TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T62449	Checkpoint kinase-1	D0A5MC	MLN8054	Phase 1	11712649	C25H15ClF2N4O2	476.9	C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B02JTN	2-({5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl}amino)propan-1-ol	Investigative	11473431	C21H19N3O2	345.4	CC(CO)NC1=C2C(=C(OC2=NC=N1)C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B03DCY	(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-(2-methoxyethyl)-amine	Investigative	11473432	C21H19N3O2	345.4	COCCNC1=C2C(=C(OC2=NC=N1)C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B08TNX	2-[(E)-[2-(4-Chloro-3-nitrophenyl)imidazo[1,2-a]pyridin-3-yl]methylideneamino]guanidine;hydrochloride	Investigative	24205073	C15H13Cl2N7O2	394.2	C1=CC2=NC(=C(N2C=C1)/C=N/N=C(N)N)C3=CC(=C(C=C3)Cl)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B08UKS	3-Naphthalen-2-yl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine	Investigative	59662448	C22H17N5	351.4	C1=CC=C2C=C(C=CC2=C1)C3=C4N=C(C=CN4N=C3)NCC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B0T1JF	4-[6-[[(4-Hydroxycyclohexyl)amino]methyl]-1,4-dihydroindeno[1,2-c]pyrazol-3-yl]benzoic acid	Investigative	10341125	C24H25N3O3	403.5	C1CC(CCC1NCC2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C(=O)O)O	EC50 ~ 59000 nM	Poor binder
T62449	Checkpoint kinase-1	B0YRI3	(2R,4S)-Methyl 4-(2-o-tolylquinazolin-4-ylamino)pyrrolidine-2-carboxylate	Investigative	53323279	C21H22N4O2	362.4	CC1=CC=CC=C1C2=NC3=CC=CC=C3C(=N2)N[C@H]4C[C@@H](NC4)C(=O)OC	IC50 = 104000 nM	Poor binder
T62449	Checkpoint kinase-1	B14THE	2-[(Z)-[6-(4-Fluorophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57390270	C14H14ClFN6S	352.8	CC1=CN2C(=C(N=C2S1)C3=CC=C(C=C3)F)/C=N\\N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B19JDT	3-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)propanamide	Investigative	44427521	C33H33N5O4	563.6	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)C(=O)NC4=C(N3)C=CC(=C4)CCC(=O)NC5=CC=C(C=C5)N6CCOCC6)N	EC50 ~ 59300 nM	Poor binder
T62449	Checkpoint kinase-1	B19UQY	N-Cyclohexyl-2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)hexanamide	Investigative	44591072	C26H31N3O2S	449.6	CCCCC(C(=O)NC1CCCCC1)SC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B1A7XV	N-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]-4,5-dihydro-1H-imidazol-2-amine;hydrochloride	Investigative	57392058	C16H15Cl2N7O2S	440.3	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/NC4=NCCN4.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B1D7AU	2-[(E)-[2-(2,5-Dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride	Investigative	54771591	C19H18ClN7O4S	475.9	COC1=CC(=C(C=C1C2=C(N3C4=CC=CC=C4SC3=N2)/C=N/N=C(N)N)OC)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B1DH3E	2-[(E)-[2-Chloro-6-(4-fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770690	C13H11Cl2FN6S	373.2	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)F.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B1FZM6	9-(4-Amino-3-methoxyphenyl)-3-hydroxy-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one	Investigative	44427507	C20H17N3O3	347.4	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)C(=O)NC4=C(N3)C=CC(=C4)O)N	EC50 ~ 59300 nM	Poor binder
