C31H26N2O6S	554.6	COC1CC2=C(C3=CC=CC=C13)N=C4N(C2C5=CC=CC=C5OC)C(=O)/C(=C/C6=CC(=CC=C6)OCC(=O)O)/S4	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B6TNX7	5-Propan-2-yl-2-pyrrolidin-1-yl-7-(2-pyrrolidin-1-ylquinolin-3-yl)quinoline	Investigative	71455247	C29H32N4	436.6	CC(C)C1=C2C=CC(=NC2=CC(=C1)C3=CC4=CC=CC=C4N=C3N5CCCC5)N6CCCC6	EC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B6UL2W	2-[3-[(Z)-[11-(2-Methoxyphenyl)-13-oxo-5-(2-phenylbenzoyl)oxy-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2(7),3,5,16-pentaen-14-ylidene]methyl]phenoxy]acetic acid	Investigative	46223559	C43H32N2O7S	720.8	COC1=CC=CC=C1C2C3=C(C4=C(CC3)C=C(C=C4)OC(=O)C5=CC=CC=C5C6=CC=CC=C6)N=C7N2C(=O)/C(=C/C8=CC(=CC=C8)OCC(=O)O)/S7	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B74LGT	2-[4-[1-[2-[4-(Carboxymethylsulfanyl)-2-hydroxybenzoyl]-4,5-dichloro-1H-pyrrol-3-yl]-4,5-dichloropyrrole-2-carbonyl]-3-hydroxyphenyl]sulfanylacetic acid	Investigative	90316425	C26H16Cl4N2O8S2	690.4	C1=CC(=C(C=C1SCC(=O)O)O)C(=O)C2=CC(=C(N2C3=C(NC(=C3Cl)Cl)C(=O)C4=C(C=C(C=C4)SCC(=O)O)O)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B7BA1Y	23-Acetoxyimberbic acid 29-methyl ester	Investigative	45267264	C33H52O6	544.8	CC(=O)OC[C@]1([C@@H]2CC[C@@]3([C@@H]([C@]2([C@H](C[C@@H]1O)O)C)CC=C4[C@]3(CC[C@@]5([C@@H]4C[C@](CC5)(C)C(=O)OC)C)C)C)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B7BS4R	4-(2,2-Diphenylethylidene)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one	Investigative	90478312	C27H21N3OS	435.5	CC\\1=NN(C(=O)/C1=C/C(C2=CC=CC=C2)C3=CC=CC=C3)C4=NC(=CS4)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B85BSA	N-[4-[[(2S)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]benzamide	Investigative	11621908	C39H47N5O7S2	762	CN(C)CC[C@@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)C4=C(C=C(C=C4)CCCN5CCOCC5)OC)[N+](=O)[O-]	EC50 = 59200 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B8OQ4E	(2S,3S,3Ar,9bR)-2-(4-benzylpiperidine-1-carbonyl)-1-(3,4-dichlorobenzyl)-3-(hydroxymethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-a]indolizin-6(9bH)-one	Investigative	44251267	C31H33Cl2N3O3	566.5	C1CN(CCC1CC2=CC=CC=C2)C(=O)[C@@H]3[C@H]([C@@H]4CN5C(=O)C=CC=C5[C@@H]4N3CC6=CC(=C(C=C6)Cl)Cl)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B9GW0B	5-(4-Chlorophenyl)-1,2-dimethyl-N-[3-(4-methylpiperazin-1-yl)propyl]-4-phenylpyrrole-3-carboxamide	Investigative	60171063	C27H33ClN4O	465	CC1=C(C(=C(N1C)C2=CC=C(C=C2)Cl)C3=CC=CC=C3)C(=O)NCCCN4CCN(CC4)C	Ki = 88000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B9M2GB	2-[1-Hydroxy-4-(thiophen-2-ylsulfonylamino)naphthalen-2-yl]sulfanylacetic acid	Investigative	1582605	C16H13NO5S3	395.5	C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=CS3	Ki = 99000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	B9O0ZS	2-[3-(3-Aminophenyl)-5-hydroxyphenyl]-4-[(2-ethoxyphenyl)diazenyl]-5-methyl-1H-pyrazol-3-one	Investigative	136934827	C24H23N5O3	