TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T63414	P2X purinoceptor 7	D0H2UB	Suramin	Phase 1	5361	C51H40N6O23S6	1297.3	CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C	EC50 = 92000 nM	Poor binder
T63414	P2X purinoceptor 7	B0Y6ML	Isoquinoline-5-sulfonic acid 4-[[3-[1-[3-(trifluoromethyl)-4-chlorobenzoyl]-4-piperidinyl]-2,5-dioxoimidazolidine-4-yl]methyl]phenyl ester	Investigative	118733194	C32H26ClF3N4O6S	687.1	C1CN(CCC1N2C(C(=O)NC2=O)CC3=CC=C(C=C3)OS(=O)(=O)C4=CC=CC5=C4C=CN=C5)C(=O)C6=CC(=C(C=C6)Cl)C(F)(F)F	IC50 = 54000 nM	Poor binder
T63414	P2X purinoceptor 7	B34JCU	N'-(2-Chlorophenyl)pentacyclo[6.4.0.02,10.03,7.04,9]dodeca-5,11-diene-8-carbohydrazide	Investigative	137652085	C19H17ClN2O	324.8	C1=CC=C(C(=C1)NNC(=O)C23C4C=CC5C4C6C2C=CC6C35)Cl	IC50 = 96000 nM	Poor binder
T63414	P2X purinoceptor 7	B4CWQ3	Bz-ATP	Investigative	44353592	C23H24N5O14P3	687.4	C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)O[C@@H]3[C@@H]([C@H](O[C@H]3N4C=NC5=C(N=CN=C54)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O	EC50 = 52000 nM	Poor binder
T63414	P2X purinoceptor 7	B5MU4A	Benzo[b][1]benzazepin-11-yl(piperidin-1-yl)methanone	Investigative	746996	C20H20N2O	304.4	C1CCN(CC1)C(=O)N2C3=CC=CC=C3C=CC4=CC=CC=C42	IC50 ~ 100000 nM	Poor binder
T63414	P2X purinoceptor 7	B92XJM	N,N-Diisopropyl-5H-dibenzo[b,f]azepine-5-carboxamide	Investigative	73669299	C21H24N2O	320.4	CC(C)N(C(C)C)C(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31	IC50 = 95200 nM	Poor binder
T63414	P2X purinoceptor 7	BF86KR	N'-[2-(Trifluoromethyl)phenyl]pentacyclo[6.4.0.02,10.03,7.04,9]dodeca-5,11-diene-8-carbohydrazide	Investigative	137650645	C20H17F3N2O	358.4	C1=CC=C(C(=C1)C(F)(F)F)NNC(=O)C23C4C=CC5C4C6C2C=CC6C35	IC50 = 132000 nM	Poor binder
T63414	P2X purinoceptor 7	BG3WF2	Dibenzo[b,f]azepin-5-yl pyrrolidinyl ketone	Investigative	779113	C19H18N2O	290.4	C1CCN(C1)C(=O)N2C3=CC=CC=C3C=CC4=CC=CC=C42	IC50 ~ 100000 nM	Poor binder
T63414	P2X purinoceptor 7	BL1JX8	N,N-Diethylbenzo[b][1]benzazepine-11-carboxamide	Investigative	766793	C19H20N2O	292.4	CCN(CC)C(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31	IC50 = 69800 nM	Poor binder
T63414	P2X purinoceptor 7	BMI50L	(S)-4-(2-(N-Methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate	Investigative	5312126	C38H35N5O6S2	721.8	CN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7	IC50 = 96000 nM	Poor binder
T63414	P2X purinoceptor 7	BUNY96	N,N-Dipropylbenzo[b][1]benzazepine-11-carboxamide	Investigative	76324694	C21H24N2O	320.4	CCCN(CCC)C(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31	IC50 ~ 100000 nM	Poor binder
T63414	P2X purinoceptor 7	D00QLM	[3H]alphabeta-meATP	Investigative	91557	C11H18N5O12P3	505.21	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(CP(=O)(O)OP(=O)(O)O)O)O)O)N	EC50 ~ 100000 nM	Poor binder
T63414	P2X purinoceptor 7	D08DOG	A-846714	Investigative	25130235	C16H18N6	294.35	CN1CCN(CC1)C2=NC(=NC(=C2)C3=CC=C(C=C3)C#N)N	IC50 ~ 100000 nM	Poor binder