T62449	Checkpoint kinase-1	B1GEA4	2-[(E)-[2-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride	Investigative	54771589	C15H11Cl3N6S2	445.8	C1=CC=C2C(=C1)N3C(=C(N=C3S2)C4=C(SC(=C4)Cl)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B1IZD9	4-({5-[(4-Aminocyclohexyl)amino][1,2,4]triazolo[1,5-A]pyrimidin-7-YL}amino)benzenesulfonamide	Investigative	23645578	C17H22N8O2S	402.5	C1CC(CCC1N)NC2=NC3=NC=NN3C(=C2)NC4=CC=C(C=C4)S(=O)(=O)N	IC50 = 93000 nM	Poor binder
T62449	Checkpoint kinase-1	B1M7AS	2-(2,3-Dihydro-1-benzofuran-5-yl)-N-(2-morpholin-4-ylphenyl)-1,3-thiazole-4-carboxamide	Investigative	70681808	C22H21N3O3S	407.5	C1COC2=C1C=C(C=C2)C3=NC(=CS3)C(=O)NC4=CC=CC=C4N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B1MQO7	3-Phenyl-6-(1H-pyrrol-2-yl)imidazo[1,2-a]pyrazine	Investigative	49797841	C16H12N4	260.29	C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CC=CN4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B1QKM3	2-[(E)-[6-(4-Nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572662	C16H18ClN7O2S	407.9	CCCC1=CN2C(=C(N=C2S1)C3=CC=C(C=C3)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B1X5HG	3-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N,N-dimethylpropanamide	Investigative	44427520	C25H26N4O3	430.5	CN(C)C(=O)CCC1=CC2=C(C=C1)NC3=C(C=CC(=C3)C4=CC(=C(C=C4)N)OC)C(=O)N2	EC50 = 51900 nM	Poor binder
T62449	Checkpoint kinase-1	B1ZUY4	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572544	C13H10Cl3N7O2S	434.7	C1=CSC2=NC(=C(N21)/C=N/N=C(N)N)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B2JXC9	4-(6-(Morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid	Investigative	10407121	C22H21N3O3	375.4	C1COCCN1CC2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C(=O)O	EC50 ~ 59000 nM	Poor binder
T62449	Checkpoint kinase-1	B2TUZ0	5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one	Investigative	98614	C10H10N2OS	206.27	C1CCC2=C(C1)C3=C(S2)N=CNC3=O	IC50 = 52000 nM	Poor binder
T62449	Checkpoint kinase-1	B3A6CW	2-[(Z)-[2-Bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57393794	C13H11BrClN7O2S	444.7	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)Br)/C=N\\N=C(N)N)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B3GZ7U	6-(1H-Pyrazol-4-yl)-3-(pyridin-3-yl)imidazo[1,2-a]pyrimidine	Investigative	49797870	C14H10N6	262.27	C1=CC(=CN=C1)C2=CN=C3N2C=C(C=N3)C4=CNN=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B3IXZ4	2-[(Z)-[6-(4-Fluoro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395515	C13H11ClFN7O2S	383.79	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)[N+](=O)[O-])F.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B4AZF8	2-[(E)-[2-(4-Chloro-3-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-1-yl]methylideneamino]guanidine;hydrochloride	Investigative	24204557	C17H13Cl2N7O2S	450.3	C1=CC=C2C(=C1)N3C(=C(N=C3S2)C4=CC(=C(C=C4)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B4I5KM	2-[(Z)-[6-(4-Fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57395511	C13H12ClFN6S	338.79	C1=CC(=CC=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)F.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B4IGA3	2-(2,3-Dihydro-1-benzofuran-5-yl)-N-[2-(3-oxopiperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide	Investigative	70683916	C22H20N4O3S	420.5	C1COC2=C1C=C(C=C2)C3=NC(=CS3)C(=O)NC4=CC=CC=C4N5CCNC(=O)C5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B4KR8E	2-[(E)-[2-Methyl-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572534	C14H14ClN7O2S	379.8	CC1=CN2C(=C(N=C2S1)C3=CC=C(C=C3)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B5HPK8	3-((3-Bromo-5-(2-fluorophenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide	Investigative	10431917	