429.5	CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=CC(=CC(=C3)C4=CC(=CC=C4)N)O)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BA54QN	4-[(2-Ethoxyphenyl)diazenyl]-2-(3-hydroxy-5-thiophen-2-ylphenyl)-5-methyl-1H-pyrazol-3-one	Investigative	136934826	C22H20N4O3S	420.5	CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=CC(=CC(=C3)C4=CC=CS4)O)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BA7C1X	(S,Z)-2-(5-((6-(3,4-Dimethoxyphenyl)pyridin-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid	Investigative	44634480	C26H22N2O5S2	506.6	COC1=C(C=C(C=C1)C2=NC=C(C=C2)/C=C\\3/C(=O)N(C(=S)S3)[C@@H](CC4=CC=CC=C4)C(=O)O)OC	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BG57SP	4,4-Bis(4-chlorophenyl)-3-butenyldimethylamine	Investigative	44344017	C18H19Cl2N	320.3	CN(C)CCC=C(C1=CC=C(C=C1)Cl)C2=CC=C(C=C2)Cl	IC50 = 180000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BGJ78X	6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[3-[[(1-methylpyrrole-2-carbonyl)amino]methyl]phenyl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamide	Investigative	127033065	C39H40Cl2N6O5S	775.7	CC1=CC(=CC(=C1Cl)C)OCCCC2=C(NC3=C2C=CC(=C3C4=C(N(N=C4C)C)C)Cl)C(=O)NS(=O)(=O)C5=CC=CC(=C5)CNC(=O)C6=CC=CN6C	Ki ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BGQO54	4-[5-Propan-2-yl-7-(2-propoxyquinolin-3-yl)quinolin-2-yl]morpholine	Investigative	71455246	C28H31N3O2	441.6	CCCOC1=NC2=CC=CC=C2C=C1C3=CC(=C4C=CC(=NC4=C3)N5CCOCC5)C(C)C	EC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BGYO70	Piperazine analogue, 22	Investigative	16109117	C36H41N7O6S2	731.9	CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)C(=O)NC5=CC=CC=C5)[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BH9VL3	(2R,3R,3As,9bS)-1-(cyclohexylmethyl)-3-(hydroxymethyl)-6-oxo-N-(4-phenoxybenzyl)-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide	Investigative	44574954	C32H37N3O4	527.7	C1CCC(CC1)CN2[C@H]3[C@H](CN4C3=CC=CC4=O)[C@H]([C@@H]2C(=O)NCC5=CC=C(C=C5)OC6=CC=CC=C6)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BHI39R	(2S)-2-[(4S)-4-[[4-(4-Chlorophenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-N-(3-nitrophenyl)sulfonyl-3-phenylpropanamide	Investigative	122194476	C31H25ClN4O7S	633.1	C1=CC=C(C=C1)C[C@@H](C(=O)NS(=O)(=O)C2=CC=CC(=C2)[N+](=O)[O-])N3C(=O)[C@@H](NC3=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)Cl	Ki ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BHZ3D8	2-Hydroxy-3,4,6-trimethoxy-benzocyclohepten-5-one	Investigative	11470999	C14H14O5	262.26	COC1=CC=CC2=CC(=C(C(=C2C1=O)OC)OC)O	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BJ53DL	(2R,3R,3As,9bS)-1-(cyclohexylmethyl)-N-(2,3-dihydro-1H-inden-2-yl)-3-(hydroxymethyl)-6-oxo-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide	Investigative	44574952	C28H35N3O3	461.6	C1CCC(CC1)CN2[C@H]3[C@H](CN4C3=CC=CC4=O)[C@H]([C@@H]2C(=O)NC5CC6=CC=CC=C6C5)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BLX1P8	