C18H13BrFN5O	414.2	C1=CC=C(C(=C1)C2=NC3=C(C=NN3C(=C2)NCC4=C[N+](=CC=C4)[O-])Br)F	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B5NSE7	4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375865	C28H28N6O2S	512.6	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C)C#N	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B5XOM2	2-[(E)-[6-(2,5-Dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572735	C15H16ClN7O4S	425.9	COC1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N/N=C(N)N)OC)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B6IT1C	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-2-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide	Investigative	44427523	C34H35N5O4	577.7	CC(C)(C1=CC2=C(C=C1)NC(=O)C3=C(N2)C=C(C=C3)C4=CC(=C(C=C4)N)OC)C(=O)NC5=CC=C(C=C5)N6CCOCC6	EC50 ~ 59300 nM	Poor binder
T62449	Checkpoint kinase-1	B6LHM8	6-Bromoquinazolin-4-ol	Investigative	135444905	C8H5BrN2O	225.04	C1=CC2=C(C=C1Br)C(=O)NC=N2	Ki = 50118.72 nM	Poor binder
T62449	Checkpoint kinase-1	B6MYQ0	Ethyl 7-amino-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate	Investigative	53318089	C14H19N5O2	289.33	CCOC(=O)C1=C2N=C(C=C(N2N=C1)N)C3CCCNC3	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B7E2TN	6-N-(Piperidin-4-ylmethyl)-4-N-pyridin-3-ylpyrimidine-4,6-diamine	Investigative	56926362	C15H20N6	284.36	C1CNCCC1CNC2=CC(=NC=N2)NC3=CN=CC=C3	IC50 = 122000 nM	Poor binder
T62449	Checkpoint kinase-1	B7J9XO	2-(4-Chlorophenyl)-5-[(1-methylpiperidin-4-yl)amino]imidazo[1,2-c]pyrimidine-8-carboxamide	Investigative	71614492	C19H21ClN6O	384.9	CN1CCC(CC1)NC2=NC=C(C3=NC(=CN32)C4=CC=C(C=C4)Cl)C(=O)N	IC50 = 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B7JZ0Q	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572656	C16H17Cl2N7O2S	442.3	CCCC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B7R2DJ	2-Amino-1-[(E)-[6-(4-chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24800836	C14H14Cl2N8O2S	429.3	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/N/C(=N/N)/N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B7W2GM	4-(2,3-Dihydro-1-benzofuran-5-yl)-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-2-carboxamide	Investigative	70694424	C22H22N4O2S	406.5	C1COC2=C1C=C(C=C2)C3=CSC(=N3)C(=O)NC4=CC=CC=C4N5CCNCC5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B80EHZ	(3S,4R)-Ethyl 4-(2-(5-fluoro-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-3-carboxylate	Investigative	135921504	C21H21FN4O3	396.4	CCOC(=O)[C@H]1CNC[C@@H]1NC2=NC(=NC3=CC=CC=C32)C4=C(C=CC(=C4)F)O	IC50 = 56000 nM	Poor binder
T62449	Checkpoint kinase-1	B87KWG	3-(5-Fluoro-6-Iodo-1-Methyl-1h-Indol-3-Yl)-4-(7-Methoxy-1-Benzofuran-3-Yl)-1h-Pyrrole-2,5-Dione	Investigative	24825779	C22H14FIN2O4	516.299	CN1C=C(C2=CC(=C(C=C21)I)F)C3=C(C(=O)NC3=O)C4=COC5=C4C=CC=C5OC	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B8G5AX	6-(3-Bromophenoxy)-3-[(E)-2-phenylethenyl]-1H-indazole	Investigative	21877478	C21H15BrN2O	391.3	C1=CC=C(C=C1)/C=C/C2=NNC3=C2C=CC(=C3)OC4=CC(=CC=C4)Br	Ki = 82000 nM	Poor binder
T62449	Checkpoint kinase-1	B8LEY9	6-(1-Methyl-1H-pyrazol-4-yl)-3-phenylimidazo[1,2-a]pyrazine	Investigative	49797839	C16H13N5	275.31	CN1C=C(C=N1)C2=CN3C(=CN=C3C=N2)C4=CC=CC=C4	IC50 = 72000 nM	Poor binder
T62449	Checkpoint kinase-1	B8O5CG	2-(4-Chlorophenyl)-5-(piperidin-3-ylmethylamino)imidazo[1,2-c]pyrimidine-8-carboxamide	Investigative	71614493	C19H21ClN6O	384.9	C1CC(CNC1)CNC2=NC=C(C3=NC(=CN32)C4=CC=C(C=C4)Cl)C(=O)N	IC50 = 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B8WFR7	1-(2-(3-(3-Chlorophenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)-3-methylbutanoyl)piperidine-4-carboxamide	Investigative	44591077	C25H27ClN4O3S	499	CC(C)C(C(=O)N1CCC(CC1)C(=O)N)SC2=NC3=CC=CC=C3C(=O)N2C4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B8ZSQ5	3-Phenyl-6-(pyridin-3-yl)imidazo[1,2-a]pyrazine	Investigative	49797868	C17H12N4	272.3	C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CN=CC=C4	IC50 = 139000 nM	Poor binder
T62449	Checkpoint kinase-1	B90IMZ	N-Tert-butyl-2-(4-oxo-3-phenyl-3,4-dihydroquinazolin-2-ylthio)hexanamide	Investigative	44591032	C24H29N3O2S	423.6	CCCCC(C(=O)NC(C)(C)C)SC1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B91ESQ	3-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)benzamide	Investigative	49797915	C16H12N6O	304.31	C1=CC(=CC(=C1)C(=O)N)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B92CJQ	3-Phenyl-6-(pyridin-4-yl)imidazo[1,2-a]pyrazine	Investigative	49797869	C17H12N4	272.3	C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CC=NC=C4	IC50 = 52000 nM	Poor binder
T62449	Checkpoint kinase-1	B94QNP	2-[Benzyl(methyl)amino]-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-4-carboxamide	Investigative	24968112	C22H25N5OS	407.5	CN(CC1=CC=CC=C1)C2=NC(=CS2)C(=O)NC3=CC=CC=C3N4CCNCC4	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	B98YUW	6-(1H-Indol-3-yl)-3-phenylimidazo[1,2-a]pyrazine	Investigative	49797842	C20H14N4	310.4	C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CNC5=CC=CC=C54	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B9HCT8	3-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)aniline	Investigative	49797916	C15H12N6	276.3	C1=CC(=CC(=C1)N)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	B9QOR2	N-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)benzamide	Investigative	1417635	C25H17N3O2	391.4	C1=CC=C(C=C1)C2=C(OC3=NC=NC(=C23)NC(=O)C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BA62QX	4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	24766030	C24H21N5OS	427.5	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)/C=C/C(=O)N5CCCC5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BBK4Q7	4-(6-((4-Hydroxypiperidin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid	Investigative	10475450	C23H23N3O3	389.4	C1CN(CCC1O)CC2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C(=O)O	EC50 ~ 59000 nM	Poor binder
T62449	Checkpoint kinase-1	BC2TH3	9-Hydroxy-4-(3-piperidinyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	Investigative	11843431	C19H17N3O3	335.4	C1CC(CNC1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BCPQ71	N-(2-Aminoethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine	Investigative	11236121	C20H18N4O	330.4	C1=CC=C(C=C1)C2=C(OC3=NC=NC(=C23)NCCN)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BCR92F	5H-Dibenzo[b,e]azepine-6,11-dione	Investigative	70836	C14H9NO2	223.23	C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3NC2=O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BCYB54	2-[(E)-[6-(2,5-Dichlorothiophen-3-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24204555	C11H9Cl3N6S2	395.7	C1=CSC2=NC(=C(N21)/C=N/N=C(N)N)C3=C(SC(=C3)Cl)Cl.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BD3H1R	1-(2-(3-(3-Chlorophenyl)-5-methyl-4-oxo-3,4-dihydroquinazolin-2-ylthio)hexanoyl)piperidine-4-carboxamide	Investigative	44591082	C27H31ClN4O3S	527.1	CCCCC(C(=O)N1CCC(CC1)C(=O)N)SC2=NC3=CC=CC(=C3C(=O)N2C4=CC(=CC=C4)Cl)C	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BDJ35Q	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide	Investigative	44427519	C34H35N5O4	577.7	CC(C)(C1=CC2=C(C=C1)NC3=C(C=CC(=C3)C4=CC(=C(C=C4)N)OC)C(=O)N2)C(=O)NC5=CC=C(C=C5)N6CCOCC6	EC50 ~ 59300 nM	Poor binder