5-[(E)-(2-Cyclohexylimino-4-methyl-1,3-thiazol-3-yl)iminomethyl]benzene-1,2,3-triol	Investigative	136229638	C17H21N3O3S	347.4	CC1=CSC(=NC2CCCCC2)N1/N=C/C3=CC(=C(C(=C3)O)O)O	IC50 ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BMJI70	4-Phenoxy-N-(4-phenylphenyl)sulfonylbenzamide	Investigative	53473228	C25H19NO4S	429.5	C1=CC=C(C=C1)C2=CC=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)OC4=CC=CC=C4	IC50 = 161300 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BMR12K	(1S,9R,10R,11R)-12-[4-(4-Chlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-10-(hydroxymethyl)-N-(2-methoxyethyl)-6-oxo-7,12-diazatricyclo[7.2.1.02,7]dodeca-2,4-diene-11-carboxamide	Investigative	44574949	C30H29ClN4O4S	577.1	COCCNC(=O)[C@@H]1[C@H]([C@@H]2CN3C(=O)C=CC=C3[C@H]1N2C4=NC(=C(S4)C5=CC=CC=C5)C6=CC=C(C=C6)Cl)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BN3SZ4	1-O-[alpha-L-(Rhamnopyranosyl]-23-acetoxy-3beta-acetylimberbic acid 29-methyl ester	Investigative	45269862	C41H64O11	732.9	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@H]2C[C@@H]([C@@]([C@H]3[C@]2([C@H]4CC=C5[C@H]6C[C@](CC[C@@]6(CC[C@]5([C@@]4(CC3)C)C)C)(C)C(=O)OC)C)(C)COC(=O)C)OC(=O)C)O)O)O	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BNG6O5	4-[3-(5-Propan-2-yl-2-propoxyquinolin-7-yl)quinolin-2-yl]morpholine	Investigative	71455243	C28H31N3O2	441.6	CCCOC1=NC2=CC(=CC(=C2C=C1)C(C)C)C3=CC4=CC=CC=C4N=C3N5CCOCC5	EC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BNM5Y4	2-[3-[4-(Dimethylamino)phenyl]phenyl]-4-[(2-ethoxyphenyl)diazenyl]-5-methyl-1H-pyrazol-3-one	Investigative	136934829	C26H27N5O2	441.5	CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=CC=CC(=C3)C4=CC=C(C=C4)N(C)C)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BO0VS9	(E)-3-[(1S,2R,3S,4S,5S,7R,8R,9R)-4-[3-(4-Hydroxyphenyl)propyl]-8-tetracyclo[5.4.0.02,5.03,9]undec-10-enyl]prop-2-enoic acid	Investigative	90645499	C23H26O3	350.4	C1[C@H]2[C@@H]3C=C[C@H]([C@@H]2/C=C/C(=O)O)[C@H]4[C@@H]3[C@@H]1[C@@H]4CCCC5=CC=C(C=C5)O	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BO2B8K	4-[8-Ethylsulfanyl-3-(4-hydroxyphenyl)-3-methyloctan-4-yl]phenol	Investigative	44286285	C23H32O2S	372.6	CCC(C)(C1=CC=C(C=C1)O)C(CCCCSCC)C2=CC=C(C=C2)O	Ki = 58900 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BO35IS	Ethyl 2-[3-[(Z)-[11-(2-methoxyphenyl)-13-oxo-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-14-ylidene]methyl]phenoxy]acetate	Investigative	46222878	C32H28N2O5S	552.6	CCOC(=O)COC1=CC=CC(=C1)/C=C\\2/C(=O)N3C(C4=C(C5=CC=CC=C5CC4)N=C3S2)C6=CC=CC=C6OC	IC50 = 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BOS5G0	(R)-4-(4-(Dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide	Investigative	11502754	C18H24N4O4S2	424.5	CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)N)[N+](=O)[O-]	Ki = 75000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BP10JG	