T62449	Checkpoint kinase-1	BDQP14	2-[(E)-[2-Chloro-6-(2,5-dichlorothiophen-3-yl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770686	C11H8Cl4N6S2	430.2	C1=C(SC(=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)Cl)Cl.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BDS73P	2-[(E)-[6-(4-Nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572239	C13H12ClN7O2S	365.8	C1=CC(=CC=C1C2=C(N3C=CSC3=N2)/C=N/N=C(N)N)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BEV60G	(3Z)-3-[(2,3-Dimethoxyphenyl)methylidene]-6-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-1H-indol-2-one	Investigative	23646833	C24H21NO5	403.4	COC1=CC=CC(=C1OC)/C=C\\2/C3=C(C=C(C=C3)C4=CC(=C(C=C4)O)OC)NC2=O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BEWX31	2-[(E)-(3-Methyl-6-pyridin-3-ylimidazo[2,1-b][1,3]thiazol-5-yl)methylideneamino]guanidine;hydrochloride	Investigative	24203624	C13H14ClN7S	335.82	CC1=CSC2=NC(=C(N12)/C=N/N=C(N)N)C3=CN=CC=C3.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BF67ZS	2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-2-phenyl-ethanol	Investigative	11304347	C26H21N3O2	407.5	C1=CC=C(C=C1)C2=C(OC3=NC=NC(=C23)NC(CO)C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BFE78D	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572658	C16H16Cl3N7O2S	476.8	CCCC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BFN1Q3	1-(3-Amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)piperidine-4-carboxylic acid	Investigative	49837568	C16H20N4O2S	332.4	CCC1=C(SC=C1)C2=CN=C(C(=N2)N3CCC(CC3)C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BFN3E1	2-[(E)-[6-(3-Nitrophenyl)-2-propylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572660	C16H18ClN7O2S	407.9	CCCC1=CN2C(=C(N=C2S1)C3=CC(=CC=C3)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BFP53Q	2-[(E)-[6-(3-Nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57402532	C13H12ClN7O2S	365.8	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(N3C=CSC3=N2)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BG16US	2-[(Z)-[6-(4-Bromo-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57394412	C13H11BrClN7O2S	444.7	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N\\N=C(N)N)[N+](=O)[O-])Br.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BG92IY	2-[(E)-[2-(2,5-Dimethoxy-4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl]methylideneamino]guanidine;hydrochloride	Investigative	54771821	C17H18ClN7O4	419.8	COC1=CC(=C(C=C1C2=C(N3C=CC=CC3=N2)/C=N/N=C(N)N)OC)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BGEI67	N-(1-Adamantyl)-2-(4-oxo-3-phenylquinazolin-2-yl)sulfanylhexanamide	Investigative	44591031	C30H35N3O2S	501.7	CCCCC(C(=O)NC12CC3CC(C1)CC(C3)C2)SC4=NC5=CC=CC=C5C(=O)N4C6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BH3I0T	2-[(E)-[2-Chloro-6-(4-fluoro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770692	C13H10Cl2FN7O2S	418.2	C1=CC(=C(C=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)[N+](=O)[O-])F.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BHN60Q	5,6-Diphenylfuro[2,3-d]pyrimidin-4-amine	Investigative	290208	C18H13N3O	287.3	C1=CC=C(C=C1)C2=C(OC3=NC=NC(=C23)N)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BHV1R9	2-(2,3-Dihydro-1-benzofuran-5-yl)-N-[2-(2-oxopiperazin-1-yl)phenyl]-1,3-thiazole-4-carboxamide	Investigative	70692362	C22H20N4O3S	420.5	C1COC2=C1C=C(C=C2)C3=NC(=CS3)C(=O)NC4=CC=CC=C4N5CCNCC5=O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BI2VA4	3-[4-(4-Hydroxyphenyl)phenyl]-N-(pyridin-4-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole-6-carboxamide	Investigative	136060555	C29H22N4O2	458.5	C1C2=C(C=CC(=C2)C(=O)NCC3=CC=NC=C3)C4=C1C(=NN4)C5=CC=C(C=C5)C6=CC=C(C=C6)O	EC50 ~ 59000 nM	Poor binder
T62449	Checkpoint kinase-1	BIR3H1	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	Investigative	135589980	C29H27N3O3	465.5	C1CC(CCC1NC(=O)C2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C6=CC=C(C=C6)O)O	EC50 ~ 59000 nM	Poor binder
T62449	Checkpoint kinase-1	BIUN82	4-(6-(Morpholinomethyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzamide	Investigative	10362050	C22H22N4O2	374.4	C1COCCN1CC2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C(=O)N	EC50 ~ 59000 nM	Poor binder
T62449	Checkpoint kinase-1	BJ28ZH	3-Phenyl-6-(1H-pyrazol-3-yl)imidazo[1,2-a]pyrazine	Investigative	49797815	C15H11N5	261.279	C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CC=NN4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BKJ67A	1-[3-Amino-6-(3,4,5-Trimethoxyphenyl)pyrazin-2-Yl]piperidine-4-Carboxylic Acid	Investigative	46926535	C19H24N4O5	388.4	COC1=CC(=CC(=C1OC)OC)C2=CN=C(C(=N2)N3CCC(CC3)C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BKOT36	9-Hydroxy-4-[2-(methylsulfanyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	Investigative	9976672	C21H14N2O3S	374.4	CSC1=CC=CC=C1C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BKU7P4	2-[(E)-[6-(4-Chloro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572243	C13H11Cl2N7O2S	400.2	C1=CC(=C(C=C1C2=C(N3C=CSC3=N2)/C=N/N=C(N)N)[N+](=O)[O-])Cl.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BKV4J0	(3Z)-5-(4-Hydroxy-3-methoxyphenyl)-3-(1H-indol-3-ylmethylidene)-2,3-dihydro-1H-indol-2-one	Investigative	23646830	C24H18N2O3	382.4	COC1=C(C=CC(=C1)C2=CC\\3=C(C=C2)NC(=O)/C3=C\\C4=CNC5=CC=CC=C54)O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BL0CE4	2-(4-Phenoxyphenyl)-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-4-carboxamide	Investigative	25095483	C26H24N4O2S	456.6	C1CN(CCN1)C2=CC=CC=C2NC(=O)C3=CSC(=N3)C4=CC=C(C=C4)OC5=CC=CC=C5	EC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BL8VQ3	3,5-Dimethyl-4-phenyl-1H-pyrazole	Investigative	2753118	C11H12N2	172.23	CC1=C(C(=NN1)C)C2=CC=CC=C2	Ki = 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BLD86E	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572532	C14H13Cl2N7O2S	414.3	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BM2E0V	2-[(E)-[2-Chloro-6-(4-chloro-3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572619	C13H10Cl3N7O2S	434.7	C1=CC(=C(C=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)[N+](=O)[O-])Cl.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BNU8F1	2-[(E)-[2-Chloro-6-(4-cyanophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	54770914	C14H11Cl2N7S	380.3	C1=CC(=CC=C1C#N)C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BO9I8T	2-[(E)-[2-Chloro-6-(3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57393797	C13H11Cl2N7O2S	400.2	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BOIH08	4-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)benzamide	Investigative	49797896	C16H12N6O	304.31	