(1R,9S,10S,11S)-12-[4-(4-Chlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-10-(hydroxymethyl)-N-(2-methoxyethyl)-6-oxo-7,12-diazatricyclo[7.2.1.02,7]dodeca-2,4-diene-11-carboxamide	Investigative	44574950	C30H29ClN4O4S	577.1	COCCNC(=O)[C@H]1[C@@H]([C@H]2CN3C(=O)C=CC=C3[C@@H]1N2C4=NC(=C(S4)C5=CC=CC=C5)C6=CC=C(C=C6)Cl)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BP1AI8	2,3,4,6-Tetramethoxybenzo[7]annulen-5-one	Investigative	234873	C15H16O5	276.28	COC1=CC=CC2=CC(=C(C(=C2C1=O)OC)OC)OC	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BPBR38	4-[[(2R)-4-(Dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitro-N-phenylbenzenesulfonamide	Investigative	57523430	C24H28N4O4S2	500.6	CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC3=CC=CC=C3)[N+](=O)[O-]	Ki = 166000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BQ63LZ	3-[5-[(Z)-[11-(3-Fluorophenyl)-8-methoxy-13-oxo-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-14-ylidene]methyl]furan-2-yl]benzoic acid	Investigative	46887151	C33H23FN2O5S	578.6	COC1CC2=C(C3=CC=CC=C13)N=C4N(C2C5=CC(=CC=C5)F)C(=O)/C(=C/C6=CC=C(O6)C7=CC(=CC=C7)C(=O)O)/S4	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BR1IA2	Lantadene A	Investigative	6436598	C35H52O5	552.8	C/C=C(/C)\\C(=O)O[C@@H]1CC(C[C@@H]2[C@]1(CC[C@@]3(C2=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CCC(=O)C5(C)C)C)C)C)C(=O)O)(C)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BR3OJ0	4-(4-Chlorophenyl)-1-[(3s)-3,4-Dihydroxybutyl]-N-[3-(4-Methylpiperazin-1-Yl)propyl]-3-Phenyl-1h-Pyrrole-2-Carboxamide	Investigative	57339126	C29H37ClN4O3	525.1	CN1CCN(CC1)CCCNC(=O)C2=C(C(=CN2CC[C@@H](CO)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4	Ki = 138000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BRUP45	(E)-4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one	Investigative	3101542	C21H19N5O2S	405.5	CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BS5MH1	(2S)-2-[(4S)-4-[[4-(3-Methylphenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-methylphenyl)sulfonyl-3-phenylpropanamide	Investigative	122194478	C33H31N3O5S	581.7	CC1=CC=C(C=C1)S(=O)(=O)NC(=O)[C@H](CC2=CC=CC=C2)N3C(=O)[C@@H](NC3=O)CC4=CC=C(C=C4)C5=CC=CC(=C5)C	Ki ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BS6DA3	(2S,3S,3Ar,9bR)-2-(4-benzylpiperidine-1-carbonyl)-3-(hydroxymethyl)-1-(4-phenoxybenzyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-a]indolizin-6(9bH)-one	Investigative	44574956	C37H39N3O4	589.7	C1CN(CCC1CC2=CC=CC=C2)C(=O)[C@@H]3[C@H]([C@@H]4CN5C(=O)C=CC=C5[C@@H]4N3CC6=CC=C(C=C6)OC7=CC=CC=C7)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BSWN29	(2S,3S,3Ar,9bR)-1-(3,4-dichlorobenzyl)-2-(4-(4-fluorophenyl)piperidine-1-carbonyl)-3-(hydroxymethyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-a]indolizin-6(9bH)-one	Investigative	44574955	C30H30Cl2FN3O3	570.5	C1CN(CCC1C2=CC=C(C=C2)F)C(=O)[C@@H]3[C@H]([C@@H]4CN5C(=O)C=CC=C5[C@@H]4N3CC6=CC(=C(C=C6)Cl)Cl)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BTL8Y1	1-Epi-Meiogynin A	Investigative	