C1=CC(=CC=C1C2=CN=C3N2C=C(N=C3)C4=CNN=C4)C(=O)N	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BP04US	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-3-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572536	C14H13Cl2N7O2S	414.3	CC1=CSC2=NC(=C(N12)/C=N/N=C(N)N)C3=CC(=C(C=C3)Cl)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BP3JW0	2-[(E)-[6-(4-Chloro-3-nitrophenyl)-2,3-dimethylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572546	C15H15Cl2N7O2S	428.3	CC1=C(SC2=NC(=C(N12)/C=N/N=C(N)N)C3=CC(=C(C=C3)Cl)[N+](=O)[O-])C.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BPYZ34	N-Benzyl-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine	Investigative	1596636	C25H19N3O	377.4	C1=CC=C(C=C1)CNC2=C3C(=C(OC3=NC=N2)C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BQ9Y5W	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide	Investigative	44427518	C32H31N5O4	549.6	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)C(=O)NC4=C(N3)C=CC(=C4)CC(=O)NC5=CC=C(C=C5)N6CCOCC6)N	EC50 ~ 59300 nM	Poor binder
T62449	Checkpoint kinase-1	BQC56B	(4-(6-(1H-Pyrazol-4-yl)imidazo[1,2-a]pyrazin-3-yl)phenyl)methanol	Investigative	49797918	C16H13N5O	291.31	C1=CC(=CC=C1CO)C2=CN=C3N2C=C(N=C3)C4=CNN=C4	IC50 = 96000 nM	Poor binder
T62449	Checkpoint kinase-1	BR06PL	2-[(E)-[6-(4-Aminophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57393796	C13H14ClN7S	335.82	C1=CC(=CC=C1C2=C(N3C=CSC3=N2)/C=N/N=C(N)N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BR5WO0	4-(6-(((1r,4r)-4-Hydroxycyclohexyl)carbamoyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid	Investigative	44428993	C24H23N3O4	417.5	C1CC(CCC1NC(=O)C2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C(=O)O)O	EC50 ~ 59000 nM	Poor binder
T62449	Checkpoint kinase-1	BRH13F	2-[(E)-(2,3-Dimethyl-6-pyridin-3-ylimidazo[2,1-b][1,3]thiazol-5-yl)methylideneamino]guanidine;hydrochloride	Investigative	24203147	C14H16ClN7S	349.8	CC1=C(SC2=NC(=C(N12)/C=N/N=C(N)N)C3=CN=CC=C3)C.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BSV1B6	9-Hydroxy-4-[2-(methylsulfinyl)phenyl]pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione	Investigative	11843143	C21H14N2O4S	390.4	CS(=O)C1=CC=CC=C1C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BTDZ39	2-[(E)-[6-(2,4-Dichloro-5-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572623	C14H12Cl3N7O2S	448.7	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3Cl)Cl)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BU14LA	3-(4-Phenoxyphenyl)-6-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrimidine	Investigative	49797892	C21H15N5O	353.4	C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=CN=C4N3C=C(C=N4)C5=CNN=C5	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BUMF04	2-[(E)-[2-Chloro-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572530	C13H11Cl2N7O2S	400.2	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)Cl)/C=N/N=C(N)N)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BV06WI	11-Hydroxy-5,11-dihydro-dibenzo[b,e]azepin-6-one	Investigative	11107024	C14H11NO2	225.24	C1=CC=C2C(=C1)C(C3=CC=CC=C3NC2=O)O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BV16YJ	11,11-Dioxo-5H-benzo[b][1,4]benzothiazepin-6-one	Investigative	13000374	C13H9NO3S	259.279	C1=CC=C2C(=C1)C(=O)NC3=CC=CC=C3S2(=O)=O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BV7BI3	3-Phenyl-6-(pyridin-2-yl)imidazo[1,2-a]pyrazine	Investigative	49797843	C17H12N4	272.3	