45270488	C30H44O4	468.7	CC1=C[C@H]([C@]2(C=C[C@@H](C[C@H]2C1)[C@H](C)CCC=C(C)C)C(=O)O)/C=C(\\C)/C3CCC(CC3)C(=O)O	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BUE5J7	4-[(2-Ethoxyphenyl)diazenyl]-2-(3-hydroxy-5-phenylphenyl)-5-methyl-1H-pyrazol-3-one	Investigative	136934824	C24H22N4O3	414.5	CCOC1=CC=CC=C1N=NC2=C(NN(C2=O)C3=CC(=CC(=C3)C4=CC=CC=C4)O)C	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BUV5T0	(2R,3R,3As,9bS)-N-((R)-1-benzylpyrrolidin-3-yl)-1-(cyclohexylmethyl)-3-(hydroxymethyl)-6-oxo-2,3,3a,4,6,9b-hexahydro-1H-pyrrolo[2,3-a]indolizine-2-carboxamide	Investigative	44574953	C30H40N4O3	504.7	C1CCC(CC1)CN2[C@H]3[C@H](CN4C3=CC=CC4=O)[C@H]([C@@H]2C(=O)N[C@@H]5CCN(C5)CC6=CC=CC=C6)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BV68YU	(2S,3S,3Ar,9bR)-2-(4-(4-fluorophenyl)piperidine-1-carbonyl)-3-(hydroxymethyl)-1-(4-phenoxybenzyl)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,3-a]indolizin-6(9bH)-one	Investigative	44574957	C36H36FN3O4	593.7	C1CN(CCC1C2=CC=C(C=C2)F)C(=O)[C@@H]3[C@H]([C@@H]4CN5C(=O)C=CC=C5[C@@H]4N3CC6=CC=C(C=C6)OC7=CC=CC=C7)CO	Ki ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BV9TA1	2,3,8-Trihydroxy-9-oxo-9H-benzocycloheptene-6-carboxylic acid ethyl ester	Investigative	11471374	C14H12O6	276.24	CCOC(=O)C1=CC(=O)C(=C2C=C(C(=CC2=C1)O)O)O	IC50 = 73000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BX8SE1	6-Chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-N-[5-(pyridin-4-ylmethylcarbamoyl)furan-2-yl]sulfonyl-7-(1,3,5-trimethylpyrazol-4-yl)-1H-indole-2-carboxamide	Investigative	127031602	C37H36Cl2N6O6S	763.7	CC1=CC(=CC(=C1Cl)C)OCCCC2=C(NC3=C2C=CC(=C3C4=C(N(N=C4C)C)C)Cl)C(=O)NS(=O)(=O)C5=CC=C(O5)C(=O)NCC6=CC=NC=C6	Ki ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BY0O2K	(-)-Marinopyrrole A	Investigative	24797083	C22H12Cl4N2O4	510.1	C1=CC=C(C(=C1)C(=O)C2=CC(=C(N2C3=C(NC(=C3Cl)Cl)C(=O)C4=CC=CC=C4O)Cl)Cl)O	IC50 ~ 80000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BY7QT1	3-(5-((Z)-((E)-9-(3-Fluorobenzylidene)-5-(3-fluorophenyl)-3-oxo-3,5,6,7,8,9-hexahydro-2H-thiazolo[2,3-b]quinazolin-2-ylidene)methyl)-furan-2-yl)benzoic Acid	Investigative	46221796	C35H24F2N2O4S	606.6	C1C/C(=C\\C2=CC(=CC=C2)F)/C3=C(C1)C(N4C(=O)/C(=C/C5=CC=C(O5)C6=CC(=CC=C6)C(=O)O)/SC4=N3)C7=CC(=CC=C7)F	IC50 ~ 100000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BYV43K	(2S)-N-(4-Chloro-3-nitrophenyl)sulfonyl-2-[(4S)-4-[[4-(4-formylphenyl)phenyl]methyl]-2,5-dioxoimidazolidin-1-yl]-3-phenylpropanamide	Investigative	122194480	C32H25ClN4O8S	661.1	C1=CC=C(C=C1)C[C@@H](C(=O)NS(=O)(=O)C2=CC(=C(C=C2)Cl)[N+](=O)[O-])N3C(=O)[C@@H](NC3=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)C=O	Ki ~ 50000 nM	Poor binder
T56510	Apoptosis regulator Bcl-xL	BZU25S	3-[5-[(E)-N-Benzamido-C-methylcarbonimidoyl]furan-2-yl]benzoic acid	Investigative	71747665	C20H16N2O4	348.4	C/C(=N\\NC(=O)C1=CC=CC=C1)/C2=CC=C(O2)C3=CC(=CC=C3)C(=O)O	IC50 ~ 100000 nM	Poor binder