C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C4=CC=CC=N4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BVKC03	2-[(E)-[2-Methyl-6-(3-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	9572625	C14H14ClN7O2S	379.8	CC1=CN2C(=C(N=C2S1)C3=CC(=CC=C3)[N+](=O)[O-])/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BWON32	3-[(5,6-Diphenylfuro[2,3-d]pyrimidin-4-yl)amino]propan-1-ol	Investigative	1583275	C21H19N3O2	345.4	C1=CC=C(C=C1)C2=C(OC3=NC=NC(=C23)NCCCO)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BX25RW	2-[(E)-[6-(2,5-Dichlorothiophen-3-yl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	24204553	C12H11Cl3N6S2	409.7	CC1=CN2C(=C(N=C2S1)C3=C(SC(=C3)Cl)Cl)/C=N/N=C(N)N.Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BX5DU3	9-(4-Amino-3-methoxyphenyl)-3-methoxy-5,11-dihydrobenzo[b][1,4]benzodiazepin-6-one	Investigative	44427508	C21H19N3O3	361.4	COC1=CC2=C(C=C1)NC3=C(C=CC(=C3)C4=CC(=C(C=C4)N)OC)C(=O)N2	EC50 ~ 59300 nM	Poor binder
T62449	Checkpoint kinase-1	BX6T4C	(3Z)-3-[(2,3-Dimethoxyphenyl)methylidene]-5-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-1H-indol-2-one	Investigative	23646832	C24H21NO5	403.4	COC1=CC=CC(=C1OC)/C=C\\2/C3=C(C=CC(=C3)C4=CC(=C(C=C4)O)OC)NC2=O	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BXC10G	5-[(4-Aminocyclohexyl)amino]-2-(4-chlorophenyl)imidazo[1,2-c]pyrimidine-8-carboxamide	Investigative	71614291	C19H21ClN6O	384.9	C1CC(CCC1N)NC2=NC=C(C3=NC(=CN32)C4=CC=C(C=C4)Cl)C(=O)N	IC50 = 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BYIV86	3,9-Dimethyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one	Investigative	136104490	C12H11N3O	213.23	CC1=C2C(=CC=C1)NC(=O)C3=C(NN=C23)C	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BZ3U6M	5-(Piperidin-3-yl)-3-(thiazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine	Investigative	53317703	C14H16N6S	300.38	C1CC(CNC1)C2=NC3=C(C=NN3C(=C2)N)C4=CSC=N4	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BZ59CX	2-[4-[(Dimethylamino)methyl]phenyl]-N-(2-piperazin-1-ylphenyl)-1,3-thiazole-4-carboxamide	Investigative	70688175	C23H27N5OS	421.6	CN(C)CC1=CC=C(C=C1)C2=NC(=CS2)C(=O)NC3=CC=CC=C3N4CCNCC4	IC50 ~ 50000 nM	Poor binder
T62449	Checkpoint kinase-1	BZB36F	1,3-Bis[(E)-[2-chloro-6-(2,5-dimethoxy-4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	135580407	C29H24Cl3N11O8S2	825.1	COC1=CC(=C(C=C1C2=C(N3C(=N2)SC(=C3)Cl)/C=N/NC(=N)N/N=C/C4=C(N=C5N4C=C(S5)Cl)C6=CC(=C(C=C6OC)[N+](=O)[O-])OC)OC)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BZR1I9	2-[(Z)-[2-Fluoro-6-(4-nitrophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57397343	C13H11ClFN7O2S	383.79	C1=CC(=CC=C1C2=C(N3C=C(SC3=N2)F)/C=N\\N=C(N)N)[N+](=O)[O-].Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	BZS41V	2-[(Z)-[6-(4-Fluoro-3-nitrophenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride	Investigative	57390272	C14H13ClFN7O2S	397.8	CC1=CN2C(=C(N=C2S1)C3=CC(=C(C=C3)F)[N+](=O)[O-])/C=N\\N=C(N)N.Cl	IC50 = 78500 nM	Poor binder
T62449	Checkpoint kinase-1	BZX1T6	1-(2-(3-(4-Chlorophenyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)hexanoyl)piperidine-4-carboxamide	Investigative	44591081	C26H29ClN4O3S	513.1	CCCCC(C(=O)N1CCC(CC1)C(=O)N)SC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	D0K0UJ	PMID20936789C31	Investigative	49837564	C21H28N4O5	416.5	C[C@H]1[C@H](N(CC[C@H]1C(=O)O)C2=NC(=CN=C2N)C3=CC(=C(C(=C3)OC)OC)OC)C	IC50 ~ 100000 nM	Poor binder
T62449	Checkpoint kinase-1	D0W7TU	NSC-73306	Investigative	947057	C16H14N4O2S	326.4	.	IC50 ~ 50000 nM	Poor binder